JP2002532542A - 性的不全の処置における吸入用cGMPPDE5阻害剤 - Google Patents
性的不全の処置における吸入用cGMPPDE5阻害剤Info
- Publication number
- JP2002532542A JP2002532542A JP2000589172A JP2000589172A JP2002532542A JP 2002532542 A JP2002532542 A JP 2002532542A JP 2000589172 A JP2000589172 A JP 2000589172A JP 2000589172 A JP2000589172 A JP 2000589172A JP 2002532542 A JP2002532542 A JP 2002532542A
- Authority
- JP
- Japan
- Prior art keywords
- pyrimidin
- inhibitor
- pyrazolo
- methyl
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Dispersion Chemistry (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9828340.1 | 1998-12-22 | ||
GBGB9828340.1A GB9828340D0 (en) | 1998-12-22 | 1998-12-22 | Organic compounds |
PCT/EP1999/010250 WO2000037061A2 (en) | 1998-12-22 | 1999-12-21 | cGMP PDE 5 INHIBITORS FOR INHALATION IN THE TREATMENT OF SEXUAL DYSFUNCTION |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002532542A true JP2002532542A (ja) | 2002-10-02 |
JP2002532542A5 JP2002532542A5 (es) | 2007-01-25 |
Family
ID=10844812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000589172A Pending JP2002532542A (ja) | 1998-12-22 | 1999-12-21 | 性的不全の処置における吸入用cGMPPDE5阻害剤 |
Country Status (11)
Country | Link |
---|---|
US (3) | US20010055570A1 (es) |
EP (1) | EP1140044B1 (es) |
JP (1) | JP2002532542A (es) |
AT (1) | ATE320247T1 (es) |
AU (1) | AU3041900A (es) |
CA (1) | CA2355368A1 (es) |
DE (1) | DE69930416T2 (es) |
ES (1) | ES2260952T3 (es) |
GB (1) | GB9828340D0 (es) |
PT (1) | PT1140044E (es) |
WO (1) | WO2000037061A2 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014516044A (ja) * | 2011-05-25 | 2014-07-07 | ユストゥス−リービッヒ−ウニヴェルジテート・ギーセン | 肺に投与するための活性成分を含有する生体適合性ナノポリマー粒子 |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI265925B (en) | 1999-10-11 | 2006-11-11 | Pfizer | Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them |
US6919337B2 (en) | 2000-04-07 | 2005-07-19 | Novartis, Ag | 8-Quinolinxanthine and 8-isoquinolinxanthine derivatives as PDE 5 inhibitors |
GB0008694D0 (en) * | 2000-04-07 | 2000-05-31 | Novartis Ag | Organic compounds |
US7019136B2 (en) | 2000-04-07 | 2006-03-28 | Novartis, Ag | 8-quinolinxanthine and 8-isoquinolinxanthine derivatives as PDE 5 inhibitors |
US7019010B2 (en) | 2001-09-27 | 2006-03-28 | Novertis Ag | Combinations |
JP2006503865A (ja) * | 2002-09-30 | 2006-02-02 | アキュスフィア, インコーポレイテッド | 吸入のための徐放性の多孔性微粒子 |
KR20080015594A (ko) * | 2006-08-16 | 2008-02-20 | 주식회사종근당 | 포스포디에스테라제 저해제로서 유용한 퀴나졸린 유도체 및그 제조방법 |
KR101129868B1 (ko) | 2006-10-04 | 2012-04-12 | 화이자 프로덕츠 인코포레이티드 | 칼슘 수용체 길항제로서의 피리도[4,3-d]피리미딘-4(3H)-온 유도체 |
US20110225023A1 (en) * | 2010-03-09 | 2011-09-15 | Target Brands, Inc. | Prioritized Product Distribution |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5294612A (en) * | 1992-03-30 | 1994-03-15 | Sterling Winthrop Inc. | 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof |
JPH06192235A (ja) * | 1992-07-15 | 1994-07-12 | Ono Pharmaceut Co Ltd | 4−アミノキナゾリン誘導体、その製造方法およびそれを含有する医薬品 |
JPH09512834A (ja) * | 1994-11-26 | 1997-12-22 | ファイザー・インコーポレーテッド | 勃起機能不全の治療のためのcGMP−PDE阻害薬 |
WO1998053819A1 (fr) * | 1997-05-29 | 1998-12-03 | Mochida Pharmaceutical Co., Ltd. | Agent therapeutique destine a traiter l'anerection |
JP2000034232A (ja) * | 1998-06-22 | 2000-02-02 | Pfizer Inc | 性障害を治療するための鼻内用製剤 |
JP2002521424A (ja) * | 1998-07-24 | 2002-07-16 | ヤゴ・リサーチ・アクチェンゲゼルシャフト | 医薬用エーロゾル製剤 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225183A (en) * | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
GB9311920D0 (en) * | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
GB9315017D0 (en) * | 1993-07-20 | 1993-09-01 | Glaxo Lab Sa | Chemical compounds |
US5728705A (en) * | 1993-10-04 | 1998-03-17 | The Trustees Of Columbia University In The City Of New York | Method of inducing vasorelaxation to treat pulmonary hypertension |
DE4420708A1 (de) * | 1994-06-14 | 1995-12-21 | Euro Celtique Sa | Entzündungshemmende Zusammensetzung zur Inhalation |
HUP9801394A3 (en) * | 1995-03-10 | 2000-07-28 | Sanofi Pharmaceuticals Inc New | 6-phenyl-pyrazolo[3,4-d]pyrimidin-4-one derivatives and pharmaceutical compositions containing them |
JPH11505539A (ja) * | 1995-05-18 | 1999-05-21 | ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング | シクロヘキシルジヒドロベンゾフラン |
AU698028B2 (en) * | 1995-05-18 | 1998-10-22 | Altana Pharma Ag | Phenyldihydrobenzofurans |
DE19541264A1 (de) * | 1995-11-06 | 1997-05-07 | Bayer Ag | Purin-6-on-derivate |
CZ289340B6 (cs) * | 1996-01-31 | 2002-01-16 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Fenanthridinové deriváty a farmaceutický prostředek s jejich obsahem |
KR20000010919A (ko) * | 1996-05-31 | 2000-02-25 | 모치다 에이 | Cgmppde 저해작용이 있는 피리도카르바졸 유도체 |
PT937075E (pt) * | 1996-11-11 | 2004-05-31 | Altana Pharma Ag | Novas imidazo- e oxazolo-piridinas como inibidores da fosfodiesterese |
US6043263A (en) * | 1996-11-12 | 2000-03-28 | Byk Gulden Lomberg Chemische Fabrik Gmbh | (2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors |
US6087368A (en) * | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
DE69916627T2 (de) * | 1998-09-04 | 2005-07-28 | Ortho-Mcneil Pharmaceutical, Inc. | 5-heterozyklyl-pyrazolo[4,3-d]pyrimidin-7-one für die behandlung von männlichen erectilen dysfunktionen |
-
1998
- 1998-12-22 GB GBGB9828340.1A patent/GB9828340D0/en not_active Ceased
-
1999
- 1999-12-21 JP JP2000589172A patent/JP2002532542A/ja active Pending
- 1999-12-21 AU AU30419/00A patent/AU3041900A/en not_active Abandoned
- 1999-12-21 DE DE69930416T patent/DE69930416T2/de not_active Expired - Fee Related
- 1999-12-21 ES ES99964644T patent/ES2260952T3/es not_active Expired - Lifetime
- 1999-12-21 PT PT99964644T patent/PT1140044E/pt unknown
- 1999-12-21 AT AT99964644T patent/ATE320247T1/de not_active IP Right Cessation
- 1999-12-21 WO PCT/EP1999/010250 patent/WO2000037061A2/en active IP Right Grant
- 1999-12-21 EP EP99964644A patent/EP1140044B1/en not_active Expired - Lifetime
- 1999-12-21 CA CA002355368A patent/CA2355368A1/en not_active Abandoned
-
2001
- 2001-06-18 US US09/883,572 patent/US20010055570A1/en not_active Abandoned
-
2004
- 2004-05-21 US US10/851,603 patent/US20040214831A1/en not_active Abandoned
-
2006
- 2006-12-22 US US11/644,659 patent/US20070197560A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5294612A (en) * | 1992-03-30 | 1994-03-15 | Sterling Winthrop Inc. | 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof |
US5541187A (en) * | 1992-03-30 | 1996-07-30 | Sterling Winthrop Inc. | 6-heterocycyclyl pyrazolo[3,4-d]pyrimidin-4-ones and compositions and method of use thereof |
JPH06192235A (ja) * | 1992-07-15 | 1994-07-12 | Ono Pharmaceut Co Ltd | 4−アミノキナゾリン誘導体、その製造方法およびそれを含有する医薬品 |
JPH09512834A (ja) * | 1994-11-26 | 1997-12-22 | ファイザー・インコーポレーテッド | 勃起機能不全の治療のためのcGMP−PDE阻害薬 |
WO1998053819A1 (fr) * | 1997-05-29 | 1998-12-03 | Mochida Pharmaceutical Co., Ltd. | Agent therapeutique destine a traiter l'anerection |
JP2000034232A (ja) * | 1998-06-22 | 2000-02-02 | Pfizer Inc | 性障害を治療するための鼻内用製剤 |
JP2002521424A (ja) * | 1998-07-24 | 2002-07-16 | ヤゴ・リサーチ・アクチェンゲゼルシャフト | 医薬用エーロゾル製剤 |
Non-Patent Citations (1)
Title |
---|
JPN7010000020, BRITISH JOURNAL OF PHARMACOLOGY, 1996, 118(6), P.1377−1384 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014516044A (ja) * | 2011-05-25 | 2014-07-07 | ユストゥス−リービッヒ−ウニヴェルジテート・ギーセン | 肺に投与するための活性成分を含有する生体適合性ナノポリマー粒子 |
Also Published As
Publication number | Publication date |
---|---|
WO2000037061A3 (en) | 2000-10-26 |
US20010055570A1 (en) | 2001-12-27 |
DE69930416D1 (de) | 2006-05-11 |
ATE320247T1 (de) | 2006-04-15 |
CA2355368A1 (en) | 2000-06-29 |
EP1140044A2 (en) | 2001-10-10 |
AU3041900A (en) | 2000-07-12 |
GB9828340D0 (en) | 1999-02-17 |
US20070197560A1 (en) | 2007-08-23 |
WO2000037061A2 (en) | 2000-06-29 |
DE69930416T2 (de) | 2006-11-02 |
EP1140044B1 (en) | 2006-03-15 |
US20040214831A1 (en) | 2004-10-28 |
ES2260952T3 (es) | 2006-11-01 |
PT1140044E (pt) | 2006-07-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20061129 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20061129 |
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A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100112 |
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A02 | Decision of refusal |
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