HUP0004338A2 - Raumatoid artritiszben szenvedő betegek széruma által felismert, citrullint tartalmazó szintetikus peptidek diagnosztikai és terápiás alkalmazásai - Google Patents
Raumatoid artritiszben szenvedő betegek széruma által felismert, citrullint tartalmazó szintetikus peptidek diagnosztikai és terápiás alkalmazásaiInfo
- Publication number
- HUP0004338A2 HUP0004338A2 HU0004338A HUP0004338A HUP0004338A2 HU P0004338 A2 HUP0004338 A2 HU P0004338A2 HU 0004338 A HU0004338 A HU 0004338A HU P0004338 A HUP0004338 A HU P0004338A HU P0004338 A2 HUP0004338 A2 HU P0004338A2
- Authority
- HU
- Hungary
- Prior art keywords
- rheumatoid arthritis
- antibodies
- diagnosis
- treatment
- citrulline
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 title abstract 4
- 235000013477 citrulline Nutrition 0.000 title abstract 4
- 229960002173 citrulline Drugs 0.000 title abstract 4
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 title abstract 3
- 206010039073 rheumatoid arthritis Diseases 0.000 title abstract 3
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 230000003302 anti-idiotype Effects 0.000 abstract 1
- 230000005859 cell recognition Effects 0.000 abstract 1
- -1 citrulline amino acids Chemical class 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000002637 immunotoxin Effects 0.000 abstract 1
- 229940051026 immunotoxin Drugs 0.000 abstract 1
- 239000002596 immunotoxin Substances 0.000 abstract 1
- 231100000608 immunotoxin Toxicity 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Rehabilitation Therapy (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97870195 | 1997-11-28 | ||
| EP98870078A EP0949270A1 (de) | 1998-04-09 | 1998-04-09 | Citrullin-enthaltende synthetische Peptide, reaktiv mit Seren von Patienten mit rheumatische Arthritis, zur Diagnose und Behandlung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0004338A2 true HUP0004338A2 (hu) | 2001-02-28 |
Family
ID=26148315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0004338A HUP0004338A2 (hu) | 1997-11-28 | 1998-11-30 | Raumatoid artritiszben szenvedő betegek széruma által felismert, citrullint tartalmazó szintetikus peptidek diagnosztikai és terápiás alkalmazásai |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1034186A2 (de) |
| JP (1) | JP2002512939A (de) |
| AU (1) | AU2155899A (de) |
| CA (1) | CA2309534A1 (de) |
| CZ (1) | CZ20001963A3 (de) |
| HU (1) | HUP0004338A2 (de) |
| PL (1) | PL344534A1 (de) |
| WO (1) | WO1999028344A2 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7184426B2 (en) | 2002-12-12 | 2007-02-27 | Qualcomm, Incorporated | Method and apparatus for burst pilot for a time division multiplex system |
| FR2773078B1 (fr) * | 1997-12-30 | 2000-05-26 | Univ Toulouse | Utilisation de peptides citrullines derives de la filaggrine pour le traitement de la polyarthrite rhumatoide |
| ES2174770T1 (es) * | 1999-12-21 | 2002-11-16 | Innogenetics Nv | Peptidos diseñados para el diagnostico y el tratamiento de artritis reumatoide. |
| FR2826124B1 (fr) * | 2001-06-13 | 2004-01-02 | Bio Merieux | Procede de detection d'auto-anticorps specifiques de la polyarthrite rhumatoide |
| NL1019540C2 (nl) * | 2001-12-11 | 2003-07-01 | Stichting Tech Wetenschapp | Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit. |
| CA2528906C (en) * | 2003-07-29 | 2013-07-16 | Solvay Pharmaceuticals Gmbh | Analytical method for pancreatin and comparable compositions |
| AT413768B (de) * | 2003-07-29 | 2006-05-15 | Herkner Kurt Dipl Ing Dr Techn | Biochemisches diagnostikum zur erkennung rheumatoider arthritis |
| EP1700129B1 (de) | 2003-12-23 | 2007-11-28 | Roche Diagnostics GmbH | Verfahren zur beurteilung rheumatoider arthritis durch messen von anti-ccp und interleukin 6 |
| JP4495208B2 (ja) | 2004-02-27 | 2010-06-30 | エフ．ホフマン−ラ ロシュ アーゲー | 抗ｃｃｐおよび血清アミロイドａの測定による慢性関節リウマチの評価方法 |
| JP5140586B2 (ja) | 2005-07-29 | 2013-02-06 | アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 滅菌パンクレアチン粉末の製法 |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| GB0525492D0 (en) * | 2005-12-15 | 2006-01-25 | Univ Dundee | Filaggrin |
| FR2900657B1 (fr) * | 2006-05-03 | 2009-04-17 | Univ Toulouse | Identification de modulateurs de l'activation des macrophages, utilisables pour le traitement de la polyarthrite rhumatoide |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| ES2545688T3 (es) | 2006-09-29 | 2015-09-15 | F. Hoffmann-La Roche Ag | Método de evaluación del riesgo de progresión de enfermedad de pacientes con artritis reumatoide |
| AU2008331381B2 (en) * | 2007-12-03 | 2013-08-22 | Sqi Diagnostics Systems Inc. | Synthetic peptides immuno-reactive with rheumatoid arthritis auto-antibodies |
| CN102056944A (zh) | 2008-06-04 | 2011-05-11 | 莫蒂克斯特私人有限公司 | 抗炎症药剂 |
| CA2757444A1 (en) * | 2009-03-30 | 2010-10-14 | Prometheus Laboratories Inc. | Citrullinated peptides for diagnosing and prognosing rheumatoid arthritis |
| EP2325195A1 (de) | 2009-11-23 | 2011-05-25 | Toscana Biomarkers S.r.l. | Virale citrullinierte Peptide und Verwendungen dafür |
| EP2336769A1 (de) | 2009-12-18 | 2011-06-22 | F. Hoffmann-La Roche AG | Assay zur Unterscheidung zwischen rheumatischen und nicht rheumatischen Leiden |
| EP2402368A1 (de) | 2010-07-02 | 2012-01-04 | Toscana Biomarkers S.r.l. | Histoncitrullinierte Peptide und deren Verwendungen |
| EP2527841A1 (de) | 2011-05-25 | 2012-11-28 | Toscana Biomarkers S.r.l. | Verfahren zur Diagnose rheumatoider Arthritis |
| KR101968779B1 (ko) * | 2011-05-27 | 2019-04-12 | 노르딕 바이오사이언스 에이/에스 | 진단용 펩티드의 검출 |
| KR101656847B1 (ko) * | 2011-08-12 | 2016-09-12 | 고쿠리츠다이가쿠호진 히로시마다이가쿠 | 석면 검출 방법 |
| AU2012353660A1 (en) | 2011-12-16 | 2014-06-12 | Olema Pharmaceuticals, Inc. | Novel benzopyran compounds, compositions and uses thereof |
| US9975944B2 (en) * | 2013-03-12 | 2018-05-22 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Synthetic peptides for the treatment of autoimmune diseases |
| US20160159922A1 (en) | 2013-07-24 | 2016-06-09 | Vilara Ab | Novel Antibodies for the Diagnosis and Treatment of Rheumatoid Arthritis |
| KR101634958B1 (ko) * | 2014-06-13 | 2016-06-30 | 한국생명공학연구원 | 필라그린 유전자 돌연변이 검출용 프로브, 키트 및 방법 |
| CN107484423A (zh) | 2015-02-13 | 2017-12-15 | 豪夫迈·罗氏有限公司 | 通过测量抗ccp和抗pik3cd来评估类风湿性关节炎的方法 |
| EP3056904A1 (de) | 2015-02-13 | 2016-08-17 | F. Hoffmann-La Roche AG | Verfahren zur Beurteilung rheumatoider Arthritis mittels Messung von Anti-CCP und Anti-MCM3 |
| EP3056903A1 (de) | 2015-02-13 | 2016-08-17 | F. Hoffmann-La Roche AG | Verfahren zur Beurteilung rheumatoider Arthritis mittels Messung von Anti-CCP und Anti-Casp8 |
| CN111007262A (zh) * | 2019-12-25 | 2020-04-14 | 漳州卫生职业学院 | 一种用于辅助诊断ra的试剂盒及检测方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5660994A (en) * | 1986-11-10 | 1997-08-26 | Progen Biotechnik Gmbh | Method of detecting tissue-specific, insoluble cytoskeletal proteins |
| DE69233366T2 (de) * | 1991-04-26 | 2005-05-19 | Biomerieux S.A. | Antigene, die von Polyarthritis Rheumatoide Antikörpern erkannt werden, ihre Herstellung und ihre Anwendungen |
| FR2752842B1 (fr) * | 1996-08-30 | 1998-11-06 | Biomerieux Sa | Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide |
| NL1004539C2 (nl) * | 1996-11-15 | 1998-05-20 | Stichting Tech Wetenschapp | Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen. |
-
1998
- 1998-11-30 CZ CZ20001963A patent/CZ20001963A3/cs unknown
- 1998-11-30 AU AU21558/99A patent/AU2155899A/en not_active Withdrawn
- 1998-11-30 WO PCT/EP1998/007714 patent/WO1999028344A2/en not_active Application Discontinuation
- 1998-11-30 HU HU0004338A patent/HUP0004338A2/hu unknown
- 1998-11-30 EP EP98965715A patent/EP1034186A2/de not_active Withdrawn
- 1998-11-30 JP JP2000523235A patent/JP2002512939A/ja active Pending
- 1998-11-30 PL PL98344534A patent/PL344534A1/xx unknown
- 1998-11-30 CA CA002309534A patent/CA2309534A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20001963A3 (cs) | 2002-04-17 |
| JP2002512939A (ja) | 2002-05-08 |
| CA2309534A1 (en) | 1999-06-10 |
| PL344534A1 (en) | 2001-11-05 |
| AU2155899A (en) | 1999-06-16 |
| WO1999028344A2 (en) | 1999-06-10 |
| WO1999028344A3 (en) | 1999-08-12 |
| EP1034186A2 (de) | 2000-09-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0004338A2 (hu) | Raumatoid artritiszben szenvedő betegek széruma által felismert, citrullint tartalmazó szintetikus peptidek diagnosztikai és terápiás alkalmazásai | |
| HUP0103758A2 (hu) | Neurotróf faktorok | |
| HUP0303173A2 (hu) | Csökkent immunogenitású, módosított anti-EGFR-ellenanyagok | |
| ATE210296T1 (de) | Immunologisches nachweisverfahren von antikörpern,die gegen gewebe-transglutaminase (ttg) gerichtet sind, verwendung von ttg zur diagnose und therapiekontrolle sowie orales pharmazeutisches mittel enthaltend ttg | |
| MX9709778A (es) | Anticuerpos monoclonales humanos de alta afinidad especificos para la proteina f del virus sincitial respiratorio. | |
| HUP0303753A2 (hu) | Fúziós fehérjék immunogenitásának csökkentése | |
| TR199801722T2 (xx) | Peptit imm�nojenler. | |
| RU2012102323A (ru) | Способ лечения ревматоидного артрита посредством лекарственного препарата на основе выделенного человеческого антитела или его антигенсвязывающего фрагмента | |
| CA2290485A1 (en) | Method for the production of non-immunogenic proteins | |
| GB9224584D0 (en) | Use of outer membrane protein d15 and its peptides as vaccine against haempohilus influenzae diseases | |
| ATE288489T1 (de) | Vp-antigene des jc-virus | |
| HUP0101734A2 (hu) | Béta-amiloid prekurzor protein és ubiquitin-B kereteltolódásos mutánsok és alkalmazásuk | |
| HUP9802212A2 (hu) | Humán terápiában alkalmazható rekombináns anti-CD4-ellenanyagok | |
| IL138424A0 (en) | Covalently reactive antigen analogs and pharmaceutical compositions containing the same | |
| DE69630457D1 (de) | Verbindungen zur immunotherapie und diagnose von tuberkulose | |
| DE68928130D1 (de) | Synthetische vom HIV-GP120-env-Protein abgeleitete Peptide und ihre Anwendung | |
| BR9810907A (pt) | Anticorpos monoclonais e policlonais, peptìdeo suscetìvel de gerar um anticorpo, agente imunogênico, sequência de nucleotìdeos, composição farmacêutica, uso de pelo menos um anticorpo, kit de diagnóstico, e, processo para preparar um agente imunogênico | |
| WO1995005604A3 (en) | Methods for the diagnosis of alzheimer's disease | |
| EP1544293A4 (de) | Antikörper gegen ein den von-willebrand-faktor spezifisch spaltendes enzym und assay-system unter verwendung davon | |
| DE59608213D1 (de) | Arzneimittel zur immuntherapie, enthaltend antikörper, die spezifisch das mhcii-antigen eines zu behandelnden patienten erkennen | |
| ATE427757T1 (de) | Verwendung von immunogenen immunsuppressiven und/oder angiogenen proteinen die inaktiviert sind, verfahren zur deren herstellung, und verwendungen als pharmazeutikum oder impfstoff | |
| AU612683B2 (en) | Synthetic peptides, antibodies directed against them, and the use thereof | |
| HUP0002265A2 (hu) | Eljárás plazmafehérjét tartalmazó gyógyszer előállítására | |
| HUP0301725A2 (hu) | Új vegyületek és eljárások | |
| HUP9901204A2 (hu) | Nagy molekulatömegű emberi MP52-proteinek |