NO20054289L - Imiciazo[4,5-b]kinolinderivater og dem anvendelse som NO-syntaseinhibitorer - Google Patents
Imiciazo[4,5-b]kinolinderivater og dem anvendelse som NO-syntaseinhibitorerInfo
- Publication number
- NO20054289L NO20054289L NO20054289A NO20054289A NO20054289L NO 20054289 L NO20054289 L NO 20054289L NO 20054289 A NO20054289 A NO 20054289A NO 20054289 A NO20054289 A NO 20054289A NO 20054289 L NO20054289 L NO 20054289L
- Authority
- NO
- Norway
- Prior art keywords
- alkoxy
- alkyl
- phenyl
- het
- substituted
- Prior art date
Links
- 102000008299 Nitric Oxide Synthase Human genes 0.000 title 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- -1 aminosulphonyl Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
1. Forbindelser med formel I R2 (1) Rl er l-4C-alkoksy; A er l-4C-alkylen; R2 er hydrogen; halogen; hydroksyl; nitro; amino; 1-7C-alkyl; trifluormetyl; 3-7C-cykloalkyl; 3-7C-cykloalkyl-l-4C-alkyl; l-4C-alkoksy; fullstendig eller overveiende flu-orsubstituert l-4C-alkoksy; l-4C-alkoksy-l-4C-alkyl; 1-4C-alkoksy-l-4C-alkoksy; mono- eller di-l-4C-alkylaminokarbo-nyl; mono- eller di-l-4C-alkylaminosulfonyl; l-4C-alkylkar-bonylamino; l-4C-alkylsulfonylamino; fenyl; fenyl-l-4C-al-kyl; fenyl-l-4C-alkoksy; R21- og/eller R22-substituert fenyl; fenyl-l-4C-alkyl hvori fenylenheten er substituert med R23; Het; R24-substituert Het; Het-l-4C-alkyl; Het-l-4C-al-kyl hvori Het-enheten er substituert med R25; hvor R21 er cyano; halogen; karboksyl; l-4C-alkyl; l-4C-alkoksy; hydroksy-l-4C-alkyl; l-4C-alkoksy-l-4C-alkyl; 3-7C-cykloal-koksy; 3-7C-cykloalkylmetoksy; fullstendig eller overveiende fluorsubstituert l-4C-alkoksy; aminokarbonyl; mono-eller di-l-4C-alkylaminokarbonyl; l-4C-alkylkarbonylamino; l-4C-alkoksykarbonyl; aminosulfonyl; mono- eller di-l-4C-alkylaminosulfonyl; amino; trifluormetyl; hydroksyl; fenyl-sulfonylamino; eller fenyl-l-4C-alkoksy; R22 er halogen; l-4C-alkyl; eller l-4C-alkoksy; eller hvori R21 og R22 sammen er en l-2C-alkylendioksy-gruppe;
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03004102 | 2003-02-25 | ||
| PCT/EP2004/050201 WO2004076451A1 (en) | 2003-02-25 | 2004-02-24 | Imidazo[4,5-b]quinoline-derivatives and their use as no-synthase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20054289L true NO20054289L (no) | 2005-09-16 |
| NO20054289D0 NO20054289D0 (no) | 2005-09-16 |
Family
ID=32921577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20054289A NO20054289D0 (no) | 2003-02-25 | 2005-09-16 | Imiciazo[4,5-b]kinolinderivater og dem anvendelse som NO-syntaseinhibitorer |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7390819B2 (no) |
| EP (1) | EP1599473B1 (no) |
| JP (1) | JP2006518724A (no) |
| KR (1) | KR20050107433A (no) |
| CN (1) | CN1751043A (no) |
| AT (1) | ATE340175T1 (no) |
| AU (1) | AU2004215664A1 (no) |
| BR (1) | BRPI0407573A (no) |
| CA (1) | CA2516522A1 (no) |
| DE (1) | DE602004002464T2 (no) |
| ES (1) | ES2273225T3 (no) |
| HR (1) | HRP20050799A8 (no) |
| IS (1) | IS8034A (no) |
| MX (1) | MXPA05008839A (no) |
| NO (1) | NO20054289D0 (no) |
| PL (1) | PL377613A1 (no) |
| RS (1) | RS20050627A (no) |
| WO (1) | WO2004076451A1 (no) |
| ZA (1) | ZA200505725B (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2328626T3 (es) * | 2005-03-31 | 2009-11-16 | Nycomed Gmbh | Derivados de imidazopiridina utiles como inhibidores de inos. |
| WO2008031788A1 (en) * | 2006-09-12 | 2008-03-20 | Nycomed Gmbh | Aminoazepine derivatives as highly efficient inhibitors of the inducible nitric oxide synthase |
| US8969349B2 (en) | 2010-05-26 | 2015-03-03 | Sunovion Pharmaceuticals Inc. | Substituted quinoxalines and quinoxalinones as PDE-10 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4045564A (en) * | 1974-02-18 | 1977-08-30 | Ab Hassle | Benzimidazole derivatives useful as gastric acid secretion inhibitors |
| SE418966B (sv) | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
| ES8401486A1 (es) * | 1981-11-10 | 1983-12-01 | Wellcome Found | Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina. |
| GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| ES2187775T3 (es) | 1996-05-15 | 2003-06-16 | Altana Pharma Ag | Imidazopiridinas. |
-
2004
- 2004-02-24 US US10/546,198 patent/US7390819B2/en not_active Expired - Fee Related
- 2004-02-24 CA CA002516522A patent/CA2516522A1/en not_active Abandoned
- 2004-02-24 BR BRPI0407573-0A patent/BRPI0407573A/pt not_active IP Right Cessation
- 2004-02-24 CN CNA2004800044466A patent/CN1751043A/zh active Pending
- 2004-02-24 KR KR1020057015245A patent/KR20050107433A/ko not_active Application Discontinuation
- 2004-02-24 ES ES04713907T patent/ES2273225T3/es not_active Expired - Lifetime
- 2004-02-24 JP JP2006502048A patent/JP2006518724A/ja not_active Withdrawn
- 2004-02-24 PL PL377613A patent/PL377613A1/pl not_active Application Discontinuation
- 2004-02-24 RS YUP-2005/0627A patent/RS20050627A/sr unknown
- 2004-02-24 MX MXPA05008839A patent/MXPA05008839A/es active IP Right Grant
- 2004-02-24 DE DE602004002464T patent/DE602004002464T2/de not_active Expired - Fee Related
- 2004-02-24 AU AU2004215664A patent/AU2004215664A1/en not_active Abandoned
- 2004-02-24 AT AT04713907T patent/ATE340175T1/de not_active IP Right Cessation
- 2004-02-24 WO PCT/EP2004/050201 patent/WO2004076451A1/en active IP Right Grant
- 2004-02-24 EP EP04713907A patent/EP1599473B1/en not_active Expired - Lifetime
-
2005
- 2005-07-18 ZA ZA200507525A patent/ZA200505725B/en unknown
- 2005-09-12 HR HR20050799A patent/HRP20050799A8/xx not_active Application Discontinuation
- 2005-09-16 IS IS8034A patent/IS8034A/is unknown
- 2005-09-16 NO NO20054289A patent/NO20054289D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0407573A (pt) | 2006-02-14 |
| ZA200505725B (en) | 2006-05-31 |
| ES2273225T3 (es) | 2007-05-01 |
| RS20050627A (en) | 2007-09-21 |
| PL377613A1 (pl) | 2006-02-06 |
| NO20054289D0 (no) | 2005-09-16 |
| WO2004076451A1 (en) | 2004-09-10 |
| MXPA05008839A (es) | 2005-10-05 |
| KR20050107433A (ko) | 2005-11-11 |
| HRP20050799A2 (en) | 2006-11-30 |
| US7390819B2 (en) | 2008-06-24 |
| EP1599473B1 (en) | 2006-09-20 |
| DE602004002464D1 (de) | 2006-11-02 |
| EP1599473A1 (en) | 2005-11-30 |
| ATE340175T1 (de) | 2006-10-15 |
| HRP20050799A8 (en) | 2007-10-31 |
| IS8034A (is) | 2005-09-16 |
| US20060160839A1 (en) | 2006-07-20 |
| CA2516522A1 (en) | 2004-09-10 |
| DE602004002464T2 (de) | 2007-10-04 |
| CN1751043A (zh) | 2006-03-22 |
| AU2004215664A1 (en) | 2004-09-10 |
| JP2006518724A (ja) | 2006-08-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CREP | Change of representative |
Representative=s name: PLOUGMANN & VINGTOFT, POSTBOKS 1003 SENTRUM, 0104 |
|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |