JP2002516276A5 - - Google Patents
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- JP2002516276A5 JP2002516276A5 JP2000550479A JP2000550479A JP2002516276A5 JP 2002516276 A5 JP2002516276 A5 JP 2002516276A5 JP 2000550479 A JP2000550479 A JP 2000550479A JP 2000550479 A JP2000550479 A JP 2000550479A JP 2002516276 A5 JP2002516276 A5 JP 2002516276A5
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- 150000001875 compounds Chemical class 0.000 description 11
- 125000003118 aryl group Chemical group 0.000 description 7
- 0 *[n]1c(-c2ccccc2)nc2c1C=CI1=C=C21 Chemical compound *[n]1c(-c2ccccc2)nc2c1C=CI1=C=C21 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 208000030961 allergic reaction Diseases 0.000 description 3
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 2
- 239000000048 adrenergic agonist Substances 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- 125000003107 substituted aryl group Chemical group 0.000 description 2
- TVNHJCBZMUWEPJ-UHFFFAOYSA-N C=C(C1)C(c(cc2)ccc2NC(c(ccc(Cl)c2)c2Cl)=O)=Nc2c1ccc(NC(C1=C[I]=CC=C1)=O)c2 Chemical compound C=C(C1)C(c(cc2)ccc2NC(c(ccc(Cl)c2)c2Cl)=O)=Nc2c1ccc(NC(C1=C[I]=CC=C1)=O)c2 TVNHJCBZMUWEPJ-UHFFFAOYSA-N 0.000 description 1
- RYCDIDFMOJAHTR-UHFFFAOYSA-N CC(Nc(cc1)cc2c1[nH]c(C(C=C1)C#CC=C1NC(c(c(Cl)c1)ccc1Cl)=O)n2)=O Chemical compound CC(Nc(cc1)cc2c1[nH]c(C(C=C1)C#CC=C1NC(c(c(Cl)c1)ccc1Cl)=O)n2)=O RYCDIDFMOJAHTR-UHFFFAOYSA-N 0.000 description 1
- JEJOWPBTKHBJEE-UHFFFAOYSA-N CC1(CC(CCC2)CC2C1)C(Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NC(c1ccc[s]1)=O)n2)=O Chemical compound CC1(CC(CCC2)CC2C1)C(Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NC(c1ccc[s]1)=O)n2)=O JEJOWPBTKHBJEE-UHFFFAOYSA-N 0.000 description 1
- WLBXNHHZYXMSFD-UHFFFAOYSA-N O=C(C1(CC(C2)C3)CC3CC2C1)Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NC(c1cc(Cl)cc(Cl)c1)=O)n2 Chemical compound O=C(C1(CC(C2)C3)CC3CC2C1)Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NC(c1cc(Cl)cc(Cl)c1)=O)n2 WLBXNHHZYXMSFD-UHFFFAOYSA-N 0.000 description 1
- GJZWFQXXXBULJS-UHFFFAOYSA-N O=C(C1(CC(C2)C3)CC3CC2C1)Nc1ccc2[nH]c(-c(cc3)ccc3NC(c(ccc(Cl)c3)c3Cl)=O)nc2c1 Chemical compound O=C(C1(CC(C2)C3)CC3CC2C1)Nc1ccc2[nH]c(-c(cc3)ccc3NC(c(ccc(Cl)c3)c3Cl)=O)nc2c1 GJZWFQXXXBULJS-UHFFFAOYSA-N 0.000 description 1
- ZDXVTKWMXWYRIW-UHFFFAOYSA-N O=C(C1CCCC1)Nc(cc1)ccc1-c1nc2cc(NC(c3cnccc3)=O)ccc2[nH]1 Chemical compound O=C(C1CCCC1)Nc(cc1)ccc1-c1nc2cc(NC(c3cnccc3)=O)ccc2[nH]1 ZDXVTKWMXWYRIW-UHFFFAOYSA-N 0.000 description 1
- YJUKOATYPJQLBR-UHFFFAOYSA-N O=C(c1ccc[s]1)Nc(cc1)ccc1-c1nc2cc(NC(c3cccnc3)=O)ccc2[nH]1 Chemical compound O=C(c1ccc[s]1)Nc(cc1)ccc1-c1nc2cc(NC(c3cccnc3)=O)ccc2[nH]1 YJUKOATYPJQLBR-UHFFFAOYSA-N 0.000 description 1
- ZBQQGGIKORZRQQ-UHFFFAOYSA-N O=C(c1cccnc1)Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NCc(c(Cl)ccc1)c1Cl)n2 Chemical compound O=C(c1cccnc1)Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NCc(c(Cl)ccc1)c1Cl)n2 ZBQQGGIKORZRQQ-UHFFFAOYSA-N 0.000 description 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 230000001078 anti-cholinergic effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 150000005350 bicyclononyls Chemical group 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- ARUKYTASOALXFG-UHFFFAOYSA-N cycloheptylcycloheptane Chemical group C1CCCCCC1C1CCCCCC1 ARUKYTASOALXFG-UHFFFAOYSA-N 0.000 description 1
- NLUNLVTVUDIHFE-UHFFFAOYSA-N cyclooctylcyclooctane Chemical group C1CCCCCCC1C1CCCCCCC1 NLUNLVTVUDIHFE-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000003199 leukotriene receptor blocking agent Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
- -1 polycyclic cycloaryl Chemical group 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8649498P | 1998-05-22 | 1998-05-22 | |
| US60/086,494 | 1998-05-22 | ||
| PCT/US1999/011322 WO1999061019A1 (en) | 1998-05-22 | 1999-05-21 | BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF IgE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002516276A JP2002516276A (ja) | 2002-06-04 |
| JP2002516276A5 true JP2002516276A5 (https=) | 2006-07-20 |
Family
ID=22198947
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000550473A Withdrawn JP2002516274A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥ影響特性を有する化合物 |
| JP2000550480A Pending JP2002516277A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥのダウンレギュレータとしてのベンゾイミダゾールアナログ |
| JP2000550479A Pending JP2002516276A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥのモジュレータとしてのベンゾイミダゾール誘導体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000550473A Withdrawn JP2002516274A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥ影響特性を有する化合物 |
| JP2000550480A Pending JP2002516277A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥのダウンレギュレータとしてのベンゾイミダゾールアナログ |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6271390B1 (https=) |
| EP (3) | EP1079830A1 (https=) |
| JP (3) | JP2002516274A (https=) |
| KR (1) | KR100591652B1 (https=) |
| CN (4) | CN1311675A (https=) |
| AT (1) | ATE292465T1 (https=) |
| AU (3) | AU754943B2 (https=) |
| BR (3) | BR9910640A (https=) |
| CA (3) | CA2332985A1 (https=) |
| CZ (2) | CZ20004351A3 (https=) |
| DE (1) | DE69924607T2 (https=) |
| ES (1) | ES2241285T3 (https=) |
| HU (3) | HUP0102128A3 (https=) |
| IL (3) | IL139826A0 (https=) |
| MX (3) | MXPA00011470A (https=) |
| NO (3) | NO20005889L (https=) |
| NZ (2) | NZ508413A (https=) |
| PL (3) | PL345219A1 (https=) |
| RU (2) | RU2236220C2 (https=) |
| UA (2) | UA67774C2 (https=) |
| WO (3) | WO1999061020A1 (https=) |
| ZA (3) | ZA200007754B (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2236220C2 (ru) * | 1998-05-22 | 2004-09-20 | Аванир Фармасьютикэлз | Аналоги бензимидазола в качестве понижающих регуляторов ige |
| US6911462B2 (en) * | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
| US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| KR20010079782A (ko) * | 1998-09-11 | 2001-08-22 | 에가시라 구니오 | 벤젠 유도체 및 이의 의약 용도 |
| US6270746B1 (en) * | 1999-02-17 | 2001-08-07 | David H. Katz | Assay for the identification of IgE antibody suppressors |
| CA2368631A1 (en) * | 1999-03-26 | 2000-10-05 | Euro-Celtique S.A. | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
| JP4609691B2 (ja) * | 1999-07-01 | 2011-01-12 | 味の素株式会社 | 複素環化合物及びその医薬用途 |
| EP1211240A4 (en) | 1999-09-01 | 2003-02-12 | Ajinomoto Kk | BISCYCLOPROPANOCARBOXYLIC ACID AMIDE COMPOUNDS AND MEDICINAL USE THEREOF |
| US6759425B2 (en) | 1999-10-21 | 2004-07-06 | Avanir Pharmaceuticals | Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| US20070208087A1 (en) | 2001-11-02 | 2007-09-06 | Sanders Virginia J | Compounds, compositions and methods for the treatment of inflammatory diseases |
| BR0208010A (pt) * | 2001-03-12 | 2004-12-21 | Avanir Pharmaceuticals | Composto de benzimidazol para modulação de ige e inibição de proliferação celular |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| JP4658473B2 (ja) * | 2001-07-27 | 2011-03-23 | キュリス，インコーポレイテッド | ヘッジホッグシグナル伝達経路メディエーター、それに関連した組成物及び利用 |
| EP1435947B1 (en) | 2001-10-19 | 2007-08-15 | Ortho-McNeil Pharmaceutical, Inc. | 2-phenyl benzimidazoles and imidazo-¬4,5|-pyridines as cds1/chk2-inhibitors and adjuvants to chemotherapy or radiation therapy in the treatment of cancer |
| US20080081788A1 (en) * | 2002-01-14 | 2008-04-03 | Lipps Binie V | Diagnosis and treatment for immunoglobulin E (IgE) implicated disorders |
| US20030157555A1 (en) * | 2002-01-14 | 2003-08-21 | Lipps Binie V. | Diagnosis and treatment for immunoglobulin E ( IgE) implicated disorders |
| TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
| PT2527315E (pt) | 2002-05-31 | 2014-06-24 | Proteotech Inc | Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson |
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| EP1534335B9 (en) | 2002-08-14 | 2016-01-13 | Macrogenics, Inc. | Fcgammariib-specific antibodies and methods of use thereof |
| AU2003270426A1 (en) | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
| TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| WO2004041280A1 (en) * | 2002-11-02 | 2004-05-21 | Kyung-Lim Lee | Composition for preventing secretion of immunoglobulin e-dependent histamine releasing factor |
| GB2397301A (en) * | 2003-01-14 | 2004-07-21 | Novo Pharmaceuticals Ltd De | Substituted 1,3,5-triazine derivatives |
| JP4726235B2 (ja) | 2003-04-17 | 2011-07-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 癌の処置のためのチェックポイントキナーゼｃｄｓ１（ｃｈｋ２）インヒビターとしての２−フェニル−ベンズイミダゾールおよび２−フェニル−イミダゾ−‘４，５！−ピリジン誘導体 |
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| HRP20130971T1 (hr) | 2004-02-20 | 2013-11-08 | Boehringer Ingelheim International Gmbh | Inhibitori virusne polimeraze |
| BRPI0510803A (pt) * | 2004-05-12 | 2007-11-06 | Proteotech Inc | composto, composição farmacêutica, artigo de fabricação, métodos de tratar ou prevenir a formação, deposição, acúmulo ou persistência de fibrilas de amilóide e de fibrilas de sinucleìna, e de tratar, prevenir ou melhorar um ou mais sintomas de uma doença amilóide ou uma sinucleinopatia em um mamìfero, e, uso do composto |
| EP1824832B1 (en) | 2004-06-30 | 2011-04-27 | Janssen Pharmaceutica NV | Aryl-substituted benzimidazole and imidazopyridine ethers as anti-cancer agents |
| WO2006040645A1 (en) * | 2004-10-11 | 2006-04-20 | Ranbaxy Laboratories Limited | N-(3,5-dichloropyridin-4-yl)-2,4,5-alkoxy and 2,3,4-alkoxy benzamide derivatives as pde-iv (phophodiesterase type-iv) inhibitors for the treatment of inflammatory diseases such as asthma |
| US8334290B2 (en) † | 2005-10-31 | 2012-12-18 | Merck Sharp & Dohme Corp. | CETP inhibitors |
| EP1790345A1 (en) * | 2005-11-02 | 2007-05-30 | Esbatech AG | Triazin beta-secretase inhibitors |
| US7671221B2 (en) * | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| CA2856037C (en) * | 2005-12-28 | 2017-03-07 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| HUE030269T2 (en) | 2006-06-26 | 2017-04-28 | Macrogenics Inc | FC RIIB-specific antibodies and methods for their use |
| US20100112606A1 (en) * | 2008-10-17 | 2010-05-06 | Michael Armstrong | Measurement and analysis of leukotrienes |
| CA2740193A1 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
| EP2367823A1 (en) | 2008-12-23 | 2011-09-28 | Abbott Laboratories | Anti-viral compounds |
| CN102459165B (zh) | 2009-04-15 | 2015-09-02 | Abbvie公司 | 抗病毒化合物 |
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| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| UA118080C2 (uk) | 2009-06-11 | 2018-11-26 | Еббві Айрленд Анлімітед Компані | Противірусні сполуки |
| JP5690839B2 (ja) * | 2009-12-04 | 2015-03-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のベンゾイミダゾール阻害薬 |
| NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
| KR20130091729A (ko) * | 2010-07-20 | 2013-08-19 | 베스타론 코포레이션 | 살충제 트라이아진 및 피리미딘 |
| EP2632915B1 (en) | 2010-10-29 | 2015-08-12 | Boehringer Ingelheim International GmbH | Benzimidazole inhibitors of leukotriene production |
| JP5789888B2 (ja) | 2010-11-01 | 2015-10-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成のベンゾイミダゾールインヒビター |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
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| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
| EP3089757A1 (en) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Solid antiviral dosage forms |
| WO2019018562A1 (en) | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | AMIDO COMPOUND AS MODULATORS OF AHR |
| IL281427B2 (en) * | 2018-09-18 | 2026-01-01 | Terns Inc | Compounds that inhibit tyrosine kinase activity for use in the treatment of leukemia |
| CN110054558B (zh) * | 2019-05-16 | 2022-03-25 | 海门瑞一医药科技有限公司 | 一种1-三氟甲基环丙烷-1-甲酸的制备方法 |
| CN112441983B (zh) * | 2019-08-29 | 2023-09-15 | 山东福长药业有限公司 | 一种基于苯并咪唑取代的硝基苯的化合物及其制备方法 |
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1999
- 1999-05-21 RU RU2000129523/15A patent/RU2236220C2/ru not_active IP Right Cessation
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- 1999-05-21 WO PCT/US1999/011490 patent/WO1999061020A1/en not_active Ceased
- 1999-05-21 HU HU0102550A patent/HUP0102550A3/hu unknown
- 1999-05-21 DE DE69924607T patent/DE69924607T2/de not_active Expired - Fee Related
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- 1999-05-21 WO PCT/US1999/011322 patent/WO1999061019A1/en not_active Ceased
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- 1999-05-21 CA CA002332999A patent/CA2332999A1/en not_active Abandoned
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- 1999-05-21 ES ES99924442T patent/ES2241285T3/es not_active Expired - Lifetime
- 1999-05-21 CN CN99809102A patent/CN1311675A/zh active Pending
- 1999-05-21 AT AT99924442T patent/ATE292465T1/de not_active IP Right Cessation
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- 1999-05-21 BR BR9910641-8A patent/BR9910641A/pt not_active Application Discontinuation
- 1999-05-21 EP EP99925756A patent/EP1077695A2/en not_active Withdrawn
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- 1999-05-21 JP JP2000550480A patent/JP2002516277A/ja active Pending
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2000
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2001
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