JP2001522274A - 電極および電極配列 - Google Patents
電極および電極配列Info
- Publication number
- JP2001522274A JP2001522274A JP54633698A JP54633698A JP2001522274A JP 2001522274 A JP2001522274 A JP 2001522274A JP 54633698 A JP54633698 A JP 54633698A JP 54633698 A JP54633698 A JP 54633698A JP 2001522274 A JP2001522274 A JP 2001522274A
- Authority
- JP
- Japan
- Prior art keywords
- electrodes
- electrode
- electrical
- array
- waveform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000005684 electric field Effects 0.000 claims description 49
- 238000011282 treatment Methods 0.000 claims description 34
- 238000004520 electroporation Methods 0.000 claims description 26
- 210000000170 cell membrane Anatomy 0.000 claims description 12
- 230000005540 biological transmission Effects 0.000 claims description 5
- 230000035699 permeability Effects 0.000 claims description 5
- 230000001225 therapeutic effect Effects 0.000 abstract description 15
- 238000001727 in vivo Methods 0.000 abstract description 7
- 210000004027 cell Anatomy 0.000 description 50
- 210000001519 tissue Anatomy 0.000 description 47
- 238000000034 method Methods 0.000 description 30
- 239000003814 drug Substances 0.000 description 23
- 229940124597 therapeutic agent Drugs 0.000 description 19
- 230000004083 survival effect Effects 0.000 description 16
- 241001465754 Metazoa Species 0.000 description 13
- 238000007920 subcutaneous administration Methods 0.000 description 12
- 230000008901 benefit Effects 0.000 description 11
- 238000002513 implantation Methods 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 9
- 239000007924 injection Substances 0.000 description 9
- 238000002347 injection Methods 0.000 description 9
- 241000700159 Rattus Species 0.000 description 6
- 238000013461 design Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 210000000988 bone and bone Anatomy 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 210000004761 scalp Anatomy 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
- 108010006654 Bleomycin Proteins 0.000 description 4
- 238000011887 Necropsy Methods 0.000 description 4
- 229960001561 bleomycin Drugs 0.000 description 4
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 4
- 210000004556 brain Anatomy 0.000 description 4
- 210000000172 cytosol Anatomy 0.000 description 4
- 238000005370 electroosmosis Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000017074 necrotic cell death Effects 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 229940127089 cytotoxic agent Drugs 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 3
- 230000008520 organization Effects 0.000 description 3
- 230000001575 pathological effect Effects 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000000451 tissue damage Effects 0.000 description 3
- 231100000827 tissue damage Toxicity 0.000 description 3
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 2
- 208000003174 Brain Neoplasms Diseases 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- 208000007660 Residual Neoplasm Diseases 0.000 description 2
- 206010039491 Sarcoma Diseases 0.000 description 2
- 206010072170 Skin wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 229940064804 betadine Drugs 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000001723 curing Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 230000005685 electric field effect Effects 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 230000005669 field effect Effects 0.000 description 2
- 230000002518 glial effect Effects 0.000 description 2
- 239000010439 graphite Substances 0.000 description 2
- 229910002804 graphite Inorganic materials 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000011810 insulating material Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000002262 irrigation Effects 0.000 description 2
- 238000003973 irrigation Methods 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000001902 propagating effect Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 230000003313 weakening effect Effects 0.000 description 2
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 2
- 229960001600 xylazine Drugs 0.000 description 2
- -1 (Trade name) Substances 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 229910000575 Ir alloy Inorganic materials 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 102100034784 Protein TANC2 Human genes 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009933 burial Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 210000003191 femoral vein Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 150000004658 ketimines Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
- A61N1/0416—Anode and cathode
- A61N1/0424—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
- A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/845,553 | 1997-04-24 | ||
| US08/845,553 US5873849A (en) | 1997-04-24 | 1997-04-24 | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
| PCT/US1998/008183 WO1998047562A1 (en) | 1997-04-24 | 1998-04-23 | Electrodes and electrode arrays |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001522274A true JP2001522274A (ja) | 2001-11-13 |
| JP2001522274A5 JP2001522274A5 (enExample) | 2005-12-02 |
Family
ID=25295503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54633698A Ceased JP2001522274A (ja) | 1997-04-24 | 1998-04-23 | 電極および電極配列 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US5873849A (enExample) |
| EP (1) | EP0973579A4 (enExample) |
| JP (1) | JP2001522274A (enExample) |
| AU (1) | AU734611B2 (enExample) |
| CA (1) | CA2287366A1 (enExample) |
| WO (1) | WO1998047562A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010533023A (ja) * | 2007-07-10 | 2010-10-21 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 神経刺激システム |
| JP2024535582A (ja) * | 2021-10-22 | 2024-09-30 | 杭州維納安可医療科技有限責任公司 | 電場発生装置及びその制御方法、コンピュータ可読記憶媒体 |
| US12303459B2 (en) | 2008-08-06 | 2025-05-20 | Serendia, Llc | Method, system, and apparatus for dermatological treatment |
Families Citing this family (287)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5702359A (en) * | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
| US5993434A (en) * | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
| US6041252A (en) * | 1995-06-07 | 2000-03-21 | Ichor Medical Systems Inc. | Drug delivery system and method |
| US5873849A (en) * | 1997-04-24 | 1999-02-23 | Ichor Medical Systems, Inc. | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| US6216034B1 (en) | 1997-08-01 | 2001-04-10 | Genetronics, Inc. | Method of programming an array of needle electrodes for electroporation therapy of tissue |
| US6241701B1 (en) | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
| WO1999011771A1 (en) * | 1997-09-04 | 1999-03-11 | Science Research Laboratory, Inc. | Cell separation using electric fields |
| AUPO907697A0 (en) * | 1997-09-09 | 1997-10-02 | Day, Robert Edward | Chemical supplementation of bone |
| US7456012B2 (en) * | 1997-11-06 | 2008-11-25 | Cellectricon Ab | Method and apparatus for spatially confined electroporation |
| US6135990A (en) * | 1997-12-17 | 2000-10-24 | University Of South Florida | Electroporation device and method |
| US6778853B1 (en) | 1997-12-17 | 2004-08-17 | University Of South Florida | Electroporation device |
| US6009347A (en) * | 1998-01-27 | 1999-12-28 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
| US6208893B1 (en) | 1998-01-27 | 2001-03-27 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
| CA2320377C (en) | 1998-02-24 | 2008-07-08 | Boston Scientific Limited | High flow rate dialysis catheters and related methods |
| US6027488A (en) * | 1998-06-03 | 2000-02-22 | Genetronics, Inc. | Flow-through electroporation system for ex vivo gene therapy |
| US20040229363A1 (en) * | 1998-06-24 | 2004-11-18 | Ed Nolan | High efficiency transfection based on low electric field strength, long pulse length |
| ES2291035T3 (es) * | 1998-06-26 | 2008-02-16 | Genetronics, Inc. | Sinergismo de efectos dinamicos y de electropermeabilizacion sobre la vitalidad celular como nuevo agente citotoxico. |
| US7922709B2 (en) * | 1998-07-13 | 2011-04-12 | Genetronics, Inc. | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation |
| US6678556B1 (en) | 1998-07-13 | 2004-01-13 | Genetronics, Inc. | Electrical field therapy with reduced histopathological change in muscle |
| CA2337652C (en) | 1998-07-13 | 2013-03-26 | Genetronics, Inc. | Skin and muscle-targeted gene therapy by pulsed electrical field |
| WO2000002620A1 (en) | 1998-07-13 | 2000-01-20 | Genetronics, Inc. | Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications |
| CA2338280A1 (en) | 1998-07-20 | 2000-02-03 | Andrew W. Hannaman | Electroporation electrodes |
| US6319901B1 (en) | 1998-10-15 | 2001-11-20 | Ichor Medical Systems, Inc. | Methods for prolonging cell membrane permeability |
| US6314316B1 (en) * | 1998-12-17 | 2001-11-06 | University Of South Florida | Nonpenetrating electroporation device and method |
| US6937890B2 (en) * | 1998-12-17 | 2005-08-30 | University Of South Florida | Nonpenetrating electroporation device |
| EP1163024B1 (en) * | 1999-01-28 | 2003-12-17 | Cyto Pulse Sciences, Inc. | Delivery of macromolecules into cells |
| US6684104B2 (en) * | 1999-04-14 | 2004-01-27 | Transneuronix, Inc. | Gastric stimulator apparatus and method for installing |
| US6542776B1 (en) * | 1999-04-14 | 2003-04-01 | Transneuronix Inc. | Gastric stimulator apparatus and method for installing |
| US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US6300108B1 (en) * | 1999-07-21 | 2001-10-09 | The Regents Of The University Of California | Controlled electroporation and mass transfer across cell membranes |
| US6522927B1 (en) | 1999-12-01 | 2003-02-18 | Vertis Neuroscience, Inc. | Electrode assembly for a percutaneous electrical therapy system |
| US6539264B1 (en) | 1999-12-01 | 2003-03-25 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with sharp point protection |
| US6493592B1 (en) | 1999-12-01 | 2002-12-10 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode position maintenance |
| US6556869B1 (en) | 1999-12-01 | 2003-04-29 | Vertis Neuroscience, Inc. | Electrode introducer for a percutaneous electrical therapy system |
| US6549797B1 (en) | 1999-12-01 | 2003-04-15 | Vertis Neuroscience, Inc. | Electrode remover for a percutaneous electrical therapy system |
| US6516226B1 (en) | 1999-12-01 | 2003-02-04 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system for minimizing electrode insertion discomfort |
| US6529776B1 (en) * | 1999-12-01 | 2003-03-04 | Vertis Neuroscience, Inc. | Method and apparatus for repositioning a percutaneous probe |
| US6549810B1 (en) | 1999-12-01 | 2003-04-15 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode depth control |
| US6622051B1 (en) | 1999-12-01 | 2003-09-16 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode entry angle control |
| US6904324B2 (en) * | 1999-12-01 | 2005-06-07 | Meagan Medical, Inc. | Method and apparatus for deploying a percutaneous probe |
| US6912424B2 (en) * | 1999-12-01 | 2005-06-28 | Meagan, Medical, Inc. | Apparatus and method for coupling therapeutic and/or monitoring equipment to a patient |
| US6560491B1 (en) | 1999-12-01 | 2003-05-06 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system providing electrode axial support |
| DE69922270T2 (de) | 1999-12-15 | 2005-11-10 | University Of South Florida, Tampa | Vorrichtung zur elektroporation |
| US6714816B1 (en) * | 2000-02-22 | 2004-03-30 | University Of South Florida | Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo |
| US8024048B2 (en) | 2000-03-13 | 2011-09-20 | Ionix Medical Inc. | Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy |
| US7742811B2 (en) | 2000-03-13 | 2010-06-22 | Onco Stim | Implantable device and method for the electrical treatment of cancer |
| US7756584B2 (en) * | 2000-07-13 | 2010-07-13 | Advanced Neuromodulation Systems, Inc. | Methods and apparatus for effectuating a lasting change in a neural-function of a patient |
| JP2004520865A (ja) * | 2000-07-25 | 2004-07-15 | リタ メディカル システムズ インコーポレイテッド | 局在化インピーダンス測定を使用する腫瘍の検出および処置のための装置 |
| US8251986B2 (en) | 2000-08-17 | 2012-08-28 | Angiodynamics, Inc. | Method of destroying tissue cells by eletroporation |
| US6892099B2 (en) | 2001-02-08 | 2005-05-10 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation |
| US6697670B2 (en) * | 2001-08-17 | 2004-02-24 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients |
| US6795728B2 (en) | 2001-08-17 | 2004-09-21 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation |
| US7118555B2 (en) * | 2000-09-21 | 2006-10-10 | Meagan Medical, Inc. | Method and apparatus for repositioning a percutaneous probe |
| USD480478S1 (en) | 2000-09-28 | 2003-10-07 | Vertis Neuroscience, Inc. | Percutaneous probe applicator |
| US6701190B2 (en) | 2000-10-10 | 2004-03-02 | Meagan Medical, Inc. | System and method for varying characteristics of electrical therapy |
| US6671557B1 (en) | 2000-10-10 | 2003-12-30 | Meagan Medical, Inc. | System and method for providing percutaneous electrical therapy |
| US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
| US7131987B2 (en) | 2000-10-16 | 2006-11-07 | Corium International, Inc. | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
| US6821281B2 (en) * | 2000-10-16 | 2004-11-23 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
| US20050043726A1 (en) * | 2001-03-07 | 2005-02-24 | Mchale Anthony Patrick | Device II |
| US6663820B2 (en) * | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
| DE20109099U1 (de) * | 2001-05-30 | 2001-08-09 | Schönfeld, Andreas, Dipl.-Ing., 76189 Karlsruhe | Vorrichtung zur Behandlung von Tumoren |
| DE10129912A1 (de) * | 2001-06-21 | 2003-01-02 | Efmt Entwicklungs Und Forschun | Nadelelektrode |
| US20040204669A1 (en) * | 2001-07-05 | 2004-10-14 | Hofmann Gunter A. | Apparatus for electroporation mediated delivery for drugs and genes |
| US7130697B2 (en) * | 2002-08-13 | 2006-10-31 | Minnesota Medical Physics Llc | Apparatus and method for the treatment of benign prostatic hyperplasia |
| US6994706B2 (en) | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
| USRE42016E1 (en) | 2001-08-13 | 2010-12-28 | Angiodynamics, Inc. | Apparatus and method for the treatment of benign prostatic hyperplasia |
| US20040087992A1 (en) * | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
| USD475463S1 (en) | 2001-09-28 | 2003-06-03 | Vertis Neuroscience, Inc. | Control device for delivering electrical therapy |
| CA2468424A1 (en) * | 2001-11-27 | 2003-06-05 | Cecilia Farre | A method for combined parallel agent delivery and electroporation for cell structures and use thereof |
| US20030170898A1 (en) * | 2001-12-04 | 2003-09-11 | Gundersen Martin A. | Method for intracellular modifications within living cells using pulsed electric fields |
| CN1630707A (zh) * | 2002-02-12 | 2005-06-22 | 色雷特康公司 | 用于快速改变传感器周围溶液环境的系统与方法 |
| US8209006B2 (en) * | 2002-03-07 | 2012-06-26 | Vgx Pharmaceuticals, Inc. | Constant current electroporation device and methods of use |
| US7245963B2 (en) * | 2002-03-07 | 2007-07-17 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
| CA2995944C (en) * | 2002-03-07 | 2023-09-12 | Advisys, Inc. | Electrode system for facilitating macromolecule introduction |
| EP1494720A4 (en) * | 2002-03-22 | 2009-12-30 | Univ California | METHOD AND APPARATUS FOR USING ELECTROMAGNETIC FIELD IN CELLULAR TRANSPLANTATION |
| US6912417B1 (en) * | 2002-04-05 | 2005-06-28 | Ichor Medical Systmes, Inc. | Method and apparatus for delivery of therapeutic agents |
| AU2003223351A1 (en) | 2002-04-16 | 2003-11-03 | Cyto Pulse Sciences, Inc. | Method of treating biological materials with translating electrical fields and electrode polarity reversal |
| EP1515775A4 (en) * | 2002-05-07 | 2010-03-03 | Oncostim Inc | METHOD AND DEVICE FOR TREATING CANCER WITH ELECTROTHERAPY ASSOCIATED WITH CHEMOTHERAPEAN MEDICAMENTS AND RADIOTHERAPY |
| EP1506039B1 (en) * | 2002-05-23 | 2008-10-29 | Gendel Limited | Ablation device |
| AU2003278461A1 (en) | 2002-10-16 | 2004-05-04 | Cellectricon Ab | Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells |
| WO2004052182A2 (en) * | 2002-12-11 | 2004-06-24 | Proteus Biomedical, Inc. | Monitoring and treating hemodynamic parameters |
| US7204798B2 (en) * | 2003-01-24 | 2007-04-17 | Proteus Biomedical, Inc. | Methods and systems for measuring cardiac parameters |
| US7578954B2 (en) * | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
| CA2432810A1 (en) * | 2003-06-19 | 2004-12-19 | Andres M. Lozano | Method of treating depression, mood disorders and anxiety disorders by brian infusion |
| GB2403148C2 (en) | 2003-06-23 | 2013-02-13 | Microsulis Ltd | Radiation applicator |
| WO2005011805A2 (en) * | 2003-08-01 | 2005-02-10 | Northstar Neuroscience, Inc. | Apparatus and methods for applying neural stimulation to a patient |
| US8298222B2 (en) | 2003-12-24 | 2012-10-30 | The Regents Of The University Of California | Electroporation to deliver chemotherapeutics and enhance tumor regression |
| ES2543832T3 (es) | 2003-12-24 | 2015-08-24 | The Regents Of The University Of California | Ablación de tejido con electroporación irreversible |
| GB0402569D0 (en) * | 2004-02-05 | 2004-03-10 | Neurodan As | Nerve and/or muscle stimulation electrodes |
| HUE025052T2 (en) | 2004-03-08 | 2016-01-28 | Ichor Medical Systems Inc | A sharpened device for electrically mediated delivery of medical substances |
| CA2560840C (en) * | 2004-03-24 | 2014-05-06 | Corium International, Inc. | Transdermal delivery device |
| JP4443278B2 (ja) * | 2004-03-26 | 2010-03-31 | テルモ株式会社 | 拡張体付カテーテル |
| EP1742588B1 (en) | 2004-04-01 | 2016-10-19 | The General Hospital Corporation | Apparatus for dermatological treatment and tissue reshaping |
| US7720549B2 (en) * | 2004-04-06 | 2010-05-18 | Oncostim, Inc. | Partially implantable system for the electrical treatment of abnormal tissue growth |
| US20050222646A1 (en) * | 2004-04-06 | 2005-10-06 | Kai Kroll | Method and device for treating cancer with modified output electrical therapy |
| US7313442B2 (en) * | 2004-04-30 | 2007-12-25 | Advanced Neuromodulation Systems, Inc. | Method of treating mood disorders and/or anxiety disorders by brain stimulation |
| US7706873B2 (en) * | 2004-05-05 | 2010-04-27 | Mario Ammirati | System and method for controlled delivery of a therapeutic agent to a target location within an internal body tissue |
| FR2872055B1 (fr) | 2004-06-24 | 2008-02-08 | Yves Leon Scherman | Dispositif pour le transfert de molecules aux cellules utilisant une force d'origine physique et combinaison permettant la mise en oeuvre du procede |
| FR2880808A1 (fr) | 2005-01-20 | 2006-07-21 | Yves Scherman | Dispositif pour l'administration de principe actif aux cellules et tissus a l'aide d'electrodes de surface non invasives |
| FR2872056B1 (fr) | 2004-06-24 | 2007-08-10 | Yves Scherman | Dispositif pour l'administration de principe actif aux cellules et tissus utilisant une ou deux forces physiques |
| GB2415630C2 (en) | 2004-07-02 | 2007-03-22 | Microsulis Ltd | Radiation applicator and method of radiating tissue |
| EP1799101A4 (en) * | 2004-09-02 | 2008-11-19 | Proteus Biomedical Inc | METHOD AND DEVICES FOR TISSUE ACTIVATION AND MONITORING |
| GB0502384D0 (en) * | 2005-02-04 | 2005-03-16 | Instrumedical Ltd | Electro-surgical needle apparatus |
| WO2006094072A2 (en) * | 2005-03-01 | 2006-09-08 | Functional Neuroscience Inc. | Method of treating cognitive disorders using neuromodulation |
| JP2008535538A (ja) * | 2005-03-01 | 2008-09-04 | ファンクショナル ニューロサイエンス インコーポレイテッド | 神経変調を用いて、鬱病、気分障害および不安障害を処置するための方法 |
| EP1698907A1 (en) * | 2005-03-04 | 2006-09-06 | Cardiatis Société Anonyme | Interventional medical device for use in MRI |
| US8036743B2 (en) * | 2005-03-31 | 2011-10-11 | Proteus Biomedical, Inc. | Automated optimization of multi-electrode pacing for cardiac resynchronization |
| US20060264752A1 (en) * | 2005-04-27 | 2006-11-23 | The Regents Of The University Of California | Electroporation controlled with real time imaging |
| EP1899001B1 (en) * | 2005-06-08 | 2017-10-25 | Novocure Limited | Apparatus for treating cancer with electric fields that are guided to desired locations within a body |
| US20060293730A1 (en) | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating restenosis sites using electroporation |
| US20060293725A1 (en) * | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating fatty tissue sites using electroporation |
| US8114070B2 (en) * | 2005-06-24 | 2012-02-14 | Angiodynamics, Inc. | Methods and systems for treating BPH using electroporation |
| US20060293731A1 (en) * | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating tumors using electroporation |
| WO2007004831A1 (en) * | 2005-06-30 | 2007-01-11 | Lg Electronics Inc. | Method and apparatus for encoding and decoding an audio signal |
| GB2434314B (en) | 2006-01-03 | 2011-06-15 | Microsulis Ltd | Microwave applicator with dipole antenna |
| WO2007021804A2 (en) * | 2005-08-12 | 2007-02-22 | Proteus Biomedical, Inc. | Evaluation of depolarization wave conduction velocity |
| US20070142885A1 (en) * | 2005-11-29 | 2007-06-21 | Reliant Technologies, Inc. | Method and Apparatus for Micro-Needle Array Electrode Treatment of Tissue |
| JP2009521276A (ja) * | 2005-12-22 | 2009-06-04 | プロテウス バイオメディカル インコーポレイテッド | 植え込み型集積回路 |
| US20070156135A1 (en) * | 2006-01-03 | 2007-07-05 | Boris Rubinsky | System and methods for treating atrial fibrillation using electroporation |
| US10369359B2 (en) * | 2006-02-11 | 2019-08-06 | Genetronics, Inc. | Device and method for single-needle in vivo electroporation |
| WO2007117651A2 (en) * | 2006-04-07 | 2007-10-18 | University Of South Florida | Passive electric field focus system for in vivo and in vitro applications |
| ES2336626T3 (es) * | 2006-06-12 | 2010-04-14 | Region Hovedstaden V/Herlev Hospital | Dispositivo introductor de electrodos. |
| EP2076313A4 (en) * | 2006-10-16 | 2012-07-25 | Univ California | GELE WITH PRE-DEFINED CONDUCTIVITY FOR THE FINAL ELECTROPORATION OF A TISSUE |
| US20080132885A1 (en) * | 2006-12-01 | 2008-06-05 | Boris Rubinsky | Methods for treating tissue sites using electroporation |
| US20080132884A1 (en) * | 2006-12-01 | 2008-06-05 | Boris Rubinsky | Systems for treating tissue sites using electroporation |
| EP2121111B1 (en) * | 2007-01-22 | 2018-03-14 | Corium International, Inc. | Applicators for microneedle arrays |
| US7655004B2 (en) | 2007-02-15 | 2010-02-02 | Ethicon Endo-Surgery, Inc. | Electroporation ablation apparatus, system, and method |
| WO2008130587A2 (en) | 2007-04-16 | 2008-10-30 | Corium International, Inc. | Solvent-cast microneedle arrays containing active |
| US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| WO2008146075A1 (de) * | 2007-05-31 | 2008-12-04 | Biophox Gmbh & Co. Kg | Einrichtung zur behandlung von tumoren |
| US20090088703A1 (en) * | 2007-09-13 | 2009-04-02 | Kouros Azar | Skin treatment system and method |
| US20100298759A1 (en) * | 2007-10-11 | 2010-11-25 | Region Hovedstaden V/Herlev Hospital | electroporation device for improved electrical field control |
| JP5178132B2 (ja) * | 2007-10-11 | 2013-04-10 | キヤノン株式会社 | 画像処理システム並びに画像処理方法 |
| US8538537B2 (en) * | 2007-12-07 | 2013-09-17 | Advanced Neuromodulations Systems, Inc. | Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropyschiatric and neuropyschological disorders |
| CA2710408C (en) | 2008-01-17 | 2023-10-31 | Genetronics, Inc. | Variable current density single needle electroporation system and method |
| US8473069B2 (en) * | 2008-02-28 | 2013-06-25 | Proteus Digital Health, Inc. | Integrated circuit implementation and fault control system, device, and method |
| US20090248012A1 (en) * | 2008-03-27 | 2009-10-01 | The Regents Of The University Of California | Irreversible electroporation device and method for attenuating neointimal |
| US20100004623A1 (en) * | 2008-03-27 | 2010-01-07 | Angiodynamics, Inc. | Method for Treatment of Complications Associated with Arteriovenous Grafts and Fistulas Using Electroporation |
| US10448989B2 (en) | 2009-04-09 | 2019-10-22 | Virginia Tech Intellectual Properties, Inc. | High-frequency electroporation for cancer therapy |
| US10245098B2 (en) | 2008-04-29 | 2019-04-02 | Virginia Tech Intellectual Properties, Inc. | Acute blood-brain barrier disruption using electrical energy based therapy |
| US9283051B2 (en) | 2008-04-29 | 2016-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating a treatment volume for administering electrical-energy based therapies |
| US10238447B2 (en) | 2008-04-29 | 2019-03-26 | Virginia Tech Intellectual Properties, Inc. | System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress |
| US10272178B2 (en) | 2008-04-29 | 2019-04-30 | Virginia Tech Intellectual Properties Inc. | Methods for blood-brain barrier disruption using electrical energy |
| US10117707B2 (en) | 2008-04-29 | 2018-11-06 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
| US9198733B2 (en) | 2008-04-29 | 2015-12-01 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for electroporation-based therapies |
| US8992517B2 (en) * | 2008-04-29 | 2015-03-31 | Virginia Tech Intellectual Properties Inc. | Irreversible electroporation to treat aberrant cell masses |
| US9867652B2 (en) | 2008-04-29 | 2018-01-16 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds |
| US10702326B2 (en) | 2011-07-15 | 2020-07-07 | Virginia Tech Intellectual Properties, Inc. | Device and method for electroporation based treatment of stenosis of a tubular body part |
| US11254926B2 (en) | 2008-04-29 | 2022-02-22 | Virginia Tech Intellectual Properties, Inc. | Devices and methods for high frequency electroporation |
| US11272979B2 (en) | 2008-04-29 | 2022-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
| WO2009134876A1 (en) | 2008-04-29 | 2009-11-05 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation to create tissue scaffolds |
| WO2009137800A2 (en) | 2008-05-09 | 2009-11-12 | Angiodynamics, Inc. | Electroporation device and method |
| US20090287266A1 (en) * | 2008-05-13 | 2009-11-19 | Mark Zdeblick | High-voltage tolerant multiplex multi-electrode stimulation systems and methods for using the same |
| US9173704B2 (en) * | 2008-06-20 | 2015-11-03 | Angiodynamics, Inc. | Device and method for the ablation of fibrin sheath formation on a venous catheter |
| WO2010008834A2 (en) * | 2008-06-23 | 2010-01-21 | Angiodynamics, Inc. | Treatment devices and methods |
| US8888792B2 (en) | 2008-07-14 | 2014-11-18 | Ethicon Endo-Surgery, Inc. | Tissue apposition clip application devices and methods |
| US10736689B2 (en) | 2008-08-20 | 2020-08-11 | Prostacare Pty Ltd | Low-corrosion electrode for treating tissue |
| JP2012508624A (ja) * | 2008-11-13 | 2012-04-12 | プロテウス バイオメディカル インコーポレイテッド | 多重化複数電極神経刺激装置 |
| JP2012508627A (ja) * | 2008-11-13 | 2012-04-12 | プロテウス バイオメディカル インコーポレイテッド | ペーシングおよび刺激システム、デバイス、および方法 |
| EP2349466A4 (en) | 2008-11-13 | 2013-03-20 | Proteus Digital Health Inc | SHIELDED STIMULATION AND DETECTION SYSTEM AND METHOD THEREFOR |
| WO2010059527A2 (en) * | 2008-11-18 | 2010-05-27 | Proteus Biomedical, Inc. | Sensing system, device, and method for therapy modulation |
| US8157834B2 (en) | 2008-11-25 | 2012-04-17 | Ethicon Endo-Surgery, Inc. | Rotational coupling device for surgical instrument with flexible actuators |
| US20110022113A1 (en) * | 2008-12-02 | 2011-01-27 | Mark Zdeblick | Analyzer Compatible Communication Protocol |
| US20100152725A1 (en) * | 2008-12-12 | 2010-06-17 | Angiodynamics, Inc. | Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation |
| US8361066B2 (en) | 2009-01-12 | 2013-01-29 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
| US8753335B2 (en) * | 2009-01-23 | 2014-06-17 | Angiodynamics, Inc. | Therapeutic energy delivery device with rotational mechanism |
| WO2010093692A2 (en) * | 2009-02-10 | 2010-08-19 | Hobbs Eamonn P | Irreversible electroporation and tissue regeneration |
| US20100240995A1 (en) * | 2009-03-17 | 2010-09-23 | Bioelectromed Corp. | System and method for treating tumors |
| US8632534B2 (en) | 2009-04-03 | 2014-01-21 | Angiodynamics, Inc. | Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD) |
| US11638603B2 (en) | 2009-04-09 | 2023-05-02 | Virginia Tech Intellectual Properties, Inc. | Selective modulation of intracellular effects of cells using pulsed electric fields |
| WO2010118387A1 (en) * | 2009-04-09 | 2010-10-14 | Virginia Tech Intellectual Properties, Inc. | Integration of very short electric pulses for minimally to noninvasive electroporation |
| US11382681B2 (en) | 2009-04-09 | 2022-07-12 | Virginia Tech Intellectual Properties, Inc. | Device and methods for delivery of high frequency electrical pulses for non-thermal ablation |
| WO2010120866A2 (en) * | 2009-04-14 | 2010-10-21 | Old Dominion University Research Foundation | Medical instrument for delivery of high voltage pulses and method of delivering the same |
| US20110006458A1 (en) * | 2009-04-24 | 2011-01-13 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
| USD630321S1 (en) | 2009-05-08 | 2011-01-04 | Angio Dynamics, Inc. | Probe handle |
| US8903488B2 (en) | 2009-05-28 | 2014-12-02 | Angiodynamics, Inc. | System and method for synchronizing energy delivery to the cardiac rhythm |
| US9895189B2 (en) | 2009-06-19 | 2018-02-20 | Angiodynamics, Inc. | Methods of sterilization and treating infection using irreversible electroporation |
| EP2457241A2 (en) | 2009-07-23 | 2012-05-30 | Proteus Biomedical, Inc. | Solid-state thin film capacitor |
| EP2470255A4 (en) * | 2009-08-24 | 2013-02-06 | Ron L Alterman | DEVICE FOR TRANSCEREBRAL ELECTROPHORESIS AND METHOD FOR THEIR USE |
| GB2474233A (en) | 2009-10-06 | 2011-04-13 | Uk Investments Associates Llc | Cooling pump comprising a detachable head portion |
| US20110098704A1 (en) | 2009-10-28 | 2011-04-28 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
| US20110118732A1 (en) | 2009-11-19 | 2011-05-19 | The Regents Of The University Of California | Controlled irreversible electroporation |
| US9028483B2 (en) | 2009-12-18 | 2015-05-12 | Ethicon Endo-Surgery, Inc. | Surgical instrument comprising an electrode |
| EP2566501B1 (en) | 2010-05-04 | 2019-03-13 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| US9700368B2 (en) | 2010-10-13 | 2017-07-11 | Angiodynamics, Inc. | System and method for electrically ablating tissue of a patient |
| US8718770B2 (en) | 2010-10-21 | 2014-05-06 | Medtronic, Inc. | Capture threshold measurement for selection of pacing vector |
| WO2012052543A1 (en) * | 2010-10-22 | 2012-04-26 | Herlev Hospital | A method for treating a tissue region with an electric field |
| WO2012082688A1 (en) * | 2010-12-15 | 2012-06-21 | Old Dominion University Research Foundation | Electroporation-induced electrosensitization |
| US9254169B2 (en) | 2011-02-28 | 2016-02-09 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
| US9233241B2 (en) * | 2011-02-28 | 2016-01-12 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
| WO2012125785A1 (en) | 2011-03-17 | 2012-09-20 | Ethicon Endo-Surgery, Inc. | Hand held surgical device for manipulating an internal magnet assembly within a patient |
| US8355784B2 (en) | 2011-05-13 | 2013-01-15 | Medtronic, Inc. | Dynamic representation of multipolar leads in a programmer interface |
| HK1197039A1 (zh) | 2011-06-15 | 2015-01-02 | Chrontech Pharma Ab | 注射针和装置 |
| US9078665B2 (en) | 2011-09-28 | 2015-07-14 | Angiodynamics, Inc. | Multiple treatment zone ablation probe |
| US9414881B2 (en) | 2012-02-08 | 2016-08-16 | Angiodynamics, Inc. | System and method for increasing a target zone for electrical ablation |
| US9427255B2 (en) | 2012-05-14 | 2016-08-30 | Ethicon Endo-Surgery, Inc. | Apparatus for introducing a steerable camera assembly into a patient |
| US9078662B2 (en) | 2012-07-03 | 2015-07-14 | Ethicon Endo-Surgery, Inc. | Endoscopic cap electrode and method for using the same |
| US9144459B2 (en) | 2012-07-19 | 2015-09-29 | Cook Medical Technologies Llc | Endoscopic ultrasound ablation needle |
| US9545290B2 (en) | 2012-07-30 | 2017-01-17 | Ethicon Endo-Surgery, Inc. | Needle probe guide |
| US10314649B2 (en) | 2012-08-02 | 2019-06-11 | Ethicon Endo-Surgery, Inc. | Flexible expandable electrode and method of intraluminal delivery of pulsed power |
| US9277957B2 (en) | 2012-08-15 | 2016-03-08 | Ethicon Endo-Surgery, Inc. | Electrosurgical devices and methods |
| US9020605B2 (en) * | 2012-10-25 | 2015-04-28 | Oncosec Medical Incorporated | Electroporation device |
| MX375307B (es) | 2012-12-21 | 2025-03-06 | Corium Inc | Microarreglo para la entrega de agente terapeutico y metodos de uso. |
| US10098527B2 (en) | 2013-02-27 | 2018-10-16 | Ethidcon Endo-Surgery, Inc. | System for performing a minimally invasive surgical procedure |
| EP2968887B1 (en) | 2013-03-12 | 2022-05-04 | Corium, Inc. | Microprojection applicators |
| AU2014237357B2 (en) | 2013-03-15 | 2019-11-28 | Corium Pharma Solutions, Inc. | Multiple impact microprojection applicators and methods of use |
| EP2968116A1 (en) | 2013-03-15 | 2016-01-20 | Corium International, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| CA2903583C (en) | 2013-03-15 | 2021-12-28 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| MX380204B (es) | 2013-03-15 | 2025-03-12 | Corium Inc | Micrordenamiento para suministro de agente terapeútico y métodos de uso. |
| CA2914195C (en) | 2013-06-03 | 2020-06-02 | Nanoblate Corporation | Methods and devices for stimulating an immune response using nanosecond pulsed electric fields |
| EP3030185B1 (en) * | 2013-08-06 | 2023-05-10 | Memorial Sloan Kettering Cancer Center | System and computer-accessible medium for in-vivo tissue ablation and/or damage |
| CN103555574A (zh) | 2013-11-11 | 2014-02-05 | 苏州文曲生物微系统有限公司 | 一种流式电穿孔装置 |
| US10166321B2 (en) | 2014-01-09 | 2019-01-01 | Angiodynamics, Inc. | High-flow port and infusion needle systems |
| EP3122278A4 (en) | 2014-03-24 | 2017-10-25 | Old Dominion University Research Foundation | Expandable catheter devices electrode array |
| AU2015259303B2 (en) | 2014-05-12 | 2021-10-28 | Arena, Christopher B. | Selective modulation of intracellular effects of cells using pulsed electric fields |
| US12114911B2 (en) | 2014-08-28 | 2024-10-15 | Angiodynamics, Inc. | System and method for ablating a tissue site by electroporation with real-time pulse monitoring |
| US10624843B2 (en) | 2014-09-04 | 2020-04-21 | Corium, Inc. | Microstructure array, methods of making, and methods of use |
| US9724155B2 (en) | 2014-12-01 | 2017-08-08 | Pulse Biosciences, Inc. | Nanoelectroablation control and vaccination |
| US10694972B2 (en) | 2014-12-15 | 2020-06-30 | Virginia Tech Intellectual Properties, Inc. | Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment |
| US10716611B2 (en) | 2015-05-15 | 2020-07-21 | ClearIt, LLC | Systems and methods for tattoo removal using cold plasma |
| WO2017004067A1 (en) | 2015-06-29 | 2017-01-05 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| US11027071B2 (en) * | 2015-12-28 | 2021-06-08 | Inovio Pharmaceuticals, Inc. | Intradermal jet injection electroporation device |
| US20190038472A1 (en) * | 2016-02-08 | 2019-02-07 | Vomaris Innovations, Inc. | Composite bioelectric devices and methods of use |
| EA038691B1 (ru) | 2016-03-28 | 2021-10-05 | Айкор Медикэл Системс, Инк. | Устройство для доставки терапевтических средств |
| US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| US10538786B2 (en) | 2016-04-13 | 2020-01-21 | Janssen Pharmaceuticals, Inc. | Recombinant arterivirus replicon systems and uses thereof |
| IT201600068691A1 (it) * | 2016-07-01 | 2018-01-01 | Igea S P A | Sistema di movimentazione e controllo per elettrodi espandibili di un manipolo utilizzabile in un procedimento di elettro-porazione |
| MX2019004499A (es) | 2016-10-17 | 2019-11-18 | Janssen Pharmaceuticals Inc Star | Sistemas de replicón de virus recombinante y usos de estos. |
| US10905492B2 (en) | 2016-11-17 | 2021-02-02 | Angiodynamics, Inc. | Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode |
| AU2017372731B2 (en) | 2016-12-05 | 2024-05-23 | Janssen Pharmaceuticals, Inc. | Compositions and methods for enhancing gene expression |
| US11045648B2 (en) | 2017-11-14 | 2021-06-29 | Boston Scientific Scimed, Inc. | Irreversible electroporation through a combination of substance injection and electrical field application |
| DE202018106744U1 (de) | 2017-11-27 | 2019-05-13 | Prostacare Pty Ltd | Vorrichtung für die Behandlung einer Prostataerkrankung |
| US11607537B2 (en) | 2017-12-05 | 2023-03-21 | Virginia Tech Intellectual Properties, Inc. | Method for treating neurological disorders, including tumors, with electroporation |
| EA202091513A1 (ru) | 2017-12-19 | 2020-09-09 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Вакцины против вируса гепатита b (hbv) и их применение |
| US11020476B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV) |
| KR20200101416A (ko) | 2017-12-19 | 2020-08-27 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | B형 간염 바이러스(hbv) 백신 및 그 용도 |
| US11389531B2 (en) | 2017-12-19 | 2022-07-19 | Janssen Sciences Ireland Unlimited Company | Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines |
| SG11202005710YA (en) | 2017-12-19 | 2020-07-29 | Janssen Sciences Ireland Unlimited Co | Methods and compositions for inducing an immune response against hepatitis b virus (hbv) |
| CA3089024A1 (en) | 2018-01-19 | 2019-07-25 | Janssen Pharmaceuticals, Inc. | Induce and enhance immune responses using recombinant replicon systems |
| EP3742998B1 (en) | 2018-01-23 | 2023-11-15 | Boston Scientific Scimed, Inc. | Enhanced needle array and therapies for tumor ablation |
| WO2019168949A1 (en) | 2018-02-28 | 2019-09-06 | Prostacare Pty Ltd | System for managing high impedance changes in a non-thermal ablation system for bph |
| US12390262B2 (en) | 2018-03-13 | 2025-08-19 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
| US11925405B2 (en) | 2018-03-13 | 2024-03-12 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
| US11311329B2 (en) | 2018-03-13 | 2022-04-26 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for immunotherapy based treatments using non-thermal ablation techniques |
| BR112021006614A2 (pt) | 2018-10-08 | 2021-07-20 | Janssen Pharmaceuticals, Inc. | replicons com base em alfavírus para administração de bioterápicos |
| WO2020094622A1 (en) * | 2018-11-05 | 2020-05-14 | Region Hovedstaden V/Herlev Hospital | An electrode assembly for improved electric field distribution |
| WO2020131544A1 (en) * | 2018-12-19 | 2020-06-25 | ClearIt, LLC | Systems and methods for tattoo removal using an applied electric field |
| WO2020190691A1 (en) | 2019-03-15 | 2020-09-24 | Boston Scientific Scimed, Inc. | Time multiplexed waveform for selective cell ablation |
| WO2020255042A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and a pyrimidine derivative |
| US20220241402A1 (en) | 2019-06-18 | 2022-08-04 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives |
| CA3140588A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and small molecule pdl1 or pd1 inhibitor |
| MA56533A (fr) | 2019-06-18 | 2022-04-27 | Janssen Sciences Ireland Unlimited Co | Combinaison de vaccins contre le virus de l'hépatite b (vhb) et d'anticorps anti-pd-1 |
| CA3141003A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and pd-l1 inhibitors |
| WO2020255019A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and a quinazoline derivative |
| WO2020255022A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and aminopyridine derivatives as hpk1 inhibitors |
| CA3140708A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives |
| WO2020255013A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being amide derivatives |
| JP2022536850A (ja) | 2019-06-18 | 2022-08-19 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | Ｂ型肝炎ウイルス（ｈｂｖ）ワクチンおよび抗ｐｄ－１または抗ｐｄ－ｌ１抗体の組合せ |
| US20220305117A1 (en) | 2019-06-18 | 2022-09-29 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai |
| US20220305107A1 (en) | 2019-06-18 | 2022-09-29 | Janssen Sciences Ireland Unlimited Company | COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAi |
| WO2020255010A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of recombinant interleukin 12 construct and hepatitis b virus (hbv) vaccines |
| WO2020255035A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and pyrimidine derivatives |
| WO2020255017A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
| US20220324916A1 (en) | 2019-06-18 | 2022-10-13 | Janssen Sciences Ireland Unlimited Company | Hepatitis B Virus (HBV) Vaccines and Uses Thereof |
| US20220305116A1 (en) | 2019-06-18 | 2022-09-29 | Janssen Sciences lreland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being sulfonamide derivatives |
| CA3140690A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
| WO2020254876A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Virus-like particle delivery of hepatitis b virus (hbv) vaccines |
| WO2020255016A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
| CA3141323A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Recombinant interleukin 12 construct and uses thereof |
| EP3986563A1 (en) | 2019-06-20 | 2022-04-27 | Janssen Sciences Ireland Unlimited Company | Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines |
| MA56534A (fr) | 2019-06-20 | 2022-04-27 | Janssen Sciences Ireland Unlimited Co | Administration par nanoporteurs glucidiques, de vaccins contre le virus de l'hépatite b (vhb) |
| US11950835B2 (en) | 2019-06-28 | 2024-04-09 | Virginia Tech Intellectual Properties, Inc. | Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy |
| US12214189B2 (en) | 2019-07-24 | 2025-02-04 | Virginia Tech Intellectual Properties, Inc. | Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies |
| US11931094B2 (en) | 2019-10-15 | 2024-03-19 | Boston Scientific Scimed, Inc. | Control system and user interface for an ablation system |
| US12121739B2 (en) | 2019-12-31 | 2024-10-22 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
| US11992260B2 (en) | 2020-03-31 | 2024-05-28 | Boston Scientific Scimed, Inc. | Smart probe identification for ablation modalities |
| IL299571A (en) | 2020-07-08 | 2023-02-01 | Janssen Sciences Ireland Unlimited Co | Rna replicon vaccines against hbv |
| US11771373B2 (en) | 2020-11-09 | 2023-10-03 | Biosense Webster (Israel) Ltd. | Staggered electrode arrangements for electrophysiological sensing |
| US12485279B2 (en) | 2020-11-25 | 2025-12-02 | Virginia Tech Intellectual Properties, Inc. | Methods for modulating temporal infrastructure of pulsed electric fields |
| TW202245809A (zh) | 2020-12-18 | 2022-12-01 | 美商詹森藥物公司 | 用於治療b型肝炎病毒感染之組合療法 |
| US20240316090A1 (en) | 2020-12-28 | 2024-09-26 | Arcturus Therapeutics, Inc. | Transcription activator-like effector nucleases (talens) targeting hbv |
| US20230330426A1 (en) * | 2022-04-16 | 2023-10-19 | Medtronic, Inc. | Implantation techniques for electric field therapy |
| WO2023233290A1 (en) | 2022-05-31 | 2023-12-07 | Janssen Sciences Ireland Unlimited Company | Rnai agents targeting pd-l1 |
| CN115102530B (zh) * | 2022-08-29 | 2023-09-29 | 赛福凯尔(绍兴)医疗科技有限公司 | 一种用于抑制肿瘤细胞的电场发生装置及系统 |
| USD1084316S1 (en) | 2023-11-20 | 2025-07-15 | Angiodynamics, Inc. | Ferrule |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3991755A (en) * | 1973-07-27 | 1976-11-16 | Medicon, Inc. | Iontophoresis apparatus for applying local anesthetics |
| US3957053A (en) * | 1975-03-03 | 1976-05-18 | Yen Kong Woo | Detachably connected acupuncture needles |
| US4141359A (en) * | 1976-08-16 | 1979-02-27 | University Of Utah | Epidermal iontophoresis device |
| US4250878A (en) * | 1978-11-22 | 1981-02-17 | Motion Control, Inc. | Non-invasive chemical species delivery apparatus and method |
| WO1981000964A1 (en) * | 1979-10-10 | 1981-04-16 | Cyclotech Med Ind | Pain blocking bandage |
| US4381789A (en) * | 1979-11-20 | 1983-05-03 | Siemens Aktiengesellschaft | Electrode system |
| US4837049A (en) * | 1986-06-17 | 1989-06-06 | Alfred E. Mann Foundation For Scientific Research | Method of making an electrode array |
| US5128257A (en) * | 1987-08-31 | 1992-07-07 | Baer Bradford W | Electroporation apparatus and process |
| US5389069A (en) * | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
| US5749847A (en) * | 1988-01-21 | 1998-05-12 | Massachusetts Institute Of Technology | Delivery of nucleotides into organisms by electroporation |
| US5547467A (en) * | 1988-01-21 | 1996-08-20 | Massachusettes Institute Of Technology | Method for rapid temporal control of molecular transport across tissue |
| JP2798459B2 (ja) * | 1988-01-21 | 1998-09-17 | マサチユセツツ・インスチチユート・オブ・テクノロジー | エレクトロポレーションを利用した診断装置及び分子の組織内移動装置 |
| CS275292B2 (en) * | 1989-02-22 | 1992-02-19 | Cvut Fakulta Elektrotechnick | Private rehabilitation apparatus with ion transcutaneous acceleration |
| US5215088A (en) * | 1989-11-07 | 1993-06-01 | The University Of Utah | Three-dimensional electrode device |
| US5545130A (en) * | 1992-04-08 | 1996-08-13 | Genetronics, Inc. | Flow through electroporation method |
| US5501662A (en) * | 1992-05-22 | 1996-03-26 | Genetronics, Inc. | Implantable electroporation method and apparatus for drug and gene delivery |
| US5507724A (en) * | 1992-07-01 | 1996-04-16 | Genetronics, Inc. | Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells |
| US5304120A (en) * | 1992-07-01 | 1994-04-19 | Btx Inc. | Electroporation method and apparatus for insertion of drugs and genes into endothelial cells |
| US5273525A (en) * | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
| US5462520A (en) * | 1992-08-17 | 1995-10-31 | Genetronics, Inc. | Transsurface drug delivery by electrofusion of microbubbles to the tissue surface |
| US5464386A (en) * | 1992-08-17 | 1995-11-07 | Genetronics, Inc. | Transdermal drug delivery by electroincorporation of vesicles |
| US5688233A (en) * | 1992-08-17 | 1997-11-18 | Genetronics, Inc. | Electronincorporation enhanced transdermal delivery of molecules |
| US5468223A (en) * | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
| US5298017A (en) * | 1992-12-29 | 1994-03-29 | Alza Corporation | Layered electrotransport drug delivery system |
| FR2703253B1 (fr) * | 1993-03-30 | 1995-06-23 | Centre Nat Rech Scient | Applicateur d'impulsions electriques pour traitement de tissus biologiques. |
| US5702359A (en) * | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
| US5993434A (en) * | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
| US5439440A (en) * | 1993-04-01 | 1995-08-08 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
| EP0716863B1 (en) * | 1993-06-08 | 2002-05-08 | Hisamitsu Pharmaceutical Co., Inc. | Iontophoresis system |
| IL108775A (en) * | 1994-02-25 | 2003-09-17 | Univ Ramot | Method for efficient incorporation of molecules into cells |
| US5704908A (en) * | 1996-10-10 | 1998-01-06 | Genetronics, Inc. | Electroporation and iontophoresis catheter with porous balloon |
| US5873849A (en) * | 1997-04-24 | 1999-02-23 | Ichor Medical Systems, Inc. | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
-
1997
- 1997-04-24 US US08/845,553 patent/US5873849A/en not_active Expired - Lifetime
-
1998
- 1998-04-23 JP JP54633698A patent/JP2001522274A/ja not_active Ceased
- 1998-04-23 AU AU71515/98A patent/AU734611B2/en not_active Ceased
- 1998-04-23 WO PCT/US1998/008183 patent/WO1998047562A1/en not_active Ceased
- 1998-04-23 EP EP98918621A patent/EP0973579A4/en not_active Withdrawn
- 1998-04-23 CA CA002287366A patent/CA2287366A1/en not_active Abandoned
- 1998-11-09 US US09/188,627 patent/US6278895B1/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010533023A (ja) * | 2007-07-10 | 2010-10-21 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 神経刺激システム |
| US8694105B2 (en) | 2007-07-10 | 2014-04-08 | Sapiens Steering Brain Stimulation B.V. | Neurostimulation system having a controller for controlling the supply of electrical pulses |
| US12303459B2 (en) | 2008-08-06 | 2025-05-20 | Serendia, Llc | Method, system, and apparatus for dermatological treatment |
| JP2024535582A (ja) * | 2021-10-22 | 2024-09-30 | 杭州維納安可医療科技有限責任公司 | 電場発生装置及びその制御方法、コンピュータ可読記憶媒体 |
| JP7783470B2 (ja) | 2021-10-22 | 2025-12-10 | 杭州維納安可医療科技有限責任公司 | 電場発生装置及びその制御方法、コンピュータ可読記憶媒体 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0973579A1 (en) | 2000-01-26 |
| US5873849A (en) | 1999-02-23 |
| EP0973579A4 (en) | 2000-11-02 |
| AU7151598A (en) | 1998-11-13 |
| CA2287366A1 (en) | 1998-10-29 |
| AU734611B2 (en) | 2001-06-21 |
| WO1998047562A1 (en) | 1998-10-29 |
| US6278895B1 (en) | 2001-08-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2001522274A (ja) | 電極および電極配列 | |
| JP4050331B2 (ja) | 接続電極テンプレートを有する電気穿孔装置 | |
| RU2168337C2 (ru) | Способ лечения с введением лекарственных препаратов и генов посредством электропорации | |
| US6972013B1 (en) | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation | |
| KR100756252B1 (ko) | 일렉트로포레이션에 의한 약제와 유전자 전달 방법 및 장치 | |
| US6697669B2 (en) | Skin and muscle-targeted gene therapy by pulsed electrical field | |
| US7171264B1 (en) | Intradermal delivery of active agents by needle-free injection and electroporation | |
| US6678556B1 (en) | Electrical field therapy with reduced histopathological change in muscle | |
| US6662044B2 (en) | Iontophoresis, electroporation and combination patches for local drug delivery to body tissues | |
| KR100260238B1 (ko) | 약물과 유전자의 전달을 매개하는 전기도입 치료방법 | |
| US7922709B2 (en) | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation | |
| JP2002535100A (ja) | 細胞内への巨大分子の送達 | |
| EP1183068A1 (en) | Method of electroporation-enhanced delivery of active agents | |
| US20040092860A1 (en) | Skin and muscle-targeted gene therapy by pulsed electrical field | |
| JP2003516829A (ja) | 電気穿孔素子及び電気穿孔方法 | |
| Abd-Elghany | Interaction of living cells with electric pulses: Parameters and possible applications |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050422 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050422 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20070831 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20071023 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080123 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080303 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080225 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080414 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080324 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080512 |
|
| A313 | Final decision of rejection without a dissenting response from the applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A313 Effective date: 20080617 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20080729 |