ATE311464T1 - Nk zellen-aktivierende rezeptoren und deren therapeutische und diagnostische verwendungen - Google Patents

Nk zellen-aktivierende rezeptoren und deren therapeutische und diagnostische verwendungen

Info

Publication number
ATE311464T1
ATE311464T1 AT01956747T AT01956747T ATE311464T1 AT E311464 T1 ATE311464 T1 AT E311464T1 AT 01956747 T AT01956747 T AT 01956747T AT 01956747 T AT01956747 T AT 01956747T AT E311464 T1 ATE311464 T1 AT E311464T1
Authority
AT
Austria
Prior art keywords
cell
therapeutic
activated receptors
diagnostic uses
targeting
Prior art date
Application number
AT01956747T
Other languages
English (en)
Inventor
Ofer Mandelboim
Angel Porgador
Original Assignee
Yissum Res Dev Co
Univ Ben Gurion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co, Univ Ben Gurion filed Critical Yissum Res Dev Co
Application granted granted Critical
Publication of ATE311464T1 publication Critical patent/ATE311464T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT01956747T 2000-07-20 2001-07-19 Nk zellen-aktivierende rezeptoren und deren therapeutische und diagnostische verwendungen ATE311464T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL13741900A IL137419A0 (en) 2000-07-20 2000-07-20 Nk cells activating receptors and their therapeutic and diagnostic uses
PCT/IL2001/000664 WO2002008287A2 (en) 2000-07-20 2001-07-19 Nk cells activating receptors and their therapeutic and diagnostic uses

Publications (1)

Publication Number Publication Date
ATE311464T1 true ATE311464T1 (de) 2005-12-15

Family

ID=11074420

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01956747T ATE311464T1 (de) 2000-07-20 2001-07-19 Nk zellen-aktivierende rezeptoren und deren therapeutische und diagnostische verwendungen

Country Status (9)

Country Link
US (1) US20040072256A1 (de)
EP (1) EP1301605B1 (de)
JP (1) JP2004504065A (de)
AT (1) ATE311464T1 (de)
AU (2) AU2001278662B2 (de)
CA (1) CA2416733A1 (de)
DE (1) DE60115452D1 (de)
IL (1) IL137419A0 (de)
WO (1) WO2002008287A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071314B2 (en) * 2001-12-14 2011-12-06 President And Fellows Of Harvard College Immunocellular receptors related to neurological disorders and therapeutic uses thereof
EP1581169A4 (de) * 2002-11-08 2008-09-17 Genentech Inc Zusammensetzungen und verfahren zurbehandlung von erkrankungen in verbindung mit natürlichen killerzellen
WO2004053054A2 (en) * 2002-12-09 2004-06-24 Natspears Ltd. Nk cell receptor conjugates for treating malignancies
EP1445614A1 (de) * 2003-02-06 2004-08-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Verfahren zur in vitro Überwachung der Entwicklung von HIV Virus eines Individuums
WO2005076001A2 (en) * 2004-02-06 2005-08-18 Inserm (Institut National De La Sante Et De La Recherche Medicale) A polypeptide derived from gp41, a vaccine composition comprising said polypeptide, and uses for treating an infection by an hiv virus in an individual
GB0305478D0 (en) 2003-03-10 2003-04-16 Bioxell Spa Diagnostic and prognostic compounds and method
WO2005000086A2 (en) 2003-06-30 2005-01-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem FRAGMENTS OF NKp44 AND NKp46 FOR TARGETING VIRAL-INFECTED AND TUMOR CELLS
WO2005051973A2 (en) * 2003-11-25 2005-06-09 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Peptides derived from natural cytotoxicity receptors and methods of use thereof
WO2006103569A2 (en) * 2005-03-18 2006-10-05 Innate Pharma Expression vectors and methods for obtaining nk cell specific expression
US7932055B2 (en) * 2006-06-22 2011-04-26 Novo Nordisk A/S Soluble heterodimeric CD94/NKG2 receptors fusion proteins
WO2007147901A1 (en) * 2006-06-22 2007-12-27 Novo Nordisk A/S Production of bispecific antibodies
US9593376B2 (en) 2008-06-02 2017-03-14 Institut Gustave Roussy Natural killer p30 (NKp30) dysfunction and the biological applications thereof
DK2408468T3 (da) 2009-03-19 2014-07-21 Yissum Res Dev Co Anvendelse af NKp46 til forebyggelse af type 1-diabetes
WO2012175613A1 (en) 2011-06-21 2012-12-27 Innate Pharma NKp46-MEDIATED NK CELL TUNING
WO2013140393A1 (en) 2012-03-21 2013-09-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Peptides derived from the d1 - domain of nkp46
CN106102776B (zh) 2014-01-24 2020-02-14 圣安德鲁斯大学董事会 免疫调节化合物
EP3433281A1 (de) * 2016-03-21 2019-01-30 Elstar Therapeutics, Inc. Multispezifische und multifunktionelle moleküle und verwendungen davon
CN109689086A (zh) 2016-07-11 2019-04-26 国家生物技术研究所公司 具有延长的血清半衰期的融合蛋白
GB201616009D0 (en) 2016-09-20 2016-11-02 Univ Court Of The Univ Of St Andrews The Treatment and/or prevention of sepsis
GB201616007D0 (en) 2016-09-20 2016-11-02 Univ Court Of The Univ Of St Andrews The Novel Adjuvants
GB201616006D0 (en) 2016-09-20 2016-11-02 Univ Court Of The Univ Of St Andrews The Cell modulation
CN116964099A (zh) * 2021-03-05 2023-10-27 上海齐鲁制药研究中心有限公司 针对NKp46的抗体及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912170A (en) * 1991-03-07 1999-06-15 The General Hospital Corporation Redirection of cellular immunity by protein-tyrosine kinase chimeras
US5641863A (en) * 1993-09-30 1997-06-24 University Of Pennsylvania Chimeric IgG Fc receptors
DE69634855T2 (de) * 1995-02-24 2006-05-18 The General Hospital Corp., Boston Neuorientierung der zellulären immunität durch rezeptorchimären
CA2217020A1 (en) * 1995-05-16 1996-11-21 Bristol-Myers Squibb Company Recombinant heregulins and their biological functions upon receptor activation
ZA9810133B (en) * 1997-11-07 1999-05-17 Biogen Inc BMOG a novel protein member of the myelin-oligodendrocyte glycoprotein family and its use for ummonomodulatory purposes

Also Published As

Publication number Publication date
AU2001278662B2 (en) 2006-09-28
WO2002008287A2 (en) 2002-01-31
IL137419A0 (en) 2001-07-24
WO2002008287A3 (en) 2002-12-19
CA2416733A1 (en) 2002-01-31
DE60115452D1 (de) 2006-01-05
EP1301605B1 (de) 2005-11-30
AU7866201A (en) 2002-02-05
JP2004504065A (ja) 2004-02-12
US20040072256A1 (en) 2004-04-15
EP1301605A2 (de) 2003-04-16

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