JP2002512939A - 診断および治療のためのツールとしての、リューマチ性関節炎の血清により認識されるシトルリン含有合成ペプチド - Google Patents

診断および治療のためのツールとしての、リューマチ性関節炎の血清により認識されるシトルリン含有合成ペプチド

Info

Publication number
JP2002512939A
JP2002512939A JP2000523235A JP2000523235A JP2002512939A JP 2002512939 A JP2002512939 A JP 2002512939A JP 2000523235 A JP2000523235 A JP 2000523235A JP 2000523235 A JP2000523235 A JP 2000523235A JP 2002512939 A JP2002512939 A JP 2002512939A
Authority
JP
Japan
Prior art keywords
peptide
antibody
rheumatoid arthritis
protein
citrulline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000523235A
Other languages
English (en)
Japanese (ja)
Inventor
リディ・メヘウス
アン・ユニオン
ヨーゼフ・ライマッケルス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujirebio Europe NV SA
Original Assignee
Fujirebio Europe NV SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP98870078A external-priority patent/EP0949270A1/de
Application filed by Fujirebio Europe NV SA filed Critical Fujirebio Europe NV SA
Publication of JP2002512939A publication Critical patent/JP2002512939A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Rehabilitation Therapy (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2000523235A 1997-11-28 1998-11-30 診断および治療のためのツールとしての、リューマチ性関節炎の血清により認識されるシトルリン含有合成ペプチド Pending JP2002512939A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP97870195.1 1997-11-28
EP97870195 1997-11-28
EP98870078A EP0949270A1 (de) 1998-04-09 1998-04-09 Citrullin-enthaltende synthetische Peptide, reaktiv mit Seren von Patienten mit rheumatische Arthritis, zur Diagnose und Behandlung
EP98870078.7 1998-04-09
PCT/EP1998/007714 WO1999028344A2 (en) 1997-11-28 1998-11-30 Synthetic peptides containing citrulline recognized by rheumatoid arthritis sera as tools for diagnosis and treatment

Publications (1)

Publication Number Publication Date
JP2002512939A true JP2002512939A (ja) 2002-05-08

Family

ID=26148315

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000523235A Pending JP2002512939A (ja) 1997-11-28 1998-11-30 診断および治療のためのツールとしての、リューマチ性関節炎の血清により認識されるシトルリン含有合成ペプチド

Country Status (8)

Country Link
EP (1) EP1034186A2 (de)
JP (1) JP2002512939A (de)
AU (1) AU2155899A (de)
CA (1) CA2309534A1 (de)
CZ (1) CZ20001963A3 (de)
HU (1) HUP0004338A2 (de)
PL (1) PL344534A1 (de)
WO (1) WO1999028344A2 (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007515647A (ja) * 2003-12-23 2007-06-14 エフ．ホフマン−ラ　ロシュ　アーゲー 抗ｃｃｐおよびインターロイキン６の測定による慢性関節リウマチの評価方法
JP2009536182A (ja) * 2006-05-03 2009-10-08 ユニヴェルシテ ポール サバティエ 慢性関節リウマチの治療に有用な、マクロファージの活性を調整するペプチド
JP4891766B2 (ja) * 2003-07-29 2012-03-07 ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング パンクレアチン及び比較可能な組成物のための分析法
JP2014517296A (ja) * 2011-05-27 2014-07-17 ノルディック・ビオサイエンス・エー／エス 診断用ペプチドの検出

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7184426B2 (en) 2002-12-12 2007-02-27 Qualcomm, Incorporated Method and apparatus for burst pilot for a time division multiplex system
FR2773078B1 (fr) * 1997-12-30 2000-05-26 Univ Toulouse Utilisation de peptides citrullines derives de la filaggrine pour le traitement de la polyarthrite rhumatoide
WO2001046222A2 (en) * 1999-12-21 2001-06-28 Innogenetics N.V. Peptides designed for the diagnosis and treatment of rheumatoid arthritis
FR2826124B1 (fr) 2001-06-13 2004-01-02 Bio Merieux Procede de detection d'auto-anticorps specifiques de la polyarthrite rhumatoide
NL1019540C2 (nl) * 2001-12-11 2003-07-01 Stichting Tech Wetenschapp Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.
AT413768B (de) * 2003-07-29 2006-05-15 Herkner Kurt Dipl Ing Dr Techn Biochemisches diagnostikum zur erkennung rheumatoider arthritis
DK1721162T3 (da) 2004-02-27 2008-12-15 Hoffmann La Roche Fremgangsmåde til at bedömme rheumatoid arthritis ved at måle anti-CCP og serumamyloid A
AU2006274835B2 (en) 2005-07-29 2012-05-24 Abbott Laboratories Gmbh Processes for the manufacture of sterilized pancreatin powder
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
GB0525492D0 (en) * 2005-12-15 2006-01-25 Univ Dundee Filaggrin
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
JP2010506147A (ja) 2006-09-29 2010-02-25 エフ．ホフマン−ラ ロシュ アーゲー 関節リウマチを有する患者のための疾患進行のリスク評価
WO2009070875A1 (en) * 2007-12-03 2009-06-11 Sqi Diagnostics Systems Inc. Synthetic peptides immuno-reactive with rheumatoid arthritis auto-antibodies
EA023302B9 (ru) * 2008-06-04 2016-10-31 Модиквест Б.В. Способ предотвращения или лечения артрита и применение антитела, специфически реактивного к цитруллинированному эпитопу в этом способе
NZ608489A (en) * 2009-03-30 2014-08-29 Nestec Sa Citrullinated peptides for diagnosing and prognosing rheumatiod arthritis
EP2325195A1 (de) 2009-11-23 2011-05-25 Toscana Biomarkers S.r.l. Virale citrullinierte Peptide und Verwendungen dafür
EP2336769A1 (de) 2009-12-18 2011-06-22 F. Hoffmann-La Roche AG Assay zur Unterscheidung zwischen rheumatischen und nicht rheumatischen Leiden
EP2402368A1 (de) 2010-07-02 2012-01-04 Toscana Biomarkers S.r.l. Histoncitrullinierte Peptide und deren Verwendungen
EP2527841A1 (de) 2011-05-25 2012-11-28 Toscana Biomarkers S.r.l. Verfahren zur Diagnose rheumatoider Arthritis
CN103733048B (zh) * 2011-08-12 2015-11-25 国立大学法人广岛大学 石棉检测方法
CA2857061A1 (en) 2011-12-16 2013-06-20 Olema Pharmaceuticals, Inc. Novel benzopyran compounds, compositions and uses thereof
US9975944B2 (en) * 2013-03-12 2018-05-22 Tel Hashomer Medical Research Infrastructure And Services Ltd. Synthetic peptides for the treatment of autoimmune diseases
US20160159922A1 (en) 2013-07-24 2016-06-09 Vilara Ab Novel Antibodies for the Diagnosis and Treatment of Rheumatoid Arthritis
KR101634958B1 (ko) * 2014-06-13 2016-06-30 한국생명공학연구원 필라그린 유전자 돌연변이 검출용 프로브, 키트 및 방법
EP3056903A1 (de) 2015-02-13 2016-08-17 F. Hoffmann-La Roche AG Verfahren zur Beurteilung rheumatoider Arthritis mittels Messung von Anti-CCP und Anti-Casp8
EP3056904A1 (de) 2015-02-13 2016-08-17 F. Hoffmann-La Roche AG Verfahren zur Beurteilung rheumatoider Arthritis mittels Messung von Anti-CCP und Anti-MCM3
CN107484423A (zh) 2015-02-13 2017-12-15 豪夫迈·罗氏有限公司 通过测量抗ccp和抗pik3cd来评估类风湿性关节炎的方法
CN111007262A (zh) * 2019-12-25 2020-04-14 漳州卫生职业学院 一种用于辅助诊断ra的试剂盒及检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5660994A (en) * 1986-11-10 1997-08-26 Progen Biotechnik Gmbh Method of detecting tissue-specific, insoluble cytoskeletal proteins
EP0511116B1 (de) * 1991-04-26 2004-06-16 Clonatec S.A. Antigene, die von Polyarthritis Rheumatoide Antikörpern erkannt werden, ihre Herstellung und ihre Anwendungen
FR2752842B1 (fr) * 1996-08-30 1998-11-06 Biomerieux Sa Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide
NL1004539C2 (nl) * 1996-11-15 1998-05-20 Stichting Tech Wetenschapp Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4891766B2 (ja) * 2003-07-29 2012-03-07 ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング パンクレアチン及び比較可能な組成物のための分析法
JP2007515647A (ja) * 2003-12-23 2007-06-14 エフ．ホフマン−ラ　ロシュ　アーゲー 抗ｃｃｐおよびインターロイキン６の測定による慢性関節リウマチの評価方法
JP2009536182A (ja) * 2006-05-03 2009-10-08 ユニヴェルシテ ポール サバティエ 慢性関節リウマチの治療に有用な、マクロファージの活性を調整するペプチド
JP2014517296A (ja) * 2011-05-27 2014-07-17 ノルディック・ビオサイエンス・エー／エス 診断用ペプチドの検出

Also Published As

Publication number Publication date
WO1999028344A2 (en) 1999-06-10
AU2155899A (en) 1999-06-16
EP1034186A2 (de) 2000-09-13
WO1999028344A3 (en) 1999-08-12
PL344534A1 (en) 2001-11-05
CA2309534A1 (en) 1999-06-10
CZ20001963A3 (cs) 2002-04-17
HUP0004338A2 (hu) 2001-02-28

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