JP2002513748A - ゲル化性薬剤組成物 - Google Patents
ゲル化性薬剤組成物Info
- Publication number
- JP2002513748A JP2002513748A JP2000546752A JP2000546752A JP2002513748A JP 2002513748 A JP2002513748 A JP 2002513748A JP 2000546752 A JP2000546752 A JP 2000546752A JP 2000546752 A JP2000546752 A JP 2000546752A JP 2002513748 A JP2002513748 A JP 2002513748A
- Authority
- JP
- Japan
- Prior art keywords
- weight
- composition according
- acid
- pharmaceutical composition
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Applications Claiming Priority (3)
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| BE9800329A BE1011899A6 (fr) | 1998-04-30 | 1998-04-30 | Compositions pharmaceutiques gelifiables utilisables. |
| BE09800329 | 1998-04-30 | ||
| PCT/EP1999/002551 WO1999056725A1 (fr) | 1998-04-30 | 1999-04-16 | Compositions pharmaceutiques gelifiables |
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| JP2002513748A true JP2002513748A (ja) | 2002-05-14 |
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| JP2000546752A Pending JP2002513748A (ja) | 1998-04-30 | 1999-04-16 | ゲル化性薬剤組成物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1011899A6 (fr) * | 1998-04-30 | 2000-02-01 | Ucb Sa | Compositions pharmaceutiques gelifiables utilisables. |
| ES2211151T3 (es) | 1998-08-19 | 2004-07-01 | Skyepharma Canada Inc. | Dispersiones acuosas inyectables de propofol. |
| US11026768B2 (en) | 1998-10-08 | 2021-06-08 | Align Technology, Inc. | Dental appliance reinforcement |
| DE10024413A1 (de) * | 2000-05-19 | 2001-12-06 | Mika Pharma Gmbh | Pharmazeutische und/oder kosmetische Zubereitung |
| DE10057769A1 (de) | 2000-11-22 | 2002-05-23 | Beiersdorf Ag | Haarpflegeprodukte mit einem Gehalt an dispersen Flüssigkristallen, welche kubische Phasen darstellen |
| AU2002335077B2 (en) * | 2001-10-19 | 2006-09-07 | Idexx Laboratories, Inc. | Injectable compositions for the controlled delivery of pharmacologically active compound |
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| EP1485066B1 (fr) * | 2002-03-12 | 2016-09-21 | Ethypharm | Composition a proprietes gelifiantes destinee a la delivrance prolongee de substances bio-actives |
| FR2837099B1 (fr) * | 2002-03-12 | 2005-03-18 | Ethypharm Sa | Composition a proprietes gelifiantes destinee a la delivrance prolongee de substances bio-actives |
| US8435942B2 (en) * | 2002-05-31 | 2013-05-07 | Transdermal Biotechnology, Inc. | Methods for formulating stabilized insulin compositions |
| US20040018237A1 (en) | 2002-05-31 | 2004-01-29 | Perricone Nicholas V. | Topical drug delivery using phosphatidylcholine |
| US20050031650A1 (en) * | 2002-08-26 | 2005-02-10 | Ethypharm | Composition with gelling properties for the sustained delivery of bioactive substances |
| DE10255195A1 (de) | 2002-11-27 | 2004-06-09 | Lipoid Gmbh | Micellare wasserlösliche Konzentrate |
| US20070232695A1 (en) * | 2004-01-28 | 2007-10-04 | Collegium Pharmaceutical, Inc. | Gelled Periodontal Anesthetic Preparation |
| US9492245B2 (en) | 2004-02-27 | 2016-11-15 | Align Technology, Inc. | Method and system for providing dynamic orthodontic assessment and treatment profiles |
| RU2288699C2 (ru) * | 2004-03-23 | 2006-12-10 | Дж. Б. Кемикалс Энд Фармасьютикалс Лимитед | Гелевая композиция для лечения стоматологических заболеваний и способ ее получения |
| GB0412530D0 (en) * | 2004-06-04 | 2004-07-07 | Camurus Ab | Formulation |
| US7858115B2 (en) * | 2004-06-24 | 2010-12-28 | Idexx Laboratories | Phospholipid gel compositions for drug delivery and methods of treating conditions using same |
| US20060115782A1 (en) * | 2004-11-30 | 2006-06-01 | Chunhua Li | Systems and methods for coating a dental appliance |
| US20060115785A1 (en) | 2004-11-30 | 2006-06-01 | Chunhua Li | Systems and methods for intra-oral drug delivery |
| US20070059350A1 (en) * | 2004-12-13 | 2007-03-15 | Kennedy John P | Agents for controlling biological fluids and methods of use thereof |
| US20060127437A1 (en) * | 2004-12-13 | 2006-06-15 | Misty Anderson Kennedy | Semisolid system and combination semisolid, multiparticulate system for sealing tissues and/or controlling biological fluids |
| US9649382B2 (en) * | 2005-01-14 | 2017-05-16 | Camurus Ab | Topical bioadhesive formulations |
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| AU2005325510B2 (en) | 2005-01-21 | 2009-07-02 | Camurus Ab | Pharmaceutical lipid compositions |
| SE531318C2 (sv) * | 2007-02-22 | 2009-02-24 | Tigran Technologies Ab Publ | Injicerbar suspension innefattande titan-,titanlegerings- eller titanoxidpartiklar av mikrostruktur |
| US7878805B2 (en) | 2007-05-25 | 2011-02-01 | Align Technology, Inc. | Tabbed dental appliance |
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| GB0716385D0 (en) | 2007-08-22 | 2007-10-03 | Camurus Ab | Formulations |
| JP5416121B2 (ja) * | 2007-09-12 | 2014-02-12 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 保存剤としての賦形剤の使用及びそれを含む医薬組成物 |
| US8738394B2 (en) | 2007-11-08 | 2014-05-27 | Eric E. Kuo | Clinical data file |
| FR2926996B1 (fr) | 2008-01-31 | 2013-06-21 | Ethypharm Sa | Composition pharmaceutique a proprietes gelifiantes contenant un derive de tyrosine |
| US8108189B2 (en) | 2008-03-25 | 2012-01-31 | Align Technologies, Inc. | Reconstruction of non-visible part of tooth |
| US9492243B2 (en) | 2008-05-23 | 2016-11-15 | Align Technology, Inc. | Dental implant positioning |
| US8092215B2 (en) | 2008-05-23 | 2012-01-10 | Align Technology, Inc. | Smile designer |
| US8172569B2 (en) | 2008-06-12 | 2012-05-08 | Align Technology, Inc. | Dental appliance |
| GB0815435D0 (en) | 2008-08-22 | 2008-10-01 | Camurus Ab | Formulations |
| WO2010033726A2 (en) | 2008-09-17 | 2010-03-25 | The Brigham And Women's Hospital, Inc. | Drug delivery composition comprising a self-assembled gelator |
| US8152518B2 (en) | 2008-10-08 | 2012-04-10 | Align Technology, Inc. | Dental positioning appliance having metallic portion |
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| US8728516B2 (en) * | 2009-04-30 | 2014-05-20 | Abbvie Inc. | Stabilized lipid formulation of apoptosis promoter |
| US8362013B2 (en) * | 2009-04-30 | 2013-01-29 | Abbvie Inc. | Salt of ABT-263 and solid-state forms thereof |
| US20100280031A1 (en) * | 2009-04-30 | 2010-11-04 | Paul David | Lipid formulation of apoptosis promoter |
| US20100297194A1 (en) * | 2009-04-30 | 2010-11-25 | Nathaniel Catron | Formulation for oral administration of apoptosis promoter |
| US20100278921A1 (en) * | 2009-04-30 | 2010-11-04 | Fischer Cristina M | Solid oral formulation of abt-263 |
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| PL2387391T3 (pl) * | 2009-07-24 | 2017-09-29 | Mika Pharma Gesellschaft Für Die Entwicklung Und Vermarktung Pharmazeutischer Produkte Mbh | Sposób otrzymywania ciekłej kompozycji stosowalnej w postaci piany na skórę oraz kompozycja do aplikowania miejscowego |
| US8765031B2 (en) | 2009-08-13 | 2014-07-01 | Align Technology, Inc. | Method of forming a dental appliance |
| KR20120098915A (ko) * | 2009-12-22 | 2012-09-05 | 아보트 러보러터리즈 | Ａｂｔ?２６３ 캡슐제 |
| JP2013521302A (ja) * | 2010-03-02 | 2013-06-10 | イマジネティクス，インコーポレイテッド | ミリスチン酸を含む組成物およびその使用 |
| US9241774B2 (en) | 2010-04-30 | 2016-01-26 | Align Technology, Inc. | Patterned dental positioning appliance |
| US9211166B2 (en) | 2010-04-30 | 2015-12-15 | Align Technology, Inc. | Individualized orthodontic treatment index |
| UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
| CA2830298C (en) | 2011-03-17 | 2016-08-16 | Transdermal Biotechnology, Inc. | Topical nitric oxide systems comprising lecithin and methods of use thereof |
| EP2699267A4 (en) * | 2011-04-18 | 2014-11-12 | Lipidor Ab | LIQUID CARRIER FOR THE ORAL DELIVERY OF A PHARMACOLOGICAL ACTIVE SUBSTANCE |
| US9403238B2 (en) | 2011-09-21 | 2016-08-02 | Align Technology, Inc. | Laser cutting |
| ES2645345T3 (es) * | 2011-12-05 | 2017-12-05 | Camurus Ab | Formulaciones de liberación controlada robustas |
| WO2013095412A1 (en) * | 2011-12-21 | 2013-06-27 | Hill's Pet Nutrition, Inc. | Treatment or reduction of dental conditions with ascorbyl esters |
| US9375300B2 (en) | 2012-02-02 | 2016-06-28 | Align Technology, Inc. | Identifying forces on a tooth |
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| MX350964B (es) | 2012-05-25 | 2017-09-27 | Camurus Ab | Formulaciones de agonistas del receptor de somatostatina. |
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| US9295636B2 (en) | 2013-03-13 | 2016-03-29 | Transdermal Biotechnology, Inc. | Wound healing using topical systems and methods |
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| US9314423B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Hair treatment systems and methods using peptides and other compositions |
| US20140271938A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Systems and methods for delivery of peptides |
| US20140271937A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Brain and neural treatments comprising peptides and other compositions |
| US9314417B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Treatment of skin, including aging skin, to improve appearance |
| US9393265B2 (en) | 2013-03-13 | 2016-07-19 | Transdermal Biotechnology, Inc. | Wound healing using topical systems and methods |
| US9314433B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Methods and systems for treating or preventing cancer |
| US9724419B2 (en) | 2013-03-13 | 2017-08-08 | Transdermal Biotechnology, Inc. | Peptide systems and methods for metabolic conditions |
| US9387159B2 (en) | 2013-03-13 | 2016-07-12 | Transdermal Biotechnology, Inc. | Treatment of skin, including aging skin, to improve appearance |
| US9687520B2 (en) | 2013-03-13 | 2017-06-27 | Transdermal Biotechnology, Inc. | Memory or learning improvement using peptide and other compositions |
| US9314422B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Peptide systems and methods for metabolic conditions |
| US9320758B2 (en) | 2013-03-13 | 2016-04-26 | Transdermal Biotechnology, Inc. | Brain and neural treatments comprising peptides and other compositions |
| US9320706B2 (en) | 2013-03-13 | 2016-04-26 | Transdermal Biotechnology, Inc. | Immune modulation using peptides and other compositions |
| US9849160B2 (en) | 2013-03-13 | 2017-12-26 | Transdermal Biotechnology, Inc. | Methods and systems for treating or preventing cancer |
| US9295647B2 (en) | 2013-03-13 | 2016-03-29 | Transdermal Biotechnology, Inc. | Systems and methods for delivery of peptides |
| US9339457B2 (en) | 2013-03-13 | 2016-05-17 | Transdermal Biotechnology, Inc. | Cardiovascular disease treatment and prevention |
| US9295637B2 (en) | 2013-03-13 | 2016-03-29 | Transdermal Biotechnology, Inc. | Compositions and methods for affecting mood states |
| US10449016B2 (en) | 2014-09-19 | 2019-10-22 | Align Technology, Inc. | Arch adjustment appliance |
| US9610141B2 (en) | 2014-09-19 | 2017-04-04 | Align Technology, Inc. | Arch expanding appliance |
| US9744001B2 (en) | 2014-11-13 | 2017-08-29 | Align Technology, Inc. | Dental appliance with cavity for an unerupted or erupting tooth |
| US10504386B2 (en) | 2015-01-27 | 2019-12-10 | Align Technology, Inc. | Training method and system for oral-cavity-imaging-and-modeling equipment |
| US9610242B2 (en) * | 2015-08-18 | 2017-04-04 | Concept Labs, Inc. | Water-gel emulsion compositions and methods |
| US11554000B2 (en) | 2015-11-12 | 2023-01-17 | Align Technology, Inc. | Dental attachment formation structure |
| US11931222B2 (en) | 2015-11-12 | 2024-03-19 | Align Technology, Inc. | Dental attachment formation structures |
| US11103330B2 (en) | 2015-12-09 | 2021-08-31 | Align Technology, Inc. | Dental attachment placement structure |
| US11596502B2 (en) | 2015-12-09 | 2023-03-07 | Align Technology, Inc. | Dental attachment placement structure |
| EP3978022A1 (en) | 2016-05-06 | 2022-04-06 | The Brigham and Women's Hospital, Inc. | Binary self assembled gels for controlled delivery of encapsulated agents to cartilage |
| US10383705B2 (en) | 2016-06-17 | 2019-08-20 | Align Technology, Inc. | Orthodontic appliance performance monitor |
| EP4670634A2 (en) | 2016-06-17 | 2025-12-31 | Align Technology, Inc. | SYSTEM FOR DETERMINING PATIENT COMPLIANCE WITH AN ORTHODONTIC TREATMENT OR RETENTION PLAN |
| CN208942463U (zh) | 2016-07-27 | 2019-06-07 | 阿莱恩技术有限公司 | 口内扫描系统和口内扫描装置 |
| CN117257492A (zh) | 2016-11-04 | 2023-12-22 | 阿莱恩技术有限公司 | 用于牙齿图像的方法和装置 |
| WO2018102811A1 (en) | 2016-12-02 | 2018-06-07 | Align Technology, Inc. | Methods and apparatuses for customizing rapid palatal expanders using digital models |
| US11376101B2 (en) | 2016-12-02 | 2022-07-05 | Align Technology, Inc. | Force control, stop mechanism, regulating structure of removable arch adjustment appliance |
| US11026831B2 (en) | 2016-12-02 | 2021-06-08 | Align Technology, Inc. | Dental appliance features for speech enhancement |
| ES2845198T3 (es) | 2016-12-02 | 2021-07-26 | Align Technology Inc | Expansor palatino |
| US10548700B2 (en) | 2016-12-16 | 2020-02-04 | Align Technology, Inc. | Dental appliance etch template |
| WO2018144991A1 (en) | 2017-02-03 | 2018-08-09 | The Brigham And Women's Hospital, Inc. | Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof |
| US10779718B2 (en) | 2017-02-13 | 2020-09-22 | Align Technology, Inc. | Cheek retractor and mobile device holder |
| US12090020B2 (en) | 2017-03-27 | 2024-09-17 | Align Technology, Inc. | Apparatuses and methods assisting in dental therapies |
| US10613515B2 (en) | 2017-03-31 | 2020-04-07 | Align Technology, Inc. | Orthodontic appliances including at least partially un-erupted teeth and method of forming them |
| AU2018266131B2 (en) | 2017-05-08 | 2021-07-29 | Alivio Therapeutics, Inc. | Formulation of nanostructured gels for increased agent loading and adhesion |
| US11045283B2 (en) | 2017-06-09 | 2021-06-29 | Align Technology, Inc. | Palatal expander with skeletal anchorage devices |
| EP3638146B1 (en) | 2017-06-16 | 2024-07-10 | Align Technology, Inc. | Automatic detection of tooth type and eruption status |
| US10639134B2 (en) | 2017-06-26 | 2020-05-05 | Align Technology, Inc. | Biosensor performance indicator for intraoral appliances |
| US10885521B2 (en) | 2017-07-17 | 2021-01-05 | Align Technology, Inc. | Method and apparatuses for interactive ordering of dental aligners |
| CN114903623A (zh) | 2017-07-21 | 2022-08-16 | 阿莱恩技术有限公司 | 颚轮廓锚固 |
| CN110996842B (zh) | 2017-07-27 | 2022-10-14 | 阿莱恩技术有限公司 | 牙齿着色、透明度和上釉 |
| CN116327391A (zh) | 2017-07-27 | 2023-06-27 | 阿莱恩技术有限公司 | 用于通过光学相干断层扫描术来处理正畸矫正器的系统和方法 |
| US12274597B2 (en) * | 2017-08-11 | 2025-04-15 | Align Technology, Inc. | Dental attachment template tray systems |
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| US12171575B2 (en) | 2017-10-04 | 2024-12-24 | Align Technology, Inc. | Intraoral systems and methods for sampling soft-tissue |
| US10813720B2 (en) | 2017-10-05 | 2020-10-27 | Align Technology, Inc. | Interproximal reduction templates |
| WO2019084326A1 (en) | 2017-10-27 | 2019-05-02 | Align Technology, Inc. | OTHER BORE ADJUSTMENT STRUCTURES |
| WO2019089773A1 (en) | 2017-10-31 | 2019-05-09 | Align Technology, Inc. | Dental appliance having selective occlusal loading and controlled intercuspation |
| CN119235481A (zh) | 2017-11-01 | 2025-01-03 | 阿莱恩技术有限公司 | 自动治疗规划 |
| US11534974B2 (en) | 2017-11-17 | 2022-12-27 | Align Technology, Inc. | Customized fabrication of orthodontic retainers based on patient anatomy |
| CN111417357B (zh) | 2017-11-30 | 2022-07-26 | 阿莱恩技术有限公司 | 用于监测口腔矫治器的传感器 |
| WO2019118876A1 (en) | 2017-12-15 | 2019-06-20 | Align Technology, Inc. | Closed loop adaptive orthodontic treatment methods and apparatuses |
| US10980613B2 (en) | 2017-12-29 | 2021-04-20 | Align Technology, Inc. | Augmented reality enhancements for dental practitioners |
| EP4437933A3 (en) | 2018-01-26 | 2025-04-23 | Align Technology, Inc. | Intraoral scanning system |
| US11937991B2 (en) | 2018-03-27 | 2024-03-26 | Align Technology, Inc. | Dental attachment placement structure |
| CN108498376B (zh) * | 2018-04-02 | 2020-11-13 | 榛硕（武汉）智能科技有限公司 | 一种甲基硅油乳液及其制备方法 |
| CN116211501A (zh) | 2018-04-11 | 2023-06-06 | 阿莱恩技术有限公司 | 腭扩张器、腭扩张器设备及系统、腭扩张器的形成方法 |
| CA3113948A1 (en) | 2018-10-11 | 2020-04-16 | Alivio Therapeutics, Inc. | Non-injectable hydrogel formulations for smart release |
| CN113164402A (zh) | 2018-10-15 | 2021-07-23 | 希普拉有限公司 | 药物制剂 |
| EP3848016A1 (en) * | 2020-01-08 | 2021-07-14 | 3M Innovative Properties Company | Oral care composition containing fatty acid components for treating caries |
| US11992483B2 (en) | 2021-03-31 | 2024-05-28 | Cali Biosciences Us, Llc | Emulsions for local anesthetics |
| WO2025110709A1 (ko) * | 2023-11-22 | 2025-05-30 | 엠엑스바이오 주식회사 | 치주 질환의 예방 또는 치료용 조성물 및 치과용 복합 항생제 연고 조성물 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5230899A (en) * | 1985-08-07 | 1993-07-27 | Smithkline Beecham Corporation | Methods and compositions for making liposomes |
| US5262164A (en) * | 1989-11-17 | 1993-11-16 | The Procter & Gamble Company | Sustained release compositions for treating periodontal disease |
| US5230895A (en) * | 1990-05-01 | 1993-07-27 | Copley Pharmaceutical Inc. | Sustained released delivery system for use in the periodontal pocket |
| US5567456A (en) * | 1991-11-04 | 1996-10-22 | Creative Products Inc. Of Rossville | Food release compositions with organic fluidizing agents |
| CA2082561A1 (en) * | 1991-11-12 | 1993-05-13 | Francis J. Leng | Antiperspirant materials and compositions |
| JP3190441B2 (ja) * | 1992-07-20 | 2001-07-23 | エーザイ株式会社 | 塩酸アゼラスチンを含有する安定な製剤 |
| GB9224010D0 (en) * | 1992-11-16 | 1993-01-06 | Phares Pharma Holland | Composition and method |
| ATE195866T1 (de) | 1993-07-28 | 2000-09-15 | Pharmaderm Lab Ltd | Zweiphasige multilamellare lipidvesikel |
| DE19536246A1 (de) * | 1994-09-30 | 1996-04-04 | Juergen Dr Regenold | Pharmazeutische Zusammensetzung |
| US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| BE1011899A6 (fr) * | 1998-04-30 | 2000-02-01 | Ucb Sa | Compositions pharmaceutiques gelifiables utilisables. |
-
1998
- 1998-04-30 BE BE9800329A patent/BE1011899A6/fr active
-
1999
- 1999-04-16 EP EP99919243A patent/EP1073414B1/fr not_active Expired - Lifetime
- 1999-04-16 JP JP2000546753A patent/JP2002513749A/ja not_active Withdrawn
- 1999-04-16 US US09/674,159 patent/US6464987B1/en not_active Expired - Fee Related
- 1999-04-16 BR BR9910066-5A patent/BR9910066A/pt not_active Application Discontinuation
- 1999-04-16 WO PCT/EP1999/002551 patent/WO1999056725A1/fr not_active Ceased
- 1999-04-16 RS YUP-666/00A patent/RS50025B/sr unknown
- 1999-04-16 AU AU40308/99A patent/AU738455B2/en not_active Ceased
- 1999-04-16 AT AT99923418T patent/ATE307569T1/de not_active IP Right Cessation
- 1999-04-16 ID IDW20002199A patent/ID26221A/id unknown
- 1999-04-16 DE DE69901951T patent/DE69901951T2/de not_active Expired - Fee Related
- 1999-04-16 CN CNB998062669A patent/CN1183901C/zh not_active Expired - Fee Related
- 1999-04-16 ES ES99919243T patent/ES2178430T3/es not_active Expired - Lifetime
- 1999-04-16 JP JP2000546752A patent/JP2002513748A/ja active Pending
- 1999-04-16 EP EP99923418A patent/EP1073415B1/fr not_active Expired - Lifetime
- 1999-04-16 NZ NZ507707A patent/NZ507707A/en unknown
- 1999-04-16 ES ES99923418T patent/ES2249891T3/es not_active Expired - Lifetime
- 1999-04-16 DK DK99923418T patent/DK1073415T3/da active
- 1999-04-16 CA CA002330500A patent/CA2330500C/fr not_active Expired - Fee Related
- 1999-04-16 WO PCT/EP1999/002552 patent/WO1999056726A1/fr not_active Ceased
- 1999-04-16 EA EA200001125A patent/EA002530B1/ru not_active IP Right Cessation
- 1999-04-16 AU AU37085/99A patent/AU3708599A/en not_active Abandoned
- 1999-04-16 HU HU0101580A patent/HU226556B1/hu not_active IP Right Cessation
- 1999-04-16 IL IL13911399A patent/IL139113A0/xx not_active IP Right Cessation
- 1999-04-16 DE DE69927963T patent/DE69927963T2/de not_active Expired - Fee Related
- 1999-04-16 AT AT99919243T patent/ATE219659T1/de not_active IP Right Cessation
- 1999-04-16 TR TR2000/03158T patent/TR200003158T2/xx unknown
- 1999-04-16 KR KR1020007011844A patent/KR100567975B1/ko not_active Expired - Fee Related
-
2000
- 2000-04-16 US US09/674,163 patent/US6471970B1/en not_active Expired - Fee Related
- 2000-10-17 IS IS5669A patent/IS2354B/is unknown
- 2000-10-17 BG BG104872A patent/BG64723B1/bg unknown
- 2000-10-23 ZA ZA200005915A patent/ZA200005915B/xx unknown
- 2000-10-27 NO NO20005431A patent/NO20005431L/no not_active Application Discontinuation
-
2002
- 2002-09-17 US US10/259,366 patent/US6818224B2/en not_active Expired - Fee Related
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