JP2001519426A5 - - Google Patents

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Publication number
JP2001519426A5
JP2001519426A5 JP2000515891A JP2000515891A JP2001519426A5 JP 2001519426 A5 JP2001519426 A5 JP 2001519426A5 JP 2000515891 A JP2000515891 A JP 2000515891A JP 2000515891 A JP2000515891 A JP 2000515891A JP 2001519426 A5 JP2001519426 A5 JP 2001519426A5
Authority
JP
Japan
Prior art keywords
cancer
composition according
treating
breast
breast cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000515891A
Other languages
English (en)
Japanese (ja)
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JP2001519426A (ja
Filing date
Publication date
Priority claimed from US08/948,226 external-priority patent/US6207842B1/en
Application filed filed Critical
Publication of JP2001519426A publication Critical patent/JP2001519426A/ja
Publication of JP2001519426A5 publication Critical patent/JP2001519426A5/ja
Pending legal-status Critical Current

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JP2000515891A 1997-10-09 1998-10-09 ポリフェノールの合成方法 Pending JP2001519426A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/948,226 US6207842B1 (en) 1997-10-09 1997-10-09 Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
US08/948,226 1997-10-09
PCT/US1998/021392 WO1999019319A1 (en) 1997-10-09 1998-10-09 Synthetic methods for polyphenols

Publications (2)

Publication Number Publication Date
JP2001519426A JP2001519426A (ja) 2001-10-23
JP2001519426A5 true JP2001519426A5 (https=) 2006-01-05

Family

ID=25487506

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000515891A Pending JP2001519426A (ja) 1997-10-09 1998-10-09 ポリフェノールの合成方法

Country Status (13)

Country Link
US (6) US6207842B1 (https=)
EP (1) EP1027345B1 (https=)
JP (1) JP2001519426A (https=)
KR (1) KR100560463B1 (https=)
CN (2) CN100341867C (https=)
AT (1) ATE232857T1 (https=)
AU (1) AU760031B2 (https=)
CA (1) CA2306851A1 (https=)
DE (1) DE69811526T2 (https=)
DK (1) DK1027345T3 (https=)
ES (1) ES2189260T3 (https=)
IL (1) IL135344A (https=)
WO (1) WO1999019319A1 (https=)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017998A1 (en) * 1997-05-16 2003-01-23 Snow Alan D. Proanthocyanidins for the treatment of amyloid and alpha-synuclein diseases
US6207842B1 (en) * 1997-10-09 2001-03-27 Mars Incorporated Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
US7015338B1 (en) * 1999-04-15 2006-03-21 Mars Incorporated Synthetic methods for preparing procyanidin oligomers
US6562864B1 (en) * 1999-09-02 2003-05-13 Drake Larson Catechin multimers as therapeutic drug delivery agents
US6476241B1 (en) * 2000-09-05 2002-11-05 Mars Incorporated Synthesis of 4α-arylepicatechins
US20070208087A1 (en) 2001-11-02 2007-09-06 Sanders Virginia J Compounds, compositions and methods for the treatment of inflammatory diseases
KR100418390B1 (ko) * 2000-12-11 2004-02-11 김도훈 녹차로부터 추출된 항암효과가 우수한 폴리페놀류 화합물
US7297800B2 (en) * 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
US7514107B2 (en) 2002-03-21 2009-04-07 Mars, Incorporated Treatment of diseases involving defective gap junctional communication
US7595074B2 (en) * 2002-04-05 2009-09-29 University Of Massachusetts Lowell Polymeric antioxidants
EP1492856A4 (en) * 2002-04-05 2010-11-10 Univ Massachusetts Lowell POLYMER ANTIOXIDANTS
US7067679B2 (en) * 2002-10-02 2006-06-27 Mars, Inc. Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest
AU2002348822A1 (en) * 2002-12-17 2004-07-09 Council Of Scientific And Industrial Research A new antioxidant from natural source
EP1524270B1 (en) * 2003-05-26 2009-08-26 Amino Up Chemical Co. Ltd. Sulfur-containing proanthocyanidin oligomer composition and process for producing the same
JP2007508316A (ja) * 2003-10-10 2007-04-05 マーズ インコーポレイテッド ErbB2キナーゼ過剰発現に関連する病気の治療
CA2575952A1 (en) * 2004-01-21 2005-08-04 University Of Massachusetts Lowell Post-coupling synthetic approach for polymeric antioxidants
EP1742656B1 (en) 2004-03-12 2010-06-16 University Of Georgia Research Foundation, Inc. Novel peanut skin extract as a vaccine adjuvant
RU2007101288A (ru) * 2004-06-14 2008-07-20 Марс Композиции и способы применения димерных дигаллатов
JP2008507613A (ja) * 2004-07-23 2008-03-13 ポルノクス コーポレーション 抗酸化マクロモノマーおよび抗酸化ポリマー、ならびにその作製方法および使用方法
US20060128930A1 (en) * 2004-12-03 2006-06-15 Ashish Dhawan Synthesis of sterically hindered phenol based macromolecular antioxidants
WO2006060803A2 (en) * 2004-12-03 2006-06-08 Polnox Corporation One pot process for making polymeric antioxidants
US7678877B2 (en) * 2004-12-03 2010-03-16 Polnox Corporation Process for the synthesis of polyalkylphenol antioxidants
WO2006060800A1 (en) 2004-12-03 2006-06-08 Polnox Corporation Synthesis of aniline and phenol-based antioxidant macromonomers and corresponding polymers
EP1861484A2 (en) 2005-02-22 2007-12-05 Polnox Corporation Nitrogen and hindered phenol containing dual functional macromolecular antioxidants: synthesis , performances and applications
CA2606303A1 (en) 2005-03-25 2006-10-05 Polnox Corporation Alkylated and polymeric macromolecular antioxidants and methods of making and using the same
WO2006116532A2 (en) * 2005-04-28 2006-11-02 University Of Massachusetts Lowell Synthesis of oligo/poly(catechins) and methods of use
AU2006263561A1 (en) * 2005-06-28 2007-01-04 Mars, Incorporated Compositions and methods of use of derivatized flavanols
US20070004796A1 (en) * 2005-06-29 2007-01-04 Romanczyk Leo Jr Processes for the preparation of protected-(+)-catechin and (-)-epicatechin monomers, for coupling the protected monomers with an activated, protected epicatechin monomer, and for the preparation of epicatechin-(4B,8)-epicatechin or -catechin dimers and their digallates
CN101248057A (zh) * 2005-06-29 2008-08-20 马尔斯公司 (+)-儿茶素、(-)-表儿茶素、(-)-儿茶素、(+)-表儿茶素以及它们的5,7,3',4'-四-o-苄基类似物的制备
CN101300007A (zh) 2005-06-29 2008-11-05 马尔斯公司 诱导周围血管的血管舒张
WO2007003068A1 (fr) * 2005-06-30 2007-01-11 Hangzhou Lixin Biotechnology Co. Ltd. Additif pour nourriture, procédé de préparation de celui-ci et application de celui-ci
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
WO2007050985A2 (en) 2005-10-27 2007-05-03 Polnox Corporation Macromolecular antioxidants based on stξrically hindered phenolic phosphites
US20070106059A1 (en) * 2005-10-27 2007-05-10 Cholli Ashok L Macromolecular antioxidants and polymeric macromolecular antioxidants
EP1966293A1 (en) * 2005-10-27 2008-09-10 Polnox Corporation Stabilized polyolefin compositions
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
WO2007053642A1 (en) * 2005-11-01 2007-05-10 Mars, Incorporated Flavanols and b-type procyanidins and cox-2 expression
US20070161522A1 (en) 2005-12-02 2007-07-12 Cholli Ashok L Lubricant oil compositions
JP2009521475A (ja) 2005-12-23 2009-06-04 マース インコーポレーテッド 皮膚の保護および改善
WO2007084648A2 (en) * 2006-01-20 2007-07-26 Mars, Incorporated Mixed 4→6 procyanidin dimers and their use
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
CN101505745A (zh) 2006-06-15 2009-08-12 玛尔斯有限公司 改善认知功能的方法和组合物
WO2008005358A2 (en) 2006-07-06 2008-01-10 Polnox Corporation Novel macromolecular antioxidants comprising differing antioxidant moieties: structures, methods of making and using the same
CA2657915A1 (en) 2006-07-21 2008-01-24 Mars, Incorporated Improvement of arginase levels/activity
EP2068872A1 (en) * 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US7767853B2 (en) 2006-10-20 2010-08-03 Polnox Corporation Antioxidants and methods of making and using the same
JP5160149B2 (ja) * 2007-06-22 2013-03-13 明治薬品株式会社 柿ポリフェノールオリゴマー
JP5295744B2 (ja) * 2008-12-11 2013-09-18 三井農林株式会社 テアシネンシンの製造方法
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US8916526B2 (en) * 2009-07-31 2014-12-23 National University Corporation Okayama University Flavanone derivative
US8932468B2 (en) * 2010-01-12 2015-01-13 The United States Of America As Represented By The Secretary Of The Army Separation of enzymatically synthesized polyepicatechin via high performance liquid chromatography
US20120238638A1 (en) * 2011-03-18 2012-09-20 Jorma Antero Virtanen Biological biocide additives for polymers
JP5437537B1 (ja) * 2012-10-05 2014-03-12 フジッコ株式会社 低重合度プロアントシアニジンの製法
US9522131B2 (en) 2013-01-11 2016-12-20 Wisconsin Alumni Research Foundation Tannin-containing gastrointestinal formulations and methods of use
WO2015077635A2 (en) 2013-11-22 2015-05-28 Polnox Corporation Macromolecular antioxidants based on dual type moiety per molecule: structures methods of making and using the same
US20180251695A1 (en) 2017-03-01 2018-09-06 Polnox Corporation Macromolecular Corrosion (McIn) Inhibitors: Structures, Methods Of Making And Using The Same
CN108047271B (zh) * 2017-12-06 2020-05-26 石家庄学院 一种槲皮素二聚体衍生物及其制备方法和应用
CN109503800B (zh) * 2018-10-30 2021-07-09 合肥科天水性科技有限责任公司 一种改性水性聚氨酯及其制备方法
JP7679064B2 (ja) * 2021-06-15 2025-05-19 国立大学法人信州大学 ガレート型エピカテキン重合体又はガレート型エピガロカテキン重合体の製造方法
CN117658967A (zh) * 2023-10-09 2024-03-08 朗华生物科学(深圳)有限公司 一种黄烷-3,4-二醇类衍生物的制备方法
CN117534646B (zh) * 2023-11-20 2025-02-25 朗华生物科学(深圳)有限公司 一种原花青素b2的制备方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE39844C (de) 1886-09-23 1887-06-22 Black John Melton Neuerung an der Controlb}chse f}r Conducteure.
DE1493976C3 (de) * 1964-01-18 1973-09-13 Merck Patent Gmbh, 6100 Darmstadt Substituierte Flavandenvate sowie Verfahren zu ihrer Herstellung
US4255336A (en) 1977-11-25 1981-03-10 Ciba-Geigy Corporation Process for the preparation of O-substituted derivatives of (+)-cyanidan-3-01
JPS58154571A (ja) 1982-03-08 1983-09-14 Nippon Shinyaku Co Ltd 新規タンニン
GB2122608B (en) 1982-06-01 1985-10-02 Zyma Sa (+)-cyanidan-3-ol derivatives
JPS61205272A (ja) 1985-03-08 1986-09-11 Tsumura Juntendo Inc 新規なタンニン
US4698360B1 (en) * 1985-04-09 1997-11-04 D Investigations Pharmacologiq Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
JPS631936A (ja) * 1986-06-23 1988-01-06 Asahi Optical Co Ltd 光電変換回路
JPH0231074B2 (ja) * 1986-08-26 1990-07-11 Nippon Shinyaku Co Ltd Shintannin
JPS63214183A (ja) * 1987-03-03 1988-09-06 Mitsui Norin Kk アンジオテンシン1変換酵素阻害剤
EP0472531B1 (fr) * 1989-05-12 1995-08-16 Cariel, Léon Composition a base de proanthocyanidols; leur application pharmacologique
US5358713A (en) * 1990-02-23 1994-10-25 Mitsui Norin Co., Ltd. Method of preventing the transmission of infection caused by methicillin-resistant Staphylococcus aureus
FR2668373B1 (fr) 1990-10-26 1994-04-08 Intertechnique Equipement respiratoire de protection d'equipage d'aeronef.
JP2857646B2 (ja) 1990-11-26 1999-02-17 キッコーマン株式会社 抗変異原性剤
GB9209734D0 (en) * 1992-05-06 1992-06-17 Philips Electronics Uk Ltd An image sensor
JP3139134B2 (ja) * 1992-06-03 2001-02-26 カシオ計算機株式会社 液晶表示装置
JP2821347B2 (ja) * 1993-10-12 1998-11-05 日本電気株式会社 電流制御型発光素子アレイ
JPH07236029A (ja) * 1993-12-29 1995-09-05 Xerox Corp コンパクト・ドキュメント・イメージャ
US5554645A (en) * 1994-10-03 1996-09-10 Mars, Incorporated Antineoplastic cocoa extracts and methods for making and using the same
US5627364A (en) * 1994-10-11 1997-05-06 Tdk Corporation Linear array image sensor with thin-film light emission element light source
US5625210A (en) * 1995-04-13 1997-04-29 Eastman Kodak Company Active pixel sensor integrated with a pinned photodiode
JP3436629B2 (ja) * 1996-01-08 2003-08-11 シャープ株式会社 表示および撮像のための装置
FI102345B1 (fi) * 1996-02-20 1998-11-13 Nokia Telecommunications Oy Menetelmä päätelaitteen nopeuden määrittämiseksi ja vastaanotin
PL329325A1 (en) * 1996-04-02 1999-03-29 Mars Inc Cocoa extract compounds, method of obtaining them and their application
WO1997036597A1 (en) * 1996-04-02 1997-10-09 Mars, Incorporated Cocoa extract compounds and methods for making and using the same
US6188380B1 (en) * 1997-02-03 2001-02-13 Nanao Corporation Photodetector of liquid crystal display and luminance control device using the same
JP3641342B2 (ja) * 1997-03-07 2005-04-20 Tdk株式会社 半導体装置及び有機elディスプレイ装置
JP3887826B2 (ja) * 1997-03-12 2007-02-28 セイコーエプソン株式会社 表示装置及び電子機器
US5912363A (en) 1997-08-29 1999-06-15 Interhealth Nutraceuticals Method for extraction of proanthocyanidins from plant material
JP4013293B2 (ja) * 1997-09-01 2007-11-28 セイコーエプソン株式会社 表示装置兼用型イメージセンサ装置及びアクティブマトリクス型表示装置
EP1014969B1 (en) * 1997-09-09 2008-11-12 Rutgers, The State University of New Jersey Plant proanthocyanidin extract effective at inhibiting adherence of bacteria with p-type fimbriae to surfaces
US6207842B1 (en) 1997-10-09 2001-03-27 Mars Incorporated Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
US6476864B1 (en) * 1998-05-11 2002-11-05 Agilent Technologies, Inc. Pixel sensor column amplifier architecture
JP4164910B2 (ja) * 1998-09-21 2008-10-15 ソニー株式会社 有機elディスプレイおよび有機elディスプレイの製造方法
US6156912A (en) 1999-04-09 2000-12-05 Mars, Incorporated 88, 66, and 68 catechin and epicatechin dimers and methods for their preparation
US7015338B1 (en) 1999-04-15 2006-03-21 Mars Incorporated Synthetic methods for preparing procyanidin oligomers
US6480305B1 (en) * 1999-05-25 2002-11-12 Hewlett-Packard Company Imaging device
JP2001075524A (ja) * 1999-09-03 2001-03-23 Rohm Co Ltd 表示装置
US6747638B2 (en) * 2000-01-31 2004-06-08 Semiconductor Energy Laboratory Co., Ltd. Adhesion type area sensor and display device having adhesion type area sensor
US6476241B1 (en) 2000-09-05 2002-11-05 Mars Incorporated Synthesis of 4α-arylepicatechins
US7067679B2 (en) 2002-10-02 2006-06-27 Mars, Inc. Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest

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