JP2003519686A5 - - Google Patents
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- Publication number
- JP2003519686A5 JP2003519686A5 JP2001551852A JP2001551852A JP2003519686A5 JP 2003519686 A5 JP2003519686 A5 JP 2003519686A5 JP 2001551852 A JP2001551852 A JP 2001551852A JP 2001551852 A JP2001551852 A JP 2001551852A JP 2003519686 A5 JP2003519686 A5 JP 2003519686A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- hydrogen
- phenyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229910052739 hydrogen Inorganic materials 0.000 description 19
- 239000001257 hydrogen Substances 0.000 description 19
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 13
- -1 1-4C-alkyl Chemical group 0.000 description 10
- 150000001204 N-oxides Chemical class 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 8
- 229910052736 halogen Inorganic materials 0.000 description 8
- 150000002367 halogens Chemical group 0.000 description 8
- 150000002431 hydrogen Chemical group 0.000 description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- 125000001424 substituent group Chemical group 0.000 description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- BIVMWDQSMDXTCT-RYUDHWBXSA-N (1s,2s)-2-(3,4-dimethoxyphenyl)cyclohexan-1-amine Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1[C@@H](N)CCCC1 BIVMWDQSMDXTCT-RYUDHWBXSA-N 0.000 description 1
- 0 CC(C(C)(*)C(*)(C(*)C1N=C(*)c2cc(*)c(*)cc22)O*)C12N Chemical compound CC(C(C)(*)C(*)(C(*)C1N=C(*)c2cc(*)c(*)cc22)O*)C12N 0.000 description 1
- 208000018569 Respiratory Tract disease Diseases 0.000 description 1
- 125000001624 naphthyl group Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00100482 | 2000-01-11 | ||
| EP00100482.9 | 2000-01-11 | ||
| PCT/EP2001/000223 WO2001051470A1 (en) | 2000-01-11 | 2001-01-10 | Phenanthridine-n-oxides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519686A JP2003519686A (ja) | 2003-06-24 |
| JP2003519686A5 true JP2003519686A5 (enExample) | 2008-02-28 |
Family
ID=8167598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001551852A Withdrawn JP2003519686A (ja) | 2000-01-11 | 2001-01-10 | フェナントリジン−ｎ−オキシド |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6630483B2 (enExample) |
| EP (1) | EP1250325B1 (enExample) |
| JP (1) | JP2003519686A (enExample) |
| AT (1) | ATE394378T1 (enExample) |
| AU (1) | AU782908B2 (enExample) |
| CA (1) | CA2396026A1 (enExample) |
| DE (1) | DE60133879D1 (enExample) |
| WO (1) | WO2001051470A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1303506T3 (da) | 2000-07-14 | 2005-05-30 | Altana Pharma Ag | 6-heteroarylphenanthridiner |
| AU2003255493B8 (en) * | 2002-08-29 | 2009-03-26 | Takeda Gmbh | 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors |
| US7423046B2 (en) * | 2002-08-29 | 2008-09-09 | Nycomed Gmbh | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| EP2589599B1 (en) | 2004-03-03 | 2014-06-25 | Takeda GmbH | Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors |
| EP2295423B1 (en) | 2005-03-02 | 2013-10-02 | Takeda GmbH | Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives |
| JP4643543B2 (ja) * | 2006-11-10 | 2011-03-02 | 株式会社東芝 | キャッシュ一貫性保証機能を有するストレージクラスタシステム |
| WO2009043784A1 (en) | 2007-10-04 | 2009-04-09 | F. Hoffmann-La Roche Ag | Cyclopropyl aryl amide derivatives and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4761403A (en) | 1986-04-09 | 1988-08-02 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
| KR100454781B1 (ko) | 1996-01-31 | 2005-04-08 | 알타나 파마 아게 | 신규한페난트리딘 |
| EP0889886B1 (de) * | 1996-03-26 | 2002-09-18 | ALTANA Pharma AG | Neue in 6-position substituierte phenanthridine |
| US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| US6121279A (en) | 1997-07-25 | 2000-09-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituted 6-phenylphenanthridines |
| CZ293725B6 (cs) | 1997-07-25 | 2004-07-14 | Altana Pharma Ag | Tetrazolové deriváty |
| SI1075477T1 (en) | 1998-05-05 | 2003-08-31 | Altana Pharma Ag | Novel Benzonaphthyridine-N-oxides |
| AU5970199A (en) | 1998-08-31 | 2000-03-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity |
| EP1147087B1 (en) | 1999-01-15 | 2005-05-11 | ALTANA Pharma AG | Phenanthridine-n-oxides with pde-iv inhibiting activity |
| ES2241571T3 (es) | 1999-01-15 | 2005-11-01 | Altana Pharma Ag | N-oxidos de fenantrinida con actividad inhividora de pde-iv. |
-
2001
- 2001-01-10 US US10/149,965 patent/US6630483B2/en not_active Expired - Fee Related
- 2001-01-10 EP EP01909597A patent/EP1250325B1/en not_active Expired - Lifetime
- 2001-01-10 JP JP2001551852A patent/JP2003519686A/ja not_active Withdrawn
- 2001-01-10 WO PCT/EP2001/000223 patent/WO2001051470A1/en not_active Ceased
- 2001-01-10 CA CA002396026A patent/CA2396026A1/en not_active Abandoned
- 2001-01-10 DE DE60133879T patent/DE60133879D1/de not_active Expired - Fee Related
- 2001-01-10 AT AT01909597T patent/ATE394378T1/de not_active IP Right Cessation
- 2001-01-10 AU AU37283/01A patent/AU782908B2/en not_active Ceased
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