NO20064220L - Nye heterocyklylsubstituerte hydroksy-6-fenylfenantridiner og deres anvendelse som PDE4-inhibitorer - Google Patents

Nye heterocyklylsubstituerte hydroksy-6-fenylfenantridiner og deres anvendelse som PDE4-inhibitorer

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Publication number
NO20064220L
NO20064220L NO20064220A NO20064220A NO20064220L NO 20064220 L NO20064220 L NO 20064220L NO 20064220 A NO20064220 A NO 20064220A NO 20064220 A NO20064220 A NO 20064220A NO 20064220 L NO20064220 L NO 20064220L
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Norway
Prior art keywords
alkyl
alkoxy
hydrogen
phenylphenanthridines
substituted
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NO20064220A
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English (en)
Inventor
Armin Hatzelmann
Dieter Flockerzi
Beate Schmidt
Johannes Barsig
Degenhard Marx
Ulrich Kautz
Christof Zitt
Hans-Peter Kley
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Nycomed Gmbh
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Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh
Publication of NO20064220L publication Critical patent/NO20064220L/no

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    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
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  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Forbindelser med formel (I), hvor R1 er hydroksyl, 1-4C-alkoksy, 3-7C-cykloalkoksy, 3-7C-cykloalkylmetoksy, 2,2-difluoretoksy, eller fullstendig eller overveiende fluorsubstituert 1-4C-alkoksy, R2 er hydroksyl, 1-4C-alkoksy, 3-7C-cykloalkoksy, 3-7C-cykloalkylmetoksy, 2,2-difluoretoksy, eller fullstendig eller overveiende fluorsubstituert 1-4C-alkoksy, eller hvor R1 og R2 sammen er en 1-2C-alkylendioksygruppe, R3 er hydrogen eller 1 4C-alkyl, R31 er hydrogen eller 1-4C-alkyl, enten, i en første utførelsesform (utførelsesform a) ifølge den foreliggende oppfinnelse, er R4 -O-R41, hvor R41 er hydrogen, 1-4C-alkyl, 1-4C-alkoksy-1-4C-alkyl, hydroksy-2-4C-alkyl, 1-7C-alkylkarbonyl, eller fullstendig eller overveiende fluorsubstituert 1-4C-alkyl, og R5 er hydrogen eller 1-4C-alkyl, eller, i en andre utførelsesform (utførelsesform b) ifølge den foreliggende oppfinnelse, er R4 hydrogen eller 1~4C-alkyl, og R5 er -O-R51, hvor R51 er hydrogen, 1-4C-alkyl, 1-4C-alkoksy-1-4C-alkyl, hydroksy-2-4C-alkyl, 1-7C-alkylkarbonyl, eller fullstendig eller overveiende fluorsubstituert 1-4C-alkyl, R6 er hydrogen, halogen, 1-4C-alkyl eller 1-4C-alkoksy, R7 er Het1, Het2, Har1, Het3 eller Har2
NO20064220A 2004-03-03 2006-09-18 Nye heterocyklylsubstituerte hydroksy-6-fenylfenantridiner og deres anvendelse som PDE4-inhibitorer NO20064220L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04005005 2004-03-03
EP04106372 2004-12-07
PCT/EP2005/050946 WO2005090311A1 (en) 2004-03-03 2005-03-03 Novel heterocyclyl-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors

Publications (1)

Publication Number Publication Date
NO20064220L true NO20064220L (no) 2006-09-18

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NO20064220A NO20064220L (no) 2004-03-03 2006-09-18 Nye heterocyklylsubstituerte hydroksy-6-fenylfenantridiner og deres anvendelse som PDE4-inhibitorer

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Country Link
US (1) US20070191413A1 (no)
EP (1) EP1812400A1 (no)
JP (1) JP2007526284A (no)
KR (1) KR20060130684A (no)
AR (1) AR049419A1 (no)
AU (1) AU2005223370A1 (no)
BR (1) BRPI0508256A (no)
CA (1) CA2557730A1 (no)
IL (1) IL177301A0 (no)
NO (1) NO20064220L (no)
NZ (1) NZ549109A (no)
TW (1) TW200540157A (no)
WO (1) WO2005090311A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2279215T3 (es) * 2002-08-29 2007-08-16 Altana Pharma Ag 2-hidroxi-6-fenilfenantridinas como inhibidores de pde-4.
CA2496459C (en) 2002-08-29 2013-06-25 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
ES2400823T3 (es) 2004-02-18 2013-04-12 Takeda Gmbh Nuevas hidroxi-6-fenilfenantridinas sustituidas con guanidinilo como inhibidores eficaces de fosfodiesterasa (PDE) 4
CN104803974A (zh) 2004-03-03 2015-07-29 塔科达有限责任公司 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途
KR20060130697A (ko) * 2004-03-10 2006-12-19 알타나 파마 아게 신규한 아미도-치환 히드록시-6-페닐페난트리딘 및 ｐｄｅ4억제제로서의 이의 용도
KR101421914B1 (ko) 2005-03-02 2014-07-22 다케다 게엠베하 6-헤테로시클릴 치환된 헥사히드로페난트리딘 유도체의 신규한 염
MX2010003155A (es) 2007-10-04 2010-04-01 Hoffmann La Roche Derivados de ciclopropil aril amida y uso de los mismos.

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EP1812400A1 (en) 2007-08-01
TW200540157A (en) 2005-12-16
AR049419A1 (es) 2006-08-02
WO2005090311A1 (en) 2005-09-29
NZ549109A (en) 2010-05-28
IL177301A0 (en) 2006-12-10
BRPI0508256A (pt) 2007-07-31
CA2557730A1 (en) 2005-09-29
US20070191413A1 (en) 2007-08-16
AU2005223370A1 (en) 2005-09-29
WO2005090311A8 (en) 2006-10-26
KR20060130684A (ko) 2006-12-19
JP2007526284A (ja) 2007-09-13

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