JP2003512441A5 - - Google Patents

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Publication number
JP2003512441A5
JP2003512441A5 JP2001532809A JP2001532809A JP2003512441A5 JP 2003512441 A5 JP2003512441 A5 JP 2003512441A5 JP 2001532809 A JP2001532809 A JP 2001532809A JP 2001532809 A JP2001532809 A JP 2001532809A JP 2003512441 A5 JP2003512441 A5 JP 2003512441A5
Authority
JP
Japan
Prior art keywords
protein drug
mucosa
activity
domain
pseudomonas exotoxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001532809A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003512441A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2000/029080 external-priority patent/WO2001030392A2/en
Publication of JP2003512441A publication Critical patent/JP2003512441A/ja
Publication of JP2003512441A5 publication Critical patent/JP2003512441A5/ja
Withdrawn legal-status Critical Current

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JP2001532809A 1999-10-22 2000-10-18 極性上皮細胞層を横断するタンパク質の送達 Withdrawn JP2003512441A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16092399P 1999-10-22 1999-10-22
US60/160,923 1999-10-22
PCT/US2000/029080 WO2001030392A2 (en) 1999-10-22 2000-10-18 Delivery of proteins across polar epithelial cell layers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011254351A Division JP2012051939A (ja) 1999-10-22 2011-11-21 極性上皮細胞層を横断するタンパク質の送達

Publications (2)

Publication Number Publication Date
JP2003512441A JP2003512441A (ja) 2003-04-02
JP2003512441A5 true JP2003512441A5 (https=) 2005-06-30

Family

ID=22579051

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001532809A Withdrawn JP2003512441A (ja) 1999-10-22 2000-10-18 極性上皮細胞層を横断するタンパク質の送達
JP2011254351A Pending JP2012051939A (ja) 1999-10-22 2011-11-21 極性上皮細胞層を横断するタンパク質の送達

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011254351A Pending JP2012051939A (ja) 1999-10-22 2011-11-21 極性上皮細胞層を横断するタンパク質の送達

Country Status (8)

Country Link
US (1) US7824695B1 (https=)
EP (1) EP1242122B1 (https=)
JP (2) JP2003512441A (https=)
AT (1) ATE444081T1 (https=)
AU (1) AU784657B2 (https=)
CA (1) CA2389302C (https=)
DE (1) DE60043070D1 (https=)
WO (1) WO2001030392A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001510683A (ja) * 1997-07-11 2001-08-07 ザ ガバメント オブ ザ ユナイテッド ステイツ リプリゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ Ｐｓｅｕｄｏｍｏｎａｓ体外毒素Ａ様キメラ免疫原
EP1242122B1 (en) * 1999-10-22 2009-09-30 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Delivery of proteins across polar epithelial cell layers
US7713737B2 (en) 2004-10-04 2010-05-11 Trinity Biosystems, Inc. Methods and compositions for needleless delivery of macromolecules
CA2631981A1 (en) * 2005-12-05 2007-06-14 Trinity Biosystems, Inc. Methods and compositions for needleless delivery of binding partners
WO2007067596A2 (en) * 2005-12-05 2007-06-14 Trinity Biosystems, Inc. Methods and compositions for needleless delivery of antibodies
CA2647168A1 (en) * 2006-03-16 2007-09-27 Trinity Biosystems, Inc. Methods for increasing the size of animals using needleless delivery constructs
US11246915B2 (en) 2010-09-15 2022-02-15 Applied Molecular Transport Inc. Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
EP4082558B1 (en) 2018-03-08 2023-08-23 Applied Molecular Transport Inc. Toxin-derived delivery constructs for oral delivery
SG11202104734YA (en) 2018-11-07 2021-06-29 Applied Molecular Transport Inc Cholix-derived carriers for oral delivery of heterologous payload
CN114599665A (zh) 2019-08-16 2022-06-07 应用分子转运公司 组合物、制剂及白细胞介素产生和纯化

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78775A (en) 1985-05-15 1992-06-21 Biotech Australia Pty Ltd Oral vaccines
CA2138020C (en) * 1992-06-23 1999-02-16 Eric A. Johnson Pharmaceutical composition containing botulinum b complex
WO1995007297A1 (en) * 1993-09-06 1995-03-16 Menarini Ricerche Sud S.P.A. Ribosome inactivating proteins extracted from seeds of saponaria ocymoides and vaccaria pyramidata, their preparation and immunotoxins containing them
DE69522216T2 (de) 1994-05-13 2002-05-02 Biovation Ltd Zielzellen-bindende chimäre Peptide
US6426075B1 (en) * 1996-11-06 2002-07-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Protease-activatable pseudomonas exotoxin A-like proproteins
AU6769998A (en) * 1997-03-26 1998-10-20 Board Of Regents, The University Of Texas System Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes
JP2001510683A (ja) * 1997-07-11 2001-08-07 ザ ガバメント オブ ザ ユナイテッド ステイツ リプリゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ Ｐｓｅｕｄｏｍｏｎａｓ体外毒素Ａ様キメラ免疫原
US20030054012A1 (en) 2000-05-12 2003-03-20 Fitzgerald David J. Pseudomonas exotoxin a-like chimeric immunogens for eliciting a secretory iga-mediated immune response
US6472140B1 (en) * 1997-09-05 2002-10-29 The General Hospital Corporation α-2- macroglobulin therapies and drug screening methods for Alzheimer's disease.
EP1242122B1 (en) 1999-10-22 2009-09-30 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Delivery of proteins across polar epithelial cell layers
DE60029119D1 (de) 1999-10-22 2006-08-10 Us Gov Nat Inst Health Disulfidkonjugierte zellgifte und verfahren zur ihrer herstellung und verwendung
US7314625B2 (en) 2000-12-21 2008-01-01 The United States As Represented By The Secretary Of The Department Of Health And Human Services Chimeric protein comprising non-toxic Pseudomonas exotoxin A and Type IV pilin sequences

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