DE19807972A1 - Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung - Google Patents

Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung

Info

Publication number
DE19807972A1
DE19807972A1 DE19807972A DE19807972A DE19807972A1 DE 19807972 A1 DE19807972 A1 DE 19807972A1 DE 19807972 A DE19807972 A DE 19807972A DE 19807972 A DE19807972 A DE 19807972A DE 19807972 A1 DE19807972 A1 DE 19807972A1
Authority
DE
Germany
Prior art keywords
calcium salt
salt according
formula
calcium
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19807972A
Other languages
German (de)
English (en)
Inventor
Laszlo Vertesy
Werner Aretz
Heinrich Decker
Eberhard Ehlers
Michael Kurz
Frank Rainer Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Hoechst Marion Roussel Deutschland GmbH
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Deutschland GmbH, Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Deutschland GmbH
Priority to DE19807972A priority Critical patent/DE19807972A1/de
Priority to ES99907547T priority patent/ES2182489T3/es
Priority to PT99907547T priority patent/PT1068223E/pt
Priority to JP2000533451A priority patent/JP4402833B2/ja
Priority to DE59902568T priority patent/DE59902568D1/de
Priority to CA002322052A priority patent/CA2322052C/en
Priority to AU27252/99A priority patent/AU2725299A/en
Priority to AT99907547T priority patent/ATE223433T1/de
Priority to PCT/EP1999/000930 priority patent/WO1999043700A1/de
Priority to US09/623,022 priority patent/US6624143B1/en
Priority to DK99907547T priority patent/DK1068223T3/da
Priority to EP99907547A priority patent/EP1068223B1/de
Priority to CO99009231A priority patent/CO4790157A1/es
Priority to TW088102584A priority patent/TW559623B/zh
Priority to ARP990100721A priority patent/AR016713A1/es
Priority to ZA9901482A priority patent/ZA991482B/xx
Publication of DE19807972A1 publication Critical patent/DE19807972A1/de
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/045—Actinoplanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19807972A 1998-02-25 1998-02-25 Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung Ceased DE19807972A1 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE19807972A DE19807972A1 (de) 1998-02-25 1998-02-25 Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung
ES99907547T ES2182489T3 (es) 1998-02-25 1999-02-12 Sales de calcio de antibioticos lipopeptidicos, procedimiento para su preparacion y utilizacion.
PT99907547T PT1068223E (pt) 1998-02-25 1999-02-12 Sais de calcio de antibioticos lipopeptidicos processo para a sua producao e sua utilizacao
JP2000533451A JP4402833B2 (ja) 1998-02-25 1999-02-12 リポペプチド抗生物質カルシウム塩、その製造方法およびその使用
DE59902568T DE59902568D1 (de) 1998-02-25 1999-02-12 Lipopeptidantibiotika-calciumsalze, verfahren zu ihrer herstellung und verwendung
CA002322052A CA2322052C (en) 1998-02-25 1999-02-12 Calcium salts of lipopeptide antibiotics, method for producing same and their use
AU27252/99A AU2725299A (en) 1998-02-25 1999-02-12 Calcium salts of lipopeptide antibiotics, method for producing same and their use
AT99907547T ATE223433T1 (de) 1998-02-25 1999-02-12 Lipopeptidantibiotika-calciumsalze, verfahren zu ihrer herstellung und verwendung
PCT/EP1999/000930 WO1999043700A1 (de) 1998-02-25 1999-02-12 Lipopeptidantibiotika-calciumsalze, verfahren zu ihrer herstellung und verwendung
US09/623,022 US6624143B1 (en) 1998-02-25 1999-02-12 Calcium salts of lipopeptide antibiotics, method for producing same and their use
DK99907547T DK1068223T3 (da) 1998-02-25 1999-02-12 Lipopeptidantibiotika-calciumsalte, fremgangsmåde til deres fremstilling og anvendelse
EP99907547A EP1068223B1 (de) 1998-02-25 1999-02-12 Lipopeptidantibiotika-calciumsalze, verfahren zu ihrer herstellung und verwendung
CO99009231A CO4790157A1 (es) 1998-02-25 1999-02-16 Sales de calcio de antibioticos lipopetidicos y procedimiento para su preparacion
TW088102584A TW559623B (en) 1998-02-25 1999-02-23 Lipopeptide antibiotic calcium salts, process for their preparation, and their use
ARP990100721A AR016713A1 (es) 1998-02-25 1999-02-23 SALES DE CALCIO DE ANTIBIOTICOS LIPOPEPTIDICOS, PROCEDIMIENTO PARA SU PREPARACIoN Y SU UTILIZACIoN PARA LA PREPARACIoN DE UN MEDICAMENTO Y SOLUCIoN INYECTABLE.
ZA9901482A ZA991482B (en) 1998-02-25 1999-02-24 Lipopeptide antibiotic calcium salts, process for their preparations, and their use.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19807972A DE19807972A1 (de) 1998-02-25 1998-02-25 Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
DE19807972A1 true DE19807972A1 (de) 1999-08-26

Family

ID=7858906

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19807972A Ceased DE19807972A1 (de) 1998-02-25 1998-02-25 Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung
DE59902568T Expired - Lifetime DE59902568D1 (de) 1998-02-25 1999-02-12 Lipopeptidantibiotika-calciumsalze, verfahren zu ihrer herstellung und verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59902568T Expired - Lifetime DE59902568D1 (de) 1998-02-25 1999-02-12 Lipopeptidantibiotika-calciumsalze, verfahren zu ihrer herstellung und verwendung

Country Status (15)

Country Link
US (1) US6624143B1 (https=)
EP (1) EP1068223B1 (https=)
JP (1) JP4402833B2 (https=)
AR (1) AR016713A1 (https=)
AT (1) ATE223433T1 (https=)
AU (1) AU2725299A (https=)
CA (1) CA2322052C (https=)
CO (1) CO4790157A1 (https=)
DE (2) DE19807972A1 (https=)
DK (1) DK1068223T3 (https=)
ES (1) ES2182489T3 (https=)
PT (1) PT1068223E (https=)
TW (1) TW559623B (https=)
WO (1) WO1999043700A1 (https=)
ZA (1) ZA991482B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007057005A1 (de) * 2005-11-21 2007-05-24 Merlion Pharmaceuticals Gmbh Lipopeptid zusammensetzungen
US7795207B2 (en) 2005-11-21 2010-09-14 Harald Labischinski Lipopeptide compositions

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2394313A1 (en) 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Novel lipopeptides as antibacterial agents
MXPA02006029A (es) 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos novedosos como agentes antibacterianos.
AU784812B2 (en) 1999-12-15 2006-06-29 Merck Sharp & Dohme Corp. Lipopeptides as antibacterial agents
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
NZ554405A (en) † 2000-12-18 2009-04-30 Cubist Pharm Inc Method for preparing crystalline and crystal-like forms of purified lipopeptides
US7125844B2 (en) 2002-01-03 2006-10-24 Migenix Inc. Dab9 derivatives of lipopeptide antibiotics and methods of making and using the same
AU2004252174A1 (en) 2003-06-26 2005-01-06 Migenix Inc. Compositions of lipopeptide antibiotic derivatives and methods of use thereof
GB0821540D0 (en) 2008-11-25 2008-12-31 Merlion Pharmaceuticals Pte Ltd Lipopeptide compounds and their use
PL2379580T3 (pl) * 2008-12-22 2014-05-30 Merck Sharp & Dohme Nowe środki przeciwbakteryjne do leczenia zakażeń wywołanych bakteriami Gram-dodatnimi
SG10201407724YA (en) 2009-11-23 2014-12-30 Cubist Pharm Inc Daptomycin compositions and related methods
US10647746B2 (en) 2016-04-08 2020-05-12 Versitech Limited Antibacterial cyclic lipopeptides
US11667674B2 (en) 2016-04-08 2023-06-06 Versitech Limited Antibacterial cyclic lipopeptides
CN109476704B (zh) * 2016-04-08 2022-08-16 港大科桥有限公司 抗菌环脂肽

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
GB8720980D0 (en) * 1987-09-07 1987-10-14 Lepetit Spa Derivatives
US5039789A (en) * 1988-04-11 1991-08-13 Eli Lilly And Company A54145 cyclic peptides
US6309440B1 (en) * 1998-08-25 2001-10-30 Thomas T. Yamashita Method and composition for promoting and controlling growth of plants
TW455591B (en) * 1993-06-08 2001-09-21 Hoechst Ag Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof
DE4411025A1 (de) * 1994-03-30 1995-10-05 Hoechst Ag Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US6291680B1 (en) * 1997-06-18 2001-09-18 Fujisawa Pharmaceutical Co., Ltd. Production process

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007057005A1 (de) * 2005-11-21 2007-05-24 Merlion Pharmaceuticals Gmbh Lipopeptid zusammensetzungen
US7795207B2 (en) 2005-11-21 2010-09-14 Harald Labischinski Lipopeptide compositions

Also Published As

Publication number Publication date
TW559623B (en) 2003-11-01
JP2002528382A (ja) 2002-09-03
US6624143B1 (en) 2003-09-23
AU2725299A (en) 1999-09-15
ATE223433T1 (de) 2002-09-15
DE59902568D1 (de) 2002-10-10
CA2322052C (en) 2009-09-29
EP1068223B1 (de) 2002-09-04
CO4790157A1 (es) 1999-05-31
CA2322052A1 (en) 1999-09-02
AR016713A1 (es) 2001-07-25
WO1999043700A1 (de) 1999-09-02
DK1068223T3 (da) 2002-12-30
ZA991482B (en) 1999-08-25
EP1068223A1 (de) 2001-01-17
PT1068223E (pt) 2003-01-31
JP4402833B2 (ja) 2010-01-20
ES2182489T3 (es) 2003-03-01

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH, 65929 FRANKFURT,

8141 Disposal/no request for examination
8110 Request for examination paragraph 44
8170 Reinstatement of the former position
8125 Change of the main classification

Ipc: C07K 754

8127 New person/name/address of the applicant

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, 65929 FRANKFURT,

8131 Rejection