NO20064220L - Nye heterocyklylsubstituerte hydroksy-6-fenylfenantridiner og deres anvendelse som PDE4-inhibitorer - Google Patents

Nye heterocyklylsubstituerte hydroksy-6-fenylfenantridiner og deres anvendelse som PDE4-inhibitorer

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Publication number
NO20064220L
NO20064220L NO20064220A NO20064220A NO20064220L NO 20064220 L NO20064220 L NO 20064220L NO 20064220 A NO20064220 A NO 20064220A NO 20064220 A NO20064220 A NO 20064220A NO 20064220 L NO20064220 L NO 20064220L
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Prior art keywords
alkyl
alkoxy
hydrogen
phenylphenanthridines
substituted
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NO20064220A
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English (en)
Inventor
Armin Hatzelmann
Dieter Flockerzi
Beate Schmidt
Johannes Barsig
Degenhard Marx
Ulrich Kautz
Christof Zitt
Hans-Peter Kley
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Nycomed Gmbh
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Publication of NO20064220L publication Critical patent/NO20064220L/no

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    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Forbindelser med formel (I), hvor R1 er hydroksyl, 1-4C-alkoksy, 3-7C-cykloalkoksy, 3-7C-cykloalkylmetoksy, 2,2-difluoretoksy, eller fullstendig eller overveiende fluorsubstituert 1-4C-alkoksy, R2 er hydroksyl, 1-4C-alkoksy, 3-7C-cykloalkoksy, 3-7C-cykloalkylmetoksy, 2,2-difluoretoksy, eller fullstendig eller overveiende fluorsubstituert 1-4C-alkoksy, eller hvor R1 og R2 sammen er en 1-2C-alkylendioksygruppe, R3 er hydrogen eller 1 4C-alkyl, R31 er hydrogen eller 1-4C-alkyl, enten, i en første utførelsesform (utførelsesform a) ifølge den foreliggende oppfinnelse, er R4 -O-R41, hvor R41 er hydrogen, 1-4C-alkyl, 1-4C-alkoksy-1-4C-alkyl, hydroksy-2-4C-alkyl, 1-7C-alkylkarbonyl, eller fullstendig eller overveiende fluorsubstituert 1-4C-alkyl, og R5 er hydrogen eller 1-4C-alkyl, eller, i en andre utførelsesform (utførelsesform b) ifølge den foreliggende oppfinnelse, er R4 hydrogen eller 1~4C-alkyl, og R5 er -O-R51, hvor R51 er hydrogen, 1-4C-alkyl, 1-4C-alkoksy-1-4C-alkyl, hydroksy-2-4C-alkyl, 1-7C-alkylkarbonyl, eller fullstendig eller overveiende fluorsubstituert 1-4C-alkyl, R6 er hydrogen, halogen, 1-4C-alkyl eller 1-4C-alkoksy, R7 er Het1, Het2, Har1, Het3 eller Har2
NO20064220A 2004-03-03 2006-09-18 Nye heterocyklylsubstituerte hydroksy-6-fenylfenantridiner og deres anvendelse som PDE4-inhibitorer NO20064220L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04005005 2004-03-03
EP04106372 2004-12-07
PCT/EP2005/050946 WO2005090311A1 (en) 2004-03-03 2005-03-03 Novel heterocyclyl-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors

Publications (1)

Publication Number Publication Date
NO20064220L true NO20064220L (no) 2006-09-18

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Country Link
US (1) US20070191413A1 (no)
EP (1) EP1812400A1 (no)
JP (1) JP2007526284A (no)
KR (1) KR20060130684A (no)
AR (1) AR049419A1 (no)
AU (1) AU2005223370A1 (no)
BR (1) BRPI0508256A (no)
CA (1) CA2557730A1 (no)
IL (1) IL177301A0 (no)
NO (1) NO20064220L (no)
NZ (1) NZ549109A (no)
TW (1) TW200540157A (no)
WO (1) WO2005090311A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2496459C (en) 2002-08-29 2013-06-25 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
AU2003255493B8 (en) * 2002-08-29 2009-03-26 Takeda Gmbh 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors
EP1720835B1 (en) 2004-02-18 2012-12-12 Nycomed GmbH Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (pde) 4 inhibitors
PL2589599T4 (pl) 2004-03-03 2015-06-30 Takeda Gmbh Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4
MXPA06009892A (es) * 2004-03-10 2007-03-01 Altana Pharma Ag Nuevas hidroxi-6-fenilfenantridinas sustituidas con amido y su uso como inhibidores de la fosfodiesterasa tipo 4 (pde4).
ES2337083T3 (es) 2005-03-02 2010-04-20 Nycomed Gmbh (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-exoti-8-metoxi-1,2,3,4,4a,10b-hexahidrofenantridin-2-ol, sal de hc1.
KR101178674B1 (ko) 2007-10-04 2012-08-30 에프. 호프만-라 로슈 아게 사이클로프로필 아릴 아마이드 유도체 및 이의 용도

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2149767T5 (es) * 1991-09-20 2005-06-16 Glaxo Group Limited Nuevo uso medico para antagonistas de taquiquininas.
EE03523B1 (et) * 1996-01-31 2001-10-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine
US6127378A (en) * 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
DK0937074T3 (da) * 1996-11-11 2003-06-23 Altana Pharma Ag Benzonaphthyridiner som bronkiale terapeutiske midler
AU753615B2 (en) * 1997-07-25 2002-10-24 Altana Pharma Ag Novel tetrazole derivatives
PT1000035E (pt) * 1997-07-25 2003-04-30 Altana Pharma Ag 6-fenilfenantridinas substituidas
PT1000034E (pt) * 1997-07-25 2003-02-28 Altana Pharma Ag 6-alquilfenantridinas substituidas
CA2330738A1 (en) * 1998-05-05 1999-11-11 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel n-oxides of benzonaphthyridines
EP1147103B1 (en) * 1999-01-15 2005-05-04 ALTANA Pharma AG Phenantrhridine-n-oxides with pde-iv inhibiting activity
EE05105B1 (et) * 1999-01-15 2008-12-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Fenlfenantridiinid, nende kasutamine ravimite valmistamiseks ning neid sisaldav ravim
AU2107700A (en) * 1999-01-15 2000-08-01 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides with pde-iv inhibiting activity
SI1303506T1 (en) * 2000-07-14 2005-06-30 Altana Pharma Ag 6-heteroarylphenanthridines
US6936622B2 (en) * 2001-02-21 2005-08-30 Altana Pharma Ag 6-phenylbenzonaphthyridines
CA2495597A1 (en) * 2002-08-17 2004-03-04 Altana Pharma Ag Novel phenanthridines
CA2496459C (en) * 2002-08-29 2013-06-25 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
AU2003255493B8 (en) * 2002-08-29 2009-03-26 Takeda Gmbh 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors
AU2003277069A1 (en) * 2002-09-30 2004-04-23 Ciphergen Biosystems, Inc. Apparatus and method for expression and capture of biomolecules and complexes on adsorbent surfaces
EP1720835B1 (en) * 2004-02-18 2012-12-12 Nycomed GmbH Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (pde) 4 inhibitors
AU2005220034A1 (en) * 2004-03-09 2005-09-15 Nycomed Gmbh Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
MXPA06009892A (es) * 2004-03-10 2007-03-01 Altana Pharma Ag Nuevas hidroxi-6-fenilfenantridinas sustituidas con amido y su uso como inhibidores de la fosfodiesterasa tipo 4 (pde4).
BRPI0508471A8 (pt) * 2004-03-10 2019-01-15 Altana Pharma Ag compostos de hidróxi-6-fenilfenantidinas substituídas por difluoroetóxi, composição farmacêutica e uso para a produção dos mesmos
CA2558390A1 (en) * 2004-03-10 2005-09-22 Altana Pharma Ag Novel thio-containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
WO2006082185A1 (en) * 2005-02-01 2006-08-10 Nycomed Gmbh Novel 6-pyridylphenanthridines
EP1856092A1 (en) * 2005-03-02 2007-11-21 Nycomed GmbH 6-heteroaryl-1,2,3,4,4a,10b-hexahydro-phenanthridines as pde-4 inhibitors for the treatment of inflammatory disorders
AU2006221957A1 (en) * 2005-03-09 2006-09-14 Nycomed Gmbh Amido-substituted 6-phenylphenanthridines
US20070154916A1 (en) * 2005-11-04 2007-07-05 Johji Inazawa Method for detecting cancer and a method for suppressing cancer

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Publication number Publication date
JP2007526284A (ja) 2007-09-13
IL177301A0 (en) 2006-12-10
BRPI0508256A (pt) 2007-07-31
NZ549109A (en) 2010-05-28
AU2005223370A1 (en) 2005-09-29
CA2557730A1 (en) 2005-09-29
TW200540157A (en) 2005-12-16
WO2005090311A1 (en) 2005-09-29
US20070191413A1 (en) 2007-08-16
EP1812400A1 (en) 2007-08-01
WO2005090311A8 (en) 2006-10-26
KR20060130684A (ko) 2006-12-19
AR049419A1 (es) 2006-08-02

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