JP2002528382A5 - - Google Patents
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- Publication number
- JP2002528382A5 JP2002528382A5 JP2000533451A JP2000533451A JP2002528382A5 JP 2002528382 A5 JP2002528382 A5 JP 2002528382A5 JP 2000533451 A JP2000533451 A JP 2000533451A JP 2000533451 A JP2000533451 A JP 2000533451A JP 2002528382 A5 JP2002528382 A5 JP 2002528382A5
- Authority
- JP
- Japan
- Prior art keywords
- embedded image
- integer
- anion
- empirical formula
- calcium salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011575 calcium Substances 0.000 description 12
- 150000001450 anions Chemical group 0.000 description 9
- 159000000007 calcium salts Chemical class 0.000 description 9
- 125000002252 acyl group Chemical group 0.000 description 5
- 125000000753 cycloalkyl group Chemical group 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 239000002798 polar solvent Substances 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 2
- 241000187844 Actinoplanes Species 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 0 CC(C)C(C(N(CCC1)C1C(NC(C)C(C1OC1N(CCCC1)C1C(NC(C(C)C(O)=O)C(NC(CC(O)=O)C(NCC(NC(CC(O)=O)C(NCC(NC1C(C)N)=O)=O)=O)=O)=O)=O)NC(C(CC(N)=O)N*)=O)=O)=O)NC1=O Chemical compound CC(C)C(C(N(CCC1)C1C(NC(C)C(C1OC1N(CCCC1)C1C(NC(C(C)C(O)=O)C(NC(CC(O)=O)C(NCC(NC(CC(O)=O)C(NCC(NC1C(C)N)=O)=O)=O)=O)=O)=O)NC(C(CC(N)=O)N*)=O)=O)=O)NC1=O 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- -1 halide anion Chemical group 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19807972A DE19807972A1 (de) | 1998-02-25 | 1998-02-25 | Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung |
| DE19807972.9 | 1998-02-25 | ||
| PCT/EP1999/000930 WO1999043700A1 (de) | 1998-02-25 | 1999-02-12 | Lipopeptidantibiotika-calciumsalze, verfahren zu ihrer herstellung und verwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002528382A JP2002528382A (ja) | 2002-09-03 |
| JP2002528382A5 true JP2002528382A5 (https=) | 2006-03-30 |
| JP4402833B2 JP4402833B2 (ja) | 2010-01-20 |
Family
ID=7858906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000533451A Expired - Fee Related JP4402833B2 (ja) | 1998-02-25 | 1999-02-12 | リポペプチド抗生物質カルシウム塩、その製造方法およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6624143B1 (https=) |
| EP (1) | EP1068223B1 (https=) |
| JP (1) | JP4402833B2 (https=) |
| AR (1) | AR016713A1 (https=) |
| AT (1) | ATE223433T1 (https=) |
| AU (1) | AU2725299A (https=) |
| CA (1) | CA2322052C (https=) |
| CO (1) | CO4790157A1 (https=) |
| DE (2) | DE19807972A1 (https=) |
| DK (1) | DK1068223T3 (https=) |
| ES (1) | ES2182489T3 (https=) |
| PT (1) | PT1068223E (https=) |
| TW (1) | TW559623B (https=) |
| WO (1) | WO1999043700A1 (https=) |
| ZA (1) | ZA991482B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2394313A1 (en) | 1999-12-15 | 2001-06-21 | Cubist Pharmaceuticals, Inc. | Novel lipopeptides as antibacterial agents |
| MXPA02006029A (es) | 1999-12-15 | 2004-08-23 | Cubist Pharm Inc | Lipopeptidos novedosos como agentes antibacterianos. |
| AU784812B2 (en) | 1999-12-15 | 2006-06-29 | Merck Sharp & Dohme Corp. | Lipopeptides as antibacterial agents |
| US6696412B1 (en) | 2000-01-20 | 2004-02-24 | Cubist Pharmaceuticals, Inc. | High purity lipopeptides, Lipopeptide micelles and processes for preparing same |
| US20060014674A1 (en) | 2000-12-18 | 2006-01-19 | Dennis Keith | Methods for preparing purified lipopeptides |
| NZ554405A (en) † | 2000-12-18 | 2009-04-30 | Cubist Pharm Inc | Method for preparing crystalline and crystal-like forms of purified lipopeptides |
| US7125844B2 (en) | 2002-01-03 | 2006-10-24 | Migenix Inc. | Dab9 derivatives of lipopeptide antibiotics and methods of making and using the same |
| AU2004252174A1 (en) | 2003-06-26 | 2005-01-06 | Migenix Inc. | Compositions of lipopeptide antibiotic derivatives and methods of use thereof |
| US7795207B2 (en) | 2005-11-21 | 2010-09-14 | Harald Labischinski | Lipopeptide compositions |
| DE102005056194A1 (de) * | 2005-11-21 | 2007-07-12 | Combinature Biopharm Ag | Neue Lipopeptid Zusammensetzungen |
| GB0821540D0 (en) | 2008-11-25 | 2008-12-31 | Merlion Pharmaceuticals Pte Ltd | Lipopeptide compounds and their use |
| PL2379580T3 (pl) * | 2008-12-22 | 2014-05-30 | Merck Sharp & Dohme | Nowe środki przeciwbakteryjne do leczenia zakażeń wywołanych bakteriami Gram-dodatnimi |
| SG10201407724YA (en) | 2009-11-23 | 2014-12-30 | Cubist Pharm Inc | Daptomycin compositions and related methods |
| US10647746B2 (en) | 2016-04-08 | 2020-05-12 | Versitech Limited | Antibacterial cyclic lipopeptides |
| US11667674B2 (en) | 2016-04-08 | 2023-06-06 | Versitech Limited | Antibacterial cyclic lipopeptides |
| CN109476704B (zh) * | 2016-04-08 | 2022-08-16 | 港大科桥有限公司 | 抗菌环脂肽 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4800162A (en) * | 1987-04-01 | 1989-01-24 | Sepracor, Inc. | Method for resolution of steroisomers in multiphase and extractive membrane reactors |
| GB8720980D0 (en) * | 1987-09-07 | 1987-10-14 | Lepetit Spa | Derivatives |
| US5039789A (en) * | 1988-04-11 | 1991-08-13 | Eli Lilly And Company | A54145 cyclic peptides |
| US6309440B1 (en) * | 1998-08-25 | 2001-10-30 | Thomas T. Yamashita | Method and composition for promoting and controlling growth of plants |
| TW455591B (en) * | 1993-06-08 | 2001-09-21 | Hoechst Ag | Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof |
| DE4411025A1 (de) * | 1994-03-30 | 1995-10-05 | Hoechst Ag | Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US6291680B1 (en) * | 1997-06-18 | 2001-09-18 | Fujisawa Pharmaceutical Co., Ltd. | Production process |
-
1998
- 1998-02-25 DE DE19807972A patent/DE19807972A1/de not_active Ceased
-
1999
- 1999-02-12 CA CA002322052A patent/CA2322052C/en not_active Expired - Fee Related
- 1999-02-12 DE DE59902568T patent/DE59902568D1/de not_active Expired - Lifetime
- 1999-02-12 ES ES99907547T patent/ES2182489T3/es not_active Expired - Lifetime
- 1999-02-12 JP JP2000533451A patent/JP4402833B2/ja not_active Expired - Fee Related
- 1999-02-12 AT AT99907547T patent/ATE223433T1/de active
- 1999-02-12 DK DK99907547T patent/DK1068223T3/da active
- 1999-02-12 AU AU27252/99A patent/AU2725299A/en not_active Abandoned
- 1999-02-12 US US09/623,022 patent/US6624143B1/en not_active Expired - Lifetime
- 1999-02-12 EP EP99907547A patent/EP1068223B1/de not_active Expired - Lifetime
- 1999-02-12 WO PCT/EP1999/000930 patent/WO1999043700A1/de not_active Ceased
- 1999-02-12 PT PT99907547T patent/PT1068223E/pt unknown
- 1999-02-16 CO CO99009231A patent/CO4790157A1/es unknown
- 1999-02-23 AR ARP990100721A patent/AR016713A1/es active IP Right Grant
- 1999-02-23 TW TW088102584A patent/TW559623B/zh not_active IP Right Cessation
- 1999-02-24 ZA ZA9901482A patent/ZA991482B/xx unknown
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