US5559137A
(en)
*
|
1994-05-16 |
1996-09-24 |
Smithkline Beecham Corp. |
Compounds
|
US6087381A
(en)
|
1997-05-22 |
2000-07-11 |
G. D. Searle & Company |
Pyrazole derivatives as p38 kinase inhibitors
|
US6979686B1
(en)
|
2001-12-07 |
2005-12-27 |
Pharmacia Corporation |
Substituted pyrazoles as p38 kinase inhibitors
|
US6514977B1
(en)
|
1997-05-22 |
2003-02-04 |
G.D. Searle & Company |
Substituted pyrazoles as p38 kinase inhibitors
|
US6087496A
(en)
*
|
1998-05-22 |
2000-07-11 |
G. D. Searle & Co. |
Substituted pyrazoles suitable as p38 kinase inhibitors
|
WO1998056377A1
(en)
|
1997-06-13 |
1998-12-17 |
Smithkline Beecham Corporation |
Novel pyrazole and pyrazoline substituted compounds
|
US6339099B1
(en)
*
|
1997-06-20 |
2002-01-15 |
Dupont Pharmaceuticals Company |
Guanidine mimics as factor Xa inhibitors
|
US7301021B2
(en)
|
1997-07-02 |
2007-11-27 |
Smithkline Beecham Corporation |
Substituted imidazole compounds
|
WO1999032111A1
(en)
*
|
1997-12-22 |
1999-07-01 |
Bayer Corporation |
INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS
|
MY132496A
(en)
*
|
1998-05-11 |
2007-10-31 |
Vertex Pharma |
Inhibitors of p38
|
WO2000002561A1
(en)
*
|
1998-07-13 |
2000-01-20 |
University Of South Florida |
Modulation of the phospholipase a2 pathway as a therapeutic
|
EP1119254A4
(en)
|
1998-10-07 |
2004-05-12 |
Smithkline Beecham Corp |
STROKE TREATMENT
|
SA99191255B1
(ar)
*
|
1998-11-30 |
2006-11-25 |
جي دي سيرل اند كو |
مركبات سيليكوكسيب celecoxib
|
JP4634613B2
(ja)
|
1998-12-16 |
2011-02-16 |
アベンティス・フアーマ・リミテッド |
ヘテロアリール環状アセタール類
|
JP4632544B2
(ja)
*
|
1998-12-25 |
2011-02-16 |
あすか製薬株式会社 |
アミノピラゾール誘導体
|
US8124630B2
(en)
|
1999-01-13 |
2012-02-28 |
Bayer Healthcare Llc |
ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
EP1158985B1
(en)
|
1999-01-13 |
2011-12-28 |
Bayer HealthCare LLC |
OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
|
JP2000281588A
(ja)
*
|
1999-03-30 |
2000-10-10 |
Sankyo Co Ltd |
ガンの予防又は治療薬及びそのスクリーニング方法
|
US7122666B2
(en)
*
|
1999-07-21 |
2006-10-17 |
Sankyo Company, Limited |
Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
|
US6808902B1
(en)
|
1999-11-12 |
2004-10-26 |
Amgen Inc. |
Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
|
AU1781601A
(en)
|
1999-11-23 |
2001-06-04 |
Smithkline Beecham Corporation |
3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
|
TR200103787T1
(tr)
|
2000-02-05 |
2002-10-21 |
Vertex Pharmaceuticals Incorporated |
Hücre-dışı sinyal ayarlı kinazların(ERK) inhibitörü olarak yararlı pirazol bileşimler
|
AU2001236720A1
(en)
*
|
2000-02-05 |
2001-08-14 |
Bemis, Guy |
Compositions useful as inhibitors of erk
|
PE20020506A1
(es)
*
|
2000-08-22 |
2002-07-09 |
Glaxo Group Ltd |
Derivados de pirazol fusionados como inhibidores de la proteina cinasa
|
US6867300B2
(en)
*
|
2000-11-17 |
2005-03-15 |
Bristol-Myers Squibb Company |
Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
|
US6670357B2
(en)
*
|
2000-11-17 |
2003-12-30 |
Bristol-Myers Squibb Company |
Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
|
EP1355903B1
(en)
*
|
2001-02-02 |
2005-03-16 |
SmithKline Beecham Corporation |
Pyrazole derivatives against tgf overexpression
|
ATE339416T1
(de)
*
|
2001-04-13 |
2006-10-15 |
Vertex Pharma |
Inhibitoren von c-jun-n-terminalen-kinasen (jnk) und anderen proteinkinasen
|
ATE402164T1
(de)
|
2001-04-26 |
2008-08-15 |
Eisai R&D Man Co Ltd |
Stickstoffhaltige verbindung mit kondensiertem ring und pyrazolylgruppe als substituent und medizinische zusammensetzung davon
|
GB0112348D0
(en)
*
|
2001-05-19 |
2001-07-11 |
Smithkline Beecham Plc |
Compounds
|
MXPA04000134A
(es)
|
2001-06-26 |
2005-06-06 |
Abgenix Inc |
Anticuerpos para ligandos de osteoprotegerina.
|
CA2456187A1
(en)
*
|
2001-08-03 |
2003-02-13 |
Qing Tang |
Pyrazole-derived kinase inhibitors and uses thereof
|
EP1419770A4
(en)
*
|
2001-08-24 |
2005-08-03 |
Shionogi & Co |
AGENT ACC L RATION OF THE EXPRESSION OF APO AI
|
KR100697482B1
(ko)
|
2001-09-25 |
2007-03-20 |
파마시아 코포레이션 |
치환된 피라졸의 제조 방법
|
US7057049B2
(en)
|
2001-09-25 |
2006-06-06 |
Pharmacia Corporation |
Process for making substituted pyrazoles
|
GB0124941D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
GB0124934D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
GB0124931D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
GB0124933D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
GB0124936D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
GB0124939D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
GB0124938D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
GB0124932D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
DE10294485T5
(de)
*
|
2001-10-29 |
2004-04-29 |
DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung |
Mit Mnk-Kinase homologe Proteine, die in die Regulation der Energiehomöostase und den Organellenmetabolismus involviert sind
|
AU2002356301A1
(en)
*
|
2001-12-21 |
2003-07-15 |
Cancer Research Technology Ltd. |
3,4-diarylpyrazoles and their use in the therapy of cancer
|
EP1478358B1
(en)
|
2002-02-11 |
2013-07-03 |
Bayer HealthCare LLC |
Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis
|
US7125898B2
(en)
*
|
2002-02-12 |
2006-10-24 |
Smithkline Beecham Corporation |
Nicotinamide derivatives useful as p38 inhibitors.
|
AR039241A1
(es)
*
|
2002-04-04 |
2005-02-16 |
Biogen Inc |
Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
|
US20050124620A1
(en)
*
|
2002-04-09 |
2005-06-09 |
Martyn Frederickson |
Pharmaceutical compounds
|
RS92004A
(en)
|
2002-04-23 |
2006-12-15 |
Bristol-Myers Squibb Company |
Pyrrolo-triazine aniline compounds useful as kinase inhibitors
|
AU2003228770A1
(en)
*
|
2002-05-10 |
2003-11-11 |
Smithkline Beecham Corporation |
Substituted pyrazolopyrimidines
|
WO2004004725A2
(en)
|
2002-07-09 |
2004-01-15 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
|
GB0217757D0
(en)
|
2002-07-31 |
2002-09-11 |
Glaxo Group Ltd |
Novel compounds
|
UA80295C2
(en)
*
|
2002-09-06 |
2007-09-10 |
Biogen Inc |
Pyrazolopyridines and using the same
|
CA2497007A1
(en)
*
|
2002-09-09 |
2004-03-18 |
Amgen Inc. |
1, 4, 5-substituted 1, 2-dihydro-pyrazol-3-one and 3-alkoxy-1h-pyrazole derivatives s tnf-alpha and interleukin lowering agents for the treatment of inflammations
|
MXPA05002332A
(es)
|
2002-09-18 |
2005-06-08 |
Pfizer Prod Inc |
Nuevos compuestos de oxazol y tiazol como inhibidores del factor de crecimiento transformador (tgf).
|
AP2005003262A0
(en)
|
2002-09-18 |
2005-03-31 |
Pfizer Prod Inc |
Novel isothiazole and isoxazole compounds as tranforming growth factor (TGF) inhibitors.
|
ES2325687T3
(es)
|
2002-09-18 |
2009-09-14 |
Pfizer Products Inc. |
Compuestos de imidazol novedosos como inhibidores del factor de crecimiento transformante (tgf).
|
PL375979A1
(en)
|
2002-09-18 |
2005-12-12 |
Pfizer Products Inc. |
Pyrazole derivatives as transforming growth factor (tgf) inhibitors
|
BR0314577A
(pt)
|
2002-09-18 |
2005-08-09 |
Pfizer Prod Inc |
Derivados de triazol como inibidores do fator de crescimento de transformação (tgf)
|
CN100519552C
(zh)
*
|
2002-09-25 |
2009-07-29 |
宇部兴产株式会社 |
吡唑化合物
|
EP1591443B1
(en)
|
2003-02-07 |
2010-08-25 |
Daiichi Sankyo Company, Limited |
Pyrazole derivative
|
CL2004000234A1
(es)
*
|
2003-02-12 |
2005-04-15 |
Biogen Idec Inc |
Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid
|
CL2004000366A1
(es)
*
|
2003-02-26 |
2005-01-07 |
Pharmacia Corp Sa Organizada B |
USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.
|
PA8595001A1
(es)
|
2003-03-04 |
2004-09-28 |
Pfizer Prod Inc |
Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
|
WO2004078261A1
(en)
*
|
2003-03-07 |
2004-09-16 |
The University Court Of The University Of Aberdeen |
Cannabinoid receptor inverse agonists and neutral antagonists as therapeutic agents for the treatment of bone disorders
|
GB0308186D0
(en)
*
|
2003-04-09 |
2003-05-14 |
Smithkline Beecham Corp |
Novel compounds
|
GB0308201D0
(en)
*
|
2003-04-09 |
2003-05-14 |
Smithkline Beecham Corp |
Novel compounds
|
GB0308185D0
(en)
*
|
2003-04-09 |
2003-05-14 |
Smithkline Beecham Corp |
Novel compounds
|
PL1745791T3
(pl)
|
2003-05-07 |
2013-11-29 |
Osteologix As |
Leczenie chorób chrząstki/kości za pomocą rozpuszczalnych w wodzie soli strontu
|
CA2526636C
(en)
|
2003-05-20 |
2012-10-02 |
Bayer Pharmaceuticals Corporation |
Diaryl ureas for diseases mediated by pdgfr
|
PT1635824E
(pt)
*
|
2003-06-03 |
2009-11-24 |
Novartis Ag |
Inibidores de p-38 à base de heterociclos de 5 membros
|
JP4838121B2
(ja)
|
2003-06-26 |
2011-12-14 |
ノバルティス アーゲー |
5員ヘテロ環を基礎とするp38キナーゼ阻害剤
|
CL2004001834A1
(es)
|
2003-07-23 |
2005-06-03 |
Bayer Pharmaceuticals Corp |
Compuesto 4-{4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenoxi}-piridin-2-metilamida, inhibidor de la raf, vegfr, p38 y pdgfr quinasas, sus sales; composiicon farmaceutica; combinacion farmaceutica; y su uso para tratar trastornos hiperprol
|
MXPA06000915A
(es)
*
|
2003-07-25 |
2006-03-30 |
Novartis Ag |
Inhibidores de quinasa p-38.
|
GB0318814D0
(en)
*
|
2003-08-11 |
2003-09-10 |
Smithkline Beecham Corp |
Novel compounds
|
US7419978B2
(en)
*
|
2003-10-22 |
2008-09-02 |
Bristol-Myers Squibb Company |
Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
|
GB0402143D0
(en)
*
|
2004-01-30 |
2004-03-03 |
Smithkline Beecham Corp |
Novel compounds
|
US7504521B2
(en)
*
|
2004-08-05 |
2009-03-17 |
Bristol-Myers Squibb Co. |
Methods for the preparation of pyrrolotriazine compounds
|
US20060035893A1
(en)
|
2004-08-07 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
|
AP2326A
(en)
|
2004-08-12 |
2011-11-24 |
Pfizer |
Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors.
|
PE20060421A1
(es)
|
2004-08-12 |
2006-06-01 |
Bristol Myers Squibb Co |
Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa
|
US20080051416A1
(en)
*
|
2004-10-05 |
2008-02-28 |
Smithkline Beecham Corporation |
Novel Compounds
|
PE20060777A1
(es)
|
2004-12-24 |
2006-10-06 |
Boehringer Ingelheim Int |
Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
|
TW200639163A
(en)
|
2005-02-04 |
2006-11-16 |
Genentech Inc |
RAF inhibitor compounds and methods
|
US20060178388A1
(en)
*
|
2005-02-04 |
2006-08-10 |
Wrobleski Stephen T |
Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
|
US20060235020A1
(en)
*
|
2005-04-18 |
2006-10-19 |
Soojin Kim |
Process for preparing salts of 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide and novel stable forms produced therein
|
EP1871770A1
(en)
*
|
2005-04-22 |
2008-01-02 |
Kalypsys, Inc. |
Ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders
|
GB0512429D0
(en)
*
|
2005-06-17 |
2005-07-27 |
Smithkline Beecham Corp |
Novel compound
|
US7473784B2
(en)
*
|
2005-08-01 |
2009-01-06 |
Bristol-Myers Squibb Company |
Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors
|
WO2007027878A2
(en)
*
|
2005-08-31 |
2007-03-08 |
Emergent Product Development Gaithersburg Inc. |
4-substituted 2-aryloxyphenol derivatives as antibacterial agents
|
ES2391783T3
(es)
*
|
2005-10-28 |
2012-11-29 |
Astrazeneca Ab |
Derivados de 4-(3-aminopirazol)pirimidina para su uso como agentes inhibidores de las tirosina cinasas en el tratamiento del cáncer
|
CA2632011A1
(en)
*
|
2005-12-23 |
2007-06-28 |
Astrazeneca Ab |
Pyrazoles for the treatment of gerd and ibs
|
WO2007103839A2
(en)
*
|
2006-03-07 |
2007-09-13 |
Bristol-Myers Squibb Company |
Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors
|
JP2007205153A
(ja)
*
|
2006-08-07 |
2007-08-16 |
Seiki Hanbai Co Ltd |
網戸用ネットの押さえ部材
|
US8128460B2
(en)
*
|
2006-09-14 |
2012-03-06 |
The Material Works, Ltd. |
Method of producing rust inhibitive sheet metal through scale removal with a slurry blasting descaling cell
|
JP2010508288A
(ja)
*
|
2006-10-27 |
2010-03-18 |
ブリストル−マイヤーズ スクイブ カンパニー |
キナーゼ阻害剤として有用なヘテロサイクリックアミド化合物
|
US7943617B2
(en)
*
|
2006-11-27 |
2011-05-17 |
Bristol-Myers Squibb Company |
Heterobicyclic compounds useful as kinase inhibitors
|
EP2366703B1
(en)
*
|
2007-02-13 |
2014-07-30 |
AB Science |
Polymorph form of 2-amino (nitroaryl) thiazole derivative
|
GB0702862D0
(en)
*
|
2007-02-14 |
2007-03-28 |
Univ Aberdeen |
Therapeutic compounds
|
US20090182035A1
(en)
*
|
2007-04-11 |
2009-07-16 |
Alcon Research, Ltd. |
Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
|
JP2010523695A
(ja)
*
|
2007-04-11 |
2010-07-15 |
アルコン リサーチ, リミテッド |
アレルギー性鼻炎およびアレルギー性結膜炎を処置するためのTNFαのインヒビターおよび抗ヒスタミン薬の使用
|
EP1992344A1
(en)
|
2007-05-18 |
2008-11-19 |
Institut Curie |
P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
|
KR20150088907A
(ko)
|
2007-08-29 |
2015-08-03 |
센주 세이야꾸 가부시키가이샤 |
각막 내피 세포 접착 촉진제
|
RU2503674C2
(ru)
*
|
2008-04-08 |
2014-01-10 |
Грюненталь Гмбх |
Замещенные производные сульфонамида
|
JP2011525183A
(ja)
|
2008-06-20 |
2011-09-15 |
ブリストル−マイヤーズ スクイブ カンパニー |
キナーゼ阻害剤として有用なイミダゾピリジンおよびイミダゾピラジン化合物
|
EP2307411B1
(en)
*
|
2008-06-20 |
2014-01-01 |
Bristol-Myers Squibb Company |
Triazolopyridine compounds useful as kinase inhibitors
|
JP2012506388A
(ja)
*
|
2008-10-23 |
2012-03-15 |
ロンザ リミテッド |
置換されたピラゾールの合成方法
|
AU2010300421B2
(en)
*
|
2009-10-01 |
2014-01-23 |
Alcon Research, Ltd. |
Olopatadine compositions and uses thereof
|
EP2308866A1
(de)
|
2009-10-09 |
2011-04-13 |
Bayer CropScience AG |
Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
|
AR079545A1
(es)
|
2009-12-21 |
2012-02-01 |
Bayer Cropscience Ag |
Tienilpiri(mi)dinilazol
|
AR081810A1
(es)
|
2010-04-07 |
2012-10-24 |
Bayer Cropscience Ag |
Piridinilpirazoles biciclicos
|
WO2012031057A1
(en)
|
2010-09-01 |
2012-03-08 |
Bristol-Myers Squibb Company |
Bms- 582949 for the treatment of resistant rheumatic disease
|
AR086992A1
(es)
|
2011-06-20 |
2014-02-05 |
Bayer Ip Gmbh |
Tienilpiri(mi)dinilpirazoles
|
BR112014008223A2
(pt)
|
2011-10-06 |
2017-04-25 |
Bayer Ip Gmbh |
heterociclilpiri (mi) dinilpirazol
|
RU2627272C2
(ru)
|
2011-10-06 |
2017-08-04 |
Байер Интеллектчуал Проперти Гмбх |
Гетероциклилпиридинилпиразолы
|
CN103360315B
(zh)
*
|
2013-07-22 |
2015-03-04 |
山东大学 |
一种芳杂氧乙酰肼类衍生物及其制备方法与应用
|
EP3886854A4
(en)
|
2018-11-30 |
2022-07-06 |
Nuvation Bio Inc. |
PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THERE
|