ATE469142T1 - Heterocyclische amid-derivate als cytokin- inhibitoren - Google Patents
Heterocyclische amid-derivate als cytokin- inhibitorenInfo
- Publication number
- ATE469142T1 ATE469142T1 AT03721619T AT03721619T ATE469142T1 AT E469142 T1 ATE469142 T1 AT E469142T1 AT 03721619 T AT03721619 T AT 03721619T AT 03721619 T AT03721619 T AT 03721619T AT E469142 T1 ATE469142 T1 AT E469142T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- amide derivatives
- cytokine inhibitors
- heterocyclic amide
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37167102P | 2002-04-11 | 2002-04-11 | |
PCT/US2003/011094 WO2003087085A1 (en) | 2002-04-11 | 2003-04-10 | Heterocyclic amide derivatives as cytokine inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE469142T1 true ATE469142T1 (de) | 2010-06-15 |
Family
ID=29250721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03721619T ATE469142T1 (de) | 2002-04-11 | 2003-04-10 | Heterocyclische amid-derivate als cytokin- inhibitoren |
Country Status (9)
Country | Link |
---|---|
US (1) | US7550461B2 (de) |
EP (1) | EP1497278B1 (de) |
JP (1) | JP4578106B2 (de) |
AT (1) | ATE469142T1 (de) |
AU (1) | AU2003224923A1 (de) |
CA (1) | CA2478232C (de) |
DE (1) | DE60332717D1 (de) |
ES (1) | ES2343787T3 (de) |
WO (1) | WO2003087085A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1497278B1 (de) * | 2002-04-11 | 2010-05-26 | Boehringer Ingelheim Pharmaceuticals Inc. | Heterocyclische amid-derivate als cytokin-inhibitoren |
US7078419B2 (en) * | 2003-03-10 | 2006-07-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cytokine inhibitors |
EP1867646A1 (de) * | 2004-05-03 | 2007-12-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cytokin-Inhibitoren |
US7285545B2 (en) | 2004-05-03 | 2007-10-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cytokine inhibitors |
WO2006026235A1 (en) * | 2004-08-25 | 2006-03-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cytokine inhibitors |
EP1824843A2 (de) * | 2004-12-07 | 2007-08-29 | Locus Pharmaceuticals, Inc. | Inhibitoren von proteinkinasen |
EP1828169A2 (de) * | 2004-12-07 | 2007-09-05 | Locus Pharmaceuticals, Inc. | Harnstoffinhibitoren von map-kinasen |
CA2587664A1 (en) * | 2004-12-21 | 2006-06-29 | Devgen N.V. | Compounds with kv4 ion channel activity |
EP1873144B1 (de) | 2005-04-20 | 2014-07-23 | Takeda Pharmaceutical Company Limited | Kondensierte heterocyclische verbindung |
WO2007081690A2 (en) * | 2006-01-04 | 2007-07-19 | Locus Pharmaceuticals, Inc. | Inhibitors of protein kinases |
CA2722923C (en) | 2008-04-29 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Indazole compounds as ccr1 receptor antagonists |
US8293917B2 (en) | 2008-05-06 | 2012-10-23 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as CCR1 antagonists |
EP2161266A1 (de) * | 2008-08-22 | 2010-03-10 | EVOTEC Neurosciences GmbH | Benzofuranderivate als Orexin-Rezeptorantagonisten |
NZ591115A (en) | 2008-09-26 | 2012-10-26 | Boehringer Ingelheim Int | Azaindazole compounds as ccr1 receptor antagonists |
CA2778060A1 (en) | 2009-10-21 | 2011-04-28 | Boehringer Ingelheim International Gmbh | Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists |
JP5542214B2 (ja) | 2009-10-27 | 2014-07-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr1受容体アンタゴニストとしての複素環化合物 |
WO2011137109A1 (en) | 2010-04-30 | 2011-11-03 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as ccr1 receptor antagonists |
US8546442B2 (en) | 2010-12-23 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Pyrazolopiperidine compounds as CCR1 receptor antagonists |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4317076A1 (de) * | 1993-05-21 | 1994-11-24 | Bayer Ag | Benzthiophencarbonsäureamid-S-oxide |
DE19642529A1 (de) * | 1996-10-15 | 1998-04-16 | Bayer Ag | Aminophenolderivate |
US5994398A (en) * | 1996-12-11 | 1999-11-30 | Elan Pharmaceuticals, Inc. | Arylsulfonamides as phospholipase A2 inhibitors |
TR200003353T2 (tr) * | 1998-05-15 | 2001-04-20 | Astrazeneca Ab | Sitokinlerin aracılık ettiği hastalıkların tedavisi için benzamit türevleri |
TR200100840T2 (tr) * | 1998-09-25 | 2001-10-22 | Astrazeneca Ab | Benzamid türevleri ve bunların sitokin inhibe edicileri olarak kullanımı |
NZ528846A (en) | 1999-03-12 | 2005-05-27 | Boehringer Ingelheim Pharma | Compounds useful as anti-inflammatory agents |
TWI288745B (en) * | 2000-04-05 | 2007-10-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
US7112594B2 (en) * | 2000-08-09 | 2006-09-26 | Mitsubishi Pharma Corporation | Fused bicyclic amide compounds and medicinal use thereof |
WO2002083628A1 (en) | 2001-04-13 | 2002-10-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzo-fused compounds |
AR034897A1 (es) * | 2001-08-07 | 2004-03-24 | Hoffmann La Roche | Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos |
EP1497278B1 (de) * | 2002-04-11 | 2010-05-26 | Boehringer Ingelheim Pharmaceuticals Inc. | Heterocyclische amid-derivate als cytokin-inhibitoren |
-
2003
- 2003-04-10 EP EP03721619A patent/EP1497278B1/de not_active Expired - Lifetime
- 2003-04-10 US US10/410,688 patent/US7550461B2/en active Active
- 2003-04-10 JP JP2003584041A patent/JP4578106B2/ja not_active Expired - Lifetime
- 2003-04-10 AT AT03721619T patent/ATE469142T1/de active
- 2003-04-10 CA CA2478232A patent/CA2478232C/en not_active Expired - Lifetime
- 2003-04-10 DE DE60332717T patent/DE60332717D1/de not_active Expired - Lifetime
- 2003-04-10 AU AU2003224923A patent/AU2003224923A1/en not_active Abandoned
- 2003-04-10 WO PCT/US2003/011094 patent/WO2003087085A1/en active Application Filing
- 2003-04-10 ES ES03721619T patent/ES2343787T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2343787T3 (es) | 2010-08-10 |
AU2003224923A1 (en) | 2003-10-27 |
EP1497278B1 (de) | 2010-05-26 |
DE60332717D1 (de) | 2010-07-08 |
EP1497278A1 (de) | 2005-01-19 |
WO2003087085A1 (en) | 2003-10-23 |
JP4578106B2 (ja) | 2010-11-10 |
US20030225053A1 (en) | 2003-12-04 |
CA2478232C (en) | 2011-06-14 |
US7550461B2 (en) | 2009-06-23 |
CA2478232A1 (en) | 2003-10-23 |
JP2005530730A (ja) | 2005-10-13 |
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Legal Events
Date | Code | Title | Description |
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UEP | Publication of translation of european patent specification |
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