JP2002506346A - Cd8 t細胞免疫応答を発生するワクチン接種のための方法および試薬 - Google Patents
Cd8 t細胞免疫応答を発生するワクチン接種のための方法および試薬Info
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 少なくとも一つの標的抗原に対する保護的CD8+ T細胞免疫応答を 発生するためのキットであって、以下: (i) 標的抗原の一つまたはそれ以上のCD8+ T細胞エピトープ源、な らびに医薬品として受容可能な担体から成る初回刺激組成物;および (ii)初回刺激組成物のCD8+ T細胞エピトープと同一である少なくと も一つのCD8+ T細胞エピトープを含む標的抗原の一つまたはそれ以上のC D8+ T細胞エピトープ源、ここでCD8+ T細胞エピトープ源は非複製ま たは複製欠陥組換えポックスウイルスベクターである、ならびに医薬品として受 容可能な担体から成る追加刺激組成物; からなり、ただし、(i)のエピトープ源がウイルスベクターであるならば、( ii)におけるウイルスベクターは異なったウイルスから誘導される、キット。 2. (i)におけるCD8+ T細胞エピトープ源が非ウイルスベクターま たは非複製または複製欠陥ウイルスベクターである請求項第1項に記載のキット 。 3. (i)におけるCD8+ T細胞エピトープ源がポックスウイルスでは ない請求項第1または2項に記載のキット。 4. (i)におけるCD8+ T細胞エピトープ源がDNAまたはRNAで ある請求項第2または3項に記載のキット。 5. (i)におけるエピトープ源が組換えDNAプラスミドである請求項第 4項に記載のキット。 6. (i)のためのアジュバントとしてGM−CSFをさらに含む請求項第 4または5項に記載のキット。 7. (i)におけるCD8+ T細胞エピトープ源が標的抗原をコードして いるまたは含んでいる請求項第1から6項の任意の項に記載のキット。 8. (i)におけるエピトープ源が単−CD8+ T細胞エピトープまたは 二つまたはそれ以上のCD8+ T細胞エピトープの組換え列をコードしている 請求項第4から6項の任意の項に記載のキット。 9. (i)におけるエピトープ源がCD8+ T細胞エピトープ中または標 的抗原中に存在する二つまたはそれ以上のCD8+ T細胞エピトープを含むペ プチド、ポリペプチド、タンパク質、多タンパク質または粒子である請求項第1 から3項の任意の項に記載のキット。 10. (i)におけるCD8+ T細胞エピトープ源がTyウイルス様粒子( VLP)のような組換えタンパク質粒子である請求項第9項に記載のキット。 11. (i)におけるエピトープ源が組換えアデノウイルスである請求項第1 から3項の任意の項に記載のキット。 12. (ii)におけるCD8+ T細胞エピトープ源が組換えワクシニアウ イルスベクターである請求項第1から11項の任意の項に記載のキット。 13. 組換えワクシニアウイルスベクターがワクシニアウイルス株修飾ウイル スアンカラ(MVA)またはそれらから誘導されたものである請求項第12項に 記載のキット。 14. 組換えワクシニアウイルスベクターが株NYVACまたはそれらから誘 導されたものである請求項第12項に記載のキット。 15. (ii)におけるCD8+ T細胞エピトープ源がカナリア痘またはニ ワトリ痘のような組換えアビポックスベクター、またはALVACのようなそれ らから誘導された株である請求項第1から11項の任意の項に記載のキット。 16. 標的抗原を含む病原体または腫瘍に対する保護的免疫応答を発生するた めの請求項第1から15項の任意の項に記載のキット。 17. 熱帯熱マラリア原虫のようなマラリア病原体に対する保護的免疫応答を 発生するための請求項第16項に記載のキット。 18. (i)におけるまたは(i)によりコードされているCD8+ T細胞 エピトープが表1に与えられているリストからの一つまたはそれ以上のマラリア エピトープを含む請求項第17項に記載のキット。 19. (i)におけるCD8+ T細胞エピトープが表1に与えられたすべて のエピトープを含んでいる請求項第18項に記載のキット。 20. HIVに対する免疫応答を発生するための請求項第16項に記載のキッ ト。 21. (i)におけるまたは(i)によりコードされているCD8+ T細胞 エピトープが表2に与えられているリストからの一つまたはそれ以上のHIVエ ピトープを含む請求項第20項に記載のキット。 22. (i)におけるまたは(i)によりコードされているCD8+ T細胞 エピトープが表2に与えられたすべてのエピトープを含んでいる請求項第20項 に記載のキット。 23. 初回刺激および追加刺激組成物は両方が(i)におけるエピトープ源お よび(ii)におけるエピトープ源を含んでいるということで同一である請求項 第1から22項の任意の項に記載のキット。 24. 初回刺激組成物および/または追加刺激組成物が遺伝子銃法による送達 に適した特別の形である請求項第1から23項の任意の項に記載のキット。 25. 少なくとも一つの標的抗原に対する保護的CD8+ T細胞免疫応答発 生させるための、請求項第1から24項の任意の項に記載のキットの成分(i) の少なくとも1回量を、続いて成分(ii)の少なくとも1回量を投与すること から成る方法。 26. 病原体または腫瘍に対する保護的CD8+ T細胞免疫応答発生させる ための、病原体または腫瘍の少なくとも一つのCD8+ T細胞エピトープまた は抗原をコードしている組換えDNAプラスミドの少なくとも1回量を、続いて 同一のエピトープまたは抗原をコードしている組換え非複製または複製欠陥ポッ クスウイルスの少なくとも1回量を投与することから成る方法。 27. 組換えワクシニアウイルスが組換えMVAベクターである請求項第25 項に記載の方法。 28. 病原体または腫瘍に対する保護的CD8+ T細胞免疫応答発生させる ための、病原体または腫瘍の少なくとも一つのエピトープまたは抗原を含む組換 えタンパク質または粒子の少なくとも1回量を、続いて同一のエピトープまたは 抗原をコードしている組換えMVAベクターの少なくとも1回量を投与すること から成る方法。 29. 熱帯熱マラリア原虫マラリアのようなマラリアに対する保護的CD8+ T細胞免疫応答を発生するための請求項第26から28項の任意の項に記載の 方法。 30. HIVに対する保護的CD8+ T細胞免疫応答を発生するための請求 項第26から28項の任意の項に記載の方法。 31. (ii)が静脈内、表皮内または皮内で送達される請求項第25から3 0項の任意の項に記載の方法。 32. 標的抗原の一つまたはそれ以上のCD8+ T細胞エピトープ源および 医薬として受容可能な担体を含むが、但しCD8+ T細胞エピトープ源は非複 製または複製欠陥組換えポックスウイルスベクターである、少なくとも一つの標 的抗原に対する初回刺激CD8+ T細胞応答を追加刺激するための医薬品。 33. ベクターがMVAのようなワクシニアウイルスベクターである請求項第 32項に記載の医薬品。 34. マラリアに対して自然に初回刺激されたCD8+ T細胞応答を追加刺 激するための請求項第32または33項に記載の医薬品。 35. 初回刺激されたCD8+ T細胞免疫応答を追加刺激する方法、本方法 は請求項第32から34項の任意の項に記載の医薬品を投与することから成って いる。 36. CD8+ T細胞免疫応答を追加刺激するための医薬品の製造における 組換え非複製または複製欠陥ポックスウイルスベクターの使用。 37. CD8+ T細胞免疫応答を追加刺激するための医薬品の製造における MVAベクターの使用。 38. 表1に掲げられたアミノ酸配列から成るエピトープ列。 39. マラリアに対して免疫するための請求項第38項に記載のエピトープ列 から成る組換えTy−VLP。 40. マラリアに対して免疫するための請求項第38項に記載のエピトープ列 をコードしている組換えDNAプラスミドまたは組換え非複製または複製欠陥ポ ックスウイルス。 41. マラリアに対して免疫するための熱帯熱マラリア原虫抗原TRAPをコ ードしている組換えDNAプラスミドまたは組換え非複製または複製欠陥ポック スウイルス。 42. MVA株の請求項第40または41項に記載の組換えワクシニアウイル ス。 43. 表2に掲げられたアミノ酸配列から成るエピトープ列。 44. マラリアからのTRAPのような全または本質的に全部の抗原およびC TLエピトープのような二つまたはそれ以上のエピトープから成る組換えポリペ プチド。
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PCT/GB1998/001681 WO1998056919A2 (en) | 1997-06-09 | 1998-06-09 | Methods and reagents for vaccination which generate a cd8 t cell immune response |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007102326A1 (ja) * | 2006-03-07 | 2007-09-13 | Yokohama City University | アデノウイルス5型/35型ベクターとワクシニアウイルスmvaベクターとの併用による強力な免疫誘導 |
JP2010523137A (ja) * | 2007-04-10 | 2010-07-15 | アイシス イノヴェイション リミテッド | マラリア抗原をコードするアデノウイルスベクター |
JP2010523138A (ja) * | 2007-04-10 | 2010-07-15 | アイシス イノヴェイション リミテッド | 免疫原性組成物 |
JP2015526403A (ja) * | 2012-07-05 | 2015-09-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ポリヌクレオチドによりコードされた免疫原性ポリペプチドに関わる新規プライムブースト投与法 |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030138454A1 (en) * | 1997-06-09 | 2003-07-24 | Oxxon Pharmaccines, Ltd. | Vaccination method |
GB0023203D0 (en) * | 2000-09-21 | 2000-11-01 | Isis Innovation | Vaccination method |
GB9711957D0 (en) | 1997-06-09 | 1997-08-06 | Isis Innovation | Methods and reagents for vaccination |
AU4078599A (en) * | 1998-05-13 | 1999-11-29 | Epimmune, Inc. | Expression vectors for stimulating an immune response and methods of using the same |
MXPA01003503A (es) | 1998-10-05 | 2005-01-14 | Pharmexa As | Nuevos metodos terapeuticos de vacunacion. |
EP1502602A3 (en) * | 1998-10-05 | 2006-05-17 | Pharmexa A/S | Methods for therapeutic vaccination |
US7148035B1 (en) | 1998-11-18 | 2006-12-12 | Oxford Biomedica (Uk) Limited | Polypeptide |
ES2246826T3 (es) * | 1999-01-28 | 2006-03-01 | Stichting Biomedical Primate Research Center | Composicion y procedimiento para obtener inmunizacion especifica contra uno o mas antigenos usando diferentes vectores recombinantes. |
US6682742B1 (en) | 1999-05-28 | 2004-01-27 | Gsf Forschungszentrum Fur Unwelt Und Gesundheit Gmbh | Vector for integration of heterologous sequences into poxviral genomes |
JP2003530307A (ja) | 1999-07-06 | 2003-10-14 | メルク・アンド・カンパニー・インコーポレーテッド | gag遺伝子保有アデノウイルスHIVワクチン |
CA2721011A1 (en) | 1999-10-22 | 2001-05-03 | Aventis Pasteur Limited | Modified gp100 and uses thereof |
CA2392877C (en) | 1999-12-23 | 2011-11-15 | Tomas Hanke | Improvements in or relating to immune responses to hiv |
WO2001047541A1 (en) * | 1999-12-28 | 2001-07-05 | Epimmune, Inc. | Optimized minigenes and peptides encoded thereby |
EP2388015A1 (en) | 2000-03-02 | 2011-11-23 | Emory University | DNA expression vectors and methods of use |
US8623379B2 (en) | 2000-03-02 | 2014-01-07 | Emory University | Compositions and methods for generating an immune response |
WO2001082964A1 (en) * | 2000-04-28 | 2001-11-08 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Improved immunogenicity using a combination of dna and vaccinia virus vector vaccines |
US6733993B2 (en) | 2000-09-15 | 2004-05-11 | Merck & Co., Inc. | Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-gag, pol, nef and modifications |
AU3941002A (en) | 2000-10-31 | 2002-06-03 | Zycos Inc | Cyp1b1 nucleic acids and methods of use |
US7445924B2 (en) | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
US7628980B2 (en) | 2000-11-23 | 2009-12-08 | Bavarian Nordic A/S | Modified vaccinia virus ankara for the vaccination of neonates |
IL154712A0 (en) | 2000-11-23 | 2003-10-31 | Bavarian Nordic As | Modified vaccinia ankara virus variant |
CA2454959C (en) | 2001-03-08 | 2018-07-10 | Bernard Moss | Mva expressing modified hiv envelope, gag, and pol genes |
GB0118532D0 (en) * | 2001-07-30 | 2001-09-19 | Isis Innovation | Materials and methods relating to improved vaccination strategies |
CA2467486A1 (en) * | 2001-11-30 | 2003-06-12 | Isis Innovation Limited | Vaccine |
US20030185854A1 (en) * | 2002-02-08 | 2003-10-02 | Fidel Zavala | Use of recombinant hepatitis B core particles to develop vaccines against infectious pathogens and malignancies |
US20050106123A1 (en) * | 2002-03-13 | 2005-05-19 | Emini Emilio A. | Method of inducing an enhanced immune response against hiv |
EP1420822B2 (en) | 2002-04-19 | 2017-07-05 | Bavarian Nordic A/S | Modified vaccinia virus ankara for the vaccination of neonates |
WO2003097087A1 (fr) * | 2002-05-20 | 2003-11-27 | Japan Science And Technology Agency | Vaccin bcg et utilisation correspondante |
PL215169B1 (pl) | 2002-09-05 | 2013-10-31 | Bavarian Nordic As | Sposób amplifikacji wirusów, kompozycja zawierajaca pokswirusa uzyskanego tym sposobem oraz jego zastosowanie do otrzymywania szczepionki |
EP1583500A4 (en) * | 2002-11-13 | 2008-02-13 | Us Navy | METHODS AND COMPOSITIONS FOR INDUCING IMMUNE RESPONSES AND PROTEIN IMMUNITY BY PRIMARY IMMUNIZATION WITH ALPHAVIRUS REPLICON VACCINES |
WO2004056391A1 (en) * | 2002-12-20 | 2004-07-08 | The University Of New South Wales | A method of immunisation and agents useful for same |
US20050175627A1 (en) * | 2003-09-24 | 2005-08-11 | Oxxon Therapeutics Ltd. | HIV pharmaccines |
CA2570998A1 (en) * | 2004-06-17 | 2006-01-26 | Mannkind Corporation | Improved efficacy of active immunotherapy by integrating diagnostic with therapeutic methods |
GB2421025A (en) * | 2004-12-09 | 2006-06-14 | Oxxon Therapeutics Ltd | HSV vaccination vectors |
WO2006120474A2 (en) * | 2005-05-13 | 2006-11-16 | Oxxon Therapeutics Ltd | Compositions for inducing an immune response against tumor antigens |
WO2007004231A1 (en) * | 2005-07-04 | 2007-01-11 | Pradeep Seth | Hiv-1 vaccinogens with immunomodulators |
FR2893254B1 (fr) | 2005-11-14 | 2007-12-21 | Biomerieux Sa | Composition comprenant un vecteur synthetique colloidal bioresorbable et un vecteur viral et son utilisation prophylactique, therapeutique et diagnostique. |
US9333249B2 (en) | 2006-02-09 | 2016-05-10 | Educational Foundation Jichi Medical University | Recombinant baculovirus vaccine |
TWI477602B (zh) | 2006-02-09 | 2015-03-21 | Educational Foundation Jichi Medical Univ | Novel viral vector |
US8241638B2 (en) * | 2006-11-09 | 2012-08-14 | The United States Of America As Represented By The Secretary Of The Navy | Induction of an immune response against dengue virus using the prime-boost approach |
US8440202B2 (en) * | 2006-11-09 | 2013-05-14 | The United States Of America As Represented By The Secretary Of The Navy | Induction of an immune response against dengue virus using the prime-boost approach |
WO2009127666A2 (en) * | 2008-04-15 | 2009-10-22 | Glaxosmithkline Biologicals S.A. | Method and compositions |
US8691502B2 (en) | 2008-10-31 | 2014-04-08 | Tremrx, Inc. | T-cell vaccination with viral vectors via mechanical epidermal disruption |
WO2011050344A2 (en) | 2009-10-23 | 2011-04-28 | Mannkind Corporation | Cancer immunotherapy and method of treatment |
EP2552490A4 (en) * | 2010-03-26 | 2013-12-18 | Emergent Product Dev Gaithersburg Inc | INFLUENZA MATRIX 2 PROTEIN ECKTOMOMAS, EXPRESSION SYSTEM THEREFOR AND USES THEREOF |
GB201007207D0 (en) | 2010-04-29 | 2010-06-16 | Univ Cork | Method |
US9109007B2 (en) | 2010-08-18 | 2015-08-18 | Purdue Pharma L.P. | MHC-I restricted epitopes containing non-natural amino acid residues |
GB201018480D0 (en) | 2010-11-02 | 2010-12-15 | Oxford Biomedica Ltd | Factors |
NZ616304A (en) * | 2011-04-08 | 2016-01-29 | Immune Design Corp | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
WO2014064534A2 (en) | 2012-10-05 | 2014-05-01 | Chrontech Pharma Ab | Injection needle, device, immunogenic compositions and method of use |
UA118340C2 (uk) * | 2012-10-28 | 2019-01-10 | Баваріан Нордік А/С | Промотор pr13.5 для стійких t-клітинних та гуморальних імунних реакцій |
GB201221133D0 (en) | 2012-11-23 | 2013-01-09 | Epiontis Gmbh | Epigenetic method for the identification of subpopulations of CD8 and T lympocytes, in particular CD8 alpha and beta T lymphocytes |
WO2014139587A1 (en) | 2013-03-15 | 2014-09-18 | Okairòs Ag | Improved poxviral vaccines |
US10576143B2 (en) * | 2013-03-15 | 2020-03-03 | Glaxosmithkline Biologicals Sa | Poxviral vaccines |
EP3154576A1 (en) | 2014-06-13 | 2017-04-19 | GlaxoSmithKline Biologicals S.A. | Immunogenic combinations |
WO2017136633A1 (en) * | 2016-02-04 | 2017-08-10 | Duke University | Cell-based vaccine compositions and methods of use |
EP3442570A1 (en) * | 2016-04-12 | 2019-02-20 | Oxford University Innovation Limited | Prime target |
US11427645B2 (en) | 2017-03-15 | 2022-08-30 | Oxford Biomedica (Uk) Limited | 5T4-targeting agents and methods |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US197349A (en) * | 1877-11-20 | Improvement in ore-mills | ||
US171272A (en) * | 1875-12-21 | Improvement in school-desks | ||
US2003A (en) * | 1841-03-12 | Improvement in horizontal windivhlls | ||
US131594A (en) * | 1872-09-24 | Improvement in pulley-blocks | ||
US138454A (en) * | 1873-04-29 | Improvement in card-racks | ||
US175365A (en) * | 1876-03-28 | Improvement in sheet-metal-straightening machines | ||
ZA754725B (en) * | 1974-08-01 | 1976-06-30 | H Stickl | Preparation for the treatment of infectious diseases, method for the manufacture thereof, and its use |
US5110587A (en) | 1981-12-24 | 1992-05-05 | Health Research, Incorporated | Immunogenic composition comprising synthetically modified vaccinia virus |
GB8405530D0 (en) * | 1984-03-02 | 1984-04-04 | Lysons R J | Vaccine for swine dysentery |
CA1341245C (en) | 1988-01-12 | 2001-06-05 | F. Hoffmann-La Roche Ag | Recombinant vaccinia virus mva |
US5225336A (en) | 1989-03-08 | 1993-07-06 | Health Research Incorporated | Recombinant poxvirus host range selection system |
JP3044062B2 (ja) | 1989-03-08 | 2000-05-22 | ヘルス・リサーチ・インク | 組換えポックスウイルス宿主選択系 |
US5462734A (en) * | 1990-11-02 | 1995-10-31 | Wisconsin Alumni Research Foundation | Bovine herpesvirus vaccine and method of using same |
US5766597A (en) * | 1991-03-07 | 1998-06-16 | Virogenetics Corporation | Malaria recombinant poxviruses |
BE1004877A3 (fr) | 1991-05-27 | 1993-02-16 | Solvay | Virus de l'avipox recombinant, culture de cellules infectees par ce virus et vaccins pour la volaille derives de ce virus. |
DK0592546T3 (da) | 1991-06-14 | 2003-09-15 | Us Gov Health & Human Serv | Immundeficiens-virus rekombinant poxvirus-vaccine |
AU670538B2 (en) | 1991-07-26 | 1996-07-25 | Virogenetics Corporation | Infectious bursal disease virus recombinant poxvirus vaccine |
DE69229390T2 (de) * | 1991-08-26 | 1999-11-11 | Immuno Ag | Direkt molekuläre Klonierung eines modifizierten Genoms eines Chordopocken-Virus |
US5972351A (en) * | 1992-04-03 | 1999-10-26 | Isis Innovation Limited | Plasmodium falciparum MHC class I-restricted CTL epitopes derived from pre-erythrocytic stage antigens |
PT638316E (pt) | 1993-08-11 | 2003-10-31 | Wyeth Corp | Vacinas de adenoviros recombinante |
DE4341770A1 (de) * | 1993-12-08 | 1995-06-14 | Basf Ag | Verfahren zur Herstellung von Milchsäureestern |
NZ290089A (en) * | 1994-07-27 | 1999-05-28 | Queensland Inst Med Res | Recombinant polyepitope cytotoxic t lymphocyte (ctl) vaccines |
FR2724945B1 (fr) * | 1994-09-27 | 1996-12-27 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en therapie genique |
US6001349A (en) * | 1995-02-22 | 1999-12-14 | Therion Biologics Corporation | Generation of human cytotoxic T-cells specific for carcinoma self-associated antigens and uses thereof |
WO1996039178A1 (en) * | 1995-06-05 | 1996-12-12 | The Wistar Institute Of Anatomy And Biology | A replication-defective adenovirus human type 5 recombinant as a vaccine carrier |
EP0753581A1 (en) | 1995-07-10 | 1997-01-15 | Immuno Ag | Improved recombinant eukaryotic cytoplasmic viruses, method for their production and their use as vaccines |
US5741492A (en) * | 1996-01-23 | 1998-04-21 | St. Jude Children's Research Hospital | Preparation and use of viral vectors for mixed envelope protein vaccines against human immunodeficiency viruses |
US20010036928A1 (en) * | 1996-04-22 | 2001-11-01 | Chamberlain Ronald S. | Heterologous boosting immunizations |
WO1997039771A1 (en) * | 1996-04-22 | 1997-10-30 | The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services | Heterologous boosting immunizations |
CA2261990A1 (en) * | 1996-07-25 | 1998-02-05 | Therion Biologics Corporation | Recombinant pox virus for immunization against tumor-associated antigens |
EP0985046B1 (en) | 1997-02-21 | 2006-04-12 | Oxxon Therapeutics Limited | Recombinant poxvirus incapable of expressing a41l gene, coding for a soluble protein that binds chemokines |
US20030138454A1 (en) * | 1997-06-09 | 2003-07-24 | Oxxon Pharmaccines, Ltd. | Vaccination method |
GB0023203D0 (en) | 2000-09-21 | 2000-11-01 | Isis Innovation | Vaccination method |
GB9711957D0 (en) | 1997-06-09 | 1997-08-06 | Isis Innovation | Methods and reagents for vaccination |
JP2002507393A (ja) | 1998-02-11 | 2002-03-12 | マキシジェン, インコーポレイテッド | 抗原ライブラリー免疫 |
US20010036929A1 (en) * | 1998-09-25 | 2001-11-01 | Arch Development Corporation. | Xrcc3 is required for assembly of Rad51-complexes in vivo |
JP2003530307A (ja) | 1999-07-06 | 2003-10-14 | メルク・アンド・カンパニー・インコーポレーテッド | gag遺伝子保有アデノウイルスHIVワクチン |
PT1212358E (pt) | 1999-08-25 | 2005-04-29 | Merck & Co Inc | Genes sinteticos de papilomavirus humano |
GB9922361D0 (en) | 1999-09-21 | 1999-11-24 | Isis Innovation | Generating an immune response to an antigen |
CA2408328C (en) | 2000-05-10 | 2012-04-17 | Aventis Pasteur Limited | Immunogenic polypeptides encoded by mage minigenes and uses thereof |
CU23235A1 (es) | 2001-02-28 | 2007-09-26 | Ct Ingenieria Genetica Biotech | POXVIRUS RECOMBINANTES PARA PROTEINAS QUIMéRICAS DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA Y SU APLICACION EN LA TERAPéUTICA Y LA PREVENCION DEL SIDA |
JP2002271316A (ja) * | 2001-03-13 | 2002-09-20 | Sanyo Electric Co Ltd | 再生装置 |
CN1164331C (zh) | 2001-05-23 | 2004-09-01 | 中国人民解放军第二军医大学 | 一种人乙型肝炎核酸疫苗 |
CA2467486A1 (en) * | 2001-11-30 | 2003-06-12 | Isis Innovation Limited | Vaccine |
US20040171272A1 (en) * | 2003-02-28 | 2004-09-02 | Applied Materials, Inc. | Method of etching metallic materials to form a tapered profile |
US6942373B2 (en) * | 2003-03-14 | 2005-09-13 | Fiberstars Incorporated | Fiberoptic lighting system with shaped collector for efficiency |
BRPI0413334A (pt) | 2003-09-05 | 2006-10-10 | Sanofi Pasteur Ltd | vetores de multiantìgenos para melanoma |
US20050175627A1 (en) * | 2003-09-24 | 2005-08-11 | Oxxon Therapeutics Ltd. | HIV pharmaccines |
CA2539864A1 (en) | 2003-09-24 | 2005-04-07 | Oxxon Therapeutics Limited | Hiv pharmaccines |
GB2421025A (en) | 2004-12-09 | 2006-06-14 | Oxxon Therapeutics Ltd | HSV vaccination vectors |
WO2006120474A2 (en) | 2005-05-13 | 2006-11-16 | Oxxon Therapeutics Ltd | Compositions for inducing an immune response against tumor antigens |
EP1888622A1 (en) | 2005-05-23 | 2008-02-20 | Oxxon Therapeutics Ltd. | Compositions for inducing an immune response against hepatitis b |
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1997
- 1997-06-09 GB GBGB9711957.2A patent/GB9711957D0/en active Pending
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- 1998-06-09 AU AU80266/98A patent/AU737780B2/en not_active Expired
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Cited By (6)
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WO2007102326A1 (ja) * | 2006-03-07 | 2007-09-13 | Yokohama City University | アデノウイルス5型/35型ベクターとワクシニアウイルスmvaベクターとの併用による強力な免疫誘導 |
JPWO2007102326A1 (ja) * | 2006-03-07 | 2009-07-23 | 公立大学法人横浜市立大学 | アデノウイルス5型/35型ベクターとワクシニアウイルスmvaベクターとの併用による強力な免疫誘導 |
JP2010523137A (ja) * | 2007-04-10 | 2010-07-15 | アイシス イノヴェイション リミテッド | マラリア抗原をコードするアデノウイルスベクター |
JP2010523138A (ja) * | 2007-04-10 | 2010-07-15 | アイシス イノヴェイション リミテッド | 免疫原性組成物 |
US9895431B1 (en) | 2007-04-10 | 2018-02-20 | Glaxosmithkline Biologicals Sa | Simian adenoviral vectors encoding malaria antigen |
JP2015526403A (ja) * | 2012-07-05 | 2015-09-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ポリヌクレオチドによりコードされた免疫原性ポリペプチドに関わる新規プライムブースト投与法 |
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