ATE444081T1 - Proteine-abgabe durch polare epithelzellen schichte - Google Patents
Proteine-abgabe durch polare epithelzellen schichteInfo
- Publication number
- ATE444081T1 ATE444081T1 AT00975326T AT00975326T ATE444081T1 AT E444081 T1 ATE444081 T1 AT E444081T1 AT 00975326 T AT00975326 T AT 00975326T AT 00975326 T AT00975326 T AT 00975326T AT E444081 T1 ATE444081 T1 AT E444081T1
- Authority
- AT
- Austria
- Prior art keywords
- bioactive
- epithelial cell
- cell layer
- moiety
- polar epithelial
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 210000002919 epithelial cell Anatomy 0.000 title 1
- 230000000975 bioactive effect Effects 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 2
- 102000001851 Low Density Lipoprotein Receptor-Related Protein-1 Human genes 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000005859 cell recognition Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000004955 epithelial membrane Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 101150084157 lrp-1 gene Proteins 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16092399P | 1999-10-22 | 1999-10-22 | |
| PCT/US2000/029080 WO2001030392A2 (en) | 1999-10-22 | 2000-10-18 | Delivery of proteins across polar epithelial cell layers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE444081T1 true ATE444081T1 (de) | 2009-10-15 |
Family
ID=22579051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00975326T ATE444081T1 (de) | 1999-10-22 | 2000-10-18 | Proteine-abgabe durch polare epithelzellen schichte |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7824695B1 (https=) |
| EP (1) | EP1242122B1 (https=) |
| JP (2) | JP2003512441A (https=) |
| AT (1) | ATE444081T1 (https=) |
| AU (1) | AU784657B2 (https=) |
| CA (1) | CA2389302C (https=) |
| DE (1) | DE60043070D1 (https=) |
| WO (1) | WO2001030392A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001510683A (ja) * | 1997-07-11 | 2001-08-07 | ザ ガバメント オブ ザ ユナイテッド ステイツ リプリゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | Ｐｓｅｕｄｏｍｏｎａｓ体外毒素Ａ様キメラ免疫原 |
| EP1242122B1 (en) * | 1999-10-22 | 2009-09-30 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Delivery of proteins across polar epithelial cell layers |
| US7713737B2 (en) | 2004-10-04 | 2010-05-11 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of macromolecules |
| CA2631981A1 (en) * | 2005-12-05 | 2007-06-14 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of binding partners |
| WO2007067596A2 (en) * | 2005-12-05 | 2007-06-14 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of antibodies |
| CA2647168A1 (en) * | 2006-03-16 | 2007-09-27 | Trinity Biosystems, Inc. | Methods for increasing the size of animals using needleless delivery constructs |
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| EP4082558B1 (en) | 2018-03-08 | 2023-08-23 | Applied Molecular Transport Inc. | Toxin-derived delivery constructs for oral delivery |
| SG11202104734YA (en) | 2018-11-07 | 2021-06-29 | Applied Molecular Transport Inc | Cholix-derived carriers for oral delivery of heterologous payload |
| CN114599665A (zh) | 2019-08-16 | 2022-06-07 | 应用分子转运公司 | 组合物、制剂及白细胞介素产生和纯化 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL78775A (en) | 1985-05-15 | 1992-06-21 | Biotech Australia Pty Ltd | Oral vaccines |
| CA2138020C (en) * | 1992-06-23 | 1999-02-16 | Eric A. Johnson | Pharmaceutical composition containing botulinum b complex |
| WO1995007297A1 (en) * | 1993-09-06 | 1995-03-16 | Menarini Ricerche Sud S.P.A. | Ribosome inactivating proteins extracted from seeds of saponaria ocymoides and vaccaria pyramidata, their preparation and immunotoxins containing them |
| DE69522216T2 (de) | 1994-05-13 | 2002-05-02 | Biovation Ltd | Zielzellen-bindende chimäre Peptide |
| US6426075B1 (en) * | 1996-11-06 | 2002-07-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Protease-activatable pseudomonas exotoxin A-like proproteins |
| AU6769998A (en) * | 1997-03-26 | 1998-10-20 | Board Of Regents, The University Of Texas System | Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes |
| JP2001510683A (ja) * | 1997-07-11 | 2001-08-07 | ザ ガバメント オブ ザ ユナイテッド ステイツ リプリゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | Ｐｓｅｕｄｏｍｏｎａｓ体外毒素Ａ様キメラ免疫原 |
| US20030054012A1 (en) | 2000-05-12 | 2003-03-20 | Fitzgerald David J. | Pseudomonas exotoxin a-like chimeric immunogens for eliciting a secretory iga-mediated immune response |
| US6472140B1 (en) * | 1997-09-05 | 2002-10-29 | The General Hospital Corporation | α-2- macroglobulin therapies and drug screening methods for Alzheimer's disease. |
| EP1242122B1 (en) | 1999-10-22 | 2009-09-30 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Delivery of proteins across polar epithelial cell layers |
| DE60029119D1 (de) | 1999-10-22 | 2006-08-10 | Us Gov Nat Inst Health | Disulfidkonjugierte zellgifte und verfahren zur ihrer herstellung und verwendung |
| US7314625B2 (en) | 2000-12-21 | 2008-01-01 | The United States As Represented By The Secretary Of The Department Of Health And Human Services | Chimeric protein comprising non-toxic Pseudomonas exotoxin A and Type IV pilin sequences |
-
2000
- 2000-10-18 EP EP00975326A patent/EP1242122B1/en not_active Expired - Lifetime
- 2000-10-18 WO PCT/US2000/029080 patent/WO2001030392A2/en not_active Ceased
- 2000-10-18 US US10/110,880 patent/US7824695B1/en not_active Expired - Fee Related
- 2000-10-18 AT AT00975326T patent/ATE444081T1/de not_active IP Right Cessation
- 2000-10-18 CA CA2389302A patent/CA2389302C/en not_active Expired - Fee Related
- 2000-10-18 DE DE60043070T patent/DE60043070D1/de not_active Expired - Lifetime
- 2000-10-18 AU AU13392/01A patent/AU784657B2/en not_active Ceased
- 2000-10-18 JP JP2001532809A patent/JP2003512441A/ja not_active Withdrawn
-
2011
- 2011-11-21 JP JP2011254351A patent/JP2012051939A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012051939A (ja) | 2012-03-15 |
| AU1339201A (en) | 2001-05-08 |
| JP2003512441A (ja) | 2003-04-02 |
| US7824695B1 (en) | 2010-11-02 |
| CA2389302C (en) | 2011-03-15 |
| WO2001030392A2 (en) | 2001-05-03 |
| AU784657B2 (en) | 2006-05-18 |
| DE60043070D1 (de) | 2009-11-12 |
| EP1242122B1 (en) | 2009-09-30 |
| CA2389302A1 (en) | 2001-05-03 |
| EP1242122A2 (en) | 2002-09-25 |
| WO2001030392A3 (en) | 2002-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |