NO20064220L - Nye heterocyklylsubstituerte hydroksy-6-fenylfenantridiner og deres anvendelse som PDE4-inhibitorer - Google Patents

Nye heterocyklylsubstituerte hydroksy-6-fenylfenantridiner og deres anvendelse som PDE4-inhibitorer

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Publication number
NO20064220L
NO20064220L NO20064220A NO20064220A NO20064220L NO 20064220 L NO20064220 L NO 20064220L NO 20064220 A NO20064220 A NO 20064220A NO 20064220 A NO20064220 A NO 20064220A NO 20064220 L NO20064220 L NO 20064220L
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Norway
Prior art keywords
alkyl
alkoxy
hydrogen
phenylphenanthridines
substituted
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NO20064220A
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English (en)
Inventor
Armin Hatzelmann
Dieter Flockerzi
Beate Schmidt
Johannes Barsig
Degenhard Marx
Ulrich Kautz
Christof Zitt
Hans-Peter Kley
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Nycomed Gmbh
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Publication of NO20064220L publication Critical patent/NO20064220L/no

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    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
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    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Forbindelser med formel (I), hvor R1 er hydroksyl, 1-4C-alkoksy, 3-7C-cykloalkoksy, 3-7C-cykloalkylmetoksy, 2,2-difluoretoksy, eller fullstendig eller overveiende fluorsubstituert 1-4C-alkoksy, R2 er hydroksyl, 1-4C-alkoksy, 3-7C-cykloalkoksy, 3-7C-cykloalkylmetoksy, 2,2-difluoretoksy, eller fullstendig eller overveiende fluorsubstituert 1-4C-alkoksy, eller hvor R1 og R2 sammen er en 1-2C-alkylendioksygruppe, R3 er hydrogen eller 1 4C-alkyl, R31 er hydrogen eller 1-4C-alkyl, enten, i en første utførelsesform (utførelsesform a) ifølge den foreliggende oppfinnelse, er R4 -O-R41, hvor R41 er hydrogen, 1-4C-alkyl, 1-4C-alkoksy-1-4C-alkyl, hydroksy-2-4C-alkyl, 1-7C-alkylkarbonyl, eller fullstendig eller overveiende fluorsubstituert 1-4C-alkyl, og R5 er hydrogen eller 1-4C-alkyl, eller, i en andre utførelsesform (utførelsesform b) ifølge den foreliggende oppfinnelse, er R4 hydrogen eller 1~4C-alkyl, og R5 er -O-R51, hvor R51 er hydrogen, 1-4C-alkyl, 1-4C-alkoksy-1-4C-alkyl, hydroksy-2-4C-alkyl, 1-7C-alkylkarbonyl, eller fullstendig eller overveiende fluorsubstituert 1-4C-alkyl, R6 er hydrogen, halogen, 1-4C-alkyl eller 1-4C-alkoksy, R7 er Het1, Het2, Har1, Het3 eller Har2
NO20064220A 2004-03-03 2006-09-18 Nye heterocyklylsubstituerte hydroksy-6-fenylfenantridiner og deres anvendelse som PDE4-inhibitorer NO20064220L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04005005 2004-03-03
EP04106372 2004-12-07
PCT/EP2005/050946 WO2005090311A1 (en) 2004-03-03 2005-03-03 Novel heterocyclyl-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors

Publications (1)

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NO20064220L true NO20064220L (no) 2006-09-18

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US (1) US20070191413A1 (no)
EP (1) EP1812400A1 (no)
JP (1) JP2007526284A (no)
KR (1) KR20060130684A (no)
AR (1) AR049419A1 (no)
AU (1) AU2005223370A1 (no)
BR (1) BRPI0508256A (no)
CA (1) CA2557730A1 (no)
IL (1) IL177301A0 (no)
NO (1) NO20064220L (no)
NZ (1) NZ549109A (no)
TW (1) TW200540157A (no)
WO (1) WO2005090311A1 (no)

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ATE348616T1 (de) * 2002-08-29 2007-01-15 Altana Pharma Ag 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer
DE60311662T2 (de) 2002-08-29 2007-10-25 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
JP4728259B2 (ja) 2004-02-18 2011-07-20 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 効果的なホスホジエステラーゼ（ｐｄｅ）４インヒビターとしての新規のグアニジニル置換されたヒドロキシ−６−フェニルフェナントリジン
KR101152488B1 (ko) 2004-03-03 2012-07-02 니코메드 게엠베하 신규 히드록시-6-헤테로아릴페난트리딘 및 ｐｄｅ4 억제제로서의 이의 용도
WO2005087745A1 (en) * 2004-03-10 2005-09-22 Altana Pharma Ag Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
SI1856093T1 (sl) 2005-03-02 2010-03-31 Nycomed Gmbh Hidrokloridna sol R aR bR dimetoksipiridin il etoksi metoksi a b heksahidrofenantridin ola
MX2010003155A (es) 2007-10-04 2010-04-01 Hoffmann La Roche Derivados de ciclopropil aril amida y uso de los mismos.

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Publication number Publication date
BRPI0508256A (pt) 2007-07-31
TW200540157A (en) 2005-12-16
CA2557730A1 (en) 2005-09-29
WO2005090311A8 (en) 2006-10-26
EP1812400A1 (en) 2007-08-01
NZ549109A (en) 2010-05-28
AU2005223370A1 (en) 2005-09-29
KR20060130684A (ko) 2006-12-19
JP2007526284A (ja) 2007-09-13
US20070191413A1 (en) 2007-08-16
AR049419A1 (es) 2006-08-02
WO2005090311A1 (en) 2005-09-29
IL177301A0 (en) 2006-12-10

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