JP2002516276A5 - - Google Patents
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- JP2002516276A5 JP2002516276A5 JP2000550479A JP2000550479A JP2002516276A5 JP 2002516276 A5 JP2002516276 A5 JP 2002516276A5 JP 2000550479 A JP2000550479 A JP 2000550479A JP 2000550479 A JP2000550479 A JP 2000550479A JP 2002516276 A5 JP2002516276 A5 JP 2002516276A5
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- 150000001875 compounds Chemical class 0.000 description 11
- 125000003118 aryl group Chemical group 0.000 description 7
- 0 *[n]1c(-c2ccccc2)nc2c1C=CI1=C=C21 Chemical compound *[n]1c(-c2ccccc2)nc2c1C=CI1=C=C21 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 208000030961 allergic reaction Diseases 0.000 description 3
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 2
- 239000000048 adrenergic agonist Substances 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- 125000003107 substituted aryl group Chemical group 0.000 description 2
- TVNHJCBZMUWEPJ-UHFFFAOYSA-N C=C(C1)C(c(cc2)ccc2NC(c(ccc(Cl)c2)c2Cl)=O)=Nc2c1ccc(NC(C1=C[I]=CC=C1)=O)c2 Chemical compound C=C(C1)C(c(cc2)ccc2NC(c(ccc(Cl)c2)c2Cl)=O)=Nc2c1ccc(NC(C1=C[I]=CC=C1)=O)c2 TVNHJCBZMUWEPJ-UHFFFAOYSA-N 0.000 description 1
- RYCDIDFMOJAHTR-UHFFFAOYSA-N CC(Nc(cc1)cc2c1[nH]c(C(C=C1)C#CC=C1NC(c(c(Cl)c1)ccc1Cl)=O)n2)=O Chemical compound CC(Nc(cc1)cc2c1[nH]c(C(C=C1)C#CC=C1NC(c(c(Cl)c1)ccc1Cl)=O)n2)=O RYCDIDFMOJAHTR-UHFFFAOYSA-N 0.000 description 1
- JEJOWPBTKHBJEE-UHFFFAOYSA-N CC1(CC(CCC2)CC2C1)C(Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NC(c1ccc[s]1)=O)n2)=O Chemical compound CC1(CC(CCC2)CC2C1)C(Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NC(c1ccc[s]1)=O)n2)=O JEJOWPBTKHBJEE-UHFFFAOYSA-N 0.000 description 1
- WLBXNHHZYXMSFD-UHFFFAOYSA-N O=C(C1(CC(C2)C3)CC3CC2C1)Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NC(c1cc(Cl)cc(Cl)c1)=O)n2 Chemical compound O=C(C1(CC(C2)C3)CC3CC2C1)Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NC(c1cc(Cl)cc(Cl)c1)=O)n2 WLBXNHHZYXMSFD-UHFFFAOYSA-N 0.000 description 1
- GJZWFQXXXBULJS-UHFFFAOYSA-N O=C(C1(CC(C2)C3)CC3CC2C1)Nc1ccc2[nH]c(-c(cc3)ccc3NC(c(ccc(Cl)c3)c3Cl)=O)nc2c1 Chemical compound O=C(C1(CC(C2)C3)CC3CC2C1)Nc1ccc2[nH]c(-c(cc3)ccc3NC(c(ccc(Cl)c3)c3Cl)=O)nc2c1 GJZWFQXXXBULJS-UHFFFAOYSA-N 0.000 description 1
- ZDXVTKWMXWYRIW-UHFFFAOYSA-N O=C(C1CCCC1)Nc(cc1)ccc1-c1nc2cc(NC(c3cnccc3)=O)ccc2[nH]1 Chemical compound O=C(C1CCCC1)Nc(cc1)ccc1-c1nc2cc(NC(c3cnccc3)=O)ccc2[nH]1 ZDXVTKWMXWYRIW-UHFFFAOYSA-N 0.000 description 1
- YJUKOATYPJQLBR-UHFFFAOYSA-N O=C(c1ccc[s]1)Nc(cc1)ccc1-c1nc2cc(NC(c3cccnc3)=O)ccc2[nH]1 Chemical compound O=C(c1ccc[s]1)Nc(cc1)ccc1-c1nc2cc(NC(c3cccnc3)=O)ccc2[nH]1 YJUKOATYPJQLBR-UHFFFAOYSA-N 0.000 description 1
- ZBQQGGIKORZRQQ-UHFFFAOYSA-N O=C(c1cccnc1)Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NCc(c(Cl)ccc1)c1Cl)n2 Chemical compound O=C(c1cccnc1)Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NCc(c(Cl)ccc1)c1Cl)n2 ZBQQGGIKORZRQQ-UHFFFAOYSA-N 0.000 description 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 230000001078 anti-cholinergic effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 150000005350 bicyclononyls Chemical group 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- ARUKYTASOALXFG-UHFFFAOYSA-N cycloheptylcycloheptane Chemical group C1CCCCCC1C1CCCCCC1 ARUKYTASOALXFG-UHFFFAOYSA-N 0.000 description 1
- NLUNLVTVUDIHFE-UHFFFAOYSA-N cyclooctylcyclooctane Chemical group C1CCCCCCC1C1CCCCCCC1 NLUNLVTVUDIHFE-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000003199 leukotriene receptor blocking agent Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
- -1 polycyclic cycloaryl Chemical group 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8649498P | 1998-05-22 | 1998-05-22 | |
| US60/086,494 | 1998-05-22 | ||
| PCT/US1999/011322 WO1999061019A1 (en) | 1998-05-22 | 1999-05-21 | BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF IgE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002516276A JP2002516276A (ja) | 2002-06-04 |
| JP2002516276A5 true JP2002516276A5 (https=) | 2006-07-20 |
Family
ID=22198947
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000550480A Pending JP2002516277A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥのダウンレギュレータとしてのベンゾイミダゾールアナログ |
| JP2000550479A Pending JP2002516276A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥのモジュレータとしてのベンゾイミダゾール誘導体 |
| JP2000550473A Withdrawn JP2002516274A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥ影響特性を有する化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000550480A Pending JP2002516277A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥのダウンレギュレータとしてのベンゾイミダゾールアナログ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000550473A Withdrawn JP2002516274A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥ影響特性を有する化合物 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6271390B1 (https=) |
| EP (3) | EP1079830A1 (https=) |
| JP (3) | JP2002516277A (https=) |
| KR (1) | KR100591652B1 (https=) |
| CN (4) | CN1311675A (https=) |
| AT (1) | ATE292465T1 (https=) |
| AU (3) | AU754562B2 (https=) |
| BR (3) | BR9910642A (https=) |
| CA (3) | CA2332985A1 (https=) |
| CZ (2) | CZ20004351A3 (https=) |
| DE (1) | DE69924607T2 (https=) |
| ES (1) | ES2241285T3 (https=) |
| HU (3) | HUP0102128A3 (https=) |
| IL (3) | IL139828A0 (https=) |
| MX (3) | MXPA00011422A (https=) |
| NO (3) | NO20005889L (https=) |
| NZ (2) | NZ508416A (https=) |
| PL (3) | PL345560A1 (https=) |
| RU (2) | RU2236221C2 (https=) |
| UA (2) | UA67775C2 (https=) |
| WO (3) | WO1999061020A1 (https=) |
| ZA (3) | ZA200007754B (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6919366B2 (en) | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| US6911462B2 (en) * | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
| BR9910642A (pt) * | 1998-05-22 | 2001-10-09 | Avanir Pharmaceuticals | Análogos de benzimidazol como reguladores descendentes de ige |
| BR9913562A (pt) | 1998-09-11 | 2001-05-22 | Ajinomoto Kk | Derivados de benzeno, inibidor de ativação de ap-1 e nf-capa b, inibidor de produção de citoquina inflamatória, inibidor de produção de metaloprotease matricial ou inibidor de aparecimento de fator de adesão de célula inflamatório, e, agente antiinflamatório, anti-reumático, imunossupressor, inibidor de metástase cancerosa, remédio para arterioesclerose e agente antiviral |
| US6270746B1 (en) * | 1999-02-17 | 2001-08-07 | David H. Katz | Assay for the identification of IgE antibody suppressors |
| TW502019B (en) * | 1999-03-26 | 2002-09-11 | Cocensys Inc | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
| BR0012046A (pt) | 1999-07-01 | 2002-05-14 | Ajinomoto Kk | Composto heterocìclico, composição farmacêutica, inibidor de ativação de ap-1 ou um inibidor da ativação de nf-kappab, inibidor da produção de citocina inflamatória, e, inibidor da produção de metaloprotease de matriz ou inibidor da expressão do fator de adesão de célula inflamatória |
| WO2001016091A1 (en) | 1999-09-01 | 2001-03-08 | Ajinomoto Co.,Inc. | Biscyclopropanecarboxylic acid amide compounds and medicinal use thereof |
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| DK1534335T4 (en) | 2002-08-14 | 2015-10-05 | Macrogenics Inc | FCGAMMARIIB-SPECIFIC ANTIBODIES AND PROCEDURES FOR USE THEREOF |
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| CN102911161A (zh) | 2004-02-20 | 2013-02-06 | 贝林格尔.英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
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| JP5301999B2 (ja) † | 2005-10-31 | 2013-09-25 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｃｅｔｐ阻害薬 |
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| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
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| CN110054558B (zh) * | 2019-05-16 | 2022-03-25 | 海门瑞一医药科技有限公司 | 一种1-三氟甲基环丙烷-1-甲酸的制备方法 |
| CN112441983B (zh) * | 2019-08-29 | 2023-09-15 | 山东福长药业有限公司 | 一种基于苯并咪唑取代的硝基苯的化合物及其制备方法 |
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| US20020023001A1 (en) * | 2000-07-11 | 2002-02-21 | Mcfarlin James A. | Method and apparatus for online creation and sale of custom local store marketing materials |
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| US20020198794A1 (en) * | 2001-06-21 | 2002-12-26 | Williams Edward P. | Inventory management system for determining suggested part stocking levels for a vehicle dealer |
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1999
- 1999-05-21 BR BR9910642-6A patent/BR9910642A/pt not_active Application Discontinuation
- 1999-05-21 KR KR1020007013141A patent/KR100591652B1/ko not_active Expired - Fee Related
- 1999-05-21 EP EP99953286A patent/EP1079830A1/en not_active Withdrawn
- 1999-05-21 MX MXPA00011422A patent/MXPA00011422A/es not_active IP Right Cessation
- 1999-05-21 WO PCT/US1999/011490 patent/WO1999061020A1/en not_active Ceased
- 1999-05-21 IL IL13982899A patent/IL139828A0/xx unknown
- 1999-05-21 EP EP99925756A patent/EP1077695A2/en not_active Withdrawn
- 1999-05-21 NZ NZ508416A patent/NZ508416A/en unknown
- 1999-05-21 RU RU2000129524/15A patent/RU2236221C2/ru not_active IP Right Cessation
- 1999-05-21 CN CN99809102A patent/CN1311675A/zh active Pending
- 1999-05-21 CA CA002332985A patent/CA2332985A1/en not_active Abandoned
- 1999-05-21 WO PCT/US1999/011363 patent/WO1999061013A2/en not_active Ceased
- 1999-05-21 HU HU0102128A patent/HUP0102128A3/hu unknown
- 1999-05-21 BR BR9910641-8A patent/BR9910641A/pt not_active Application Discontinuation
- 1999-05-21 UA UA2000116724A patent/UA67775C2/uk unknown
- 1999-05-21 IL IL13982799A patent/IL139827A0/xx unknown
- 1999-05-21 CA CA002332989A patent/CA2332989A1/en not_active Abandoned
- 1999-05-21 CA CA002332999A patent/CA2332999A1/en not_active Abandoned
- 1999-05-21 PL PL99345560A patent/PL345560A1/xx not_active IP Right Cessation
- 1999-05-21 AU AU40942/99A patent/AU754562B2/en not_active Ceased
- 1999-05-21 ES ES99924442T patent/ES2241285T3/es not_active Expired - Lifetime
- 1999-05-21 DE DE69924607T patent/DE69924607T2/de not_active Expired - Fee Related
- 1999-05-21 CN CNA2005100859764A patent/CN1721411A/zh active Pending
- 1999-05-21 HU HU0102550A patent/HUP0102550A3/hu unknown
- 1999-05-21 CN CN99809101A patent/CN1317965A/zh active Pending
- 1999-05-21 MX MXPA00011470A patent/MXPA00011470A/es unknown
- 1999-05-21 UA UA2000116723A patent/UA67774C2/uk unknown
- 1999-05-21 WO PCT/US1999/011322 patent/WO1999061019A1/en not_active Ceased
- 1999-05-21 CN CNB998091057A patent/CN1219510C/zh not_active Expired - Fee Related
- 1999-05-21 PL PL99345952A patent/PL345952A1/xx unknown
- 1999-05-21 JP JP2000550480A patent/JP2002516277A/ja active Pending
- 1999-05-21 CZ CZ20004351A patent/CZ20004351A3/cs unknown
- 1999-05-21 EP EP99924442A patent/EP1077700B1/en not_active Expired - Lifetime
- 1999-05-21 NZ NZ508413A patent/NZ508413A/en unknown
- 1999-05-21 AU AU43120/99A patent/AU754943B2/en not_active Ceased
- 1999-05-21 JP JP2000550479A patent/JP2002516276A/ja active Pending
- 1999-05-21 US US09/316,870 patent/US6271390B1/en not_active Expired - Fee Related
- 1999-05-21 BR BR9910640-0A patent/BR9910640A/pt not_active IP Right Cessation
- 1999-05-21 MX MXPA00011467A patent/MXPA00011467A/es unknown
- 1999-05-21 RU RU2000129523/15A patent/RU2236220C2/ru not_active IP Right Cessation
- 1999-05-21 HU HU0101894A patent/HUP0101894A3/hu unknown
- 1999-05-21 IL IL13982699A patent/IL139826A0/xx unknown
- 1999-05-21 CZ CZ20004350A patent/CZ20004350A3/cs unknown
- 1999-05-21 AU AU41978/99A patent/AU4197899A/en not_active Abandoned
- 1999-05-21 PL PL99345219A patent/PL345219A1/xx unknown
- 1999-05-21 JP JP2000550473A patent/JP2002516274A/ja not_active Withdrawn
- 1999-05-21 AT AT99924442T patent/ATE292465T1/de not_active IP Right Cessation
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2000
- 2000-02-21 ZA ZA200007754A patent/ZA200007754B/en unknown
- 2000-11-21 NO NO20005889A patent/NO20005889L/no unknown
- 2000-11-21 NO NO20005888A patent/NO20005888L/no unknown
- 2000-11-21 NO NO20005887A patent/NO20005887L/no not_active Application Discontinuation
- 2000-12-21 ZA ZA200007752A patent/ZA200007752B/en unknown
- 2000-12-21 ZA ZA200007753A patent/ZA200007753B/xx unknown
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2001
- 2001-06-14 US US09/882,340 patent/US6451829B2/en not_active Expired - Fee Related
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