DE60133879D1 - Phenanthridin -n- oxide - Google Patents

Phenanthridin -n- oxide

Info

Publication number
DE60133879D1
DE60133879D1 DE60133879T DE60133879T DE60133879D1 DE 60133879 D1 DE60133879 D1 DE 60133879D1 DE 60133879 T DE60133879 T DE 60133879T DE 60133879 T DE60133879 T DE 60133879T DE 60133879 D1 DE60133879 D1 DE 60133879D1
Authority
DE
Germany
Prior art keywords
alkoxy
substituted
phenanthridine
oxide
cycloalkylmethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60133879T
Other languages
German (de)
English (en)
Inventor
Dieter Flockerzi
Gerhard Grundler
Armin Hatzelmann
Daniela Bundschuh
Hans-Peter Kley
Beate Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Nycomed GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed GmbH filed Critical Nycomed GmbH
Application granted granted Critical
Publication of DE60133879D1 publication Critical patent/DE60133879D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
DE60133879T 2000-01-11 2001-01-10 Phenanthridin -n- oxide Expired - Fee Related DE60133879D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00100482 2000-01-11
PCT/EP2001/000223 WO2001051470A1 (en) 2000-01-11 2001-01-10 Phenanthridine-n-oxides

Publications (1)

Publication Number Publication Date
DE60133879D1 true DE60133879D1 (de) 2008-06-19

Family

ID=8167598

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60133879T Expired - Fee Related DE60133879D1 (de) 2000-01-11 2001-01-10 Phenanthridin -n- oxide

Country Status (8)

Country Link
US (1) US6630483B2 (enExample)
EP (1) EP1250325B1 (enExample)
JP (1) JP2003519686A (enExample)
AT (1) ATE394378T1 (enExample)
AU (1) AU782908B2 (enExample)
CA (1) CA2396026A1 (enExample)
DE (1) DE60133879D1 (enExample)
WO (1) WO2001051470A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1303506T3 (da) 2000-07-14 2005-05-30 Altana Pharma Ag 6-heteroarylphenanthridiner
AU2003255493B8 (en) * 2002-08-29 2009-03-26 Takeda Gmbh 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors
US7423046B2 (en) * 2002-08-29 2008-09-09 Nycomed Gmbh 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
EP2589599B1 (en) 2004-03-03 2014-06-25 Takeda GmbH Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors
EP2295423B1 (en) 2005-03-02 2013-10-02 Takeda GmbH Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
JP4643543B2 (ja) * 2006-11-10 2011-03-02 株式会社東芝 キャッシュ一貫性保証機能を有するストレージクラスタシステム
WO2009043784A1 (en) 2007-10-04 2009-04-09 F. Hoffmann-La Roche Ag Cyclopropyl aryl amide derivatives and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761403A (en) 1986-04-09 1988-08-02 Abbott Laboratories Lipoxygenase inhibiting compounds
KR100454781B1 (ko) 1996-01-31 2005-04-08 알타나 파마 아게 신규한페난트리딘
EP0889886B1 (de) * 1996-03-26 2002-09-18 ALTANA Pharma AG Neue in 6-position substituierte phenanthridine
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
US6121279A (en) 1997-07-25 2000-09-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituted 6-phenylphenanthridines
CZ293725B6 (cs) 1997-07-25 2004-07-14 Altana Pharma Ag Tetrazolové deriváty
SI1075477T1 (en) 1998-05-05 2003-08-31 Altana Pharma Ag Novel Benzonaphthyridine-N-oxides
AU5970199A (en) 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity
EP1147087B1 (en) 1999-01-15 2005-05-11 ALTANA Pharma AG Phenanthridine-n-oxides with pde-iv inhibiting activity
ES2241571T3 (es) 1999-01-15 2005-11-01 Altana Pharma Ag N-oxidos de fenantrinida con actividad inhividora de pde-iv.

Also Published As

Publication number Publication date
EP1250325B1 (en) 2008-05-07
CA2396026A1 (en) 2001-07-19
AU3728301A (en) 2001-07-24
ATE394378T1 (de) 2008-05-15
US6630483B2 (en) 2003-10-07
US20030105123A1 (en) 2003-06-05
JP2003519686A (ja) 2003-06-24
EP1250325A1 (en) 2002-10-23
WO2001051470A1 (en) 2001-07-19
AU782908B2 (en) 2005-09-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee