JP2001522274A - 電極および電極配列 - Google Patents

電極および電極配列

Info

Publication number
JP2001522274A
JP2001522274A JP54633698A JP54633698A JP2001522274A JP 2001522274 A JP2001522274 A JP 2001522274A JP 54633698 A JP54633698 A JP 54633698A JP 54633698 A JP54633698 A JP 54633698A JP 2001522274 A JP2001522274 A JP 2001522274A
Authority
JP
Japan
Prior art keywords
electrodes
electrode
electrical
array
waveform
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP54633698A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001522274A5 (enExample
Inventor
バーナード、ロバート・エム
Original Assignee
アイコー・メディカル・システムズ・インク
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アイコー・メディカル・システムズ・インク filed Critical アイコー・メディカル・システムズ・インク
Publication of JP2001522274A publication Critical patent/JP2001522274A/ja
Publication of JP2001522274A5 publication Critical patent/JP2001522274A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Electrotherapy Devices (AREA)
JP54633698A 1997-04-24 1998-04-23 電極および電極配列 Ceased JP2001522274A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/845,553 1997-04-24
US08/845,553 US5873849A (en) 1997-04-24 1997-04-24 Electrodes and electrode arrays for generating electroporation inducing electrical fields
PCT/US1998/008183 WO1998047562A1 (en) 1997-04-24 1998-04-23 Electrodes and electrode arrays

Publications (2)

Publication Number Publication Date
JP2001522274A true JP2001522274A (ja) 2001-11-13
JP2001522274A5 JP2001522274A5 (enExample) 2005-12-02

Family

ID=25295503

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54633698A Ceased JP2001522274A (ja) 1997-04-24 1998-04-23 電極および電極配列

Country Status (6)

Country Link
US (2) US5873849A (enExample)
EP (1) EP0973579A4 (enExample)
JP (1) JP2001522274A (enExample)
AU (1) AU734611B2 (enExample)
CA (1) CA2287366A1 (enExample)
WO (1) WO1998047562A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010533023A (ja) * 2007-07-10 2010-10-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 神経刺激システム
JP2024535582A (ja) * 2021-10-22 2024-09-30 杭州維納安可医療科技有限責任公司 電場発生装置及びその制御方法、コンピュータ可読記憶媒体
US12303459B2 (en) 2008-08-06 2025-05-20 Serendia, Llc Method, system, and apparatus for dermatological treatment

Families Citing this family (291)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US6041252A (en) * 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
WO1999011771A1 (en) * 1997-09-04 1999-03-11 Science Research Laboratory, Inc. Cell separation using electric fields
AUPO907697A0 (en) * 1997-09-09 1997-10-02 Day, Robert Edward Chemical supplementation of bone
US7456012B2 (en) * 1997-11-06 2008-11-25 Cellectricon Ab Method and apparatus for spatially confined electroporation
US6778853B1 (en) 1997-12-17 2004-08-17 University Of South Florida Electroporation device
US6135990A (en) * 1997-12-17 2000-10-24 University Of South Florida Electroporation device and method
US6208893B1 (en) 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6009347A (en) * 1998-01-27 1999-12-28 Genetronics, Inc. Electroporation apparatus with connective electrode template
EP1056501B1 (en) 1998-02-24 2005-11-16 Boston Scientific Limited High flow rate dialysis catheters and related methods
US6027488A (en) * 1998-06-03 2000-02-22 Genetronics, Inc. Flow-through electroporation system for ex vivo gene therapy
US20040229363A1 (en) * 1998-06-24 2004-11-18 Ed Nolan High efficiency transfection based on low electric field strength, long pulse length
DK1100576T3 (da) * 1998-06-26 2007-12-03 Genetronics Inc Synergisme af fotodynamisk effekt og elektropermeringseffekt på cellevitalitet som nyt cytotoksisk middel
US6302874B1 (en) 1998-07-13 2001-10-16 Genetronics, Inc. Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
US6678556B1 (en) * 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
US7922709B2 (en) * 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
EP2428250A1 (en) 1998-07-13 2012-03-14 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
EP1100580A1 (en) 1998-07-20 2001-05-23 Ichor Medical Systems, Inc. Electroporation electrodes
US6319901B1 (en) 1998-10-15 2001-11-20 Ichor Medical Systems, Inc. Methods for prolonging cell membrane permeability
US6937890B2 (en) * 1998-12-17 2005-08-30 University Of South Florida Nonpenetrating electroporation device
US6314316B1 (en) * 1998-12-17 2001-11-06 University Of South Florida Nonpenetrating electroporation device and method
WO2000044438A1 (en) * 1999-01-28 2000-08-03 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
US6542776B1 (en) * 1999-04-14 2003-04-01 Transneuronix Inc. Gastric stimulator apparatus and method for installing
US6684104B2 (en) 1999-04-14 2004-01-27 Transneuronix, Inc. Gastric stimulator apparatus and method for installing
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6300108B1 (en) * 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US6556869B1 (en) 1999-12-01 2003-04-29 Vertis Neuroscience, Inc. Electrode introducer for a percutaneous electrical therapy system
US6522927B1 (en) 1999-12-01 2003-02-18 Vertis Neuroscience, Inc. Electrode assembly for a percutaneous electrical therapy system
US6912424B2 (en) * 1999-12-01 2005-06-28 Meagan, Medical, Inc. Apparatus and method for coupling therapeutic and/or monitoring equipment to a patient
US6904324B2 (en) * 1999-12-01 2005-06-07 Meagan Medical, Inc. Method and apparatus for deploying a percutaneous probe
US6493592B1 (en) 1999-12-01 2002-12-10 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode position maintenance
US6560491B1 (en) 1999-12-01 2003-05-06 Vertis Neuroscience, Inc. Percutaneous electrical therapy system providing electrode axial support
US6549810B1 (en) 1999-12-01 2003-04-15 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode depth control
US6542780B1 (en) * 1999-12-01 2003-04-01 Vertis Neuroscience, Inc. Method and apparatus for electrically coupling a percutaneous probe
US6549797B1 (en) 1999-12-01 2003-04-15 Vertis Neuroscience, Inc. Electrode remover for a percutaneous electrical therapy system
US6539264B1 (en) 1999-12-01 2003-03-25 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with sharp point protection
US6516226B1 (en) 1999-12-01 2003-02-04 Vertis Neuroscience, Inc. Percutaneous electrical therapy system for minimizing electrode insertion discomfort
US6622051B1 (en) 1999-12-01 2003-09-16 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode entry angle control
AU2189000A (en) * 1999-12-15 2001-06-25 University Of South Florida Electroporation device and method
US6714816B1 (en) * 2000-02-22 2004-03-30 University Of South Florida Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo
US7742811B2 (en) 2000-03-13 2010-06-22 Onco Stim Implantable device and method for the electrical treatment of cancer
US8024048B2 (en) 2000-03-13 2011-09-20 Ionix Medical Inc. Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US7756584B2 (en) * 2000-07-13 2010-07-13 Advanced Neuromodulation Systems, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
AU2001279026B2 (en) * 2000-07-25 2005-12-22 Angiodynamics, Inc. Apparatus for detecting and treating tumors using localized impedance measurement
US8251986B2 (en) 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US7118555B2 (en) * 2000-09-21 2006-10-10 Meagan Medical, Inc. Method and apparatus for repositioning a percutaneous probe
USD480478S1 (en) 2000-09-28 2003-10-07 Vertis Neuroscience, Inc. Percutaneous probe applicator
US6701190B2 (en) 2000-10-10 2004-03-02 Meagan Medical, Inc. System and method for varying characteristics of electrical therapy
US6671557B1 (en) 2000-10-10 2003-12-30 Meagan Medical, Inc. System and method for providing percutaneous electrical therapy
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US20050043726A1 (en) * 2001-03-07 2005-02-24 Mchale Anthony Patrick Device II
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
DE20109099U1 (de) * 2001-05-30 2001-08-09 Schönfeld, Andreas, Dipl.-Ing., 76189 Karlsruhe Vorrichtung zur Behandlung von Tumoren
DE10129912A1 (de) * 2001-06-21 2003-01-02 Efmt Entwicklungs Und Forschun Nadelelektrode
US20040204669A1 (en) * 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
USRE42016E1 (en) 2001-08-13 2010-12-28 Angiodynamics, Inc. Apparatus and method for the treatment of benign prostatic hyperplasia
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US7130697B2 (en) * 2002-08-13 2006-10-31 Minnesota Medical Physics Llc Apparatus and method for the treatment of benign prostatic hyperplasia
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
USD475463S1 (en) 2001-09-28 2003-06-03 Vertis Neuroscience, Inc. Control device for delivering electrical therapy
AU2002353741A1 (en) * 2001-11-27 2003-06-10 Cellectricon Ab A method for combined sequential agent delivery and electroporation for cell structures and use thereof
WO2003047684A2 (en) * 2001-12-04 2003-06-12 University Of Southern California Method for intracellular modifications within living cells using pulsed electric fields
CN1630707A (zh) * 2002-02-12 2005-06-22 色雷特康公司 用于快速改变传感器周围溶液环境的系统与方法
TWI239855B (en) * 2002-03-07 2005-09-21 Advisys Inc Electrode assembly for constant-current electroporation and use
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US7697981B2 (en) * 2002-03-22 2010-04-13 The Regents Of The University Of California Method and apparatus for using an electromagnetic field in cellular transplantation
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
AU2003223351A1 (en) 2002-04-16 2003-11-03 Cyto Pulse Sciences, Inc. Method of treating biological materials with translating electrical fields and electrode polarity reversal
AU2003299471A1 (en) 2002-05-07 2004-05-13 Kai Kroll Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
ES2315493T3 (es) * 2002-05-23 2009-04-01 Gendel Limited Dispositivo de ablacion.
AU2003278461A1 (en) 2002-10-16 2004-05-04 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
WO2004052182A2 (en) * 2002-12-11 2004-06-24 Proteus Biomedical, Inc. Monitoring and treating hemodynamic parameters
JP4465349B2 (ja) * 2003-01-24 2010-05-19 プロテウス バイオメディカル インコーポレイテッド 心臓のパラメーターを測定するための方法およびシステム
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
CA2432810A1 (en) 2003-06-19 2004-12-19 Andres M. Lozano Method of treating depression, mood disorders and anxiety disorders by brian infusion
GB2403148C2 (en) 2003-06-23 2013-02-13 Microsulis Ltd Radiation applicator
EP1654032A2 (en) * 2003-08-01 2006-05-10 Northstar Neuroscience, Inc. Apparatus and methods for applying neural stimulation to a patient
US20050171574A1 (en) 2003-12-24 2005-08-04 The Regents Of The University Of California Electroporation to interrupt blood flow
US8298222B2 (en) 2003-12-24 2012-10-30 The Regents Of The University Of California Electroporation to deliver chemotherapeutics and enhance tumor regression
GB0402569D0 (en) * 2004-02-05 2004-03-10 Neurodan As Nerve and/or muscle stimulation electrodes
KR101261642B1 (ko) 2004-03-08 2013-05-06 아이커 메디칼 시스템스 인코포레이티드 치료 제제의 전기 매개식 이송을 위한 개선된 장치
AU2005228145B2 (en) * 2004-03-24 2011-03-03 Corium Pharma Solutions, Inc. Transdermal delivery device
JP4443278B2 (ja) * 2004-03-26 2010-03-31 テルモ株式会社 拡張体付カテーテル
EP1742588B1 (en) 2004-04-01 2016-10-19 The General Hospital Corporation Apparatus for dermatological treatment and tissue reshaping
US7720549B2 (en) * 2004-04-06 2010-05-18 Oncostim, Inc. Partially implantable system for the electrical treatment of abnormal tissue growth
US20050222646A1 (en) * 2004-04-06 2005-10-06 Kai Kroll Method and device for treating cancer with modified output electrical therapy
WO2005107858A1 (en) * 2004-04-30 2005-11-17 Advanced Neuromodulation Systems, Inc. Method of treating mood disorders and/or anxiety disorders by brain stimulation
US7706873B2 (en) * 2004-05-05 2010-04-27 Mario Ammirati System and method for controlled delivery of a therapeutic agent to a target location within an internal body tissue
FR2872056B1 (fr) 2004-06-24 2007-08-10 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus utilisant une ou deux forces physiques
FR2872055B1 (fr) 2004-06-24 2008-02-08 Yves Leon Scherman Dispositif pour le transfert de molecules aux cellules utilisant une force d'origine physique et combinaison permettant la mise en oeuvre du procede
FR2880808A1 (fr) 2005-01-20 2006-07-21 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus a l'aide d'electrodes de surface non invasives
GB2415630C2 (en) 2004-07-02 2007-03-22 Microsulis Ltd Radiation applicator and method of radiating tissue
WO2006029090A2 (en) * 2004-09-02 2006-03-16 Proteus Biomedical, Inc. Methods and apparatus for tissue activation and monitoring
GB0502384D0 (en) * 2005-02-04 2005-03-16 Instrumedical Ltd Electro-surgical needle apparatus
US20060212090A1 (en) * 2005-03-01 2006-09-21 Functional Neuroscience Inc. Method of treating cognitive disorders using neuromodulation
US9931500B2 (en) * 2005-03-01 2018-04-03 Andres M. Lozano Method of treating depression, mood disorders and anxiety disorders using neuromodulation
EP1698907A1 (en) * 2005-03-04 2006-09-06 Cardiatis Société Anonyme Interventional medical device for use in MRI
EP1871470A4 (en) * 2005-03-31 2011-06-01 Proteus Biomedical Inc AUTOMATIC OPTIMIZATION OF MULTIELECTROPIC PACING FOR CARDIAL RESYNCHRONIZATION
US20060264752A1 (en) * 2005-04-27 2006-11-23 The Regents Of The University Of California Electroporation controlled with real time imaging
DK1899001T3 (en) * 2005-06-08 2017-12-04 Novocure Ltd DEVICE FOR CANCER TREATMENT WITH ELECTRIC FIELDS MADE FOR DESIRED LOCATIONS IN A BODY
US20060293730A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating restenosis sites using electroporation
US8114070B2 (en) * 2005-06-24 2012-02-14 Angiodynamics, Inc. Methods and systems for treating BPH using electroporation
US20060293731A1 (en) * 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating tumors using electroporation
US20060293725A1 (en) * 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating fatty tissue sites using electroporation
AU2006266579B2 (en) * 2005-06-30 2009-10-22 Lg Electronics Inc. Method and apparatus for encoding and decoding an audio signal
GB2434314B (en) 2006-01-03 2011-06-15 Microsulis Ltd Microwave applicator with dipole antenna
US7983751B2 (en) * 2005-08-12 2011-07-19 Proteus Biomedical, Inc. Measuring conduction velocity using one or more satellite devices
US20070142885A1 (en) * 2005-11-29 2007-06-21 Reliant Technologies, Inc. Method and Apparatus for Micro-Needle Array Electrode Treatment of Tissue
JP2009521276A (ja) * 2005-12-22 2009-06-04 プロテウス バイオメディカル インコーポレイテッド 植え込み型集積回路
US20070156135A1 (en) * 2006-01-03 2007-07-05 Boris Rubinsky System and methods for treating atrial fibrillation using electroporation
CA3063263C (en) * 2006-02-11 2024-01-16 Genetronics, Inc. Device and method for single-needle in vivo electroporation
WO2007117651A2 (en) * 2006-04-07 2007-10-18 University Of South Florida Passive electric field focus system for in vivo and in vitro applications
ES2336626T3 (es) * 2006-06-12 2010-04-14 Region Hovedstaden V/Herlev Hospital Dispositivo introductor de electrodos.
EP2076313A4 (en) * 2006-10-16 2012-07-25 Univ California GELE WITH PRE-DEFINED CONDUCTIVITY FOR THE FINAL ELECTROPORATION OF A TISSUE
US20080132885A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Methods for treating tissue sites using electroporation
US20080132884A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Systems for treating tissue sites using electroporation
JP5553612B2 (ja) * 2007-01-22 2014-07-16 コリウム インターナショナル， インコーポレイテッド マイクロニードルアレイ用アプリケータ
US7655004B2 (en) 2007-02-15 2010-02-02 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US8911749B2 (en) * 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
WO2008130587A2 (en) 2007-04-16 2008-10-30 Corium International, Inc. Solvent-cast microneedle arrays containing active
WO2008146075A1 (de) * 2007-05-31 2008-12-04 Biophox Gmbh & Co. Kg Einrichtung zur behandlung von tumoren
US20090088703A1 (en) * 2007-09-13 2009-04-02 Kouros Azar Skin treatment system and method
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
AU2008310156A1 (en) * 2007-10-11 2009-04-16 Region Hovedstaden V/Herlev Hospital An electroporation device for improved electrical field control
WO2009073891A1 (en) * 2007-12-07 2009-06-11 Northstar Neuroscience, Inc. Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropyschiatric and neuropyschological disorders
WO2009091578A1 (en) 2008-01-17 2009-07-23 Genetronics, Inc. Variable current density single needle electroporation system and method
WO2009131749A2 (en) * 2008-02-28 2009-10-29 Proteus Biomedical, Inc. Integrated circuit implementation and fault control system, device, and method
WO2009121017A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California Balloon catheter for reducing restenosis via irreversible electroporation
US20100004623A1 (en) * 2008-03-27 2010-01-07 Angiodynamics, Inc. Method for Treatment of Complications Associated with Arteriovenous Grafts and Fistulas Using Electroporation
US12697172B2 (en) 2008-04-29 2026-08-04 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US8926606B2 (en) * 2009-04-09 2015-01-06 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
US10448989B2 (en) 2009-04-09 2019-10-22 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
EP2280741A4 (en) 2008-04-29 2012-06-13 Virginia Tech Intell Prop IRREVERSIBLE ELECTROPORATION FOR THE PRODUCTION OF TISSUE OBJECTS
US20090281477A1 (en) 2008-05-09 2009-11-12 Angiodynamics, Inc. Electroporation device and method
US20090287266A1 (en) * 2008-05-13 2009-11-19 Mark Zdeblick High-voltage tolerant multiplex multi-electrode stimulation systems and methods for using the same
US9173704B2 (en) * 2008-06-20 2015-11-03 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
US9681909B2 (en) * 2008-06-23 2017-06-20 Angiodynamics, Inc. Treatment devices and methods
US8888792B2 (en) 2008-07-14 2014-11-18 Ethicon Endo-Surgery, Inc. Tissue apposition clip application devices and methods
US10736689B2 (en) 2008-08-20 2020-08-11 Prostacare Pty Ltd Low-corrosion electrode for treating tissue
WO2010057063A2 (en) * 2008-11-13 2010-05-20 Proteus Biomedical, Inc. Pacing and stimulation system, device and method
WO2010056438A2 (en) 2008-11-13 2010-05-20 Proteus Biomedical, Inc. Shielded stimulation and sensing system and method
EP2346567A4 (en) * 2008-11-13 2012-04-25 Proteus Biomedical Inc MULTIPLEX MULTI ELECTRODE NEURO STIMULATION DEVICE
EP2346391A4 (en) * 2008-11-18 2012-08-15 Proteus Biomedical Inc DETECTION SYSTEM, APPARATUS AND METHOD FOR THERAPY MODULATION
US8157834B2 (en) 2008-11-25 2012-04-17 Ethicon Endo-Surgery, Inc. Rotational coupling device for surgical instrument with flexible actuators
EP2358429A4 (en) * 2008-12-02 2013-05-29 Proteus Digital Health Inc COMPATIBLE COMMUNICATION PROTOCOL WITH AN ANALYZER
US20100152725A1 (en) * 2008-12-12 2010-06-17 Angiodynamics, Inc. Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation
US8361066B2 (en) 2009-01-12 2013-01-29 Ethicon Endo-Surgery, Inc. Electrical ablation devices
WO2010085765A2 (en) * 2009-01-23 2010-07-29 Moshe Meir H Therapeutic energy delivery device with rotational mechanism
WO2010093692A2 (en) * 2009-02-10 2010-08-19 Hobbs Eamonn P Irreversible electroporation and tissue regeneration
US20100240995A1 (en) * 2009-03-17 2010-09-23 Bioelectromed Corp. System and method for treating tumors
US8632534B2 (en) 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
WO2010120866A2 (en) * 2009-04-14 2010-10-21 Old Dominion University Research Foundation Medical instrument for delivery of high voltage pulses and method of delivering the same
JP5820805B2 (ja) * 2009-04-24 2015-11-24 コリウム インターナショナル， インコーポレイテッド マイクロプロジェクションのアレイの製造のためのプロセス
USD630321S1 (en) 2009-05-08 2011-01-04 Angio Dynamics, Inc. Probe handle
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
JP5730872B2 (ja) 2009-07-23 2015-06-10 プロテウス デジタル ヘルス， インコーポレイテッド 固体薄膜コンデンサ
US20110046540A1 (en) * 2009-08-24 2011-02-24 Alterman Ron L Apparatus for Trans-Cerebral Electrophoresis and Methods of Use Thereof
GB2474233A (en) 2009-10-06 2011-04-13 Uk Investments Associates Llc Cooling pump comprising a detachable head portion
US20110098704A1 (en) 2009-10-28 2011-04-28 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US20110118732A1 (en) 2009-11-19 2011-05-19 The Regents Of The University Of California Controlled irreversible electroporation
US9028483B2 (en) 2009-12-18 2015-05-12 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
JP6327852B2 (ja) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス
WO2012051433A2 (en) 2010-10-13 2012-04-19 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
US8718770B2 (en) 2010-10-21 2014-05-06 Medtronic, Inc. Capture threshold measurement for selection of pacing vector
WO2012052543A1 (en) * 2010-10-22 2012-04-26 Herlev Hospital A method for treating a tissue region with an electric field
WO2012082688A1 (en) * 2010-12-15 2012-06-21 Old Dominion University Research Foundation Electroporation-induced electrosensitization
US9254169B2 (en) 2011-02-28 2016-02-09 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9233241B2 (en) * 2011-02-28 2016-01-12 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9049987B2 (en) 2011-03-17 2015-06-09 Ethicon Endo-Surgery, Inc. Hand held surgical device for manipulating an internal magnet assembly within a patient
US8355784B2 (en) 2011-05-13 2013-01-15 Medtronic, Inc. Dynamic representation of multipolar leads in a programmer interface
KR20140068000A (ko) 2011-06-15 2014-06-05 크론테크 파마 아베 주사 바늘 및 장치
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
US9427255B2 (en) 2012-05-14 2016-08-30 Ethicon Endo-Surgery, Inc. Apparatus for introducing a steerable camera assembly into a patient
US9078662B2 (en) 2012-07-03 2015-07-14 Ethicon Endo-Surgery, Inc. Endoscopic cap electrode and method for using the same
US9144459B2 (en) 2012-07-19 2015-09-29 Cook Medical Technologies Llc Endoscopic ultrasound ablation needle
US9545290B2 (en) 2012-07-30 2017-01-17 Ethicon Endo-Surgery, Inc. Needle probe guide
US10314649B2 (en) 2012-08-02 2019-06-11 Ethicon Endo-Surgery, Inc. Flexible expandable electrode and method of intraluminal delivery of pulsed power
US9277957B2 (en) 2012-08-15 2016-03-08 Ethicon Endo-Surgery, Inc. Electrosurgical devices and methods
WO2014066655A2 (en) * 2012-10-25 2014-05-01 Oncosec Medical Incorporation Electroporation device
RU2698095C2 (ru) 2012-12-21 2019-08-22 Кориум Интернэшнл, Инк. Микроматрица для доставки терапевтического средства и способы использования
US10098527B2 (en) 2013-02-27 2018-10-16 Ethidcon Endo-Surgery, Inc. System for performing a minimally invasive surgical procedure
BR122020006959B1 (pt) 2013-03-12 2022-04-26 Corium, Inc Aplicador de microprojeções
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
WO2014144973A1 (en) 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
AU2014233695A1 (en) 2013-03-15 2015-10-01 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
CA2914195C (en) 2013-06-03 2020-06-02 Nanoblate Corporation Methods and devices for stimulating an immune response using nanosecond pulsed electric fields
US10709491B2 (en) * 2013-08-06 2020-07-14 Memorial Sloan-Kettering Cancer Center System, method and computer-accessible medium for in-vivo tissue ablation and/or damage
CN103555574A (zh) 2013-11-11 2014-02-05 苏州文曲生物微系统有限公司 一种流式电穿孔装置
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
AU2015236341B2 (en) 2014-03-24 2020-03-05 Old Dominion University Research Foundation Expandable catheter devices electrode array
EP3143124B1 (en) 2014-05-12 2025-01-22 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US12114911B2 (en) 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
US9724155B2 (en) 2014-12-01 2017-08-08 Pulse Biosciences, Inc. Nanoelectroablation control and vaccination
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
CA2986031C (en) 2015-05-15 2024-03-19 ClearIt, LLC Systems and methods for tattoo removal using cold plasma
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11027071B2 (en) * 2015-12-28 2021-06-08 Inovio Pharmaceuticals, Inc. Intradermal jet injection electroporation device
WO2017139253A1 (en) * 2016-02-08 2017-08-17 Vomaris Innovations, Inc. Composite bioelectric devices and methods of use
NZ747635A (en) 2016-03-28 2024-05-31 Ichor Medical Systems Inc Method and apparatus for delivery of therapeutic agents
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
JP7250520B2 (ja) 2016-04-13 2023-04-03 ヤンセン ファーマシューティカルズ，インコーポレーテッド 組換えアルテリウイルスレプリコン系およびその使用
IT201600068691A1 (it) * 2016-07-01 2018-01-01 Igea S P A Sistema di movimentazione e controllo per elettrodi espandibili di un manipolo utilizzabile in un procedimento di elettro-porazione
ES2993107T3 (en) 2016-10-17 2024-12-23 Janssen Pharmaceuticals Inc Recombinant virus replicon systems and uses thereof
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
JP7788787B2 (ja) 2016-12-05 2025-12-19 ヤンセン ファーマシューティカルズ，インコーポレーテッド 遺伝子発現増強のための組成物および方法
US11045648B2 (en) 2017-11-14 2021-06-29 Boston Scientific Scimed, Inc. Irreversible electroporation through a combination of substance injection and electrical field application
US11457975B2 (en) 2017-11-27 2022-10-04 Prostacare Pty Ltd Apparatus and a method for the treatment of a prostatic disease
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
EA202091517A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и устройство для доставки вакцин против вируса гепатита b (hbv)
EA202091516A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv)
EA202091513A1 (ru) 2017-12-19 2020-09-09 Янссен Сайенсиз Айрлэнд Анлимитед Компани Вакцины против вируса гепатита b (hbv) и их применение
MA51311A (fr) 2017-12-19 2020-10-28 Janssen Sciences Ireland Unlimited Co Vaccins contre le virus de l'hépatite b (vhb) et utilisations associées
JP2021506300A (ja) 2017-12-19 2021-02-22 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー Ｂ型肝炎ウイルス（ｈｂｖ）に対する免疫応答を誘導するための方法および組成物
KR20200111729A (ko) 2018-01-19 2020-09-29 얀센 파마슈티칼즈, 인코포레이티드 재조합 레플리콘 시스템을 이용한 면역 반응 유도 및 증진
JP7045464B2 (ja) 2018-01-23 2022-03-31 ボストン サイエンティフィック サイムド，インコーポレイテッド 腫瘍アブレーションのための強化ニードルアレイと治療方法
WO2019168949A1 (en) 2018-02-28 2019-09-06 Prostacare Pty Ltd System for managing high impedance changes in a non-thermal ablation system for bph
US12390262B2 (en) 2018-03-13 2025-08-19 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
EP3864027A1 (en) 2018-10-08 2021-08-18 Janssen Pharmaceuticals, Inc. Alphavirus-based replicons for administration of biotherapeutics
US12226148B2 (en) 2018-11-05 2025-02-18 Region Hovedstaden V/Herlev Hospital Electrode assembly for improved electric field distribution
CA3124411A1 (en) * 2018-12-19 2020-06-25 ClearIt, LLC Systems and methods for tattoo removal using an applied electric field
CN118948428A (zh) 2019-03-15 2024-11-15 波士顿科学国际有限公司 用于选择性细胞消融的时间多路复用波形
EP3937810A1 (en) 2019-03-15 2022-01-19 Boston Scientific Scimed, Inc. Spatially multiplexed waveform for selective cell ablation
WO2020190693A1 (en) 2019-03-15 2020-09-24 Boston Scientific Scimed, Inc. Waveform generator and control for selective cell ablation
WO2020255035A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pyrimidine derivatives
WO2020255022A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and aminopyridine derivatives as hpk1 inhibitors
WO2020255008A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAi
JP2022536945A (ja) 2019-06-18 2022-08-22 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー Ｂ型肝炎ウイルス（ＨＢＶ）ワクチンおよびＨＢＶを標的化するＲＮＡｉの組合せ
WO2020255019A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and a quinazoline derivative
US20220305116A1 (en) 2019-06-18 2022-09-29 Janssen Sciences lreland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being sulfonamide derivatives
CN114630675A (zh) 2019-06-18 2022-06-14 爱尔兰詹森科学公司 乙型肝炎病毒(hbv)疫苗和抗pd-1或抗pd-l1抗体的组合
EP3986915A1 (en) 2019-06-18 2022-04-27 Janssen Sciences Ireland Unlimited Company Recombinant interleukin 12 construct and uses thereof
WO2020255013A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being amide derivatives
CA3140588A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and small molecule pdl1 or pd1 inhibitor
WO2020255038A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives
WO2020255010A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of recombinant interleukin 12 construct and hepatitis b virus (hbv) vaccines
CA3140690A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
US20220233526A1 (en) 2019-06-18 2022-07-28 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
US20220241402A1 (en) 2019-06-18 2022-08-04 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
WO2020254876A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Virus-like particle delivery of hepatitis b virus (hbv) vaccines
CA3143634A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 antibody
US20220233684A1 (en) 2019-06-18 2022-07-28 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pd-l1 inhibitors
WO2020255042A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and a pyrimidine derivative
CA3141238A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Hepatitis b virus (hbv) vaccines and uses thereof
EP3986563A1 (en) 2019-06-20 2022-04-27 Janssen Sciences Ireland Unlimited Company Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines
CA3143627A1 (en) 2019-06-20 2020-12-24 Janssen Sciences Ireland Unlimited Company Carbohydrate nanocarrier delivery of hepatitis b virus (hbv) vaccines
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
US12214189B2 (en) 2019-07-24 2025-02-04 Virginia Tech Intellectual Properties, Inc. Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies
CN114945338A (zh) 2019-10-15 2022-08-26 波士顿科学国际有限公司 用于消融系统的控制系统和用户界面
US12121739B2 (en) * 2019-12-31 2024-10-22 Novocure Gmbh Methods, systems, and apparatuses for managing temperatures induced by alternating fields
US11992260B2 (en) 2020-03-31 2024-05-28 Boston Scientific Scimed, Inc. Smart probe identification for ablation modalities
IL299571A (en) 2020-07-08 2023-02-01 Janssen Sciences Ireland Unlimited Co Rna replicon vaccines against hbv
US11771373B2 (en) 2020-11-09 2023-10-03 Biosense Webster (Israel) Ltd. Staggered electrode arrangements for electrophysiological sensing
US12485279B2 (en) 2020-11-25 2025-12-02 Virginia Tech Intellectual Properties, Inc. Methods for modulating temporal infrastructure of pulsed electric fields
TW202245809A (zh) 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
AU2021412833A1 (en) 2020-12-28 2023-07-06 Arcturus Therapeutics, Inc. Transcription activator-like effector nucleases (talens) targeting hbv
WO2023097113A1 (en) 2021-11-29 2023-06-01 Boston Scientific Scimed, Inc. Bipolar needle with adjustable electrode for geometrically controlled thermal ablation of biological tissue
US20230330426A1 (en) * 2022-04-16 2023-10-19 Medtronic, Inc. Implantation techniques for electric field therapy
WO2023233290A1 (en) 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Rnai agents targeting pd-l1
CN115102530B (zh) * 2022-08-29 2023-09-29 赛福凯尔(绍兴)医疗科技有限公司 一种用于抑制肿瘤细胞的电场发生装置及系统
USD1084316S1 (en) 2023-11-20 2025-07-15 Angiodynamics, Inc. Ferrule

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991755A (en) * 1973-07-27 1976-11-16 Medicon, Inc. Iontophoresis apparatus for applying local anesthetics
US3957053A (en) * 1975-03-03 1976-05-18 Yen Kong Woo Detachably connected acupuncture needles
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
JPS56501274A (enExample) * 1979-10-10 1981-09-10
US4381789A (en) * 1979-11-20 1983-05-03 Siemens Aktiengesellschaft Electrode system
US4837049A (en) * 1986-06-17 1989-06-06 Alfred E. Mann Foundation For Scientific Research Method of making an electrode array
US5128257A (en) * 1987-08-31 1992-07-07 Baer Bradford W Electroporation apparatus and process
US5547467A (en) * 1988-01-21 1996-08-20 Massachusettes Institute Of Technology Method for rapid temporal control of molecular transport across tissue
US5749847A (en) * 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
DE68925030T2 (de) * 1988-01-21 1996-07-25 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
CS275292B2 (en) * 1989-02-22 1992-02-19 Cvut Fakulta Elektrotechnick Private rehabilitation apparatus with ion transcutaneous acceleration
US5215088A (en) * 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
US5545130A (en) * 1992-04-08 1996-08-13 Genetronics, Inc. Flow through electroporation method
US5501662A (en) * 1992-05-22 1996-03-26 Genetronics, Inc. Implantable electroporation method and apparatus for drug and gene delivery
US5507724A (en) * 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US5304120A (en) * 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5688233A (en) * 1992-08-17 1997-11-18 Genetronics, Inc. Electronincorporation enhanced transdermal delivery of molecules
US5462520A (en) * 1992-08-17 1995-10-31 Genetronics, Inc. Transsurface drug delivery by electrofusion of microbubbles to the tissue surface
US5464386A (en) * 1992-08-17 1995-11-07 Genetronics, Inc. Transdermal drug delivery by electroincorporation of vesicles
US5468223A (en) * 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
US5298017A (en) * 1992-12-29 1994-03-29 Alza Corporation Layered electrotransport drug delivery system
FR2703253B1 (fr) * 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
WO1994028967A1 (en) * 1993-06-08 1994-12-22 Hisamitsu Pharmaceutical Co., Inc. Iontophoresis system
IL108775A (en) * 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
US5704908A (en) * 1996-10-10 1998-01-06 Genetronics, Inc. Electroporation and iontophoresis catheter with porous balloon
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields

Cited By (5)

* Cited by examiner, † Cited by third party
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JP2010533023A (ja) * 2007-07-10 2010-10-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 神経刺激システム
US8694105B2 (en) 2007-07-10 2014-04-08 Sapiens Steering Brain Stimulation B.V. Neurostimulation system having a controller for controlling the supply of electrical pulses
US12303459B2 (en) 2008-08-06 2025-05-20 Serendia, Llc Method, system, and apparatus for dermatological treatment
JP2024535582A (ja) * 2021-10-22 2024-09-30 杭州維納安可医療科技有限責任公司 電場発生装置及びその制御方法、コンピュータ可読記憶媒体
JP7783470B2 (ja) 2021-10-22 2025-12-10 杭州維納安可医療科技有限責任公司 電場発生装置及びその制御方法、コンピュータ可読記憶媒体

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US5873849A (en) 1999-02-23
EP0973579A1 (en) 2000-01-26
AU734611B2 (en) 2001-06-21
AU7151598A (en) 1998-11-13
US6278895B1 (en) 2001-08-21
WO1998047562A1 (en) 1998-10-29
CA2287366A1 (en) 1998-10-29

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