JP2002501762A - 還元性条件に感受性のトランスフェクション用組成物、該組成物を含有する医薬組成物及びそれらの用途 - Google Patents

還元性条件に感受性のトランスフェクション用組成物、該組成物を含有する医薬組成物及びそれらの用途

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Publication number
JP2002501762A
JP2002501762A JP2000530060A JP2000530060A JP2002501762A JP 2002501762 A JP2002501762 A JP 2002501762A JP 2000530060 A JP2000530060 A JP 2000530060A JP 2000530060 A JP2000530060 A JP 2000530060A JP 2002501762 A JP2002501762 A JP 2002501762A
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JP
Japan
Prior art keywords
nucleic acid
agent
transfection
introducing
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000530060A
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English (en)
Japanese (ja)
Other versions
JP2002501762A5 (enExample
Inventor
ビイク，ゲラルド
デユベルトレ，カトリーヌ
ピタール，ブリユノ
シエルマン，ダニエル
Original Assignee
アバンテイス・フアルマ・エス・アー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9801065A external-priority patent/FR2774394B1/fr
Application filed by アバンテイス・フアルマ・エス・アー filed Critical アバンテイス・フアルマ・エス・アー
Publication of JP2002501762A publication Critical patent/JP2002501762A/ja
Publication of JP2002501762A5 publication Critical patent/JP2002501762A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2000530060A 1998-01-30 1999-01-28 還元性条件に感受性のトランスフェクション用組成物、該組成物を含有する医薬組成物及びそれらの用途 Pending JP2002501762A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR9801065A FR2774394B1 (fr) 1998-01-30 1998-01-30 Composes transfectants sensibles aux conditions reductrices, compositions pharmaceutiques les contenant, et leurs applications
US7702698P 1998-03-06 1998-03-06
US98/01065 1998-03-06
US60/077,026 1998-03-06
PCT/FR1999/000162 WO1999038821A2 (fr) 1998-01-30 1999-01-28 Composes transfectants sensibles aux conditions reductrices, compositions pharmaceutiques les contenant, et leurs applications

Publications (2)

Publication Number Publication Date
JP2002501762A true JP2002501762A (ja) 2002-01-22
JP2002501762A5 JP2002501762A5 (enExample) 2009-09-17

Family

ID=26234096

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000530060A Pending JP2002501762A (ja) 1998-01-30 1999-01-28 還元性条件に感受性のトランスフェクション用組成物、該組成物を含有する医薬組成物及びそれらの用途

Country Status (14)

Country Link
US (1) US6521252B1 (enExample)
EP (1) EP1049793B1 (enExample)
JP (1) JP2002501762A (enExample)
KR (1) KR20010081924A (enExample)
CN (1) CN1289371A (enExample)
AT (1) ATE306556T1 (enExample)
AU (1) AU759197B2 (enExample)
BR (1) BR9907269A (enExample)
CA (1) CA2318512C (enExample)
DE (1) DE69927669T2 (enExample)
HU (1) HUP0101393A3 (enExample)
IL (1) IL137247A0 (enExample)
NO (1) NO20003880L (enExample)
WO (1) WO1999038821A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016510729A (ja) * 2013-02-28 2016-04-11 タフツ ユニバーシティー 薬剤のデリバリーのためのジスルフィド化合物

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169078B1 (en) * 1998-05-12 2001-01-02 University Of Florida Materials and methods for the intracellular delivery of substances
US6379698B1 (en) * 1999-04-06 2002-04-30 Isis Pharmaceuticals, Inc. Fusogenic lipids and vesicles
CA2424619C (en) * 2000-10-04 2010-05-18 Kyowa Hakko Kogyo Co., Ltd. Method for coating fine particles with lipid membrane
CA2698812A1 (en) * 2007-09-14 2009-03-19 Nitto Denko Corporation Drug carriers
FR2921369B1 (fr) * 2007-09-25 2014-07-11 Pf Medicament Nouveau procede de preparation de derives (poly) aminoalkylaminoacetamide d'epipodophyllotoxine,utiles pour leurs applications en therapeutique comme agent anticancereux.
GB0720486D0 (en) * 2007-10-19 2007-11-28 Univ Edinburgh Cationic lipids
US11433128B2 (en) * 2017-04-07 2022-09-06 Tianxin Wang Cell surface anchoring antigen conjugates to treat cancer
CN111918668A (zh) * 2018-02-16 2020-11-10 王天欣 治疗肿瘤细胞和癌症的方法和药剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2645866B1 (fr) 1989-04-17 1991-07-05 Centre Nat Rech Scient Nouvelles lipopolyamines, leur preparation et leur emploi
WO1991014696A1 (en) 1990-03-29 1991-10-03 Gilead Sciences, Inc. Oligonucleotide-transport agent disulfide conjugates
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5837533A (en) * 1994-09-28 1998-11-17 American Home Products Corporation Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent
FR2727679B1 (fr) 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
FR2730637B1 (fr) * 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
KR19990022597A (ko) 1995-06-07 1999-03-25 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 티오양이온성 지질, 제약조성물 및 그 사용 방법
FR2741066B1 (fr) * 1995-11-14 1997-12-12 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
US5942634A (en) * 1997-05-09 1999-08-24 Genzyme Corporation Cationic amphiphiles for cell transfections
EP0945138A1 (en) 1997-12-04 1999-09-29 Université Louis Pasteur de Strasbourg Transfection particles
US6169078B1 (en) 1998-05-12 2001-01-02 University Of Florida Materials and methods for the intracellular delivery of substances

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016510729A (ja) * 2013-02-28 2016-04-11 タフツ ユニバーシティー 薬剤のデリバリーのためのジスルフィド化合物

Also Published As

Publication number Publication date
HUP0101393A3 (en) 2004-10-28
BR9907269A (pt) 2001-04-03
DE69927669D1 (de) 2006-02-23
HUP0101393A1 (hu) 2001-08-28
CN1289371A (zh) 2001-03-28
AU759197B2 (en) 2003-04-10
KR20010081924A (ko) 2001-08-29
ATE306556T1 (de) 2005-10-15
EP1049793A2 (fr) 2000-11-08
AU4384300A (en) 2001-04-05
WO1999038821A2 (fr) 1999-08-05
CA2318512C (fr) 2009-10-13
EP1049793B1 (fr) 2005-10-12
NO20003880D0 (no) 2000-07-28
IL137247A0 (en) 2001-07-24
WO1999038821A3 (fr) 1999-09-23
US6521252B1 (en) 2003-02-18
CA2318512A1 (fr) 1999-08-05
DE69927669T2 (de) 2006-07-20
NO20003880L (no) 2000-07-28

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