JP2002525358A5 - - Google Patents
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- JP2002525358A5 JP2002525358A5 JP2000572198A JP2000572198A JP2002525358A5 JP 2002525358 A5 JP2002525358 A5 JP 2002525358A5 JP 2000572198 A JP2000572198 A JP 2000572198A JP 2000572198 A JP2000572198 A JP 2000572198A JP 2002525358 A5 JP2002525358 A5 JP 2002525358A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylamino
- amino
- alkoxy
- alkanoylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 description 160
- -1 cyano, mercapto, nitro, amino, carboxy, carbamoyl Chemical group 0.000 description 144
- 125000003282 alkyl amino group Chemical group 0.000 description 106
- 125000003545 alkoxy group Chemical group 0.000 description 65
- 125000005236 alkanoylamino group Chemical group 0.000 description 45
- 125000001424 substituent group Chemical group 0.000 description 29
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 27
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 26
- 229910052757 nitrogen Inorganic materials 0.000 description 20
- 150000001408 amides Chemical class 0.000 description 14
- 150000003839 salts Chemical class 0.000 description 13
- 125000001072 heteroaryl group Chemical group 0.000 description 10
- 125000005843 halogen group Chemical group 0.000 description 9
- 125000000623 heterocyclic group Chemical group 0.000 description 9
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 9
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 8
- 125000003118 aryl group Chemical group 0.000 description 8
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 7
- 150000002148 esters Chemical class 0.000 description 7
- 238000001727 in vivo Methods 0.000 description 7
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 6
- 125000001589 carboacyl group Chemical group 0.000 description 6
- 125000006264 diethylaminomethyl group Chemical group [H]C([H])([H])C([H])([H])N(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 6
- 125000005115 alkyl carbamoyl group Chemical group 0.000 description 5
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 description 4
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 125000005241 heteroarylamino group Chemical group 0.000 description 4
- 125000005224 heteroarylcarbonylamino group Chemical group 0.000 description 4
- 125000005553 heteroaryloxy group Chemical group 0.000 description 4
- 125000005419 heteroarylsulfonylamino group Chemical group 0.000 description 4
- 125000001064 morpholinomethyl group Chemical group [H]C([H])(*)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 description 4
- 125000004193 piperazinyl group Chemical group 0.000 description 4
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 3
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 3
- YVGKCZBJWCNRSO-UHFFFAOYSA-N 4-(diethylaminomethyl)benzamide Chemical compound CCN(CC)CC1=CC=C(C(N)=O)C=C1 YVGKCZBJWCNRSO-UHFFFAOYSA-N 0.000 description 3
- 125000003342 alkenyl group Chemical group 0.000 description 3
- 125000004414 alkyl thio group Chemical group 0.000 description 3
- 125000005530 alkylenedioxy group Chemical group 0.000 description 3
- 125000000304 alkynyl group Chemical group 0.000 description 3
- 125000001309 chloro group Chemical group Cl* 0.000 description 3
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 125000005844 heterocyclyloxy group Chemical group 0.000 description 3
- 125000002757 morpholinyl group Chemical group 0.000 description 3
- 125000003386 piperidinyl group Chemical group 0.000 description 3
- 125000004076 pyridyl group Chemical group 0.000 description 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 125000004423 acyloxy group Chemical group 0.000 description 2
- 125000004947 alkyl aryl amino group Chemical group 0.000 description 2
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 description 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 description 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 2
- 238000010976 amide bond formation reaction Methods 0.000 description 2
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 description 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 2
- 125000005239 aroylamino group Chemical group 0.000 description 2
- 125000001769 aryl amino group Chemical group 0.000 description 2
- 125000004657 aryl sulfonyl amino group Chemical group 0.000 description 2
- 125000004104 aryloxy group Chemical group 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 125000002619 bicyclic group Chemical group 0.000 description 2
- 125000001246 bromo group Chemical group Br* 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- 125000006534 ethyl amino methyl group Chemical group [H]N(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 125000002883 imidazolyl group Chemical group 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 125000002950 monocyclic group Chemical group 0.000 description 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 2
- 125000006239 protecting group Chemical group 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 229910052717 sulfur Chemical group 0.000 description 2
- 239000011593 sulfur Chemical group 0.000 description 2
- ZSOKBQPCTOHHMO-UHFFFAOYSA-N 3-(piperazin-1-ylmethyl)benzamide Chemical compound NC(=O)C1=CC=CC(CN2CCNCC2)=C1 ZSOKBQPCTOHHMO-UHFFFAOYSA-N 0.000 description 1
- ZZLCFHIKESPLTH-UHFFFAOYSA-N 4-Methylbiphenyl Chemical compound C1=CC(C)=CC=C1C1=CC=CC=C1 ZZLCFHIKESPLTH-UHFFFAOYSA-N 0.000 description 1
- BLYJJFSGDSMLMJ-UHFFFAOYSA-N CCN(CC)CC1=CC=CC(C(N)=O)=C1 Chemical compound CCN(CC)CC1=CC=CC(C(N)=O)=C1 BLYJJFSGDSMLMJ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 1
- 125000004601 benzofurazanyl group Chemical group N1=C2C(=NO1)C(=CC=C2)* 0.000 description 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 description 1
- INOUWZSYSIRLAI-UHFFFAOYSA-N dibenzofuran-4-carboxamide Chemical compound C1=CC=C(C=2OC3=C(C=21)C=CC=C3)C(=O)N INOUWZSYSIRLAI-UHFFFAOYSA-N 0.000 description 1
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- WCDWBPCFGJXFJZ-UHFFFAOYSA-N etanidazole Chemical group OCCNC(=O)CN1C=CN=C1[N+]([O-])=O WCDWBPCFGJXFJZ-UHFFFAOYSA-N 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 description 1
- 125000001041 indolyl group Chemical group 0.000 description 1
- 125000005956 isoquinolyl group Chemical group 0.000 description 1
- 125000001786 isothiazolyl group Chemical group 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000006533 methyl amino methyl group Chemical group [H]N(C([H])([H])[H])C([H])([H])* 0.000 description 1
- RXZIRKRDXDRFAA-UHFFFAOYSA-N n-[3-[[4-[(3-hydroxypyrrolidin-1-yl)methyl]benzoyl]amino]-4-methylphenyl]-2-morpholin-4-ylpyridine-4-carboxamide Chemical compound C1=C(NC(=O)C=2C=CC(CN3CC(O)CC3)=CC=2)C(C)=CC=C1NC(=O)C(C=1)=CC=NC=1N1CCOCC1 RXZIRKRDXDRFAA-UHFFFAOYSA-N 0.000 description 1
- ZCMCJFZYZYUTRF-UHFFFAOYSA-N n-[4-methyl-3-[(3-piperidin-4-yloxybenzoyl)amino]phenyl]-2-morpholin-4-ylpyridine-4-carboxamide Chemical compound C1=C(NC(=O)C=2C=C(OC3CCNCC3)C=CC=2)C(C)=CC=C1NC(=O)C(C=1)=CC=NC=1N1CCOCC1 ZCMCJFZYZYUTRF-UHFFFAOYSA-N 0.000 description 1
- LAOPKCSMEAUUDY-UHFFFAOYSA-N n-[4-methyl-3-[(3-pyrrolidin-3-yloxybenzoyl)amino]phenyl]-2-morpholin-4-ylpyridine-4-carboxamide Chemical compound C1=C(NC(=O)C=2C=C(OC3CNCC3)C=CC=2)C(C)=CC=C1NC(=O)C(C=1)=CC=NC=1N1CCOCC1 LAOPKCSMEAUUDY-UHFFFAOYSA-N 0.000 description 1
- DJGVVEBKFSLTAC-UHFFFAOYSA-N n-[4-methyl-3-[[3-[(4-methylpiperazin-1-yl)methyl]benzoyl]amino]phenyl]-1,2-oxazole-5-carboxamide Chemical compound C1CN(C)CCN1CC1=CC=CC(C(=O)NC=2C(=CC=C(NC(=O)C=3ON=CC=3)C=2)C)=C1 DJGVVEBKFSLTAC-UHFFFAOYSA-N 0.000 description 1
- UDSRUJPSZUHVOI-UHFFFAOYSA-N n-[4-methyl-3-[[3-[(4-methylpiperazin-1-yl)methyl]benzoyl]amino]phenyl]furan-2-carboxamide Chemical compound C1CN(C)CCN1CC1=CC=CC(C(=O)NC=2C(=CC=C(NC(=O)C=3OC=CC=3)C=2)C)=C1 UDSRUJPSZUHVOI-UHFFFAOYSA-N 0.000 description 1
- XLWOLGYQFOJFCG-UHFFFAOYSA-N n-[4-methyl-3-[[3-[2-(1-methylpyrrolidin-2-yl)ethoxy]benzoyl]amino]phenyl]-2-morpholin-4-ylpyridine-4-carboxamide Chemical compound CN1CCCC1CCOC1=CC=CC(C(=O)NC=2C(=CC=C(NC(=O)C=3C=C(N=CC=3)N3CCOCC3)C=2)C)=C1 XLWOLGYQFOJFCG-UHFFFAOYSA-N 0.000 description 1
- RBWVIIJQUSKMOF-UHFFFAOYSA-N n-[4-methyl-3-[[4-(morpholin-4-ylmethyl)benzoyl]amino]phenyl]-2-morpholin-4-ylpyridine-4-carboxamide Chemical compound C1=C(NC(=O)C=2C=CC(CN3CCOCC3)=CC=2)C(C)=CC=C1NC(=O)C(C=1)=CC=NC=1N1CCOCC1 RBWVIIJQUSKMOF-UHFFFAOYSA-N 0.000 description 1
- BSYDZPCFCUVMPO-UHFFFAOYSA-N n-[4-methyl-3-[[4-[(2-methyl-1,3-thiazol-4-yl)methoxy]benzoyl]amino]phenyl]-2-morpholin-4-ylpyridine-4-carboxamide Chemical compound S1C(C)=NC(COC=2C=CC(=CC=2)C(=O)NC=2C(=CC=C(NC(=O)C=3C=C(N=CC=3)N3CCOCC3)C=2)C)=C1 BSYDZPCFCUVMPO-UHFFFAOYSA-N 0.000 description 1
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9820770.7A GB9820770D0 (en) | 1998-09-25 | 1998-09-25 | Amide derivatives |
| GB9820770.7 | 1998-09-25 | ||
| GB9826938.4 | 1998-12-09 | ||
| GBGB9826938.4A GB9826938D0 (en) | 1998-12-09 | 1998-12-09 | Amide derivatives |
| GB9905969.3 | 1999-03-17 | ||
| GBGB9905969.3A GB9905969D0 (en) | 1999-03-17 | 1999-03-17 | Amide derivatives |
| PCT/GB1999/003144 WO2000018738A1 (en) | 1998-09-25 | 1999-09-21 | Benzamide derivatives and their use as cytokine inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002525358A JP2002525358A (ja) | 2002-08-13 |
| JP2002525358A5 true JP2002525358A5 (enExample) | 2006-10-19 |
Family
ID=27269489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000572198A Pending JP2002525358A (ja) | 1998-09-25 | 1999-09-21 | ベンズアミド誘導体及びサイトカイン阻害剤としてのその使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6455520B1 (enExample) |
| EP (1) | EP1115707B1 (enExample) |
| JP (1) | JP2002525358A (enExample) |
| KR (1) | KR100618074B1 (enExample) |
| CN (1) | CN1146542C (enExample) |
| AT (1) | ATE254105T1 (enExample) |
| AU (1) | AU761361B2 (enExample) |
| BR (1) | BR9913947A (enExample) |
| CA (1) | CA2340454A1 (enExample) |
| DE (1) | DE69912823T2 (enExample) |
| DK (1) | DK1115707T3 (enExample) |
| ES (1) | ES2211172T3 (enExample) |
| HU (1) | HUP0104060A3 (enExample) |
| ID (1) | ID28267A (enExample) |
| IL (2) | IL141979A0 (enExample) |
| NO (1) | NO318800B1 (enExample) |
| NZ (1) | NZ509836A (enExample) |
| PL (1) | PL346854A1 (enExample) |
| PT (1) | PT1115707E (enExample) |
| RU (1) | RU2219171C2 (enExample) |
| SK (1) | SK285520B6 (enExample) |
| TR (1) | TR200100840T2 (enExample) |
| WO (1) | WO2000018738A1 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9816837D0 (en) | 1998-08-04 | 1998-09-30 | Zeneca Ltd | Amide derivatives |
| US7772432B2 (en) | 1991-09-19 | 2010-08-10 | Astrazeneca Ab | Amidobenzamide derivatives which are useful as cytokine inhibitors |
| US6171705B1 (en) | 1997-02-10 | 2001-01-09 | Dofasco, Inc. | Structural panel and method of manufacture |
| DK1017378T3 (da) | 1997-09-23 | 2003-03-17 | Astrazeneca Ab | Amidderivater til behandling af sygdomme medieret af cytokiner |
| SK286247B6 (sk) | 1998-05-15 | 2008-06-06 | Astrazeneca Ab | Benzamidové deriváty, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú a ich použitie pri príprave liečiva na liečbu chorobných stavov sprostredkovaných cytokínmi |
| PL195600B1 (pl) | 1998-05-15 | 2007-10-31 | Astrazeneca Ab | Pochodne benzamidowe, sposób ich wytwarzania, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie do wytwarzania leku do leczenia stanów medycznych powstających za pośrednictwem cytokin |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| WO2000007991A1 (en) | 1998-08-04 | 2000-02-17 | Astrazeneca Ab | Amide derivatives useful as inhibitors of the production of cytokines |
| CA2341370A1 (en) * | 1998-08-20 | 2000-03-02 | Smithkline Beecham Corporation | Novel substituted triazole compounds |
| ATE254105T1 (de) | 1998-09-25 | 2003-11-15 | Astrazeneca Ab | Benzamid-derivate und ihre verwendung als cytokine inhibitoren |
| DE69914357T2 (de) | 1998-11-04 | 2004-11-11 | Smithkline Beecham Corp. | Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine |
| AU761453B2 (en) | 1999-03-17 | 2003-06-05 | Astrazeneca Ab | Amide derivatives |
| JP2002539187A (ja) * | 1999-03-17 | 2002-11-19 | アストラゼネカ アクチボラグ | アミド誘導体 |
| GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
| GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
| JP2003514900A (ja) | 1999-11-23 | 2003-04-22 | スミスクライン・ビーチャム・コーポレイション | ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４−ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物 |
| ATE281439T1 (de) | 1999-11-23 | 2004-11-15 | Smithkline Beecham Corp | 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren |
| US6759410B1 (en) * | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
| EP1233950B1 (en) | 1999-11-23 | 2005-10-05 | Smithkline Beecham Corporation | 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/P39 kINASE INHIBITORS |
| US6943161B2 (en) | 1999-12-28 | 2005-09-13 | Pharmacopela Drug Discovery, Inc. | Pyrimidine and triazine kinase inhibitors |
| US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| UA76977C2 (en) | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
| EP1395561A1 (en) * | 2001-05-25 | 2004-03-10 | Boehringer Ingelheim Pharmaceuticals Inc. | Carbamate and oxamide compounds as inhibitors of cytokine production |
| GB0202873D0 (en) | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
| ATE469142T1 (de) * | 2002-04-11 | 2010-06-15 | Boehringer Ingelheim Pharma | Heterocyclische amid-derivate als cytokin- inhibitoren |
| WO2004004720A1 (en) * | 2002-07-03 | 2004-01-15 | Astex Technology Limited | 3-`(hetero) arylmethoxy ! pyridines and their analogues as p38 map kinase inhibitors |
| ES2278170T3 (es) | 2002-07-09 | 2007-08-01 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | Composiciones farmaceuticas de anticolinergicos e inhibidores de la quinasa p38 en el tratamiento de enfermedades respiratorias. |
| ATE329909T1 (de) | 2002-11-27 | 2006-07-15 | Boehringer Ingelheim Pharma | 1,2,3-triazolamid-derivate als cytokininhibitoren |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| EP2385041B1 (en) * | 2003-05-01 | 2013-09-18 | Bristol-Myers Squibb Company | Pyrazole-amine compounds useful as kinase inhibitors |
| JP5001650B2 (ja) * | 2003-07-11 | 2012-08-15 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンズイミダゾールカルボキサミド |
| WO2005023761A2 (en) | 2003-09-11 | 2005-03-17 | Kemia, Inc. | Cytokine inhibitors |
| GB0324790D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Amide derivatives |
| ATE501128T1 (de) * | 2003-12-03 | 2011-03-15 | Boehringer Ingelheim Pharma | 1,2,3-triazolamidderivate als inhibitoren der cytokinproduktion |
| PE20060213A1 (es) * | 2004-04-30 | 2006-04-24 | Irm Llc | Compuestos y composiciones como inhibidores de catepsinas |
| BRPI0510929A (pt) | 2004-06-18 | 2007-07-17 | Chiron Corp | derivados de n-(1-(1-benzil-4-fenil-1h-imidazol-2-il)-2,2-dimetilpropil) benzamida e compostos relacionados como inibidores de proteìna de eixo de kinesin (ksp) para o tratamento de cáncer |
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- 1999-09-21 CN CNB998112968A patent/CN1146542C/zh not_active Expired - Fee Related
- 1999-09-21 SK SK421-2001A patent/SK285520B6/sk unknown
- 1999-09-21 BR BR9913947-2A patent/BR9913947A/pt not_active Application Discontinuation
- 1999-09-21 CA CA002340454A patent/CA2340454A1/en not_active Abandoned
- 1999-09-21 RU RU2001111320/04A patent/RU2219171C2/ru not_active IP Right Cessation
- 1999-09-21 EP EP99947653A patent/EP1115707B1/en not_active Expired - Lifetime
- 1999-09-21 PT PT99947653T patent/PT1115707E/pt unknown
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- 1999-09-21 IL IL14197999A patent/IL141979A0/xx active IP Right Grant
- 1999-09-21 DK DK99947653T patent/DK1115707T3/da active
- 1999-09-21 WO PCT/GB1999/003144 patent/WO2000018738A1/en not_active Ceased
- 1999-09-21 PL PL99346854A patent/PL346854A1/xx not_active Application Discontinuation
- 1999-09-21 JP JP2000572198A patent/JP2002525358A/ja active Pending
- 1999-09-21 ID IDW20010593A patent/ID28267A/id unknown
- 1999-09-21 US US09/787,882 patent/US6455520B1/en not_active Expired - Fee Related
- 1999-09-21 TR TR2001/00840T patent/TR200100840T2/xx unknown
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- 1999-09-21 DE DE69912823T patent/DE69912823T2/de not_active Expired - Fee Related
- 1999-09-21 AU AU61034/99A patent/AU761361B2/en not_active Ceased
- 1999-09-21 NZ NZ509836A patent/NZ509836A/xx unknown
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