RU94045826A - Моноклональные антитела против рецептора интерферона, с нейтрализующим действием против интерферона типа i - Google Patents

Моноклональные антитела против рецептора интерферона, с нейтрализующим действием против интерферона типа i

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Publication number
RU94045826A
RU94045826A RU94045826/13A RU94045826A RU94045826A RU 94045826 A RU94045826 A RU 94045826A RU 94045826/13 A RU94045826/13 A RU 94045826/13A RU 94045826 A RU94045826 A RU 94045826A RU 94045826 A RU94045826 A RU 94045826A
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RU
Russia
Prior art keywords
against interferon
ifn
neutralizing activity
monoclonal antibodies
type
Prior art date
Application number
RU94045826/13A
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English (en)
Inventor
Бенуа Патрик
Fr]
Мейер Франсуа
Мажуир Дебора
Плавек Иван
Товей Михаэль
Original Assignee
Лаборатуар Ойропеен де Биотехноложи С.А. (FR)
Лаборатуар Ойропеен де Биотехноложи С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лаборатуар Ойропеен де Биотехноложи С.А. (FR), Лаборатуар Ойропеен де Биотехноложи С.А. filed Critical Лаборатуар Ойропеен де Биотехноложи С.А. (FR)
Publication of RU94045826A publication Critical patent/RU94045826A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7156—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Изобретение относится к моноклональному антителу против рецептора человеческого интерферона класса I (IFN-R), отличающееся следующими свойствами: распознает внеклеточный домен человеческого IFN-R и обладает нейтрализующей способностью в отношении биологических свойств человеческого интерферона типа I-IFN. Оно относится также к использованию этих антител для диагноза.

Claims (1)

  1. Изобретение относится к моноклональному антителу против рецептора человеческого интерферона класса I (IFN-R), отличающееся следующими свойствами: распознает внеклеточный домен человеческого IFN-R и обладает нейтрализующей способностью в отношении биологических свойств человеческого интерферона типа I-IFN. Оно относится также к использованию этих антител для диагноза.
RU94045826/13A 1992-03-31 1993-03-30 Моноклональные антитела против рецептора интерферона, с нейтрализующим действием против интерферона типа i RU94045826A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92400902.0 1992-03-31
EP92400902A EP0563487A1 (en) 1992-03-31 1992-03-31 Monoclonal antibodies against the interferon receptor, with neutralizing activity against type I interferon

Publications (1)

Publication Number Publication Date
RU94045826A true RU94045826A (ru) 1996-11-10

Family

ID=8211644

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94045826/13A RU94045826A (ru) 1992-03-31 1993-03-30 Моноклональные антитела против рецептора интерферона, с нейтрализующим действием против интерферона типа i

Country Status (18)

Country Link
US (5) US5919453A (ru)
EP (3) EP0563487A1 (ru)
JP (2) JP3836500B2 (ru)
AT (2) ATE368055T1 (ru)
AU (2) AU679909B2 (ru)
BG (1) BG99141A (ru)
CA (1) CA2133106C (ru)
CZ (1) CZ236994A3 (ru)
DE (2) DE69334158T2 (ru)
DK (2) DK0633931T3 (ru)
ES (2) ES2290241T3 (ru)
FI (1) FI944509A (ru)
HU (1) HUT69995A (ru)
NO (1) NO943625L (ru)
NZ (1) NZ251343A (ru)
PT (2) PT633931E (ru)
RU (1) RU94045826A (ru)
WO (1) WO1993020187A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2600884C2 (ru) * 2004-06-21 2016-10-27 Е. Р. Сквибб энд Сонз, Эл,Эл.Си Антитела рецептора 1 интерферона альфа и их применение

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WO1995007716A1 (en) * 1993-09-17 1995-03-23 Laboratoire Europeen De Biotechnologie S.A. Pharmaceutical composition comprising monoclonal antibodies against the interferon receptor, with neutralizing activity against type i interferon
IL118096A0 (en) * 1996-05-01 1996-09-12 Yeda Res & Dev Antibodies against interferon alpha/beta receptor
US6713609B1 (en) 1996-07-16 2004-03-30 Genentech, Inc. Monoclonal antibodies to type I interferon receptor
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US6376067B1 (en) * 1998-12-21 2002-04-23 Mitsubishi Polyester Film, Llc Silicone coated film with back side slip control coating and method of controlling slip of such film
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DK2418220T3 (da) 2003-12-10 2017-11-06 Squibb & Sons Llc Interferon-alpha-antistoffer og anvendelser deraf
US20060292554A1 (en) * 2004-05-18 2006-12-28 Genentech, Inc. Major coat protein variants for C-terminal and bi-terminal display
AU2005291741B2 (en) * 2004-10-07 2011-11-24 Universitat Zurich Type I interferon blocking agents for prevention and treatment of psoriasis
US7888481B2 (en) * 2005-02-10 2011-02-15 Baylor Research Institute Anti-interferon alpha monoclonal antibodies and methods for use
KR101363120B1 (ko) * 2005-02-10 2014-02-13 베일러 리서치 인스티튜트 항-인터페론 알파 모노클로날 항체 및 사용 방법
EP1893646A2 (en) * 2005-06-22 2008-03-05 Genentech, Inc. Methods and compositions for targeting ifnar2
EP2687232A1 (en) 2006-12-06 2014-01-22 MedImmune, LLC Methods of treating systemic lupus erythematosus
US8685400B2 (en) * 2007-07-30 2014-04-01 University Of Miami Modulating inflammasome activity and inflammation in the central nervous system
SI2250279T1 (sl) 2008-02-08 2016-10-28 Medimmune, Llc Protitelesa anti-IFNAR1 z zmanjšano afiniteto do FC liganda
BRPI0912570B8 (pt) 2008-05-07 2021-05-25 Argos Therapeutics Inc anticorpo anti-ifn-alfa humanizado, ou um fragmento de ligação ao antígeno do mesmo, composição terapêutica e seus usos
MX2012010116A (es) * 2010-03-01 2013-02-26 Alexion Pharma Inc Metodos y composiciones para el tratamiento de la enfermedad de degos.
WO2013134146A1 (en) * 2012-03-07 2013-09-12 The Regents Of The University Of California Methods and compositions for treating viral infections by blocking type i interferon activity
WO2018010140A1 (zh) * 2016-07-14 2018-01-18 中国科学院生物物理研究所 I型干扰素受体抗体及其用途
CN111315767A (zh) 2017-08-22 2020-06-19 萨纳生物有限责任公司 可溶性干扰素受体及其用途
EP3917965A4 (en) * 2019-01-31 2023-03-08 Immunecent Biotechnology, Inc. NEW ANTI-IFNAR1 ANTIBODIES
CN117500816A (zh) 2021-08-26 2024-02-02 映恩生物制药（苏州）有限公司 一种甾体化合物及其缀合物
CN115028730B (zh) * 2022-05-17 2022-11-08 诺赛联合(北京)生物医学科技有限公司 一种成体干细胞衍生的类器官制备方法

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2600884C2 (ru) * 2004-06-21 2016-10-27 Е. Р. Сквибб энд Сонз, Эл,Эл.Си Антитела рецептора 1 интерферона альфа и их применение

Also Published As

Publication number Publication date
EP1329459A2 (en) 2003-07-23
NZ251343A (en) 1997-07-27
EP0563487A1 (en) 1993-10-06
DE69332997T2 (de) 2004-05-19
PT1329459E (pt) 2007-11-07
US20070128701A1 (en) 2007-06-07
NO943625L (no) 1994-11-11
US7179465B2 (en) 2007-02-20
CA2133106A1 (en) 1993-10-14
US20080226647A1 (en) 2008-09-18
ES2290241T3 (es) 2008-02-16
CZ236994A3 (en) 1995-02-15
ATE241008T1 (de) 2003-06-15
BG99141A (bg) 1995-07-28
EP0633931A1 (en) 1995-01-18
CA2133106C (en) 2009-06-30
HU9402823D0 (en) 1995-01-30
EP1329459B1 (en) 2007-07-25
HUT69995A (en) 1995-09-28
DK0633931T3 (da) 2003-09-15
US20020055492A1 (en) 2002-05-09
US5919453A (en) 1999-07-06
FI944509A0 (fi) 1994-09-29
US20040191840A1 (en) 2004-09-30
DE69332997D1 (de) 2003-06-26
PT633931E (pt) 2003-09-30
EP1329459A3 (en) 2003-09-10
FI944509A (fi) 1994-11-29
ATE368055T1 (de) 2007-08-15
DK1329459T3 (da) 2007-11-26
ES2199941T3 (es) 2004-03-01
DE69334158T2 (de) 2008-04-10
AU679909B2 (en) 1997-07-17
JP3836500B2 (ja) 2006-10-25
EP0633931B1 (en) 2003-05-21
NO943625D0 (no) 1994-09-29
AU706473B2 (en) 1999-06-17
US7465451B2 (en) 2008-12-16
WO1993020187A1 (en) 1993-10-14
DE69334158D1 (de) 2007-09-06
JP2006089494A (ja) 2006-04-06
AU3890793A (en) 1993-11-08
US6787634B2 (en) 2004-09-07
JPH07505526A (ja) 1995-06-22
AU2349697A (en) 1997-07-24

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