DE69927669T2 - Für reduzierende bedingungen empfindliche transfektions-verbindungen, pharmazeutische zusammensezungen die diese enthalten und deren verwendung. - Google Patents
Für reduzierende bedingungen empfindliche transfektions-verbindungen, pharmazeutische zusammensezungen die diese enthalten und deren verwendung. Download PDFInfo
- Publication number
- DE69927669T2 DE69927669T2 DE69927669T DE69927669T DE69927669T2 DE 69927669 T2 DE69927669 T2 DE 69927669T2 DE 69927669 T DE69927669 T DE 69927669T DE 69927669 T DE69927669 T DE 69927669T DE 69927669 T2 DE69927669 T2 DE 69927669T2
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- transmission means
- composition according
- cells
- transfection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 CC(C)(C)OC(NC(CSS*)C(O)=O)=O Chemical compound CC(C)(C)OC(NC(CSS*)C(O)=O)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9801065 | 1998-01-30 | ||
| FR9801065A FR2774394B1 (fr) | 1998-01-30 | 1998-01-30 | Composes transfectants sensibles aux conditions reductrices, compositions pharmaceutiques les contenant, et leurs applications |
| US7702698P | 1998-03-06 | 1998-03-06 | |
| US77026P | 1998-03-06 | ||
| PCT/FR1999/000162 WO1999038821A2 (fr) | 1998-01-30 | 1999-01-28 | Composes transfectants sensibles aux conditions reductrices, compositions pharmaceutiques les contenant, et leurs applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69927669D1 DE69927669D1 (de) | 2006-02-23 |
| DE69927669T2 true DE69927669T2 (de) | 2006-07-20 |
Family
ID=26234096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69927669T Expired - Lifetime DE69927669T2 (de) | 1998-01-30 | 1999-01-28 | Für reduzierende bedingungen empfindliche transfektions-verbindungen, pharmazeutische zusammensezungen die diese enthalten und deren verwendung. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6521252B1 (enExample) |
| EP (1) | EP1049793B1 (enExample) |
| JP (1) | JP2002501762A (enExample) |
| KR (1) | KR20010081924A (enExample) |
| CN (1) | CN1289371A (enExample) |
| AT (1) | ATE306556T1 (enExample) |
| AU (1) | AU759197B2 (enExample) |
| BR (1) | BR9907269A (enExample) |
| CA (1) | CA2318512C (enExample) |
| DE (1) | DE69927669T2 (enExample) |
| HU (1) | HUP0101393A3 (enExample) |
| IL (1) | IL137247A0 (enExample) |
| NO (1) | NO20003880L (enExample) |
| WO (1) | WO1999038821A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6169078B1 (en) * | 1998-05-12 | 2001-01-02 | University Of Florida | Materials and methods for the intracellular delivery of substances |
| US6379698B1 (en) * | 1999-04-06 | 2002-04-30 | Isis Pharmaceuticals, Inc. | Fusogenic lipids and vesicles |
| CA2424619C (en) * | 2000-10-04 | 2010-05-18 | Kyowa Hakko Kogyo Co., Ltd. | Method for coating fine particles with lipid membrane |
| CA2698812A1 (en) * | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
| FR2921369B1 (fr) * | 2007-09-25 | 2014-07-11 | Pf Medicament | Nouveau procede de preparation de derives (poly) aminoalkylaminoacetamide d'epipodophyllotoxine,utiles pour leurs applications en therapeutique comme agent anticancereux. |
| GB0720486D0 (en) * | 2007-10-19 | 2007-11-28 | Univ Edinburgh | Cationic lipids |
| US9765022B2 (en) * | 2013-02-28 | 2017-09-19 | Tufts University | Disulfide compounds for delivery of pharmaceutical agents |
| US11433128B2 (en) * | 2017-04-07 | 2022-09-06 | Tianxin Wang | Cell surface anchoring antigen conjugates to treat cancer |
| CN111918668A (zh) * | 2018-02-16 | 2020-11-10 | 王天欣 | 治疗肿瘤细胞和癌症的方法和药剂 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2645866B1 (fr) | 1989-04-17 | 1991-07-05 | Centre Nat Rech Scient | Nouvelles lipopolyamines, leur preparation et leur emploi |
| WO1991014696A1 (en) | 1990-03-29 | 1991-10-03 | Gilead Sciences, Inc. | Oligonucleotide-transport agent disulfide conjugates |
| US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| US5837533A (en) * | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| FR2727679B1 (fr) | 1994-12-05 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux agents de transfection et leurs applications pharmaceutiques |
| FR2730637B1 (fr) * | 1995-02-17 | 1997-03-28 | Rhone Poulenc Rorer Sa | Composition pharmaceutique contenant des acides nucleiques, et ses utilisations |
| KR19990022597A (ko) | 1995-06-07 | 1999-03-25 | 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 | 티오양이온성 지질, 제약조성물 및 그 사용 방법 |
| FR2741066B1 (fr) * | 1995-11-14 | 1997-12-12 | Rhone Poulenc Rorer Sa | Nouveaux agents de transfection et leurs applications pharmaceutiques |
| US5942634A (en) * | 1997-05-09 | 1999-08-24 | Genzyme Corporation | Cationic amphiphiles for cell transfections |
| EP0945138A1 (en) | 1997-12-04 | 1999-09-29 | Université Louis Pasteur de Strasbourg | Transfection particles |
| US6169078B1 (en) | 1998-05-12 | 2001-01-02 | University Of Florida | Materials and methods for the intracellular delivery of substances |
-
1999
- 1999-01-28 BR BR9907269-6A patent/BR9907269A/pt not_active IP Right Cessation
- 1999-01-28 DE DE69927669T patent/DE69927669T2/de not_active Expired - Lifetime
- 1999-01-28 IL IL13724799A patent/IL137247A0/xx unknown
- 1999-01-28 WO PCT/FR1999/000162 patent/WO1999038821A2/fr not_active Ceased
- 1999-01-28 CN CN99802464A patent/CN1289371A/zh active Pending
- 1999-01-28 EP EP99901639A patent/EP1049793B1/fr not_active Expired - Lifetime
- 1999-01-28 JP JP2000530060A patent/JP2002501762A/ja active Pending
- 1999-01-28 HU HU0101393A patent/HUP0101393A3/hu unknown
- 1999-01-28 KR KR1020007008257A patent/KR20010081924A/ko not_active Ceased
- 1999-01-28 AT AT99901639T patent/ATE306556T1/de not_active IP Right Cessation
- 1999-01-28 CA CA002318512A patent/CA2318512C/fr not_active Expired - Fee Related
-
2000
- 2000-07-04 AU AU43843/00A patent/AU759197B2/en not_active Ceased
- 2000-07-06 US US09/610,727 patent/US6521252B1/en not_active Expired - Fee Related
- 2000-07-28 NO NO20003880A patent/NO20003880L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0101393A3 (en) | 2004-10-28 |
| BR9907269A (pt) | 2001-04-03 |
| DE69927669D1 (de) | 2006-02-23 |
| HUP0101393A1 (hu) | 2001-08-28 |
| CN1289371A (zh) | 2001-03-28 |
| AU759197B2 (en) | 2003-04-10 |
| KR20010081924A (ko) | 2001-08-29 |
| ATE306556T1 (de) | 2005-10-15 |
| EP1049793A2 (fr) | 2000-11-08 |
| AU4384300A (en) | 2001-04-05 |
| JP2002501762A (ja) | 2002-01-22 |
| WO1999038821A2 (fr) | 1999-08-05 |
| CA2318512C (fr) | 2009-10-13 |
| EP1049793B1 (fr) | 2005-10-12 |
| NO20003880D0 (no) | 2000-07-28 |
| IL137247A0 (en) | 2001-07-24 |
| WO1999038821A3 (fr) | 1999-09-23 |
| US6521252B1 (en) | 2003-02-18 |
| CA2318512A1 (fr) | 1999-08-05 |
| NO20003880L (no) | 2000-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |