DE69332997D1 - Monoklonale antikörper gegen den interferonrezeptor, mit neutralisierender aktivität gegen typ i-interferon - Google Patents

Monoklonale antikörper gegen den interferonrezeptor, mit neutralisierender aktivität gegen typ i-interferon

Info

Publication number
DE69332997D1
DE69332997D1 DE69332997T DE69332997T DE69332997D1 DE 69332997 D1 DE69332997 D1 DE 69332997D1 DE 69332997 T DE69332997 T DE 69332997T DE 69332997 T DE69332997 T DE 69332997T DE 69332997 D1 DE69332997 D1 DE 69332997D1
Authority
DE
Germany
Prior art keywords
interferon
monoclonal antibodies
neutralizing activity
receptor
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332997T
Other languages
English (en)
Other versions
DE69332997T2 (de
Inventor
Patrick Benoit
Francois Meyer
Debborah Maguire
Ivan Plavec
G Tovey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medisup Internat N V
Original Assignee
Medisup Internat N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medisup Internat N V filed Critical Medisup Internat N V
Application granted granted Critical
Publication of DE69332997D1 publication Critical patent/DE69332997D1/de
Publication of DE69332997T2 publication Critical patent/DE69332997T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7156—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69332997T 1992-03-31 1993-03-30 Monoklonale antikörper gegen den interferonrezeptor, mit neutralisierender aktivität gegen typ i-interferon Expired - Lifetime DE69332997T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP92400902A EP0563487A1 (de) 1992-03-31 1992-03-31 Monoklonale Antikörper gegen den Interferonrezeptor, mit neutralisierender Aktivität gegen Typ I-Interferon
EP92400902 1992-03-31
PCT/EP1993/000770 WO1993020187A1 (en) 1992-03-31 1993-03-30 Monoclonal antibodies against the interferon receptor, with neutralizing activity against type i interferon

Publications (2)

Publication Number Publication Date
DE69332997D1 true DE69332997D1 (de) 2003-06-26
DE69332997T2 DE69332997T2 (de) 2004-05-19

Family

ID=8211644

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69334158T Expired - Lifetime DE69334158T2 (de) 1992-03-31 1993-03-30 Monoklonale Antikörper gegen den Interferonrezeptor, mit neutralisierender Aktivität gegen Typ I-Interferon
DE69332997T Expired - Lifetime DE69332997T2 (de) 1992-03-31 1993-03-30 Monoklonale antikörper gegen den interferonrezeptor, mit neutralisierender aktivität gegen typ i-interferon

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69334158T Expired - Lifetime DE69334158T2 (de) 1992-03-31 1993-03-30 Monoklonale Antikörper gegen den Interferonrezeptor, mit neutralisierender Aktivität gegen Typ I-Interferon

Country Status (18)

Country Link
US (5) US5919453A (de)
EP (3) EP0563487A1 (de)
JP (2) JP3836500B2 (de)
AT (2) ATE241008T1 (de)
AU (2) AU679909B2 (de)
BG (1) BG99141A (de)
CA (1) CA2133106C (de)
CZ (1) CZ236994A3 (de)
DE (2) DE69334158T2 (de)
DK (2) DK0633931T3 (de)
ES (2) ES2290241T3 (de)
FI (1) FI944509A (de)
HU (1) HUT69995A (de)
NO (1) NO943625L (de)
NZ (1) NZ251343A (de)
PT (2) PT1329459E (de)
RU (1) RU94045826A (de)
WO (1) WO1993020187A1 (de)

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EP0563487A1 (de) * 1992-03-31 1993-10-06 Laboratoire Europeen De Biotechnologie S.A. Monoklonale Antikörper gegen den Interferonrezeptor, mit neutralisierender Aktivität gegen Typ I-Interferon
WO1995007716A1 (en) * 1993-09-17 1995-03-23 Laboratoire Europeen De Biotechnologie S.A. Pharmaceutical composition comprising monoclonal antibodies against the interferon receptor, with neutralizing activity against type i interferon
IL118096A0 (en) * 1996-05-01 1996-09-12 Yeda Res & Dev Antibodies against interferon alpha/beta receptor
US6713609B1 (en) 1996-07-16 2004-03-30 Genentech, Inc. Monoclonal antibodies to type I interferon receptor
CN1068524C (zh) * 1997-06-23 2001-07-18 叶庆炜 一种治疗顽症牛皮癣的药物
US6376067B1 (en) * 1998-12-21 2002-04-23 Mitsubishi Polyester Film, Llc Silicone coated film with back side slip control coating and method of controlling slip of such film
GB0001712D0 (en) * 2000-01-25 2000-03-15 Pharma Pacific Pty Ltd Therapeutic peptides
AU2007202840B2 (en) * 2001-01-09 2011-07-28 Baylor Research Institute Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays
JP4394350B2 (ja) * 2001-01-09 2010-01-06 ベイラー リサーチ インスティテュート 対象における自己免疫疾患の治療法及びｉｎｖｉｔｒｏ診断アッセイ
US7087726B2 (en) 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
US7619070B2 (en) * 2003-04-23 2009-11-17 Medarex, Inc. Humanized antibodies to interferon alpha receptor-1 (IFNAR-1)
CA2823468A1 (en) * 2003-04-23 2004-11-04 Medarex, L.L.C. Compositions and methods for the therapy of inflammatory bowel disease
AU2007203559B2 (en) * 2003-04-23 2010-09-02 E. R. Squibb & Sons, L.L.C. Compositions and methods for the therapy of inflammatory bowel disease
EP1711207B1 (de) 2003-12-10 2012-11-28 Medarex, Inc. Interferon-alpha-antikörper und deren verwendungen
US20060292554A1 (en) * 2004-05-18 2006-12-28 Genentech, Inc. Major coat protein variants for C-terminal and bi-terminal display
LT2662390T (lt) * 2004-06-21 2017-10-10 E. R. Squibb & Sons, L.L.C. Interferono-alfa receptoriaus-1 antikūnai ir jų panaudojimas
RU2007116988A (ru) * 2004-10-07 2008-11-20 Универзитет Цюрих (CH) Применение блокаторов интерферона типа i для профилактики и лечения псориаза
US7888481B2 (en) * 2005-02-10 2011-02-15 Baylor Research Institute Anti-interferon alpha monoclonal antibodies and methods for use
RU2431638C2 (ru) 2005-02-10 2011-10-20 Бэйлор Рисерч Инститьют Моноклональные антитела против интерферона-альфа и способы применения
EP1893646A2 (de) * 2005-06-22 2008-03-05 Genentech, Inc. Verfahren und zusammensetzungen für ifnar2-targeting
EP2687232A1 (de) 2006-12-06 2014-01-22 MedImmune, LLC Verfahren zur Behandlung von systemischem Lupus erythematodes
US8685400B2 (en) * 2007-07-30 2014-04-01 University Of Miami Modulating inflammasome activity and inflammation in the central nervous system
PL2250279T3 (pl) 2008-02-08 2016-11-30 Przeciwciała anty-ifnar1 o zmniejszonym powinowactwie do liganda fc
US8163885B2 (en) 2008-05-07 2012-04-24 Argos Therapeutics, Inc. Humanized antibodies against human interferon-alpha
JP5852021B2 (ja) * 2010-03-01 2016-02-03 アレクシオン ファーマシューティカルズ， インコーポレイテッド ドゴー病を処置するための方法および組成物
WO2013134146A1 (en) * 2012-03-07 2013-09-12 The Regents Of The University Of California Methods and compositions for treating viral infections by blocking type i interferon activity
CN109790526A (zh) 2016-07-01 2019-05-21 分解治疗有限责任公司 优化的二核酸酶融合体和方法
CN107074943B (zh) 2016-07-14 2018-08-24 中国科学院生物物理研究所 I型干扰素受体抗体及其用途
KR20200039778A (ko) 2017-08-22 2020-04-16 사나바이오, 엘엘씨 가용성 인터페론 수용체 및 그의 용도
CA3127890A1 (en) * 2019-01-31 2020-08-06 Immunecent Biotechnology, Inc. Anti-ifnar1 antibodies
JP2024531480A (ja) 2021-08-26 2024-08-29 デュアリティ バイオロジクス（スーチョウ）カンパニー，リミティド ステロイド化合物及びそのコンジュゲート
CN115028730B (zh) * 2022-05-17 2022-11-08 诺赛联合(北京)生物医学科技有限公司 一种成体干细胞衍生的类器官制备方法

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US3066671A (en) 1959-10-27 1962-12-04 Milton J Cohen Disposable additive container
US3608550A (en) 1969-05-07 1971-09-28 Becton Dickinson Co Transfer needle assembly
BE791340A (fr) 1972-01-06 1973-03-01 Becton Dickinson Co Nouveaux procede et appareil de prelevement de culture et d'identification de micro-organismes des humeurs
US4024857A (en) 1974-12-23 1977-05-24 Becton, Dickinson And Company Micro blood collection device
US4300404A (en) 1977-12-01 1981-11-17 Becton, Dickinson And Company Liquid specimen container
US4116066A (en) 1977-12-12 1978-09-26 Becton, Dickinson And Company Specimen sampler cup
US5516515A (en) * 1986-02-05 1996-05-14 Interferon Sciences, Inc. Separation of alpha interferon receptor proteins and antibodies therefor
IL88377A (en) * 1988-11-14 1996-09-12 Yeda Res & Dev Cloning and expression of a protein which modulates cellular response to type I interferon
FR2653445B1 (fr) * 1989-10-20 1994-07-29 Centre Nat Rech Scient Fragment d'adnc codant pour le gene du recepteur de l'interferon alpha et procede de preparation d'une proteine correspondante.
US5889151A (en) * 1989-10-20 1999-03-30 Societe Leb-Tech Purified human alpha interferon receptor
GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
FR2657881A1 (fr) * 1990-02-05 1991-08-09 Europ Biotechnologie Lab Nouveaux polypeptides hydrosolubles, sequences d'adn, nouvelles cellules, procede de preparation, applications et compositions renfermant lesdits polypeptides.
IL99232A0 (en) * 1990-08-20 1992-07-15 Univ Columbia Methods for producing rna viruses from cdna
EP0537166B1 (de) * 1991-04-17 1999-07-07 Medisup International N.V. Neue wasserlösliche polypeptide mit hoher affinität für alpha- und beta- interferone
EP0563487A1 (de) 1992-03-31 1993-10-06 Laboratoire Europeen De Biotechnologie S.A. Monoklonale Antikörper gegen den Interferonrezeptor, mit neutralisierender Aktivität gegen Typ I-Interferon
EP0671926B1 (de) * 1992-08-11 2002-11-13 President And Fellows Of Harvard College Immunmodulierende peptide
ES2126094T3 (es) * 1992-12-29 1999-03-16 Genentech Inc Tratamiento de la enfermedad inflamatoria de los intestinos con inhibidores del interferon-gamma.
EP0741577B1 (de) * 1994-03-07 2002-11-06 IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE Verwendung von Interferon-alpha 8 subtype zur Herstellung von Medikamenten zur Behandlung von Viralinfektionen der Leber
IL118096A0 (en) * 1996-05-01 1996-09-12 Yeda Res & Dev Antibodies against interferon alpha/beta receptor

Also Published As

Publication number Publication date
AU679909B2 (en) 1997-07-17
PT633931E (pt) 2003-09-30
EP1329459B1 (de) 2007-07-25
EP1329459A2 (de) 2003-07-23
US6787634B2 (en) 2004-09-07
JP3836500B2 (ja) 2006-10-25
FI944509A (fi) 1994-11-29
US20080226647A1 (en) 2008-09-18
RU94045826A (ru) 1996-11-10
DE69332997T2 (de) 2004-05-19
DK1329459T3 (da) 2007-11-26
DK0633931T3 (da) 2003-09-15
EP1329459A3 (de) 2003-09-10
BG99141A (bg) 1995-07-28
CZ236994A3 (en) 1995-02-15
JPH07505526A (ja) 1995-06-22
EP0633931A1 (de) 1995-01-18
ES2199941T3 (es) 2004-03-01
FI944509A0 (fi) 1994-09-29
ES2290241T3 (es) 2008-02-16
US5919453A (en) 1999-07-06
US20070128701A1 (en) 2007-06-07
CA2133106C (en) 2009-06-30
US7465451B2 (en) 2008-12-16
CA2133106A1 (en) 1993-10-14
AU3890793A (en) 1993-11-08
DE69334158D1 (de) 2007-09-06
ATE241008T1 (de) 2003-06-15
NO943625L (no) 1994-11-11
EP0563487A1 (de) 1993-10-06
AU706473B2 (en) 1999-06-17
DE69334158T2 (de) 2008-04-10
NO943625D0 (no) 1994-09-29
PT1329459E (pt) 2007-11-07
HU9402823D0 (en) 1995-01-30
EP0633931B1 (de) 2003-05-21
AU2349697A (en) 1997-07-24
HUT69995A (en) 1995-09-28
US20020055492A1 (en) 2002-05-09
JP2006089494A (ja) 2006-04-06
US7179465B2 (en) 2007-02-20
US20040191840A1 (en) 2004-09-30
ATE368055T1 (de) 2007-08-15
NZ251343A (en) 1997-07-27
WO1993020187A1 (en) 1993-10-14

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