KR100567975B1 - 겔화될 수 있는 약제학적 조성물 - Google Patents

겔화될 수 있는 약제학적 조성물 Download PDF

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Publication number
KR100567975B1
KR100567975B1 KR1020007011844A KR20007011844A KR100567975B1 KR 100567975 B1 KR100567975 B1 KR 100567975B1 KR 1020007011844 A KR1020007011844 A KR 1020007011844A KR 20007011844 A KR20007011844 A KR 20007011844A KR 100567975 B1 KR100567975 B1 KR 100567975B1
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pharmaceutical composition
composition according
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active substance
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Korean (ko)
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KR20010043000A (ko
Inventor
도메니코 파나라
헨리 브랑크스
미첼 델레르스
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유씨비 소시에떼아노님
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063Periodont
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020007011844A 1998-04-30 1999-04-16 겔화될 수 있는 약제학적 조성물 Expired - Fee Related KR100567975B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE9800329 1998-04-30
BE9800329A BE1011899A6 (fr) 1998-04-30 1998-04-30 Compositions pharmaceutiques gelifiables utilisables.

Publications (2)

Publication Number Publication Date
KR20010043000A KR20010043000A (ko) 2001-05-25
KR100567975B1 true KR100567975B1 (ko) 2006-04-07

Family

ID=3891230

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007011844A Expired - Fee Related KR100567975B1 (ko) 1998-04-30 1999-04-16 겔화될 수 있는 약제학적 조성물

Country Status (25)

Country Link
US (3) US6464987B1 (enExample)
EP (2) EP1073415B1 (enExample)
JP (2) JP2002513749A (enExample)
KR (1) KR100567975B1 (enExample)
CN (1) CN1183901C (enExample)
AT (2) ATE307569T1 (enExample)
AU (2) AU738455B2 (enExample)
BE (1) BE1011899A6 (enExample)
BG (1) BG64723B1 (enExample)
BR (1) BR9910066A (enExample)
CA (1) CA2330500C (enExample)
DE (2) DE69901951T2 (enExample)
DK (1) DK1073415T3 (enExample)
EA (1) EA002530B1 (enExample)
ES (2) ES2178430T3 (enExample)
HU (1) HU226556B1 (enExample)
ID (1) ID26221A (enExample)
IL (1) IL139113A0 (enExample)
IS (1) IS2354B (enExample)
NO (1) NO20005431L (enExample)
NZ (1) NZ507707A (enExample)
RS (1) RS50025B (enExample)
TR (1) TR200003158T2 (enExample)
WO (2) WO1999056726A1 (enExample)
ZA (1) ZA200005915B (enExample)

Families Citing this family (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1011899A6 (fr) * 1998-04-30 2000-02-01 Ucb Sa Compositions pharmaceutiques gelifiables utilisables.
EP1105096B1 (en) 1998-08-19 2003-10-29 Skyepharma Canada Inc. Injectable aqueous dispersions of propofol
US11026768B2 (en) 1998-10-08 2021-06-08 Align Technology, Inc. Dental appliance reinforcement
DE10024413A1 (de) * 2000-05-19 2001-12-06 Mika Pharma Gmbh Pharmazeutische und/oder kosmetische Zubereitung
DE10057769A1 (de) 2000-11-22 2002-05-23 Beiersdorf Ag Haarpflegeprodukte mit einem Gehalt an dispersen Flüssigkristallen, welche kubische Phasen darstellen
RU2292871C2 (ru) * 2001-10-19 2007-02-10 Айдекс Лэборэтериз, Инк. Инъецируемые композиции для контролируемой доставки фармакологически активного соединения
US6946137B2 (en) * 2001-10-19 2005-09-20 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
FR2837099B1 (fr) * 2002-03-12 2005-03-18 Ethypharm Sa Composition a proprietes gelifiantes destinee a la delivrance prolongee de substances bio-actives
BRPI0308360B8 (pt) * 2002-03-12 2021-05-25 Ethypharm Sa composição termossensível sob forma liquida compreendendo substância organogelificante, utilização de uma composição e processo de preparação de uma composição
US8435942B2 (en) * 2002-05-31 2013-05-07 Transdermal Biotechnology, Inc. Methods for formulating stabilized insulin compositions
US20040018237A1 (en) 2002-05-31 2004-01-29 Perricone Nicholas V. Topical drug delivery using phosphatidylcholine
US20050031650A1 (en) * 2002-08-26 2005-02-10 Ethypharm Composition with gelling properties for the sustained delivery of bioactive substances
DE10255195A1 (de) * 2002-11-27 2004-06-09 Lipoid Gmbh Micellare wasserlösliche Konzentrate
WO2006075124A1 (en) * 2005-01-14 2006-07-20 Camurus Ab Somatostatin analogue formulations
PL1682091T3 (pl) * 2003-11-07 2017-09-29 Camurus Ab Kompozycje lipidów i kationowych peptydów
US20070232695A1 (en) * 2004-01-28 2007-10-04 Collegium Pharmaceutical, Inc. Gelled Periodontal Anesthetic Preparation
US9492245B2 (en) 2004-02-27 2016-11-15 Align Technology, Inc. Method and system for providing dynamic orthodontic assessment and treatment profiles
RU2288699C2 (ru) * 2004-03-23 2006-12-10 Дж. Б. Кемикалс Энд Фармасьютикалс Лимитед Гелевая композиция для лечения стоматологических заболеваний и способ ее получения
PL1768650T3 (pl) * 2004-06-04 2009-01-30 Camurus Ab Ciekłe formulacje depot
GB0412530D0 (en) * 2004-06-04 2004-07-07 Camurus Ab Formulation
US7858115B2 (en) * 2004-06-24 2010-12-28 Idexx Laboratories Phospholipid gel compositions for drug delivery and methods of treating conditions using same
US8293253B2 (en) * 2004-10-28 2012-10-23 Idexx Laboratories, Inc. Compositions for controlled delivery of pharmaceutically active compounds
US20060115785A1 (en) 2004-11-30 2006-06-01 Chunhua Li Systems and methods for intra-oral drug delivery
US20060115782A1 (en) * 2004-11-30 2006-06-01 Chunhua Li Systems and methods for coating a dental appliance
US20060127437A1 (en) * 2004-12-13 2006-06-15 Misty Anderson Kennedy Semisolid system and combination semisolid, multiparticulate system for sealing tissues and/or controlling biological fluids
US20070059350A1 (en) * 2004-12-13 2007-03-15 Kennedy John P Agents for controlling biological fluids and methods of use thereof
WO2006075125A1 (en) * 2005-01-14 2006-07-20 Camurus Ab GnRH ANALOGUE FORMULATIONS
DE602005026998D1 (de) * 2005-01-14 2011-04-28 Camurus Ab Somatostatin-analog-formulierungen
US9649382B2 (en) * 2005-01-14 2017-05-16 Camurus Ab Topical bioadhesive formulations
US8920782B2 (en) * 2005-01-14 2014-12-30 Camurus Ab Topical bioadhesive formulations
CA2595385C (en) 2005-01-21 2011-01-25 Camurus Ab Pharmaceutical lipid compositions
CA2609810C (en) 2005-06-06 2012-05-22 Camurus Ab Glp-1 analogue formulations
SE531318C2 (sv) * 2007-02-22 2009-02-24 Tigran Technologies Ab Publ Injicerbar suspension innefattande titan-,titanlegerings- eller titanoxidpartiklar av mikrostruktur
US7878805B2 (en) 2007-05-25 2011-02-01 Align Technology, Inc. Tabbed dental appliance
GB0711656D0 (en) 2007-06-15 2007-07-25 Camurus Ab Formulations
GB0716385D0 (en) 2007-08-22 2007-10-03 Camurus Ab Formulations
ES2411983T3 (es) * 2007-09-12 2013-07-09 Galderma Research & Development Utilización de excipientes como conservantes y composiciones farmacéuticas que los contienen
US8738394B2 (en) 2007-11-08 2014-05-27 Eric E. Kuo Clinical data file
FR2926996B1 (fr) 2008-01-31 2013-06-21 Ethypharm Sa Composition pharmaceutique a proprietes gelifiantes contenant un derive de tyrosine
US8108189B2 (en) 2008-03-25 2012-01-31 Align Technologies, Inc. Reconstruction of non-visible part of tooth
US8092215B2 (en) 2008-05-23 2012-01-10 Align Technology, Inc. Smile designer
US9492243B2 (en) 2008-05-23 2016-11-15 Align Technology, Inc. Dental implant positioning
US8172569B2 (en) 2008-06-12 2012-05-08 Align Technology, Inc. Dental appliance
GB0815435D0 (en) 2008-08-22 2008-10-01 Camurus Ab Formulations
US20110229565A1 (en) 2008-09-17 2011-09-22 Karp Jeffrey M Drug Delivery Composition Comprising a Self-Assembled Gelator
US8152518B2 (en) 2008-10-08 2012-04-10 Align Technology, Inc. Dental positioning appliance having metallic portion
US8292617B2 (en) 2009-03-19 2012-10-23 Align Technology, Inc. Dental wire attachment
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
US8362013B2 (en) * 2009-04-30 2013-01-29 Abbvie Inc. Salt of ABT-263 and solid-state forms thereof
US20100278921A1 (en) * 2009-04-30 2010-11-04 Fischer Cristina M Solid oral formulation of abt-263
US20100280031A1 (en) * 2009-04-30 2010-11-04 Paul David Lipid formulation of apoptosis promoter
US20100297194A1 (en) * 2009-04-30 2010-11-25 Nathaniel Catron Formulation for oral administration of apoptosis promoter
TWI540132B (zh) * 2009-06-08 2016-07-01 亞培公司 Bcl-2族群抑制劑之口服醫藥劑型
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
DE102010027315A1 (de) * 2009-07-24 2011-01-27 Mika Pharma Gesellschaft Für Die Entwicklung Und Vermarktung Pharmazeutischer Produkte Mbh Verfahren zur Entwicklung einer als Schaum auf die Haut zu applizierende flüssige Zusammensetzung sowie eine topisch applizierbare Zusammensetzung
US8765031B2 (en) 2009-08-13 2014-07-01 Align Technology, Inc. Method of forming a dental appliance
BR112012014499A2 (pt) * 2009-12-22 2016-08-16 Abbott Lab cápsula de abt-263
JP2013521302A (ja) * 2010-03-02 2013-06-10 イマジネティクス,インコーポレイテッド ミリスチン酸を含む組成物およびその使用
US9211166B2 (en) 2010-04-30 2015-12-15 Align Technology, Inc. Individualized orthodontic treatment index
US9241774B2 (en) 2010-04-30 2016-01-26 Align Technology, Inc. Patterned dental positioning appliance
JP2013540757A (ja) 2010-09-24 2013-11-07 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド カプセル化された作用物質の放出を制御する能力を有するナノ構造ゲル
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
US8668937B2 (en) 2011-03-17 2014-03-11 Transdermal Biotechnology, Inc. Topical nitric oxide systems and methods of use thereof
EP2699267A4 (en) * 2011-04-18 2014-11-12 Lipidor Ab LIQUID CARRIER FOR THE ORAL DELIVERY OF A PHARMACOLOGICAL ACTIVE SUBSTANCE
US9403238B2 (en) 2011-09-21 2016-08-02 Align Technology, Inc. Laser cutting
US8716363B2 (en) * 2011-09-28 2014-05-06 Globus Medical, Inc. Biodegradable putty compositions and implant devices, methods, and kits relating to the same
DK2787974T3 (en) * 2011-12-05 2017-07-17 Camurus Ab Robust PEPTID FORMULATIONS WITH CONTROLLED RELEASE
CN104302188A (zh) * 2011-12-21 2015-01-21 希尔氏宠物营养品公司 使用抗坏血酸酯治疗或减轻牙科病症
US9375300B2 (en) 2012-02-02 2016-06-28 Align Technology, Inc. Identifying forces on a tooth
US9220580B2 (en) 2012-03-01 2015-12-29 Align Technology, Inc. Determining a dental treatment difficulty
US9849088B2 (en) 2012-05-10 2017-12-26 Painreform Ltd. Depot formulations of a hydrophobic active ingredient and methods for preparation thereof
US9414897B2 (en) 2012-05-22 2016-08-16 Align Technology, Inc. Adjustment of tooth position in a virtual dental model
IN2014DN09831A (enExample) 2012-05-25 2015-08-07 Camurus Ab
AU2013294915C1 (en) 2012-07-26 2019-11-21 Camurus Ab Opioid formulations
MX387722B (es) 2012-07-26 2025-03-18 Camurus Ab Formulaciones de opioides.
US8871254B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US8871258B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment and prevention of learning and memory disorders
US8871255B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment of skin and soft tissue infection with nitric oxide
US8871259B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Techniques and systems for treatment of neuropathic pain and other indications
US8871260B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and compositions for muscular and neuromuscular diseases
US8871262B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Compositions and methods for treatment of osteoporosis and other indications
US8871256B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US8871261B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Cancer treatments and compositions for use thereof
US8871257B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US9320706B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9314422B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9387159B2 (en) 2013-03-13 2016-07-12 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9393264B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9687520B2 (en) 2013-03-13 2017-06-27 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US20140271937A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9295647B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9849160B2 (en) 2013-03-13 2017-12-26 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US20140271731A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9241899B2 (en) 2013-03-13 2016-01-26 Transdermal Biotechnology, Inc. Topical systems and methods for treating sexual dysfunction
US9314423B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Hair treatment systems and methods using peptides and other compositions
US9750787B2 (en) 2013-03-13 2017-09-05 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9393265B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9295636B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9295637B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Compositions and methods for affecting mood states
US9339457B2 (en) 2013-03-13 2016-05-17 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9314417B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9314433B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9724419B2 (en) 2013-03-13 2017-08-08 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9320758B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US20140271938A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9610141B2 (en) 2014-09-19 2017-04-04 Align Technology, Inc. Arch expanding appliance
US10449016B2 (en) 2014-09-19 2019-10-22 Align Technology, Inc. Arch adjustment appliance
US9744001B2 (en) 2014-11-13 2017-08-29 Align Technology, Inc. Dental appliance with cavity for an unerupted or erupting tooth
US10504386B2 (en) 2015-01-27 2019-12-10 Align Technology, Inc. Training method and system for oral-cavity-imaging-and-modeling equipment
US9610242B2 (en) * 2015-08-18 2017-04-04 Concept Labs, Inc. Water-gel emulsion compositions and methods
EP3359128A1 (en) * 2015-10-08 2018-08-15 The Brigham and Women's Hospital, Inc. Stabilized assembled nanostructures for delivery of encapsulated agents
US11554000B2 (en) 2015-11-12 2023-01-17 Align Technology, Inc. Dental attachment formation structure
US11931222B2 (en) 2015-11-12 2024-03-19 Align Technology, Inc. Dental attachment formation structures
US11596502B2 (en) 2015-12-09 2023-03-07 Align Technology, Inc. Dental attachment placement structure
US11103330B2 (en) 2015-12-09 2021-08-31 Align Technology, Inc. Dental attachment placement structure
EP3452094B1 (en) 2016-05-06 2021-11-17 The Brigham and Women's Hospital, Inc. Binary self assembled gels for controlled delivery of encapsulated agents to cartilage
US10470847B2 (en) 2016-06-17 2019-11-12 Align Technology, Inc. Intraoral appliances with sensing
US10383705B2 (en) 2016-06-17 2019-08-20 Align Technology, Inc. Orthodontic appliance performance monitor
EP3578131B1 (en) 2016-07-27 2020-12-09 Align Technology, Inc. Intraoral scanner with dental diagnostics capabilities
CN113648088B (zh) 2016-11-04 2023-08-22 阿莱恩技术有限公司 用于牙齿图像的方法和装置
WO2018102702A1 (en) 2016-12-02 2018-06-07 Align Technology, Inc. Dental appliance features for speech enhancement
EP3547952B1 (en) 2016-12-02 2020-11-04 Align Technology, Inc. Palatal expander
WO2018102770A1 (en) 2016-12-02 2018-06-07 Align Technology, Inc. Force control, stop mechanism, regulating structure of removable arch adjustment appliance
WO2018102811A1 (en) 2016-12-02 2018-06-07 Align Technology, Inc. Methods and apparatuses for customizing rapid palatal expanders using digital models
US10548700B2 (en) 2016-12-16 2020-02-04 Align Technology, Inc. Dental appliance etch template
US11020410B2 (en) 2017-02-03 2021-06-01 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
US10779718B2 (en) 2017-02-13 2020-09-22 Align Technology, Inc. Cheek retractor and mobile device holder
WO2018183358A1 (en) 2017-03-27 2018-10-04 Align Technology, Inc. Apparatuses and methods assisting in dental therapies
US10613515B2 (en) 2017-03-31 2020-04-07 Align Technology, Inc. Orthodontic appliances including at least partially un-erupted teeth and method of forming them
WO2018208822A1 (en) 2017-05-08 2018-11-15 Alivio Therapeutics, Inc. Formulation of nanostructured gels for increased agent loading and adhesion
US11045283B2 (en) 2017-06-09 2021-06-29 Align Technology, Inc. Palatal expander with skeletal anchorage devices
EP3638146B1 (en) 2017-06-16 2024-07-10 Align Technology, Inc. Automatic detection of tooth type and eruption status
WO2019005808A1 (en) 2017-06-26 2019-01-03 Align Technology, Inc. BIOCAPTOR PERFORMANCE INDICATOR FOR INTRABUCCAL DEVICES
US10885521B2 (en) 2017-07-17 2021-01-05 Align Technology, Inc. Method and apparatuses for interactive ordering of dental aligners
CN114903623A (zh) 2017-07-21 2022-08-16 阿莱恩技术有限公司 颚轮廓锚固
EP3658070B1 (en) 2017-07-27 2025-11-26 Align Technology, Inc. Tooth shading, transparency and glazing
CN110996836B (zh) 2017-07-27 2023-04-11 阿莱恩技术有限公司 用于通过光学相干断层扫描术来处理正畸矫正器的系统和方法
US12274597B2 (en) * 2017-08-11 2025-04-15 Align Technology, Inc. Dental attachment template tray systems
WO2019035979A1 (en) 2017-08-15 2019-02-21 Align Technology, Inc. EVALUATION AND CALCULATION OF BUCCAL CORRIDOR
WO2019036677A1 (en) 2017-08-17 2019-02-21 Align Technology, Inc. SURVEILLANCE OF CONFORMITY OF DENTAL DEVICE
US12171575B2 (en) 2017-10-04 2024-12-24 Align Technology, Inc. Intraoral systems and methods for sampling soft-tissue
US10813720B2 (en) 2017-10-05 2020-10-27 Align Technology, Inc. Interproximal reduction templates
CN114939001B (zh) 2017-10-27 2025-02-18 阿莱恩技术有限公司 替代咬合调整结构
WO2019089773A1 (en) 2017-10-31 2019-05-09 Align Technology, Inc. Dental appliance having selective occlusal loading and controlled intercuspation
CN115252177B (zh) 2017-11-01 2024-10-11 阿莱恩技术有限公司 自动治疗规划
US11534974B2 (en) 2017-11-17 2022-12-27 Align Technology, Inc. Customized fabrication of orthodontic retainers based on patient anatomy
CN118948478A (zh) 2017-11-30 2024-11-15 阿莱恩技术有限公司 用于监测口腔矫治器的传感器
US11432908B2 (en) 2017-12-15 2022-09-06 Align Technology, Inc. Closed loop adaptive orthodontic treatment methods and apparatuses
US10980613B2 (en) 2017-12-29 2021-04-20 Align Technology, Inc. Augmented reality enhancements for dental practitioners
CN114587237B (zh) 2018-01-26 2025-09-30 阿莱恩技术有限公司 诊断性口内扫描和追踪
US11937991B2 (en) 2018-03-27 2024-03-26 Align Technology, Inc. Dental attachment placement structure
CN108498376B (zh) * 2018-04-02 2020-11-13 榛硕(武汉)智能科技有限公司 一种甲基硅油乳液及其制备方法
EP3773320B1 (en) 2018-04-11 2024-05-15 Align Technology, Inc. Releasable palatal expanders
EP3863602A1 (en) 2018-10-11 2021-08-18 Alivio Therapeutics, Inc. Non-injectable hydrogel formulations for smart release
CA3116298A1 (en) 2018-10-15 2020-04-23 Cipla Limited Pharmaceutical formulation
EP3848016A1 (en) * 2020-01-08 2021-07-14 3M Innovative Properties Company Oral care composition containing fatty acid components for treating caries
US11992483B2 (en) 2021-03-31 2024-05-28 Cali Biosciences Us, Llc Emulsions for local anesthetics
JP7092922B1 (ja) * 2021-06-11 2022-06-28 キユーピー株式会社 製剤
WO2025110709A1 (ko) * 2023-11-22 2025-05-30 엠엑스바이오 주식회사 치주 질환의 예방 또는 치료용 조성물 및 치과용 복합 항생제 연고 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5230899A (en) * 1985-08-07 1993-07-27 Smithkline Beecham Corporation Methods and compositions for making liposomes
US5262164A (en) * 1989-11-17 1993-11-16 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5230895A (en) * 1990-05-01 1993-07-27 Copley Pharmaceutical Inc. Sustained released delivery system for use in the periodontal pocket
US5567456A (en) * 1991-11-04 1996-10-22 Creative Products Inc. Of Rossville Food release compositions with organic fluidizing agents
CA2082561A1 (en) * 1991-11-12 1993-05-13 Francis J. Leng Antiperspirant materials and compositions
JP3190441B2 (ja) * 1992-07-20 2001-07-23 エーザイ株式会社 塩酸アゼラスチンを含有する安定な製剤
GB9224010D0 (en) * 1992-11-16 1993-01-06 Phares Pharma Holland Composition and method
DE69425750T2 (de) 1993-07-28 2001-04-26 Pharmaderm Laboratories Ltd., Saskatoon Zweiphasige multilamellare lipidvesikel
DE19536244A1 (de) * 1994-09-30 1996-04-04 Juergen Dr Regenold Pharmazeutische Zusammensetzung zur lokalen Applikation
US5736152A (en) * 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
BE1011899A6 (fr) * 1998-04-30 2000-02-01 Ucb Sa Compositions pharmaceutiques gelifiables utilisables.

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