JP2003524018A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003524018A5 JP2003524018A5 JP2001562581A JP2001562581A JP2003524018A5 JP 2003524018 A5 JP2003524018 A5 JP 2003524018A5 JP 2001562581 A JP2001562581 A JP 2001562581A JP 2001562581 A JP2001562581 A JP 2001562581A JP 2003524018 A5 JP2003524018 A5 JP 2003524018A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- conjugate
- domain
- angiogenesis
- affinity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 description 10
- 230000033115 angiogenesis Effects 0.000 description 8
- 102000016359 Fibronectins Human genes 0.000 description 6
- 108010067306 Fibronectins Proteins 0.000 description 6
- 230000023555 blood coagulation Effects 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 239000003504 photosensitizing agent Substances 0.000 description 4
- 206010053648 Vascular occlusion Diseases 0.000 description 3
- 208000021331 vascular occlusion disease Diseases 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- MLKYWECXFLBPGE-UHFFFAOYSA-N 3-trimethylstannylbenzoic acid Chemical compound C[Sn](C)(C)C1=CC=CC(C(O)=O)=C1 MLKYWECXFLBPGE-UHFFFAOYSA-N 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- DDCIMZXBRKWQPW-UHFFFAOYSA-N [Cl+].[Sn+4] Chemical group [Cl+].[Sn+4] DDCIMZXBRKWQPW-UHFFFAOYSA-N 0.000 description 1
- 206010064930 age-related macular degeneration Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- JCXGWMGPZLAOME-AKLPVKDBSA-N bismuth-212 Chemical compound [212Bi] JCXGWMGPZLAOME-AKLPVKDBSA-N 0.000 description 1
- JCXGWMGPZLAOME-RNFDNDRNSA-N bismuth-213 Chemical compound [213Bi] JCXGWMGPZLAOME-RNFDNDRNSA-N 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51208200A | 2000-02-24 | 2000-02-24 | |
| US09/512,082 | 2000-02-24 | ||
| PCT/EP2001/002062 WO2001062800A1 (en) | 2000-02-24 | 2001-02-23 | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003524018A JP2003524018A (ja) | 2003-08-12 |
| JP2003524018A5 true JP2003524018A5 (https=) | 2008-04-17 |
Family
ID=24037588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001562581A Abandoned JP2003524018A (ja) | 2000-02-24 | 2001-02-23 | フィブロネクチンのｅｄ‐ｂドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8097254B2 (https=) |
| EP (1) | EP1259548A1 (https=) |
| JP (1) | JP2003524018A (https=) |
| AU (2) | AU2001242432B2 (https=) |
| CA (1) | CA2400622A1 (https=) |
| WO (1) | WO2001062800A1 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| AU2001239470A1 (en) * | 2000-02-24 | 2001-09-03 | Philogen S.R.L. | Compositions and methods for treatment of angiogenesis in pathological lesions |
| JP2003524018A (ja) | 2000-02-24 | 2003-08-12 | アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ | フィブロネクチンのｅｄ‐ｂドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用 |
| MXPA04006517A (es) | 2002-01-03 | 2005-03-31 | Schering Ag | Conjugados que comprenden un anticuerpo especifico para el dominio ed-b de fibronectina y sus usos para la deteccion y tratamiento de tumores. |
| EP2174958A1 (en) * | 2002-03-11 | 2010-04-14 | Philogen S.p.A. | Antibodies derived from anti ed-b l19 and targeting tumor vasculature |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| EP1514561A1 (en) * | 2003-09-10 | 2005-03-16 | Philogen S.p.A. | Targeting of tumor vasculature using radiolabelled antibody L19 against fibronectin ED-B |
| DE10348319A1 (de) * | 2003-10-17 | 2005-05-19 | Schering Ag | Bindemoleküle für die Extra-Domäne B von Fibronectin zur Detektion von atherosklerotischen Plaques |
| ATE374367T1 (de) * | 2004-07-22 | 2007-10-15 | Bayer Schering Pharma Ag | Verwendung von cyanin-farbstoffen zur diagnose von krankheiten, welche mit angiogenese assoziert sind |
| US7785591B2 (en) | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
| AU2005304031B2 (en) | 2004-11-09 | 2009-04-23 | Philogen Spa | Antibodies against tenascin-C |
| ATE463512T1 (de) | 2005-11-09 | 2010-04-15 | Morphosys Ag | Identifizierung und charakterisierung von funktionsblockierenden anti-ed-b-fibronektin antikörpern |
| EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| EP2100621A1 (en) | 2008-03-10 | 2009-09-16 | mivenion GmbH | Polyether polyol dendron conjugates with effector molecules for biological targeting |
| EP2461832B1 (en) | 2009-08-05 | 2017-06-28 | Philogen S.p.A. | Targeting of bone marrow neovasculature |
| RU2553333C2 (ru) | 2009-12-14 | 2015-06-10 | Сцил Протеинс Гмбх | Способ идентификации гетеромультимерных модифицированных убиквитиновых белков со способностью связываться с лигандами |
| WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
| CA2837804C (en) | 2011-06-15 | 2018-03-20 | Scil Proteins Gmbh | Dimeric binding proteins based on modified ubiquitins |
| EP2861616A1 (en) | 2012-06-13 | 2015-04-22 | Scil Proteins GmbH | Human fusion proteins comprising single chain tnfalpha and targeting domains |
| WO2014094799A1 (en) | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Ubiquitin moieties as a means for prolonging serum half-life |
| JP6738340B2 (ja) | 2015-02-06 | 2020-08-12 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 新規なｅｇｆｒ結合タンパク質 |
| JP6856938B2 (ja) | 2015-07-16 | 2021-04-14 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 新規な免疫グロブリン結合タンパク質およびアフィニティ精製におけるそれらの使用 |
| WO2017013136A1 (en) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
| US11813336B2 (en) | 2016-05-04 | 2023-11-14 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| CN109963864B (zh) | 2016-08-11 | 2024-01-02 | 瑞普利金公司 | 用于亲和色谱的碱性稳定性fc结合蛋白 |
| ES3007557T3 (en) | 2016-10-17 | 2025-03-20 | Pfizer | Anti-edb antibodies and antibody-drug conjugates |
| CN111148759B (zh) * | 2017-09-30 | 2023-09-19 | 合肥立方制药股份有限公司 | 结合至纤维连接蛋白b结构域的蛋白 |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
| TWI844524B (zh) | 2018-02-09 | 2024-06-11 | 義大利商費洛根公司 | 靶向edb之il-12組合物 |
| MX2021007283A (es) | 2018-12-18 | 2021-07-15 | Navigo Proteins Gmbh | Proteinas de union especificas del folr1 novedosas para diagnostico y tratamiento del cancer. |
| WO2021016091A1 (en) | 2019-07-19 | 2021-01-28 | St. Jude Children's Research Hospital, Inc. | Chimeric antigen receptors for direct and indirect targeting of fibronectin-positive tumors |
| CA3164226A1 (en) * | 2019-12-11 | 2021-06-17 | Cilag Gmbh International | Multispecific binding molecules comprising ltbr and edb binding domains and uses thereof |
| JP7352040B2 (ja) | 2020-05-22 | 2023-09-27 | フィロジェン エッセ．ピー．アー． | 脳腫瘍の治療のためのＴＮＦα免疫コンジュゲート療法 |
| JP2025513943A (ja) | 2022-03-21 | 2025-05-01 | ピロゲン エス．ピー．エー | ＴＮＦα免疫複合体製剤 |
| CA3246548A1 (en) | 2022-03-23 | 2023-09-28 | Philogen S.P.A | Immunoconjugate preparation IL2 |
| US20250368738A1 (en) | 2022-07-22 | 2025-12-04 | Philogen S.P.A | Anti-cd28 antibodies |
| US12576154B2 (en) | 2022-08-01 | 2026-03-17 | Philochem Ag | Conjugates of PSMA-binding moieties with cytotoxic agents |
| CN115505040A (zh) * | 2022-08-01 | 2022-12-23 | 江苏艾洛特医药研究院有限公司 | 一种用于检测edb蛋白的免疫组化试剂盒及其应用 |
| CA3266566A1 (en) | 2022-09-06 | 2024-03-14 | Philochem Ag | MULTIVALENT FIBROBLAST ACTIVATING PROTEIN LIGANDS FOR TARGETED DELIVERY APPLICATIONS |
| CN118108796B (zh) * | 2024-04-08 | 2024-12-24 | 中国科学院近代物理研究所 | 靶向治疗脑胶质瘤的211At标记多肽及其制备方法 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4341223A (en) | 1981-02-04 | 1982-07-27 | Lutz Lauralee A | Fluoresceable composition and method of determining fluid flow |
| US4741900A (en) * | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| ATE101203T1 (de) | 1985-01-28 | 1994-02-15 | Xoma Corp | Arab-promoter und verfahren zur herstellung von polypeptiden einschliesslich cecropinen mittels mikrobiologischer verfahren. |
| US5576195A (en) | 1985-11-01 | 1996-11-19 | Xoma Corporation | Vectors with pectate lyase signal sequence |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5243029A (en) | 1986-04-09 | 1993-09-07 | Fred Hutchinson Cancer Research Center | Oncofetal structure of fibronectin |
| US4894326A (en) | 1986-04-09 | 1990-01-16 | Fred Hutchinson Cancer Research Center | Monoclonal antibody defining oncofetal structure of fibronectin |
| CA1341235C (en) | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
| EP0396612B1 (en) | 1988-01-11 | 1996-07-24 | Xoma Corporation | Novel plasmid vector with pectate lyase signal sequence |
| EP0330506A3 (en) | 1988-02-26 | 1990-06-20 | Dana Farber Cancer Institute | Vla proteins |
| IT1217724B (it) | 1988-05-26 | 1990-03-30 | Ist Naz Ric Sul Cancro | Anticorpo monoclonale specifico per una sequenza di fibronettina espressa in cellule trasformate ibridoma secernente tale anticorpo e impiego dell'anticorpo monoclonale per la diagnosi di tumori |
| US5177015A (en) | 1988-08-12 | 1993-01-05 | Fred Hutchinson Cancer Research Centre | Onco-developmentally regulated α-N-acetylgalactosaminyltransferase |
| US5843156A (en) | 1988-08-24 | 1998-12-01 | Endoluminal Therapeutics, Inc. | Local polymeric gel cellular therapy |
| JPH0276598A (ja) | 1988-09-14 | 1990-03-15 | Fujita Gakuen | 抗ｅｄ−ｂ抗体 |
| US5270030A (en) * | 1988-12-29 | 1993-12-14 | Bio-Technology General Corp. | Fibrin binding domain polypeptide and method of producing |
| DK0486622T3 (da) | 1989-08-09 | 1999-07-19 | Rhomed Inc | Direkte radiomærkning af antistoffer og andre proteiner med technetium eller rhenium |
| US5460785A (en) * | 1989-08-09 | 1995-10-24 | Rhomed Incorporated | Direct labeling of antibodies and other protein with metal ions |
| US5120830A (en) | 1990-10-25 | 1992-06-09 | Washington University | Inhibitory peptides against α-2, β-1 mediated mg++ dependent adhesion of platelets to collagen |
| JPH04169195A (ja) | 1990-10-31 | 1992-06-17 | Fujita Gakuen | 抗ｅｄ―ｂモノクローナル抗体 |
| US5140470A (en) * | 1991-01-07 | 1992-08-18 | New Focus, Inc. | Optical mounting apparatus |
| ATE207080T1 (de) | 1991-11-25 | 2001-11-15 | Enzon Inc | Multivalente antigen-bindende proteine |
| US5629291A (en) | 1992-01-31 | 1997-05-13 | La Jolla Cancer Research Foundation | Methods of modulating fibronectin extracellular matrix assembly |
| CA2372813A1 (en) | 1992-02-06 | 1993-08-19 | L.L. Houston | Biosynthetic binding protein for cancer marker |
| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US6036955A (en) * | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
| US6093399A (en) * | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
| US6749853B1 (en) * | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| US6004555A (en) * | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
| US5877289A (en) * | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| US5976535A (en) | 1992-06-09 | 1999-11-02 | Neorx Corporation | Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore |
| US5561114A (en) | 1992-09-25 | 1996-10-01 | Otsuka Pharmaceutical Factory Inc. | Adsorbent for cellular fibronectin, a method for fractional purification of fibronectin and a method of hemocatharisis |
| EP0627932B1 (en) | 1992-11-04 | 2002-05-08 | City Of Hope | Antibody construct |
| US5491130A (en) | 1992-11-10 | 1996-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Peptide inhibitors of fibronectin and related collagen-binding proteins |
| ES2156149T3 (es) | 1992-12-04 | 2001-06-16 | Medical Res Council | Proteinas de union multivalente y multiespecificas, su fabricacion y su uso. |
| US5348485A (en) * | 1993-04-12 | 1994-09-20 | Electronic Retailing Systems Int'l Inc. | Electronic price display system with vertical rail |
| GB9324807D0 (en) | 1993-12-03 | 1994-01-19 | Cancer Res Campaign Tech | Tumour antibody |
| US6015897A (en) | 1993-12-07 | 2000-01-18 | Neorx Corporation | Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota |
| US5523229A (en) | 1994-03-22 | 1996-06-04 | Trustees Of The University Of Pennsylvania | Antibodies specific for oncofetal fibronectin |
| DE4417865A1 (de) | 1994-05-20 | 1995-11-23 | Behringwerke Ag | Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie |
| ITFI940095A1 (it) | 1994-05-23 | 1995-11-23 | Molteni & C | Coniugati fotodinamici aventi proprieta' biocide |
| US5648485A (en) | 1994-10-26 | 1997-07-15 | University Of British Columbia | β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins |
| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| CA2165228A1 (en) | 1994-12-27 | 1996-06-28 | Yoshitoshi Itaya | Metal chelate forming peptides and use thereof |
| WO1996023816A1 (en) | 1995-02-01 | 1996-08-08 | British Technology Group Limited | Radiolabelled proteins |
| US5796535A (en) * | 1995-05-12 | 1998-08-18 | Cirrus Logic, Inc. | Sampled amplitude read channel employing a user data frequency synthesizer and a servo data frequency synthesizer |
| WO1997002479A2 (en) | 1995-06-30 | 1997-01-23 | Yale University | Human monoclonal anti-tumor antibodies |
| US5808146A (en) | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
| GB9610967D0 (en) * | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| US5913884A (en) | 1996-09-19 | 1999-06-22 | The General Hospital Corporation | Inhibition of fibrosis by photodynamic therapy |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| US6267722B1 (en) | 1998-02-03 | 2001-07-31 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| US6394952B1 (en) | 1998-02-03 | 2002-05-28 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| BR9909346A (pt) | 1998-04-02 | 2001-09-11 | Univ Oklahoma | Segmento de ácido nucleico, vetor recombinante, célula hospedeira, composição, processos para detectar uma espécie de dna, uma célula bacteriana e infecção, para produzir ácido hialurÈnico e para criar uma vacina, sequência de ácido nucleico e de cdna, vacina e teste diagnóstico |
| US6296831B1 (en) | 1998-04-10 | 2001-10-02 | Battelle Memorial Institute | Stimulus sensitive gel with radioisotope and methods of making |
| US5997842A (en) * | 1998-04-13 | 1999-12-07 | Light Sciences Limited Partnership | Radionuclide excited phosphorescent material for administering PDT |
| US20030045681A1 (en) * | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| US20030176663A1 (en) * | 1998-05-11 | 2003-09-18 | Eidgenossische Technische Hochscule | Specific binding molecules for scintigraphy |
| TWI259837B (en) | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| US6630570B1 (en) | 1999-04-09 | 2003-10-07 | Insitut für Diagnostikforschung GmbH | Short-chain peptide-dye conjugates as contrast media for optical diagnosis |
| US6171578B1 (en) | 1999-04-14 | 2001-01-09 | Diatide, Inc. | Benzodiazepine derivatives for imaging thrombi |
| US6342219B1 (en) | 1999-04-28 | 2002-01-29 | Board Of Regents, The University Of Texas System | Antibody compositions for selectively inhibiting VEGF |
| DE19947559A1 (de) | 1999-09-24 | 2001-04-19 | Schering Ag | Antikörper-Farbstoffkonjugate gegen Zielstrukturen der Angiogenese zur intraoperativen Tumorranddarstellung |
| US20020049247A1 (en) * | 2000-01-12 | 2002-04-25 | Chen James C. | Novel treatment for eye disease |
| JP2003524018A (ja) | 2000-02-24 | 2003-08-12 | アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ | フィブロネクチンのｅｄ‐ｂドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用 |
| AU2001239470A1 (en) * | 2000-02-24 | 2001-09-03 | Philogen S.R.L. | Compositions and methods for treatment of angiogenesis in pathological lesions |
| EP1130099A1 (en) | 2000-02-25 | 2001-09-05 | Crucell Holland B.V. | Activated vitronectin as a marker of angiogenesis detected with phage antibodies |
| US6342326B1 (en) | 2000-05-10 | 2002-01-29 | Beckman Coulter, Inc. | Synthesis and use of acyl fluorides of cyanine dyes |
| WO2001096599A2 (en) | 2000-06-15 | 2001-12-20 | Philogen S.R.L. | Methods for quantitative determination of b-fibronectin in biological fluids and tissues |
| CN1246333C (zh) | 2000-09-07 | 2006-03-22 | 舍林股份公司 | EDb－纤粘连蛋白结构域(II)的受体 |
| US6693245B2 (en) * | 2000-09-29 | 2004-02-17 | Anritsu Corporation | Electronic balance which is easily assembled, maintained, downsized and improved with respect to weighing performance, and method for manufacturing the same |
| US7252824B2 (en) * | 2001-03-07 | 2007-08-07 | Mannkind Corporation | Anti-neovasculature preparations for cancer |
| WO2003008537A2 (en) * | 2001-04-06 | 2003-01-30 | Mannkind Corporation | Epitope sequences |
| MXPA04006517A (es) | 2002-01-03 | 2005-03-31 | Schering Ag | Conjugados que comprenden un anticuerpo especifico para el dominio ed-b de fibronectina y sus usos para la deteccion y tratamiento de tumores. |
| EP2174958A1 (en) | 2002-03-11 | 2010-04-14 | Philogen S.p.A. | Antibodies derived from anti ed-b l19 and targeting tumor vasculature |
| AR040956A1 (es) | 2002-07-31 | 2005-04-27 | Schering Ag | Nuevos conjugados de efectores, procedimientos para su preparacion y su uso farmaceutico |
| JP4169195B2 (ja) | 2003-06-24 | 2008-10-22 | 株式会社河合楽器製作所 | 電子楽音発生装置の記録制御装置 |
| EP1514561A1 (en) * | 2003-09-10 | 2005-03-16 | Philogen S.p.A. | Targeting of tumor vasculature using radiolabelled antibody L19 against fibronectin ED-B |
| DE10348319A1 (de) * | 2003-10-17 | 2005-05-19 | Schering Ag | Bindemoleküle für die Extra-Domäne B von Fibronectin zur Detektion von atherosklerotischen Plaques |
| US7785591B2 (en) * | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
| EP2036576A1 (en) * | 2007-09-17 | 2009-03-18 | Bayer Schering Pharma Aktiengesellschaft | ED-B fibronectin as stratification marker for antitumor drugs |
-
2001
- 2001-02-23 JP JP2001562581A patent/JP2003524018A/ja not_active Abandoned
- 2001-02-23 AU AU2001242432A patent/AU2001242432B2/en not_active Ceased
- 2001-02-23 WO PCT/EP2001/002062 patent/WO2001062800A1/en not_active Ceased
- 2001-02-23 AU AU4243201A patent/AU4243201A/xx active Pending
- 2001-02-23 CA CA002400622A patent/CA2400622A1/en not_active Abandoned
- 2001-02-23 EP EP01915294A patent/EP1259548A1/en not_active Withdrawn
-
2004
- 2004-04-12 US US10/821,930 patent/US8097254B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003524018A5 (https=) | ||
| JP2002514405A5 (https=) | ||
| JP7722990B2 (ja) | アミロイド沈着物を標的化するための修飾免疫グロブリン | |
| CA2333833A1 (en) | Specific binding molecules for scintigraphy,conjugates containing them and therapeutic method for treatment of angiogenesis | |
| AU2011298369B2 (en) | Peptide or peptide complex binding to 2 integrin and methods and uses involving the same | |
| US7456260B2 (en) | Humanized antibody | |
| CN101981053B (zh) | 聚乙二醇化的AβFAB | |
| ES2440652T3 (es) | Anticuerpos humanizados anti-MAG y sus usos para el tratamiento de apoplejía | |
| JP5221641B2 (ja) | 腫瘍転移の血管新生と関連するフィブロネクチンのｅｄ−ａ抗原 | |
| WO2000034337A1 (en) | Humanized monoclonal antibodies against vascular endothelial cell growth factor | |
| JP2017503511A5 (https=) | ||
| US5811522A (en) | Recombinant humanized anti-FB5 antibodies | |
| JP2009149686A (ja) | フィブリンのｄ二量体断片に特異的なｄｄ−３ｂ６／２２から誘導されるヒト化抗体 | |
| JP2009514540A (ja) | 機能−阻止抗−ｅｄ−ｂ−フィブロネクチン抗体（ｐｒｉｖａｔｅ）の同定及び特徴化 | |
| RU2004130428A (ru) | Избирательный направленный перенос в сосудистую сеть опухоли с использованием молекул антител | |
| JP2004135675A (ja) | 哺乳動物ケモカイン | |
| JP2003516934A (ja) | ヒト骨髄前駆細胞阻害性因子−１（ｍｐｉｆ−１）を用いる、細胞、組織および器官の損傷を処置または予防する方法 | |
| JP6605331B2 (ja) | 抗体−薬物複合体治療での使用のための免疫造影剤 | |
| KR20230042301A (ko) | 샘플에서 sars-cov-2 단백질을 검출하기 위한 개선된 방법 및 키트 | |
| JP2026513849A (ja) | Ｐｄｇｆｒアルファを発現するがんを画像診断するための試薬及び方法 | |
| KR20260005222A (ko) | Pdgfr알파를 발현하는 암을 이미징하기 위한 시약 및 방법 | |
| JP2016515093A (ja) | 抗体−薬物コンジュゲート療法とともに使用するための免疫イメージング剤 | |
| EA048681B1 (ru) | Модифицированные иммуноглобулины для нацеливания на амилоидные отложения | |
| BR112018000650B1 (pt) | Anticorpos anti-trf e sua utilização no tratamento de transtornos proliferativos e inflamatórios |