JP2002514405A5 - - Google Patents

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Publication number
JP2002514405A5
JP2002514405A5 JP2000548372A JP2000548372A JP2002514405A5 JP 2002514405 A5 JP2002514405 A5 JP 2002514405A5 JP 2000548372 A JP2000548372 A JP 2000548372A JP 2000548372 A JP2000548372 A JP 2000548372A JP 2002514405 A5 JP2002514405 A5 JP 2002514405A5
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JP
Japan
Prior art keywords
antibody
domain
fibronectin
affinity
angiogenesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000548372A
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English (en)
Japanese (ja)
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JP2002514405A (ja
Filing date
Publication date
Priority claimed from US09/300,425 external-priority patent/US20030045681A1/en
Application filed filed Critical
Priority claimed from PCT/EP1999/003210 external-priority patent/WO1999058570A2/en
Publication of JP2002514405A publication Critical patent/JP2002514405A/ja
Publication of JP2002514405A5 publication Critical patent/JP2002514405A5/ja
Pending legal-status Critical Current

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JP2000548372A 1998-05-11 1999-05-11 フィブロネクチンのed−bドメインに対する抗体、それを含有する抱合体、および、腫瘍および血管新生関連の疾病の診断および治療をするためのそれの用途 Pending JP2002514405A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7533898A 1998-05-11 1998-05-11
US09/075,338 1998-05-11
US09/300,425 1999-04-28
US09/300,425 US20030045681A1 (en) 1998-05-11 1999-04-28 Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
PCT/EP1999/003210 WO1999058570A2 (en) 1998-05-11 1999-05-11 Antibodies to the ed-b domain of fibronectin, conjugates containing them and use therefor for diagnosis and therapy of tumors and diseases associated with angiogenesis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009191668A Division JP2009280607A (ja) 1998-05-11 2009-08-21 フィブロネクチンのed−bドメインに対する抗体、それを含有する抱合体、および、腫瘍および血管新生関連の疾病の診断および治療をするためのそれの用途

Publications (2)

Publication Number Publication Date
JP2002514405A JP2002514405A (ja) 2002-05-21
JP2002514405A5 true JP2002514405A5 (https=) 2006-01-05

Family

ID=26756726

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000548372A Pending JP2002514405A (ja) 1998-05-11 1999-05-11 フィブロネクチンのed−bドメインに対する抗体、それを含有する抱合体、および、腫瘍および血管新生関連の疾病の診断および治療をするためのそれの用途

Country Status (24)

Country Link
US (1) US20070189963A1 (https=)
EP (1) EP1084145B1 (https=)
JP (1) JP2002514405A (https=)
CN (1) CN1250571C (https=)
AT (1) ATE301676T1 (https=)
AU (1) AU759207B2 (https=)
BR (1) BRPI9910394B8 (https=)
CA (1) CA2333833C (https=)
CZ (1) CZ300495B6 (https=)
DE (1) DE69926630T2 (https=)
DK (1) DK1084145T3 (https=)
EA (1) EA005685B1 (https=)
EE (1) EE05435B1 (https=)
ES (1) ES2247802T3 (https=)
HU (1) HU225675B1 (https=)
IL (1) IL139452A0 (https=)
IS (1) IS2522B (https=)
NO (1) NO327732B1 (https=)
NZ (1) NZ508600A (https=)
PL (1) PL199353B1 (https=)
SK (1) SK286822B6 (https=)
TR (1) TR200003317T2 (https=)
TW (1) TWI259837B (https=)
WO (1) WO1999058570A2 (https=)

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US20030100010A1 (en) * 2001-11-23 2003-05-29 George Jackowski Fibrinogen biopolymer Marker predictive of type II diabetes
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MXPA04006517A (es) 2002-01-03 2005-03-31 Schering Ag Conjugados que comprenden un anticuerpo especifico para el dominio ed-b de fibronectina y sus usos para la deteccion y tratamiento de tumores.
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KR20120068769A (ko) 2002-07-15 2012-06-27 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 음이온성 인지질 및 아미노인지질에 결합하는 선택된 항체 및 치료하는데 있어서 이의 용도
DE10324447A1 (de) 2003-05-28 2004-12-30 Scil Proteins Gmbh Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
DE10348319A1 (de) * 2003-10-17 2005-05-19 Schering Ag Bindemoleküle für die Extra-Domäne B von Fibronectin zur Detektion von atherosklerotischen Plaques
US7785591B2 (en) 2004-10-14 2010-08-31 Morphosys Ag Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies
ES2577292T3 (es) * 2005-11-07 2016-07-14 Genentech, Inc. Polipéptidos de unión con secuencias hipervariables de VH/VL diversificadas y consenso
ATE463512T1 (de) * 2005-11-09 2010-04-15 Morphosys Ag Identifizierung und charakterisierung von funktionsblockierenden anti-ed-b-fibronektin antikörpern
EP1842553A1 (en) * 2006-04-07 2007-10-10 Bayer Schering Pharma Aktiengesellschaft Combination of an anti-EDb fibronectin domain antibody/IL2 fusion protein and a further small molecule
EP1925664A1 (en) 2006-11-15 2008-05-28 Scil proteins GmbH Artificial binding proteins based on a modified alpha helical region of ubiquitin
ATE548052T1 (de) 2008-01-17 2012-03-15 Philogen Spa Kombination aus einem anti-edb-fibronectin- antikörper-il-2-fusionsprotein und einem b-zellen bindenden molekül, b-zellen-vorläufern und/oder deren krebserregendem gegenspieler
EP2100621A1 (en) 2008-03-10 2009-09-16 mivenion GmbH Polyether polyol dendron conjugates with effector molecules for biological targeting
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US20110306065A1 (en) * 2008-11-12 2011-12-15 The Trustees Of The University Of Pennsylvania Use of an antibody and a rare-earth based crystal
RU2553333C2 (ru) 2009-12-14 2015-06-10 Сцил Протеинс Гмбх Способ идентификации гетеромультимерных модифицированных убиквитиновых белков со способностью связываться с лигандами
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EP2734232B1 (en) 2011-07-19 2017-11-01 Philogen S.p.A. Sequential anti-ctla4 and targeted il-2 therapy
RU2481839C2 (ru) * 2011-08-16 2013-05-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Башкирский государственный медицинский университет Министерства здравоохранения и социального развития" Способ лечения ишемической болезни сердца с дистальным или диффузным поражением коронарных артерий
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WO2014094799A1 (en) 2012-12-19 2014-06-26 Scil-Proteins-Gmbh Ubiquitin moieties as a means for prolonging serum half-life
CN104395342B (zh) * 2013-06-06 2017-07-04 合肥立方制药股份有限公司 人源抗纤连蛋白ed‑b结构域的抗体及其用途
JP6738340B2 (ja) 2015-02-06 2020-08-12 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH 新規なegfr結合タンパク質
JP6856938B2 (ja) 2015-07-16 2021-04-14 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH 新規な免疫グロブリン結合タンパク質およびアフィニティ精製におけるそれらの使用
WO2017013136A1 (en) 2015-07-20 2017-01-26 Scil Proteins Gmbh Novel binding proteins based on di-ubiquitin muteins and methods for generation
WO2017084017A1 (zh) * 2015-11-16 2017-05-26 合肥立方制药股份有限公司 Ed-b蛋白在诊断组织增生中的应用
US11813336B2 (en) 2016-05-04 2023-11-14 Navigo Proteins Gmbh Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker
GB201612317D0 (en) 2016-07-15 2016-08-31 Philogen Spa Antibody compositions
CN109963864B (zh) 2016-08-11 2024-01-02 瑞普利金公司 用于亲和色谱的碱性稳定性fc结合蛋白
ES3007557T3 (en) 2016-10-17 2025-03-20 Pfizer Anti-edb antibodies and antibody-drug conjugates
GB201621806D0 (en) 2016-12-21 2017-02-01 Philogen Spa Immunocytokines with progressive activation mechanism
CN111148759B (zh) * 2017-09-30 2023-09-19 合肥立方制药股份有限公司 结合至纤维连接蛋白b结构域的蛋白
US11414466B2 (en) 2017-11-07 2022-08-16 Navigo Proteins Gmbh Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer
WO2019185792A1 (en) 2018-03-29 2019-10-03 Philogen S.P.A Cancer treatment using immunoconjugates and immune check-point inhibitors
EP3660039A1 (en) 2018-11-30 2020-06-03 Philogen S.p.A. Il2 immunoconjugates
WO2020070150A1 (en) 2018-10-02 2020-04-09 Philogen S.P.A Il2 immunoconjugates
MX2021007283A (es) 2018-12-18 2021-07-15 Navigo Proteins Gmbh Proteinas de union especificas del folr1 novedosas para diagnostico y tratamiento del cancer.
WO2022268983A2 (en) 2021-06-23 2022-12-29 Cytune Pharma Interleukin-15 based immunocytokines
CN117597355A (zh) 2021-06-23 2024-02-23 赛腾制药 白细胞介素15变体
JP7690131B2 (ja) 2022-01-04 2025-06-09 フィロジェン ソチエタ ペル アツィオーニ Il-12を含むイムノサイトカインとキナーゼ阻害剤の組合せ
US12576154B2 (en) 2022-08-01 2026-03-17 Philochem Ag Conjugates of PSMA-binding moieties with cytotoxic agents
CN119836298A (zh) 2022-09-01 2025-04-15 菲洛根股份公司 用于非黑色素瘤皮肤癌的TNFα和白细胞介素-2组合疗法
CA3266566A1 (en) 2022-09-06 2024-03-14 Philochem Ag MULTIVALENT FIBROBLAST ACTIVATING PROTEIN LIGANDS FOR TARGETED DELIVERY APPLICATIONS
WO2025061801A1 (en) 2023-09-19 2025-03-27 Philochem Ag Therapeutic combination of an anti-edb fibronectin domain antibody il2 or il12 fusion protein and a lutetium-177 radioconjugate
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Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
GB9610967D0 (en) * 1996-05-24 1996-07-31 Cambridge Antibody Tech Specific binding members,materials and methods

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