JP2002534062A - Chlamydiatrachomatis抗原 - Google Patents
Chlamydiatrachomatis抗原Info
- Publication number
- JP2002534062A JP2002534062A JP2000589563A JP2000589563A JP2002534062A JP 2002534062 A JP2002534062 A JP 2002534062A JP 2000589563 A JP2000589563 A JP 2000589563A JP 2000589563 A JP2000589563 A JP 2000589563A JP 2002534062 A JP2002534062 A JP 2002534062A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- nucleic acid
- antibody
- chlamydia
- detecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- Animal Behavior & Ethology (AREA)
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| GB9828000.1 | 1998-12-18 | ||
| PCT/IB1999/002065 WO2000037494A2 (en) | 1998-12-18 | 1999-12-17 | Chlamydia trachomatis antigens |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2010113606A Division JP2010220622A (ja) | 1998-12-18 | 2010-05-17 | Chlamydiatrachomatis抗原 |
Publications (2)
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| JP2002534062A true JP2002534062A (ja) | 2002-10-15 |
| JP2002534062A5 JP2002534062A5 (enExample) | 2007-02-08 |
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| JP2010113606A Pending JP2010220622A (ja) | 1998-12-18 | 2010-05-17 | Chlamydiatrachomatis抗原 |
Family Applications After (1)
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| JP2010113606A Pending JP2010220622A (ja) | 1998-12-18 | 2010-05-17 | Chlamydiatrachomatis抗原 |
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| EP (3) | EP1857464B1 (enExample) |
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| DE (1) | DE69937004T2 (enExample) |
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| ES (1) | ES2292261T3 (enExample) |
| GB (1) | GB9828000D0 (enExample) |
| PT (1) | PT1140997E (enExample) |
| WO (1) | WO2000037494A2 (enExample) |
Families Citing this family (94)
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| DE69737413T2 (de) | 1996-01-04 | 2007-10-31 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Bakterioferritin aus helicobacter pylori |
| US6686339B1 (en) | 1998-08-20 | 2004-02-03 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia |
| CA2340330A1 (en) | 1998-08-20 | 2000-03-02 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein c of chlamydia |
| CA2340283A1 (en) | 1998-08-20 | 2000-03-02 | Aventis Pasteur Limited | Nucleic acid molecules encoding pomp91a protein of chlamydia |
| US6649370B1 (en) | 1998-10-28 | 2003-11-18 | Aventis Pasteur Limited | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| US6607730B1 (en) | 1998-11-02 | 2003-08-19 | Aventis Pasteur Limited/Aventis Pasteur Limitee | Chlamydia antigens and corresponding DNA fragments and uses thereof |
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| US20020061848A1 (en) | 2000-07-20 | 2002-05-23 | Ajay Bhatia | Compounds and methods for treatment and diagnosis of chlamydial infection |
| IL143531A0 (en) | 1998-12-08 | 2002-04-21 | Corixa Corp | Polypeptides containing an antigenic portion of a chlamydia antigen, dna sequences encoding said polypeptides and pharmaceutical compositions and vaccines containing the same |
| GB9828000D0 (en) * | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
| US7297341B1 (en) | 1998-12-23 | 2007-11-20 | Sanofi Pasteur Limited | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| US6808713B1 (en) | 1998-12-28 | 2004-10-26 | Aventis Pasteur Limited | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| CA2356057A1 (en) | 1998-12-28 | 2000-07-06 | Aventis Pasteur Limited | Chlamydia antigens and corresponding dna fragments and uses thereof |
| GB9902555D0 (en) | 1999-02-05 | 1999-03-24 | Neutec Pharma Plc | Medicament |
| MXPA01009256A (es) | 1999-03-12 | 2003-07-14 | Aventis Pasteur | Antigenos de chlamydia y fragmentos de acido desoxirribonucleico correspondientes y usos de los mismos. |
| US20030095973A1 (en) | 1999-05-03 | 2003-05-22 | Murdin Andrew D. | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| NZ517952A (en) | 1999-09-20 | 2004-01-30 | Aventis Pasteur | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| US6632663B1 (en) | 1999-09-22 | 2003-10-14 | Aventis Pasteur Limited | DNA immunization against chlamydia infection |
| CA2395499C (en) | 1999-12-22 | 2011-10-25 | Aventis Pasteur Limited | Chlamydia antigens and corresponding dna fragments and uses thereof |
| DE60133190T2 (de) | 2000-04-21 | 2009-04-02 | CORIXA CORP., Wilmington | Verbindungen und verfahren zur behandlung und diagnose von chlamydia-infektionen |
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| JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
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| WO2012085668A2 (en) | 2010-12-24 | 2012-06-28 | Novartis Ag | Compounds |
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| US9320748B2 (en) | 2012-03-07 | 2016-04-26 | Novartis Ag | Immunologically useful arginine salts |
| RU2014140521A (ru) | 2012-03-08 | 2016-04-27 | Новартис Аг | Адъювантные составы бустерных вакцин |
| MX2014014067A (es) | 2012-05-22 | 2015-02-04 | Novartis Ag | Conjugado de serogrupo x de meningococo. |
| US9827190B2 (en) | 2013-02-01 | 2017-11-28 | Glaxosmithkline Biologicals Sa | Intradermal delivery of immunological compositions comprising toll-like receptor 7 agonists |
| JP7005504B2 (ja) | 2016-02-22 | 2022-01-21 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 生体分子の固定化方法 |
| BE1024634B1 (fr) | 2016-04-05 | 2018-05-14 | Gsk Vaccines S.R.L. | Compositions immunogenes |
| NL2019320B1 (en) * | 2017-03-02 | 2018-09-21 | Biosparq B V | Diagnostic method and system for diagnosis |
| CA3090271A1 (en) | 2018-02-12 | 2019-08-15 | Inimmune Corporation | Toll-like receptor ligands |
| WO2020086408A1 (en) | 2018-10-26 | 2020-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A high-yield perfusion-based transient gene expression bioprocess |
| IL302449A (en) | 2020-11-04 | 2023-06-01 | Eligo Bioscience | CUTIBACTERIUM ACNES PHAGES RECOMBINANT, the production method and their uses |
| CN113637703B (zh) * | 2021-08-06 | 2023-08-25 | 河北科技师范学院 | 一种布鲁氏菌L7/L12和GroES真核表达载体的构建方法及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10503922A (ja) * | 1994-04-19 | 1998-04-14 | カイロン エセ.ピー.アー. | 組換えpgp3、調製方法、ならびに診断および治療における使用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1244706B (it) | 1991-02-07 | 1994-08-08 | Sclavo Spa | Plasmide pctd isolato da chlamydia trachomatis serotipo d, suoi geni e proteine da essi codificate; plasmidi ricombinanti per l'espressionedi detti geni in sistemi eterologhi come proteine ricombinanti di fusione, preparazione di dette proteine ricombinanti e loro uso nella formulazione di vaccini e/o diagnostici |
| US7459524B1 (en) | 1997-10-02 | 2008-12-02 | Emergent Product Development Gaithersburg Inc. | Chlamydia protein, sequence and uses thereof |
| KR100769104B1 (ko) | 1997-11-28 | 2007-10-23 | 세로노 제네틱스 인스티튜트 에스.에이. | 클라미디아 트라코마티스 게놈 서열과 폴리펩티드, 이의단편 및 이의 용도, 특히, 감염의 진단, 예방 및 치료 용도 |
| US7041490B1 (en) * | 1997-11-28 | 2006-05-09 | Serono Genetics Institute, S.A. | Chlamydia trachomatis polynucleotides and vectors, recombinant host cells, DNA chips or kits containing the same |
| CA2326002A1 (en) | 1998-04-20 | 1999-10-28 | The State Of Oregon Acting By And Through The State Board Of Higher Educ Ation On Behalf Of Oregon State University | Chlamydia proteins and their uses |
| US6822071B1 (en) * | 1998-11-12 | 2004-11-23 | The Regents Of The University Of California | Polypeptides from Chlamydia pneumoniae and their use in the diagnosis, prevention and treatment of disease |
| CA2350775A1 (en) | 1998-11-12 | 2000-05-18 | The Regents Of The University Of California | Chlamydia pneumoniae genome sequence |
| US6565856B1 (en) | 1998-12-08 | 2003-05-20 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| US20020061848A1 (en) | 2000-07-20 | 2002-05-23 | Ajay Bhatia | Compounds and methods for treatment and diagnosis of chlamydial infection |
| IL143531A0 (en) | 1998-12-08 | 2002-04-21 | Corixa Corp | Polypeptides containing an antigenic portion of a chlamydia antigen, dna sequences encoding said polypeptides and pharmaceutical compositions and vaccines containing the same |
| GB9828000D0 (en) | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
| GB9902555D0 (en) | 1999-02-05 | 1999-03-24 | Neutec Pharma Plc | Medicament |
| US20030095973A1 (en) | 1999-05-03 | 2003-05-22 | Murdin Andrew D. | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| NZ517952A (en) | 1999-09-20 | 2004-01-30 | Aventis Pasteur | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| US6632663B1 (en) | 1999-09-22 | 2003-10-14 | Aventis Pasteur Limited | DNA immunization against chlamydia infection |
| CA2395499C (en) | 1999-12-22 | 2011-10-25 | Aventis Pasteur Limited | Chlamydia antigens and corresponding dna fragments and uses thereof |
| DE60133190T2 (de) | 2000-04-21 | 2009-04-02 | CORIXA CORP., Wilmington | Verbindungen und verfahren zur behandlung und diagnose von chlamydia-infektionen |
| ATE348892T1 (de) | 2000-05-08 | 2007-01-15 | Sanofi Pasteur Ltd | Chlamydia antigene, entsprechende dns fragmente und ihre verwendungen |
| WO2002002606A2 (en) | 2000-07-03 | 2002-01-10 | Chiron S.P.A. | Immunisation against chlamydia pneumoniae |
| EP1412757A2 (en) | 2001-04-09 | 2004-04-28 | Allan Christian Shaw | Method for identification of proteins from intracellular bacteria |
-
1998
- 1998-12-18 GB GBGB9828000.1A patent/GB9828000D0/en not_active Ceased
-
1999
- 1999-12-17 EP EP07075666A patent/EP1857464B1/en not_active Expired - Lifetime
- 1999-12-17 DE DE69937004T patent/DE69937004T2/de not_active Expired - Lifetime
- 1999-12-17 DK DK99958455T patent/DK1140997T3/da active
- 1999-12-17 ES ES99958455T patent/ES2292261T3/es not_active Expired - Lifetime
- 1999-12-17 PT PT99958455T patent/PT1140997E/pt unknown
- 1999-12-17 CA CA002355876A patent/CA2355876A1/en not_active Abandoned
- 1999-12-17 AT AT07075666T patent/ATE516299T1/de not_active IP Right Cessation
- 1999-12-17 JP JP2000589563A patent/JP2002534062A/ja active Pending
- 1999-12-17 WO PCT/IB1999/002065 patent/WO2000037494A2/en not_active Ceased
- 1999-12-17 EP EP05076929A patent/EP1598362A3/en not_active Withdrawn
- 1999-12-17 EP EP99958455A patent/EP1140997B1/en not_active Expired - Lifetime
- 1999-12-17 AT AT99958455T patent/ATE371668T1/de active
-
2005
- 2005-11-14 US US11/272,051 patent/US20060188516A1/en not_active Abandoned
-
2007
- 2007-11-26 CY CY20071101509T patent/CY1107024T1/el unknown
-
2009
- 2009-09-24 US US12/586,601 patent/US8114401B2/en not_active Expired - Fee Related
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2010
- 2010-05-17 JP JP2010113606A patent/JP2010220622A/ja active Pending
-
2012
- 2012-01-05 US US13/344,490 patent/US20130156775A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10503922A (ja) * | 1994-04-19 | 1998-04-14 | カイロン エセ.ピー.アー. | 組換えpgp3、調製方法、ならびに診断および治療における使用 |
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| EP1140997A2 (en) | 2001-10-10 |
| US20100098697A1 (en) | 2010-04-22 |
| EP1857464B1 (en) | 2011-07-13 |
| US20060188516A1 (en) | 2006-08-24 |
| ATE371668T1 (de) | 2007-09-15 |
| EP1140997B1 (en) | 2007-08-29 |
| GB9828000D0 (en) | 1999-02-10 |
| WO2000037494A2 (en) | 2000-06-29 |
| EP1598362A3 (en) | 2006-03-22 |
| EP1857464A3 (en) | 2008-04-02 |
| US8114401B2 (en) | 2012-02-14 |
| ES2292261T3 (es) | 2008-03-01 |
| ATE516299T1 (de) | 2011-07-15 |
| DK1140997T3 (da) | 2007-12-27 |
| WO2000037494A3 (en) | 2000-10-12 |
| CA2355876A1 (en) | 2000-06-29 |
| DE69937004T2 (de) | 2008-05-21 |
| JP2010220622A (ja) | 2010-10-07 |
| US20130156775A1 (en) | 2013-06-20 |
| EP1598362A2 (en) | 2005-11-23 |
| DE69937004D1 (de) | 2007-10-11 |
| EP1857464A2 (en) | 2007-11-21 |
| CY1107024T1 (el) | 2012-09-26 |
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