JP2001525669A - 細胞遊走の阻害のための方法および構築物 - Google Patents
細胞遊走の阻害のための方法および構築物Info
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- JP2001525669A JP2001525669A JP54907798A JP54907798A JP2001525669A JP 2001525669 A JP2001525669 A JP 2001525669A JP 54907798 A JP54907798 A JP 54907798A JP 54907798 A JP54907798 A JP 54907798A JP 2001525669 A JP2001525669 A JP 2001525669A
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- 230000001177 retroviral effect Effects 0.000 description 1
- 210000003752 saphenous vein Anatomy 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 230000015590 smooth muscle cell migration Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000003146 transient transfection Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000003422 vasoregulatory effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201423 | 1997-05-12 | ||
| EP97201423.7 | 1997-05-12 | ||
| PCT/NL1998/000259 WO1998051788A2 (fr) | 1997-05-12 | 1998-05-11 | Procede et construction pouvant inhiber une migration cellulaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001525669A true JP2001525669A (ja) | 2001-12-11 |
Family
ID=8228315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54907798A Ceased JP2001525669A (ja) | 1997-05-12 | 1998-05-11 | 細胞遊走の阻害のための方法および構築物 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0981606A2 (fr) |
| JP (1) | JP2001525669A (fr) |
| AU (1) | AU7553698A (fr) |
| CA (1) | CA2289117A1 (fr) |
| NO (1) | NO995564L (fr) |
| NZ (1) | NZ500656A (fr) |
| WO (1) | WO1998051788A2 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999055365A1 (fr) | 1998-04-30 | 1999-11-04 | Cornell Research Foundation, Inc. | Vecteurs adenoviraux avec proteines a deux types de genes de fibre |
| US6455314B1 (en) | 1998-09-11 | 2002-09-24 | Genvec, Inc. | Alternatively targeted adenovirus |
| DE10020125A1 (de) | 2000-04-18 | 2001-10-25 | Friedrich Schiller Uni Jena Bu | Agens für den postoperativen Einsatz nach Entfernung von Knochentumoren |
| EP1903113A1 (fr) * | 2000-12-18 | 2008-03-26 | Arriva Pharmaceuticals, Inc. | Inhibiteurs de protéase multifonctionnels et leur utilisation dans le traitement de maladies |
| AU2002241661B2 (en) * | 2000-12-18 | 2007-05-31 | Arriva Pharmaceuticals, Inc | Multifunctional protease inhibitors and their use in treatment of disease |
| US7247704B2 (en) | 2000-12-18 | 2007-07-24 | Arriva Pharmaceuticals, Inc. | Multifunctional protease inhibitors and their use in treatment of disease |
| ATE467680T1 (de) | 2001-10-11 | 2010-05-15 | Merck Sharp & Dohme | Hepatitis-c-virus-impfstoff |
| DE60236364D1 (en) * | 2001-10-11 | 2010-06-24 | Angeletti P Ist Richerche Bio | Hepatitis-c-virus-impfstoff |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0318554B2 (fr) * | 1987-05-21 | 2005-01-12 | Micromet AG | Proteines mutifonctionnelles a cible predeterminee |
| US5504001A (en) * | 1987-11-25 | 1996-04-02 | Zymogenetics, Inc. | Hybrid plasminogen activator |
| DE69025211T2 (de) * | 1989-02-17 | 1996-09-19 | Merck & Co Inc | Protein-Antikrebsmittel |
| JP2877509B2 (ja) * | 1989-05-19 | 1999-03-31 | アムジエン・インコーポレーテツド | メタロプロテイナーゼ阻害剤 |
| ES2060134T3 (es) * | 1989-05-26 | 1994-11-16 | Univ Washington | Inhibidor de tejido de metaloproteasas (timp-2). |
| AU657087B2 (en) * | 1989-12-22 | 1995-03-02 | Seragen Incorporated | Hybrid molecules having translocation region and cell-binding region |
| ATE212059T1 (de) * | 1990-02-15 | 2002-02-15 | Methoden zur identifizierung heterofunktionaler fusionsproteine | |
| GB2246779B (en) * | 1990-08-03 | 1994-08-17 | Delta Biotechnology Ltd | Tumour-associated protease inhibitors targeted to tumour cells |
| JPH09504174A (ja) * | 1993-10-29 | 1997-04-28 | インサイト ファーマシューティカルズ，インク． | プロテアーゼネキシン１変異体を含むキメラ蛋白 |
| WO1995013091A1 (fr) * | 1993-11-12 | 1995-05-18 | International Technology Management Associates, Ltd. | Procedes pour la reparation de tissu conjonctif |
| US5550213A (en) * | 1993-12-27 | 1996-08-27 | Rutgers, The State University Of New Jersey | Inhibitors of urokinase plasminogen activator |
| DE69533472T2 (de) * | 1994-01-11 | 2006-01-12 | Dyax Corp., Cambridge | Kallikreinhemmende "kunitz-domäne"-proteine und derivaten davon |
| WO1995028955A1 (fr) * | 1994-04-22 | 1995-11-02 | Gliemann Joergen | PEPTIDES SE LIANT A LA PROTEINE ASSOCIEE AU RECEPTEUR DE MACROGLOBULINE-α2/RECEPTEUR DE LIPOPROTEINE DE FAIBLE DENSITE |
| US5712149A (en) * | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| US5843724A (en) * | 1995-04-27 | 1998-12-01 | Rutgers University | Chimeric nucleic acids and proteins for inhibiting HIV-1 expression |
| US5726050A (en) * | 1995-06-20 | 1998-03-10 | Massachusetts Institute Of Technology | Z-DNA binding protein and applications |
| AU1210797A (en) * | 1996-01-08 | 1997-08-01 | Nissin Food Products Co., Ltd. | Cancerous metastasis inhibitor |
-
1998
- 1998-05-11 EP EP98923197A patent/EP0981606A2/fr not_active Withdrawn
- 1998-05-11 CA CA002289117A patent/CA2289117A1/fr not_active Abandoned
- 1998-05-11 NZ NZ500656A patent/NZ500656A/en unknown
- 1998-05-11 JP JP54907798A patent/JP2001525669A/ja not_active Ceased
- 1998-05-11 AU AU75536/98A patent/AU7553698A/en not_active Abandoned
- 1998-05-11 WO PCT/NL1998/000259 patent/WO1998051788A2/fr not_active Application Discontinuation
-
1999
- 1999-11-12 NO NO995564A patent/NO995564L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0981606A2 (fr) | 2000-03-01 |
| WO1998051788A3 (fr) | 1999-05-20 |
| NZ500656A (en) | 2001-11-30 |
| NO995564D0 (no) | 1999-11-12 |
| NO995564L (no) | 2000-01-11 |
| WO1998051788A2 (fr) | 1998-11-19 |
| CA2289117A1 (fr) | 1998-11-19 |
| AU7553698A (en) | 1998-12-08 |
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