JP2003512441A5 - - Google Patents

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Publication number
JP2003512441A5
JP2003512441A5 JP2001532809A JP2001532809A JP2003512441A5 JP 2003512441 A5 JP2003512441 A5 JP 2003512441A5 JP 2001532809 A JP2001532809 A JP 2001532809A JP 2001532809 A JP2001532809 A JP 2001532809A JP 2003512441 A5 JP2003512441 A5 JP 2003512441A5
Authority
JP
Japan
Prior art keywords
protein drug
mucosa
activity
domain
pseudomonas exotoxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001532809A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003512441A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2000/029080 external-priority patent/WO2001030392A2/en
Publication of JP2003512441A publication Critical patent/JP2003512441A/ja
Publication of JP2003512441A5 publication Critical patent/JP2003512441A5/ja
Withdrawn legal-status Critical Current

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JP2001532809A 1999-10-22 2000-10-18 極性上皮細胞層を横断するタンパク質の送達 Withdrawn JP2003512441A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16092399P 1999-10-22 1999-10-22
US60/160,923 1999-10-22
PCT/US2000/029080 WO2001030392A2 (en) 1999-10-22 2000-10-18 Delivery of proteins across polar epithelial cell layers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011254351A Division JP2012051939A (ja) 1999-10-22 2011-11-21 極性上皮細胞層を横断するタンパク質の送達

Publications (2)

Publication Number Publication Date
JP2003512441A JP2003512441A (ja) 2003-04-02
JP2003512441A5 true JP2003512441A5 (https=) 2005-06-30

Family

ID=22579051

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001532809A Withdrawn JP2003512441A (ja) 1999-10-22 2000-10-18 極性上皮細胞層を横断するタンパク質の送達
JP2011254351A Pending JP2012051939A (ja) 1999-10-22 2011-11-21 極性上皮細胞層を横断するタンパク質の送達

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011254351A Pending JP2012051939A (ja) 1999-10-22 2011-11-21 極性上皮細胞層を横断するタンパク質の送達

Country Status (8)

Country Link
US (1) US7824695B1 (https=)
EP (1) EP1242122B1 (https=)
JP (2) JP2003512441A (https=)
AT (1) ATE444081T1 (https=)
AU (1) AU784657B2 (https=)
CA (1) CA2389302C (https=)
DE (1) DE60043070D1 (https=)
WO (1) WO2001030392A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1000163T3 (da) * 1997-07-11 2006-02-06 Us Gov Health & Human Serv Pseudomonas-exotoksin A-lignende kimære immunogener
DE60043070D1 (de) * 1999-10-22 2009-11-12 Genentech Inc Proteine-abgabe durch polare epithelzellen schichte
US20090285771A1 (en) 2004-10-04 2009-11-19 Trinity Biosystems, Inc. Methods and compositions for needleless delivery of macromolecules
WO2007067597A2 (en) * 2005-12-05 2007-06-14 Trinity Biosystems, Inc. Methods and compositions for needleless delivery of binding partners
WO2007067596A2 (en) * 2005-12-05 2007-06-14 Trinity Biosystems, Inc. Methods and compositions for needleless delivery of antibodies
WO2007109110A2 (en) * 2006-03-16 2007-09-27 Trinity Biosystems, Inc. Methods for increasing the size of animals using needleless delivery constructs
US11246915B2 (en) 2010-09-15 2022-02-15 Applied Molecular Transport Inc. Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
CN121513216A (zh) 2018-03-08 2026-02-13 应用分子转运公司 用于经口递送的毒素衍生的递送构建体
WO2020096695A1 (en) 2018-11-07 2020-05-14 Applied Molecular Transport Inc. Cholix-derived carriers for oral delivery of heterologous payload
MX2022001975A (es) 2019-08-16 2022-03-11 Applied Molecular Transport Inc Composiciones, formulaciones y produccion y purificacion de interleucinas.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78775A (en) * 1985-05-15 1992-06-21 Biotech Australia Pty Ltd Oral vaccines
WO1994000481A1 (en) * 1992-06-23 1994-01-06 Associated Synapse Biologics Pharmaceutical composition containing botulinum b complex
AU7694594A (en) 1993-09-06 1995-03-27 Menarini Ricerche Sud S.P.A. Ribosome inactivating proteins extracted from seeds of saponaria ocymoides and vaccaria pyramidata, their preparation and immunotoxins containing them
ATE204300T1 (de) 1994-05-13 2001-09-15 Biovation Ltd Zielzellen-bindende chimäre peptide
JP2001504334A (ja) * 1996-11-06 2001-04-03 アメリカ合衆国 プロテアーゼ活性化可能なＰｓｅｕｄｏｍｏｎａｓ体外毒素Ａ様プロタンパク質
US6086900A (en) * 1997-03-26 2000-07-11 Board Of Regents, The University Of Texas Systems Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes
DK1000163T3 (da) * 1997-07-11 2006-02-06 Us Gov Health & Human Serv Pseudomonas-exotoksin A-lignende kimære immunogener
US20030054012A1 (en) 2000-05-12 2003-03-20 Fitzgerald David J. Pseudomonas exotoxin a-like chimeric immunogens for eliciting a secretory iga-mediated immune response
US6472140B1 (en) * 1997-09-05 2002-10-29 The General Hospital Corporation α-2- macroglobulin therapies and drug screening methods for Alzheimer's disease.
DE60043070D1 (de) * 1999-10-22 2009-11-12 Genentech Inc Proteine-abgabe durch polare epithelzellen schichte
WO2001031020A1 (en) * 1999-10-22 2001-05-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Disulfide conjugated cell toxins and methods of making and using them
DE60137969D1 (de) 2000-12-21 2009-04-23 Us Gov Health & Human Serv Ein chimäres protein das nichttoxische pseudomonas exotoxin a und typ iv pilin sequenzen enthält

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