ATE306556T1 - Für reduzierende bedingungen empfindliche transfektions-verbindungen, pharmazeutische zusammensezungen die diese enthalten und deren verwendung. - Google Patents
Für reduzierende bedingungen empfindliche transfektions-verbindungen, pharmazeutische zusammensezungen die diese enthalten und deren verwendung.Info
- Publication number
- ATE306556T1 ATE306556T1 AT99901639T AT99901639T ATE306556T1 AT E306556 T1 ATE306556 T1 AT E306556T1 AT 99901639 T AT99901639 T AT 99901639T AT 99901639 T AT99901639 T AT 99901639T AT E306556 T1 ATE306556 T1 AT E306556T1
- Authority
- AT
- Austria
- Prior art keywords
- reducing conditions
- pharmaceutical compositions
- compositions containing
- containing same
- compounds sensitive
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000001890 transfection Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9801065A FR2774394B1 (fr) | 1998-01-30 | 1998-01-30 | Composes transfectants sensibles aux conditions reductrices, compositions pharmaceutiques les contenant, et leurs applications |
| US7702698P | 1998-03-06 | 1998-03-06 | |
| PCT/FR1999/000162 WO1999038821A2 (fr) | 1998-01-30 | 1999-01-28 | Composes transfectants sensibles aux conditions reductrices, compositions pharmaceutiques les contenant, et leurs applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE306556T1 true ATE306556T1 (de) | 2005-10-15 |
Family
ID=26234096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99901639T ATE306556T1 (de) | 1998-01-30 | 1999-01-28 | Für reduzierende bedingungen empfindliche transfektions-verbindungen, pharmazeutische zusammensezungen die diese enthalten und deren verwendung. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6521252B1 (enExample) |
| EP (1) | EP1049793B1 (enExample) |
| JP (1) | JP2002501762A (enExample) |
| KR (1) | KR20010081924A (enExample) |
| CN (1) | CN1289371A (enExample) |
| AT (1) | ATE306556T1 (enExample) |
| AU (1) | AU759197B2 (enExample) |
| BR (1) | BR9907269A (enExample) |
| CA (1) | CA2318512C (enExample) |
| DE (1) | DE69927669T2 (enExample) |
| HU (1) | HUP0101393A3 (enExample) |
| IL (1) | IL137247A0 (enExample) |
| NO (1) | NO20003880L (enExample) |
| WO (1) | WO1999038821A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6169078B1 (en) * | 1998-05-12 | 2001-01-02 | University Of Florida | Materials and methods for the intracellular delivery of substances |
| US6379698B1 (en) * | 1999-04-06 | 2002-04-30 | Isis Pharmaceuticals, Inc. | Fusogenic lipids and vesicles |
| CA2424619C (en) * | 2000-10-04 | 2010-05-18 | Kyowa Hakko Kogyo Co., Ltd. | Method for coating fine particles with lipid membrane |
| CA2698812A1 (en) * | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
| FR2921369B1 (fr) * | 2007-09-25 | 2014-07-11 | Pf Medicament | Nouveau procede de preparation de derives (poly) aminoalkylaminoacetamide d'epipodophyllotoxine,utiles pour leurs applications en therapeutique comme agent anticancereux. |
| GB0720486D0 (en) * | 2007-10-19 | 2007-11-28 | Univ Edinburgh | Cationic lipids |
| US9765022B2 (en) * | 2013-02-28 | 2017-09-19 | Tufts University | Disulfide compounds for delivery of pharmaceutical agents |
| US11433128B2 (en) * | 2017-04-07 | 2022-09-06 | Tianxin Wang | Cell surface anchoring antigen conjugates to treat cancer |
| CN111918668A (zh) * | 2018-02-16 | 2020-11-10 | 王天欣 | 治疗肿瘤细胞和癌症的方法和药剂 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2645866B1 (fr) | 1989-04-17 | 1991-07-05 | Centre Nat Rech Scient | Nouvelles lipopolyamines, leur preparation et leur emploi |
| WO1991014696A1 (en) | 1990-03-29 | 1991-10-03 | Gilead Sciences, Inc. | Oligonucleotide-transport agent disulfide conjugates |
| US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| US5837533A (en) * | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| FR2727679B1 (fr) | 1994-12-05 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux agents de transfection et leurs applications pharmaceutiques |
| FR2730637B1 (fr) * | 1995-02-17 | 1997-03-28 | Rhone Poulenc Rorer Sa | Composition pharmaceutique contenant des acides nucleiques, et ses utilisations |
| KR19990022597A (ko) | 1995-06-07 | 1999-03-25 | 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 | 티오양이온성 지질, 제약조성물 및 그 사용 방법 |
| FR2741066B1 (fr) * | 1995-11-14 | 1997-12-12 | Rhone Poulenc Rorer Sa | Nouveaux agents de transfection et leurs applications pharmaceutiques |
| US5942634A (en) * | 1997-05-09 | 1999-08-24 | Genzyme Corporation | Cationic amphiphiles for cell transfections |
| EP0945138A1 (en) | 1997-12-04 | 1999-09-29 | Université Louis Pasteur de Strasbourg | Transfection particles |
| US6169078B1 (en) | 1998-05-12 | 2001-01-02 | University Of Florida | Materials and methods for the intracellular delivery of substances |
-
1999
- 1999-01-28 BR BR9907269-6A patent/BR9907269A/pt not_active IP Right Cessation
- 1999-01-28 DE DE69927669T patent/DE69927669T2/de not_active Expired - Lifetime
- 1999-01-28 IL IL13724799A patent/IL137247A0/xx unknown
- 1999-01-28 WO PCT/FR1999/000162 patent/WO1999038821A2/fr not_active Ceased
- 1999-01-28 CN CN99802464A patent/CN1289371A/zh active Pending
- 1999-01-28 EP EP99901639A patent/EP1049793B1/fr not_active Expired - Lifetime
- 1999-01-28 JP JP2000530060A patent/JP2002501762A/ja active Pending
- 1999-01-28 HU HU0101393A patent/HUP0101393A3/hu unknown
- 1999-01-28 KR KR1020007008257A patent/KR20010081924A/ko not_active Ceased
- 1999-01-28 AT AT99901639T patent/ATE306556T1/de not_active IP Right Cessation
- 1999-01-28 CA CA002318512A patent/CA2318512C/fr not_active Expired - Fee Related
-
2000
- 2000-07-04 AU AU43843/00A patent/AU759197B2/en not_active Ceased
- 2000-07-06 US US09/610,727 patent/US6521252B1/en not_active Expired - Fee Related
- 2000-07-28 NO NO20003880A patent/NO20003880L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0101393A3 (en) | 2004-10-28 |
| BR9907269A (pt) | 2001-04-03 |
| DE69927669D1 (de) | 2006-02-23 |
| HUP0101393A1 (hu) | 2001-08-28 |
| CN1289371A (zh) | 2001-03-28 |
| AU759197B2 (en) | 2003-04-10 |
| KR20010081924A (ko) | 2001-08-29 |
| EP1049793A2 (fr) | 2000-11-08 |
| AU4384300A (en) | 2001-04-05 |
| JP2002501762A (ja) | 2002-01-22 |
| WO1999038821A2 (fr) | 1999-08-05 |
| CA2318512C (fr) | 2009-10-13 |
| EP1049793B1 (fr) | 2005-10-12 |
| NO20003880D0 (no) | 2000-07-28 |
| IL137247A0 (en) | 2001-07-24 |
| WO1999038821A3 (fr) | 1999-09-23 |
| US6521252B1 (en) | 2003-02-18 |
| CA2318512A1 (fr) | 1999-08-05 |
| DE69927669T2 (de) | 2006-07-20 |
| NO20003880L (no) | 2000-07-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE313642T1 (de) | Nukleinsäure enthaltende zusammensetzung, herstellung und verwendung | |
| YU83600A (sh) | Adenozin a3 receptorski modulatori | |
| DE69828045D1 (de) | Verbindungen, ihre herstellung und ihre verwendung für den transfer von nucleinsäuren in zellen | |
| DE69942610D1 (de) | Die bindung von integrinen zu deren rezeptoren verhindernde verbindungen | |
| ATE517125T1 (de) | ANTIKÖRPER GEGEN ßDEATH RECEPTOR 4ß (DR4) UND DEREN VERWENDUNGEN | |
| ID24730A (id) | Senyawa-senyawa heterosiklik untuk penghambatan sekresi asam lambung, proses pembuatan dan komposisi-komposisi farmasinya | |
| FR2714830B1 (fr) | Composition contenant des acides nucléiques, préparation et utilisations. | |
| PT892849E (pt) | Metodo para utilizacao do gene obeso e seu produto genico para estimular o desenvolvimento hematopoietico | |
| BR9810372A (pt) | Processo de transferência de ácido nucléico para o interior de células de organismos eucarióticos pluricelulares in vivo, composição, ácido nucléico e campo elétrico, e, produto de combinação | |
| EE03955B1 (et) | Nukleiinhappe kasutamine ravimi valmistamiseks imetaja reproduktiivtrakti vähemalt mõne raku transfekteerimiseks | |
| ATE226947T1 (de) | 2-substituierte 1,2,5-thiadiazolidin-3-on-1,1- dioxiden, zusammensetzung und deren verwendung | |
| ATE306556T1 (de) | Für reduzierende bedingungen empfindliche transfektions-verbindungen, pharmazeutische zusammensezungen die diese enthalten und deren verwendung. | |
| BR0010349B1 (pt) | derivados de ácido propanóico que inibem a ligação de integrinas aos seus receptores. | |
| DE69516066D1 (de) | Flüssigkristallzusammensetzung und Zellen, die diese enthalten | |
| ES2126652T3 (es) | Metodo de citodiagnostico utilizando la alstonina como marcador selectivo y kit de diagnostico conteniendo dicho marcador. | |
| HUP0102413A1 (hu) | Vektorok nukleinsavak bevitelére, ezeket tartalmazó készítmények és alkalmazásuk | |
| DE69928524D1 (de) | Biologisch aktive zusammensetzung | |
| TR200100801T2 (tr) | Benzoilguanidin türevleri, imalatlarına yönelik yöntemler, ilaç yapımında kullanımı | |
| NO20001812D0 (no) | Gallesyresalter av metaller med fysiologisk virkning, samt terapeutisk anvendelse derav | |
| DE3671444D1 (de) | Biologisch aktive substanz, girolline genannt, extrahiert aus dem schwamm pseudaxinyssa cantharella, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
| AR014969A1 (es) | Formulacion que contienen por lo menos una proteina tardia (proteina l) de uno o mas papilomavirus y/o por lo menos una proteina temprana (proteina e) deuno o mas papilomavirus, procedimiento para la preparacion de la formulacion mencionada asi como su utilizacion para la manufactura de un medicamen | |
| DE69836096D1 (de) | Anti-idiotypische monoklonale antikörper, deren verwendung zur aktiven immuntherapie bösartiger tumoren, und zusammensetzungen die diese enthalten | |
| BR9915897A (pt) | Agentes de transferência de ácidos nucleicos, composição, utilização de um agente de transferência e processos de tratamento de corpo humano ou animal e de transferência de ácidos nucleicos. | |
| MX9801920A (es) | Composicion farmaceutica util para la transfeccion de acidos nucleicos y sus usos. | |
| BR0115182A (pt) | Composição de substância carreadora de produtos à base de papaìna e hialuronidase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |