JP2002525317A5 - - Google Patents
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- Publication number
- JP2002525317A5 JP2002525317A5 JP2000571905A JP2000571905A JP2002525317A5 JP 2002525317 A5 JP2002525317 A5 JP 2002525317A5 JP 2000571905 A JP2000571905 A JP 2000571905A JP 2000571905 A JP2000571905 A JP 2000571905A JP 2002525317 A5 JP2002525317 A5 JP 2002525317A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- moxifloxacin
- salt
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 description 32
- 239000000203 mixture Substances 0.000 description 21
- FABPRXSRWADJSP-MEDUHNTESA-N moxifloxacin Chemical compound COC1=C(N2C[C@H]3NCCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 FABPRXSRWADJSP-MEDUHNTESA-N 0.000 description 14
- 229960003702 moxifloxacin Drugs 0.000 description 14
- 150000003839 salts Chemical class 0.000 description 13
- 229960003957 dexamethasone Drugs 0.000 description 6
- 208000001860 Eye Infections Diseases 0.000 description 5
- 210000001742 aqueous humor Anatomy 0.000 description 5
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 5
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 5
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 5
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 3
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 3
- 239000002260 anti-inflammatory agent Substances 0.000 description 3
- 229940124599 anti-inflammatory drug Drugs 0.000 description 3
- 239000003862 glucocorticoid Substances 0.000 description 3
- 230000003637 steroidlike Effects 0.000 description 3
- 206010010741 Conjunctivitis Diseases 0.000 description 2
- 102000010907 Cyclooxygenase 2 Human genes 0.000 description 2
- 108010037462 Cyclooxygenase 2 Proteins 0.000 description 2
- 241000606768 Haemophilus influenzae Species 0.000 description 2
- 229940124639 Selective inhibitor Drugs 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000191963 Staphylococcus epidermidis Species 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 208000011323 eye infectious disease Diseases 0.000 description 2
- 229960001048 fluorometholone Drugs 0.000 description 2
- FAOZLTXFLGPHNG-KNAQIMQKSA-N fluorometholone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@]2(F)[C@@H](O)C[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FAOZLTXFLGPHNG-KNAQIMQKSA-N 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 229960000890 hydrocortisone Drugs 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 206010023332 keratitis Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229960001664 mometasone Drugs 0.000 description 2
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 description 2
- 229960005205 prednisolone Drugs 0.000 description 2
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 229960001487 rimexolone Drugs 0.000 description 2
- QTTRZHGPGKRAFB-OOKHYKNYSA-N rimexolone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CC)(C)[C@@]1(C)C[C@@H]2O QTTRZHGPGKRAFB-OOKHYKNYSA-N 0.000 description 2
- 239000012049 topical pharmaceutical composition Substances 0.000 description 2
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 1
- FABPRXSRWADJSP-UHFFFAOYSA-N COc(c(N1CC2NCCCC2C1)c(cc12)F)c1N(C1CC1)C=C(C(O)=O)C2=O Chemical compound COc(c(N1CC2NCCCC2C1)c(cc12)F)c1N(C1CC1)C=C(C(O)=O)C2=O FABPRXSRWADJSP-UHFFFAOYSA-N 0.000 description 1
- 206010064996 Ulcerative keratitis Diseases 0.000 description 1
- MVLBCBPGBUAVJQ-CENSZEJFSA-N [(6s,8s,9r,10s,11s,13s,14s,16r,17r)-17-(chloromethylsulfanylcarbonyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCCl)(OC(=O)CC)[C@@]2(C)C[C@@H]1O MVLBCBPGBUAVJQ-CENSZEJFSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 1
- 229940092705 beclomethasone Drugs 0.000 description 1
- 208000010217 blepharitis Diseases 0.000 description 1
- 229960004436 budesonide Drugs 0.000 description 1
- 229950011341 cloticasone Drugs 0.000 description 1
- 201000007717 corneal ulcer Diseases 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 229960000676 flunisolide Drugs 0.000 description 1
- 229960002714 fluticasone Drugs 0.000 description 1
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 1
- 208000008025 hordeolum Diseases 0.000 description 1
- 229960004752 ketorolac Drugs 0.000 description 1
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229960001002 nepafenac Drugs 0.000 description 1
- QEFAQIPZVLVERP-UHFFFAOYSA-N nepafenac Chemical compound NC(=O)CC1=CC=CC(C(=O)C=2C=CC=CC=2)=C1N QEFAQIPZVLVERP-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 229940021506 stye Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003848 thrombocyte activating factor antagonist Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10250498P | 1998-09-30 | 1998-09-30 | |
| US10250698P | 1998-09-30 | 1998-09-30 | |
| US60/102,504 | 1998-09-30 | ||
| US60/102,506 | 1998-09-30 | ||
| PCT/US1999/022622 WO2000018386A2 (en) | 1998-09-30 | 1999-09-29 | Antibiotic compositions for treatment of the eye, ear and nose |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008213954A Division JP2009007375A (ja) | 1998-09-30 | 2008-08-22 | 眼、耳および鼻治療用の抗生物質組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002525317A JP2002525317A (ja) | 2002-08-13 |
| JP2002525317A5 true JP2002525317A5 (OSRAM) | 2007-07-05 |
Family
ID=26799441
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000571905A Pending JP2002525317A (ja) | 1998-09-30 | 1999-09-29 | 眼、耳および鼻治療用の抗生物質組成物 |
| JP2008213954A Withdrawn JP2009007375A (ja) | 1998-09-30 | 2008-08-22 | 眼、耳および鼻治療用の抗生物質組成物 |
| JP2012002159A Withdrawn JP2012067141A (ja) | 1998-09-30 | 2012-01-10 | 眼、耳および鼻治療用の抗生物質組成物 |
| JP2012242519A Expired - Lifetime JP5563041B2 (ja) | 1998-09-30 | 2012-11-02 | 眼、耳および鼻治療用の抗生物質組成物 |
| JP2014103658A Pending JP2014144982A (ja) | 1998-09-30 | 2014-05-19 | 眼、耳および鼻治療用の抗生物質組成物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008213954A Withdrawn JP2009007375A (ja) | 1998-09-30 | 2008-08-22 | 眼、耳および鼻治療用の抗生物質組成物 |
| JP2012002159A Withdrawn JP2012067141A (ja) | 1998-09-30 | 2012-01-10 | 眼、耳および鼻治療用の抗生物質組成物 |
| JP2012242519A Expired - Lifetime JP5563041B2 (ja) | 1998-09-30 | 2012-11-02 | 眼、耳および鼻治療用の抗生物質組成物 |
| JP2014103658A Pending JP2014144982A (ja) | 1998-09-30 | 2014-05-19 | 眼、耳および鼻治療用の抗生物質組成物 |
Country Status (18)
| Country | Link |
|---|---|
| EP (5) | EP2269602B1 (OSRAM) |
| JP (5) | JP2002525317A (OSRAM) |
| KR (1) | KR101463243B1 (OSRAM) |
| CN (2) | CN1184968C (OSRAM) |
| AR (2) | AR020661A1 (OSRAM) |
| AT (2) | ATE254458T1 (OSRAM) |
| AU (1) | AU762827B2 (OSRAM) |
| BR (1) | BRPI9914151B1 (OSRAM) |
| CA (3) | CA2659064A1 (OSRAM) |
| CY (3) | CY1111404T1 (OSRAM) |
| DE (2) | DE69943287D1 (OSRAM) |
| DK (5) | DK2301541T3 (OSRAM) |
| ES (4) | ES2602956T3 (OSRAM) |
| HK (1) | HK1038691B (OSRAM) |
| PT (5) | PT1117401E (OSRAM) |
| TR (2) | TR200704370T2 (OSRAM) |
| TW (1) | TWI222361B (OSRAM) |
| WO (1) | WO2000018386A2 (OSRAM) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395746B1 (en) | 1998-09-30 | 2002-05-28 | Alcon Manufacturing, Ltd. | Methods of treating ophthalmic, otic and nasal infections and attendant inflammation |
| US6716830B2 (en) | 1998-09-30 | 2004-04-06 | Alcon, Inc. | Ophthalmic antibiotic compositions containing moxifloxacin |
| US6509327B1 (en) | 1998-09-30 | 2003-01-21 | Alcon Manufacturing, Ltd. | Compositions and methods for treating otic, ophthalmic and nasal infections |
| AR020661A1 (es) | 1998-09-30 | 2002-05-22 | Alcon Lab Inc | Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento |
| DE19937116A1 (de) | 1999-08-06 | 2001-02-08 | Bayer Ag | Moxifloxacin Kochsalzformulierung |
| DE19937115A1 (de) | 1999-08-06 | 2001-02-08 | Bayer Ag | Wäßrige Arzneimittelformulierung von Moxifloxacin oder Salzen davon |
| MXPA02003130A (es) | 1999-09-24 | 2004-04-21 | Alcon Inc | Formulaciones topicas en suspension que contienen ciprofloxacino y dexametasona. |
| DE19962470A1 (de) * | 1999-12-22 | 2001-07-12 | Schulz Hans Herrmann | Verwendung von Chemotherapeutika |
| AU2001261748A1 (en) * | 2000-05-19 | 2001-12-03 | Alcon Laboratories Inc. | Antibiotic compositions for treatment of the eye, ear and nose |
| CA2412575C (en) | 2000-07-26 | 2009-12-29 | Onkar N. Singh | Improved process for manufacturing compositions containing ciprofloxacin and hydrocortisone |
| AU2002214308A1 (en) * | 2000-11-16 | 2002-05-27 | Wakamoto Pharmaceutical Co., Ltd. | Antibacterial gel eye drops |
| WO2002049627A2 (en) * | 2000-12-20 | 2002-06-27 | Alcon, Inc. | Antifungal compositions containing an antibiotic and one or more amidoamines |
| WO2002049633A2 (en) | 2000-12-20 | 2002-06-27 | Alcon, Inc. | Use of amidoamines to treat or prevent acanthamoeba and fungal infections |
| EP1429780B1 (en) | 2001-09-21 | 2005-12-21 | Alcon, Inc. | Method of treating middle ear infections |
| US7220431B2 (en) | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| DK1666477T3 (da) | 2003-09-10 | 2013-07-29 | Kyorin Seiyaku Kk | 7-(4-trisubstitueret 3-cyclopropylaminomethyl-1- pyrrolidinyl)-quinoloncarboxylsyre-derivat |
| WO2006015545A1 (fr) * | 2004-08-11 | 2006-02-16 | Shenzhen Tys R & D Co., Ltd. | Capsule de gelatine de moxifloxacin et procede pour sa preparation |
| US20080124385A1 (en) * | 2004-09-03 | 2008-05-29 | Piedmont Pharmaceuticals,Llc. | Methods for Transmembrane Treatment and Prevention of Otitis Media |
| DE102005055385A1 (de) * | 2004-12-09 | 2006-06-14 | Bayer Healthcare Ag | Arzneimittel zur hygienischen Applikation im Ohr |
| WO2006065301A2 (en) * | 2004-12-10 | 2006-06-22 | Alcon, Inc. | Compositions for treatment of ear infections |
| CN101317847B (zh) * | 2007-06-06 | 2010-10-13 | 深圳市瑞谷医药技术有限公司 | 一种眼用或耳鼻用药物组合物及其用途 |
| TWI544934B (zh) * | 2008-06-09 | 2016-08-11 | 愛爾康研究有限公司 | 含有氟喹諾酮抗生素藥物之經改良藥學組成物 |
| AR077372A1 (es) * | 2009-07-02 | 2011-08-24 | Alcon Res Ltd | Composiciones y metodos para tratar infecciones oftalmicas oticas o nasales |
| CN106309356A (zh) * | 2010-01-07 | 2017-01-11 | 明尼苏达大学董事会 | 将莫西沙星应用于耳的方法和组合物 |
| BR112014012885A2 (pt) | 2011-12-06 | 2017-06-13 | Alcon Res Ltd | composição de gel celulósica com estabilidade de viscosidade aperfeiçoada |
| RU2472507C1 (ru) * | 2012-02-01 | 2013-01-20 | Закрытое акционерное общество "Брынцалов-А" | Водный состав на основе моксифлоксацина для парентерального введения |
| US9504691B2 (en) * | 2012-12-06 | 2016-11-29 | Alcon Research, Ltd. | Finafloxacin suspension compositions |
| US20150164882A1 (en) | 2013-07-22 | 2015-06-18 | Imprimis Pharmaceuticals, Inc. | Pharmaceutical compositions for intraocular administration and methods for fabricating thereof |
| US20160279055A1 (en) | 2013-07-22 | 2016-09-29 | Imprimis Pharmaceuticals, Inc. | Pharmaceutical ophthalmic compositions for intraocular administration and methods for fabricating thereof |
| CN104224802B (zh) * | 2014-09-19 | 2017-12-12 | 南京优科生物医药研究有限公司 | 一种盐酸莫西沙星滴耳剂及其制备方法 |
| RU2595837C2 (ru) * | 2014-09-29 | 2016-08-27 | Открытое Акционерное Общество "Татхимфармпрепараты" | Состав и способ получения глазных капель |
| CN108348516B (zh) * | 2015-10-29 | 2021-02-12 | 特一华制药株式会社 | 外用剂 |
| JP2021524861A (ja) * | 2018-04-03 | 2021-09-16 | ハイデラバード アイ リサーチ ファウンデーション | フルオロキノロン系抗生物質の眼内投与のための粘膜付着性薬物送達システム |
| IT201900005280A1 (it) * | 2019-04-05 | 2020-10-05 | Ntc S R L | Composizione otologica |
| WO2021252054A1 (en) * | 2020-06-10 | 2021-12-16 | Ocular Science, Inc. | Compositions and uses in method for post-operative ocular care |
| CN116270662A (zh) * | 2021-12-03 | 2023-06-23 | 苏州欧康维视生物科技有限公司 | 盐酸莫西沙星地塞米松磷酸钠滴眼液 |
| KR102656260B1 (ko) | 2022-10-14 | 2024-04-09 | 주식회사태준제약 | 목시플록사신을 포함하는 안과용 조성물 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223493A (en) | 1984-12-28 | 1993-06-29 | Alcon Laboratories, Inc. | Anti-inflammatory compounds for ophthalmic use |
| US4910225A (en) * | 1988-01-27 | 1990-03-20 | Senju Pharmaceutical Co., Ltd. | Locally administrable therapeutic composition for inflammatory disease |
| DE3906365A1 (de) * | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| AU4201189A (en) * | 1988-08-26 | 1990-03-23 | Alcon Laboratories, Inc. | Combination of quinolone antibiotics and steroids for topical ophthalmic use |
| JPH085779B2 (ja) * | 1989-09-22 | 1996-01-24 | 杏林製薬株式会社 | フレロキサシン点眼液 |
| JPH03109236A (ja) * | 1989-09-22 | 1991-05-09 | Hoya Corp | 半導体超微粒子分散ガラスの製造方法 |
| TW209865B (OSRAM) * | 1992-01-10 | 1993-07-21 | Bayer Ag | |
| DK0639070T4 (da) | 1992-05-06 | 2010-12-13 | Alcon Lab Inc | Anvendelse af borat-polyolkomplekser til ophtalmiske præparater |
| DE4424369A1 (de) * | 1994-07-11 | 1996-01-18 | Bayer Ag | Pyrido[3,2,1.i,j][3,1]benzoxazinderivate |
| JPH0892241A (ja) * | 1994-09-22 | 1996-04-09 | Ss Pharmaceut Co Ltd | ５−ヒドラジノキノロンカルボン酸誘導体及びこれを有効成分とする抗菌剤 |
| US5631287A (en) | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| ZA964653B (en) * | 1995-06-06 | 1996-12-12 | Bayer Ag | Non-irritation non-sensitizing non-ototoxic otic anti-bacterial compositions |
| JP3290914B2 (ja) * | 1997-03-17 | 2002-06-10 | 参天製薬株式会社 | 眼組織におけるキノロン系抗菌剤の定量装置 |
| TR200000752T2 (tr) * | 1997-09-25 | 2000-09-21 | Bayer Aktiengesellschaft | Etkin terkibin kontrollü salınımı için ilaç formülü. |
| WO2000018366A1 (en) | 1998-09-23 | 2000-04-06 | Unilever N.V. | Oral composition with an improved teeth whitening effect |
| AR020661A1 (es) | 1998-09-30 | 2002-05-22 | Alcon Lab Inc | Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento |
| US20020001617A1 (en) * | 2000-05-26 | 2002-01-03 | Chang-Hyun Lee | Rapidly disintegrating tablet and process for the manufacture thereof |
-
1999
- 1999-09-27 AR ARP990104866A patent/AR020661A1/es not_active Application Discontinuation
- 1999-09-29 HK HK02100003.3A patent/HK1038691B/en not_active IP Right Cessation
- 1999-09-29 EP EP10176412.4A patent/EP2269602B1/en not_active Expired - Lifetime
- 1999-09-29 CA CA002659064A patent/CA2659064A1/en not_active Abandoned
- 1999-09-29 AT AT99956504T patent/ATE254458T1/de not_active IP Right Cessation
- 1999-09-29 ES ES14176366.4T patent/ES2602956T3/es not_active Expired - Lifetime
- 1999-09-29 ES ES10176412.4T patent/ES2526521T3/es not_active Expired - Lifetime
- 1999-09-29 PT PT99956504T patent/PT1117401E/pt unknown
- 1999-09-29 KR KR1020017003377A patent/KR101463243B1/ko not_active Expired - Lifetime
- 1999-09-29 AU AU13101/00A patent/AU762827B2/en not_active Expired
- 1999-09-29 CA CA002342211A patent/CA2342211C/en not_active Expired - Lifetime
- 1999-09-29 BR BRPI9914151-5A patent/BRPI9914151B1/pt not_active IP Right Cessation
- 1999-09-29 DE DE69943287T patent/DE69943287D1/de not_active Expired - Lifetime
- 1999-09-29 PT PT03020587T patent/PT1384478E/pt unknown
- 1999-09-29 DK DK10178657.2T patent/DK2301541T3/da active
- 1999-09-29 TR TR2007/04370T patent/TR200704370T2/xx unknown
- 1999-09-29 EP EP14176366.4A patent/EP2796138B1/en not_active Expired - Lifetime
- 1999-09-29 WO PCT/US1999/022622 patent/WO2000018386A2/en not_active Ceased
- 1999-09-29 EP EP99956504A patent/EP1117401B1/en not_active Revoked
- 1999-09-29 PT PT141763664T patent/PT2796138T/pt unknown
- 1999-09-29 CA CA2774207A patent/CA2774207A1/en not_active Abandoned
- 1999-09-29 ES ES99956504T patent/ES2207307T3/es not_active Expired - Lifetime
- 1999-09-29 TR TR2001/00883T patent/TR200100883T2/xx unknown
- 1999-09-29 DK DK10176412.4T patent/DK2269602T3/en active
- 1999-09-29 CN CNB998115096A patent/CN1184968C/zh not_active Ceased
- 1999-09-29 DK DK99956504T patent/DK1117401T3/da active
- 1999-09-29 EP EP10178657.2A patent/EP2301541B1/en not_active Expired - Lifetime
- 1999-09-29 JP JP2000571905A patent/JP2002525317A/ja active Pending
- 1999-09-29 DE DE69912972T patent/DE69912972T2/de not_active Revoked
- 1999-09-29 PT PT101764124T patent/PT2269602E/pt unknown
- 1999-09-29 CN CNB2004100973271A patent/CN100374114C/zh not_active Expired - Lifetime
- 1999-09-29 EP EP03020587A patent/EP1384478B1/en not_active Expired - Lifetime
- 1999-09-29 PT PT101786572T patent/PT2301541E/pt unknown
- 1999-09-29 DK DK03020587.6T patent/DK1384478T3/da active
- 1999-09-29 AT AT03020587T patent/ATE501732T1/de active
- 1999-09-29 ES ES10178657.2T patent/ES2519190T3/es not_active Expired - Lifetime
- 1999-09-29 DK DK14176366.4T patent/DK2796138T3/en active
- 1999-11-03 TW TW088116726A patent/TWI222361B/zh not_active IP Right Cessation
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2008
- 2008-08-22 JP JP2008213954A patent/JP2009007375A/ja not_active Withdrawn
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2011
- 2011-04-21 CY CY20111100409T patent/CY1111404T1/el unknown
- 2011-05-12 AR ARP110101646A patent/AR081393A2/es not_active Application Discontinuation
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2012
- 2012-01-10 JP JP2012002159A patent/JP2012067141A/ja not_active Withdrawn
- 2012-11-02 JP JP2012242519A patent/JP5563041B2/ja not_active Expired - Lifetime
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2014
- 2014-05-19 JP JP2014103658A patent/JP2014144982A/ja active Pending
- 2014-10-09 CY CY20141100819T patent/CY1115759T1/el unknown
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2015
- 2015-01-09 CY CY20151100023T patent/CY1115916T1/el unknown
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