JP2002505006A - 分取クロマトグラフィーによる分離のためのモノリシック吸着剤の使用 - Google Patents
分取クロマトグラフィーによる分離のためのモノリシック吸着剤の使用Info
- Publication number
- JP2002505006A JP2002505006A JP50369899A JP50369899A JP2002505006A JP 2002505006 A JP2002505006 A JP 2002505006A JP 50369899 A JP50369899 A JP 50369899A JP 50369899 A JP50369899 A JP 50369899A JP 2002505006 A JP2002505006 A JP 2002505006A
- Authority
- JP
- Japan
- Prior art keywords
- separation
- adsorbent
- monolithic
- adsorbents
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
- B01D15/1821—Simulated moving beds
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- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
- B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2215/00—Separating processes involving the treatment of liquids with adsorbents
- B01D2215/02—Separating processes involving the treatment of liquids with adsorbents with moving adsorbents
- B01D2215/023—Simulated moving beds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/52—Sorbents specially adapted for preparative chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/56—Use in the form of a bed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/58—Use in a single column
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/80—Aspects related to sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J2220/82—Shaped bodies, e.g. monoliths, plugs, tubes, continuous beds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/52—Physical parameters
- G01N2030/524—Physical parameters structural properties
- G01N2030/528—Monolithic sorbent material
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Sustainable Development (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 少なくとも2つの物質の分取クロマトグラフィーによる分離方法であって 、 マクロ孔が2μmから20μmの範囲の直径を有し、メソ孔が2nmから100 nm(各々の場合、中央値)の範囲の直径を有する成形SiO2成形体に基づく モノリシック吸着剤を使用して、分離を行うことを特徴とする、前記方法。 2. さらに、クロマトグラフィーによる分離がバッチプロセスとして行われる ことを特徴とする、請求項1に記載の方法。 3. さらに、クロマトグラフィー分離が連続プロセスとして行われることを特 徴とする、請求項1に記載の方法。
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19725639.2 | 1997-06-18 | ||
DE19725639A DE19725639A1 (de) | 1997-06-18 | 1997-06-18 | Gradientenelutionsverfahren |
DE19726152.3 | 1997-06-20 | ||
DE1997126152 DE19726152A1 (de) | 1997-06-20 | 1997-06-20 | Verwendung von monolithischen Sorbentien für die Enantiomerentrennung |
DE19726151.5 | 1997-06-20 | ||
DE1997126151 DE19726151B4 (de) | 1997-06-20 | 1997-06-20 | Verwendung monolithischer Sorbentien für "Simulated Moving Bed" Trennverfahren |
DE1998101575 DE19801575A1 (de) | 1998-01-19 | 1998-01-19 | Verwendung monolithischer Sorbentien für präparative chromatographische Trennverfahren |
DE19801575.5 | 1998-01-19 | ||
PCT/EP1998/003546 WO1998058253A1 (de) | 1997-06-18 | 1998-06-12 | Verwendung monolithischer sorbentien für präparative chromatographische trennverfahren |
Publications (2)
Publication Number | Publication Date |
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JP2002505006A true JP2002505006A (ja) | 2002-02-12 |
JP2002505006A5 JP2002505006A5 (ja) | 2005-12-22 |
Family
ID=27438625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP50369899A Withdrawn JP2002505006A (ja) | 1997-06-18 | 1998-06-12 | 分取クロマトグラフィーによる分離のためのモノリシック吸着剤の使用 |
Country Status (6)
Country | Link |
---|---|
US (1) | US6398962B1 (ja) |
EP (1) | EP0991940B1 (ja) |
JP (1) | JP2002505006A (ja) |
AT (1) | ATE478732T1 (ja) |
DE (1) | DE59814468D1 (ja) |
WO (1) | WO1998058253A1 (ja) |
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JP2006504515A (ja) * | 2002-10-31 | 2006-02-09 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 有機ポリマーでコーティングした無機一体成形品 |
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- 1998-06-12 US US09/445,585 patent/US6398962B1/en not_active Expired - Lifetime
- 1998-06-12 WO PCT/EP1998/003546 patent/WO1998058253A1/de active Application Filing
- 1998-06-12 DE DE59814468T patent/DE59814468D1/de not_active Expired - Lifetime
- 1998-06-12 AT AT98933607T patent/ATE478732T1/de active
- 1998-06-12 EP EP98933607A patent/EP0991940B1/de not_active Expired - Lifetime
- 1998-06-12 JP JP50369899A patent/JP2002505006A/ja not_active Withdrawn
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Also Published As
Publication number | Publication date |
---|---|
EP0991940A1 (de) | 2000-04-12 |
ATE478732T1 (de) | 2010-09-15 |
EP0991940B1 (de) | 2010-08-25 |
WO1998058253A1 (de) | 1998-12-23 |
DE59814468D1 (de) | 2010-10-07 |
US6398962B1 (en) | 2002-06-04 |
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