JP2001523465A5 - - Google Patents
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- Publication number
- JP2001523465A5 JP2001523465A5 JP2000521213A JP2000521213A JP2001523465A5 JP 2001523465 A5 JP2001523465 A5 JP 2001523465A5 JP 2000521213 A JP2000521213 A JP 2000521213A JP 2000521213 A JP2000521213 A JP 2000521213A JP 2001523465 A5 JP2001523465 A5 JP 2001523465A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- linker
- variant
- subunit
- expression system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 description 20
- 102000004169 proteins and genes Human genes 0.000 description 20
- 125000005647 linker group Chemical group 0.000 description 10
- 102000003886 Glycoproteins Human genes 0.000 description 6
- 108090000288 Glycoproteins Proteins 0.000 description 6
- 239000005556 hormone Substances 0.000 description 6
- 229940088597 hormone Drugs 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- 239000000556 agonist Substances 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000000540 fraction c Anatomy 0.000 description 1
- 102000035122 glycosylated proteins Human genes 0.000 description 1
- 108091005608 glycosylated proteins Proteins 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/971,439 | 1997-11-17 | ||
| US08/971,439 US6103501A (en) | 1997-11-17 | 1997-11-17 | Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof |
| PCT/US1998/023744 WO1999025849A1 (en) | 1997-11-17 | 1998-11-09 | Single-chain bifunctional glycoprotein hormones |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001523465A JP2001523465A (ja) | 2001-11-27 |
| JP2001523465A5 true JP2001523465A5 (https=) | 2006-01-05 |
| JP4255618B2 JP4255618B2 (ja) | 2009-04-15 |
Family
ID=25518394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000521213A Expired - Fee Related JP4255618B2 (ja) | 1997-11-17 | 1998-11-09 | 単鎖二官能性糖タンパク質ホルモン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6103501A (https=) |
| EP (1) | EP1032688B1 (https=) |
| JP (1) | JP4255618B2 (https=) |
| KR (1) | KR20010032147A (https=) |
| CN (1) | CN1173037C (https=) |
| AU (1) | AU754296B2 (https=) |
| BR (1) | BR9814880A (https=) |
| CA (1) | CA2308571C (https=) |
| CZ (1) | CZ299742B6 (https=) |
| DE (1) | DE69839779D1 (https=) |
| HU (1) | HUP0004394A3 (https=) |
| IL (2) | IL135995A0 (https=) |
| NO (1) | NO20002527L (https=) |
| PL (1) | PL342853A1 (https=) |
| TR (1) | TR200001406T2 (https=) |
| WO (1) | WO1999025849A1 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6319504B1 (en) | 1996-06-24 | 2001-11-20 | University Of Maryland Biotechnology Institute | Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin |
| US6583109B1 (en) | 1997-06-24 | 2003-06-24 | Robert C. Gallo | Therapeutic polypeptides from β-hCG and derivatives |
| US6635256B1 (en) * | 1998-10-19 | 2003-10-21 | Washington University | Glycoprotein hormone compositions comprising two β subunits and methods of use thereof |
| US7994278B1 (en) | 1999-08-06 | 2011-08-09 | Nobel Biosciences Llc | Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA) |
| WO2001027292A2 (en) * | 1999-10-08 | 2001-04-19 | Biofocus Discovery Limited | Methods and compositions for targeting a cell |
| GB9924351D0 (en) | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
| AU2001255624A1 (en) * | 2000-04-25 | 2001-11-07 | Washington University | Single-chain fertility hormones with variable lh activity |
| JP2001333772A (ja) * | 2000-04-25 | 2001-12-04 | Washington Univ | 可変性の活性を有する単鎖稔性ホルモン |
| US6987172B2 (en) * | 2001-03-05 | 2006-01-17 | Washington University In St. Louis | Multifunctional single chain glycoprotein hormones comprising three or more β subunits |
| US7081446B2 (en) * | 2002-01-31 | 2006-07-25 | The Trustees Of Columbia University In The City Of New York | Long-acting follicle stimulating hormone analogues and uses thereof |
| DE602004030546D1 (de) | 2003-03-04 | 2011-01-27 | Aspenbio Pharma Inc | LH zur Verwendung der Erhaltung einer oder mehreren Schwangerschaften durch Induktion der Bildung des sekundären Gelbkörpers. |
| JP4412989B2 (ja) * | 2003-12-15 | 2010-02-10 | 株式会社日立製作所 | 複数の記憶システムを有するデータ処理システム |
| US20080039372A1 (en) * | 2005-07-21 | 2008-02-14 | The Trustees Of Columbia University In The City Of New York | Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation |
| EP1954815B1 (en) * | 2005-11-15 | 2015-02-25 | GlycoFi, Inc. | Production of glycoproteins with reduced o-glycosylation |
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8048848B2 (en) | 2006-02-03 | 2011-11-01 | Prolor Biotech Ltd. | Long-acting interferons and derivatives thereof and methods thereof |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US7553941B2 (en) | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting polypeptides and methods of producing same |
| US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| ATE536347T1 (de) | 2008-05-20 | 2011-12-15 | Merck Sharp & Dohme | Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren |
| CA2733567A1 (en) | 2008-08-12 | 2010-02-18 | Glycofi, Inc. | Improved vectors and yeast strains for protein production: ca2+ atpase overexpression |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| KR20140053991A (ko) | 2011-07-18 | 2014-05-08 | 아츠 바이올로직스 에이/에스 | 장기간 작용하는 황체 형성 호르몬 (ｌｈ) 화합물 |
| BR112014025951A2 (pt) | 2012-04-19 | 2017-07-11 | Opko Biologics Ltd | variantes de oxintomodulina de longa ação e métodos de produção do mesmo |
| EA033788B1 (ru) | 2012-11-20 | 2019-11-26 | Opko Biologics Ltd | Способ увеличения гидродинамического объема полипептида путем присоединения карбоксиконцевого пептида гонадотропина |
| EP2968391A1 (en) | 2013-03-13 | 2016-01-20 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| HRP20230405T8 (hr) | 2014-12-10 | 2023-09-29 | Opko Biologics Ltd. | Metode proizvodnje dugo djelujućih ctp-modificiranih polipeptida hormona rasta |
| ES2893616T3 (es) | 2015-06-19 | 2022-02-09 | Opko Biologics Ltd | Factores de coagulación de acción prolongada y métodos para la producción de los mismos |
| MY206271A (en) | 2016-07-11 | 2024-12-06 | Opko Biologics Ltd | Long-acting coagulation factor vii and methods of producing same |
| CN106279437B (zh) | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| US11123438B2 (en) | 2016-08-19 | 2021-09-21 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
| CN107759697B (zh) * | 2016-08-19 | 2023-03-24 | 安源医药科技（上海）有限公司 | 制备融合蛋白的方法 |
| CN106279436B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 活化的人凝血因子vii融合蛋白及其制备方法与用途 |
| CN106256835A (zh) * | 2016-08-19 | 2016-12-28 | 安源医药科技（上海）有限公司 | 高糖基化人生长激素融合蛋白及其制备方法与用途 |
| CN107827987B (zh) * | 2017-01-04 | 2021-04-27 | 华侨大学 | 一种促黄体激素类似物及其制备方法 |
| CN110950964B (zh) * | 2018-09-26 | 2021-06-18 | 安源医药科技（上海）有限公司 | 突变型单链人凝血因子viii融合蛋白及其制备方法与用途 |
| BR102019004147A2 (pt) | 2019-02-28 | 2020-10-06 | Ouro Fino Saude Animal Participacoes S.A. | Gonadotrofina coriônica equina recombinante (recg) biologicamente ativa e processo para obtenção da mesma, composição veterinária e uso |
| CA3140267A1 (en) | 2019-05-16 | 2020-11-19 | Ceva Sante Animale | Compositions and methods for increasing reproduction performance in non-human mammals using recombinant luteinizing hormone |
| JP7555398B2 (ja) * | 2019-08-30 | 2024-09-24 | シンテックス エス．エー． | 組換え絨毛性性腺刺激ホルモン、その調製のための方法、医薬組成物、及び使用 |
| US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0578328B1 (en) * | 1983-11-02 | 1999-12-29 | Applied Research Systems ARS Holding N.V. | Material and methods for the production of a heterodimeric human LH with a Met42 Val55 alpha subunit |
| CA1213537A (en) * | 1984-05-01 | 1986-11-04 | Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee | Polypeptide expression method |
| ES2098261T3 (es) * | 1989-02-21 | 1997-05-01 | Univ Washington | Formas modificadas de hormonas reproductoras. |
| WO1991016922A1 (en) * | 1990-05-08 | 1991-11-14 | University Of Medicine & Dentistry Of New Jersey | Analogs of glycoprotein hormones having altered immunological characteristics, efficacy and/or receptor specificity |
| CA2097291A1 (en) * | 1990-12-13 | 1992-06-14 | David P. Gearing | Leukemia inhibitory factor receptors |
| ZA942206B (en) * | 1993-04-01 | 1994-10-31 | Amgen Inc | Biologically active polypeptide fusion dimers |
| DK0751782T3 (da) * | 1994-02-18 | 2007-01-29 | Applied Research Systems | Anvendelse af et ikke-neutraliserende antistof, som er specifikt for beta-subunit'en i luteiniserende hormon, til forbedring af fertilitet |
| PT725795E (pt) * | 1994-08-12 | 2004-05-31 | Univ Washington | Formas de cadeia simples do quarteto de hormonas glicoproteicas |
-
1997
- 1997-11-17 US US08/971,439 patent/US6103501A/en not_active Expired - Lifetime
-
1998
- 1998-11-09 JP JP2000521213A patent/JP4255618B2/ja not_active Expired - Fee Related
- 1998-11-09 CA CA2308571A patent/CA2308571C/en not_active Expired - Fee Related
- 1998-11-09 CN CNB988112353A patent/CN1173037C/zh not_active Expired - Fee Related
- 1998-11-09 AU AU13131/99A patent/AU754296B2/en not_active Ceased
- 1998-11-09 KR KR1020007005334A patent/KR20010032147A/ko not_active Abandoned
- 1998-11-09 EP EP98956662A patent/EP1032688B1/en not_active Expired - Lifetime
- 1998-11-09 IL IL13599598A patent/IL135995A0/xx active IP Right Grant
- 1998-11-09 TR TR2000/01406T patent/TR200001406T2/xx unknown
- 1998-11-09 PL PL98342853A patent/PL342853A1/xx not_active IP Right Cessation
- 1998-11-09 WO PCT/US1998/023744 patent/WO1999025849A1/en not_active Ceased
- 1998-11-09 DE DE69839779T patent/DE69839779D1/de not_active Expired - Lifetime
- 1998-11-09 BR BR9814880-0A patent/BR9814880A/pt not_active Application Discontinuation
- 1998-11-09 CZ CZ20001774A patent/CZ299742B6/cs not_active IP Right Cessation
- 1998-11-09 HU HU0004394A patent/HUP0004394A3/hu unknown
-
2000
- 2000-05-05 IL IL135995A patent/IL135995A/en not_active IP Right Cessation
- 2000-05-16 NO NO20002527A patent/NO20002527L/no not_active Application Discontinuation
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