JP2001525669A - 細胞遊走の阻害のための方法および構築物 - Google Patents

細胞遊走の阻害のための方法および構築物

Info

Publication number
JP2001525669A
JP2001525669A JP54907798A JP54907798A JP2001525669A JP 2001525669 A JP2001525669 A JP 2001525669A JP 54907798 A JP54907798 A JP 54907798A JP 54907798 A JP54907798 A JP 54907798A JP 2001525669 A JP2001525669 A JP 2001525669A
Authority
JP
Japan
Prior art keywords
nucleic acid
acid molecule
domain
recombinant nucleic
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP54907798A
Other languages
English (en)
Japanese (ja)
Inventor
フベルツス アンドレアス クアクス、パウルス
ヘンドリクス フェルヘイエン、ヨハン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Original Assignee
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO filed Critical Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Publication of JP2001525669A publication Critical patent/JP2001525669A/ja
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6456Plasminogen activators
    • C12N9/6459Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/485Epidermal growth factor [EGF], i.e. urogastrone
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114Kunitz type inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114Kunitz type inhibitors
    • C07K14/8117Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21069Protein C activated (3.4.21.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP54907798A 1997-05-12 1998-05-11 細胞遊走の阻害のための方法および構築物 Ceased JP2001525669A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97201423 1997-05-12
EP97201423.7 1997-05-12
PCT/NL1998/000259 WO1998051788A2 (fr) 1997-05-12 1998-05-11 Procede et construction pouvant inhiber une migration cellulaire

Publications (1)

Publication Number Publication Date
JP2001525669A true JP2001525669A (ja) 2001-12-11

Family

ID=8228315

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54907798A Ceased JP2001525669A (ja) 1997-05-12 1998-05-11 細胞遊走の阻害のための方法および構築物

Country Status (7)

Country Link
EP (1) EP0981606A2 (fr)
JP (1) JP2001525669A (fr)
AU (1) AU7553698A (fr)
CA (1) CA2289117A1 (fr)
NO (1) NO995564L (fr)
NZ (1) NZ500656A (fr)
WO (1) WO1998051788A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055365A1 (fr) 1998-04-30 1999-11-04 Cornell Research Foundation, Inc. Vecteurs adenoviraux avec proteines a deux types de genes de fibre
US6455314B1 (en) 1998-09-11 2002-09-24 Genvec, Inc. Alternatively targeted adenovirus
DE10020125A1 (de) 2000-04-18 2001-10-25 Friedrich Schiller Uni Jena Bu Agens für den postoperativen Einsatz nach Entfernung von Knochentumoren
EP1903113A1 (fr) * 2000-12-18 2008-03-26 Arriva Pharmaceuticals, Inc. Inhibiteurs de protéase multifonctionnels et leur utilisation dans le traitement de maladies
AU2002241661B2 (en) * 2000-12-18 2007-05-31 Arriva Pharmaceuticals, Inc Multifunctional protease inhibitors and their use in treatment of disease
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
ATE467680T1 (de) 2001-10-11 2010-05-15 Merck Sharp & Dohme Hepatitis-c-virus-impfstoff
DE60236364D1 (en) * 2001-10-11 2010-06-24 Angeletti P Ist Richerche Bio Hepatitis-c-virus-impfstoff

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0318554B2 (fr) * 1987-05-21 2005-01-12 Micromet AG Proteines mutifonctionnelles a cible predeterminee
US5504001A (en) * 1987-11-25 1996-04-02 Zymogenetics, Inc. Hybrid plasminogen activator
DE69025211T2 (de) * 1989-02-17 1996-09-19 Merck & Co Inc Protein-Antikrebsmittel
JP2877509B2 (ja) * 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド メタロプロテイナーゼ阻害剤
ES2060134T3 (es) * 1989-05-26 1994-11-16 Univ Washington Inhibidor de tejido de metaloproteasas (timp-2).
AU657087B2 (en) * 1989-12-22 1995-03-02 Seragen Incorporated Hybrid molecules having translocation region and cell-binding region
ATE212059T1 (de) * 1990-02-15 2002-02-15 Methoden zur identifizierung heterofunktionaler fusionsproteine
GB2246779B (en) * 1990-08-03 1994-08-17 Delta Biotechnology Ltd Tumour-associated protease inhibitors targeted to tumour cells
JPH09504174A (ja) * 1993-10-29 1997-04-28 インサイト ファーマシューティカルズ,インク. プロテアーゼネキシン1変異体を含むキメラ蛋白
WO1995013091A1 (fr) * 1993-11-12 1995-05-18 International Technology Management Associates, Ltd. Procedes pour la reparation de tissu conjonctif
US5550213A (en) * 1993-12-27 1996-08-27 Rutgers, The State University Of New Jersey Inhibitors of urokinase plasminogen activator
DE69533472T2 (de) * 1994-01-11 2006-01-12 Dyax Corp., Cambridge Kallikreinhemmende "kunitz-domäne"-proteine und derivaten davon
WO1995028955A1 (fr) * 1994-04-22 1995-11-02 Gliemann Joergen PEPTIDES SE LIANT A LA PROTEINE ASSOCIEE AU RECEPTEUR DE MACROGLOBULINE-α2/RECEPTEUR DE LIPOPROTEINE DE FAIBLE DENSITE
US5712149A (en) * 1995-02-03 1998-01-27 Cell Genesys, Inc. Chimeric receptor molecules for delivery of co-stimulatory signals
US5843724A (en) * 1995-04-27 1998-12-01 Rutgers University Chimeric nucleic acids and proteins for inhibiting HIV-1 expression
US5726050A (en) * 1995-06-20 1998-03-10 Massachusetts Institute Of Technology Z-DNA binding protein and applications
AU1210797A (en) * 1996-01-08 1997-08-01 Nissin Food Products Co., Ltd. Cancerous metastasis inhibitor

Also Published As

Publication number Publication date
EP0981606A2 (fr) 2000-03-01
WO1998051788A3 (fr) 1999-05-20
NZ500656A (en) 2001-11-30
NO995564D0 (no) 1999-11-12
NO995564L (no) 2000-01-11
WO1998051788A2 (fr) 1998-11-19
CA2289117A1 (fr) 1998-11-19
AU7553698A (en) 1998-12-08

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