JP2001518468A - β３アドレナリン受容体拮抗薬、拮抗薬合成物およびこれらの応用方法 - Google Patents
β３アドレナリン受容体拮抗薬、拮抗薬合成物およびこれらの応用方法Info
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- JP2001518468A JP2001518468A JP2000513838A JP2000513838A JP2001518468A JP 2001518468 A JP2001518468 A JP 2001518468A JP 2000513838 A JP2000513838 A JP 2000513838A JP 2000513838 A JP2000513838 A JP 2000513838A JP 2001518468 A JP2001518468 A JP 2001518468A
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- MRBDMNSDAVCSSF-UHFFFAOYSA-N phentolamine Chemical compound C1=CC(C)=CC=C1N(C=1C=C(O)C=CC=1)CC1=NCCN1 MRBDMNSDAVCSSF-UHFFFAOYSA-N 0.000 description 1
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- 239000003279 phenylacetic acid Substances 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 description 1
- 229960002508 pindolol Drugs 0.000 description 1
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- 229920003023 plastic Polymers 0.000 description 1
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- 235000009566 rice Nutrition 0.000 description 1
- 229940074569 salsolinol Drugs 0.000 description 1
- IBRKLUSXDYATLG-UHFFFAOYSA-N salsolinol hydrobromide Natural products OC1=C(O)C=C2C(C)NCCC2=C1 IBRKLUSXDYATLG-UHFFFAOYSA-N 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000012916 structural analysis Methods 0.000 description 1
- 238000005556 structure-activity relationship Methods 0.000 description 1
- 231100000456 subacute toxicity Toxicity 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000001975 sympathomimetic effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- JDZUSDQWLLQILY-UHFFFAOYSA-N tert-butyl 1-[(4-amino-3-iodophenyl)methyl]-6,7-bis(phenylmethoxy)-3,4-dihydro-1h-isoquinoline-2-carboxylate Chemical compound C=1C=CC=CC=1COC=1C=C2C(CC=3C=C(I)C(N)=CC=3)N(C(=O)OC(C)(C)C)CCC2=CC=1OCC1=CC=CC=C1 JDZUSDQWLLQILY-UHFFFAOYSA-N 0.000 description 1
- RBBWXFIQCRBSMN-UHFFFAOYSA-N tert-butyl 1-[(4-aminophenyl)methyl]-6,7-bis(phenylmethoxy)-3,4-dihydro-1h-isoquinoline-2-carboxylate Chemical compound C=1C=CC=CC=1COC=1C=C2C(CC=3C=CC(N)=CC=3)N(C(=O)OC(C)(C)C)CCC2=CC=1OCC1=CC=CC=C1 RBBWXFIQCRBSMN-UHFFFAOYSA-N 0.000 description 1
- RWBJBVJVUCAMQW-UHFFFAOYSA-N tert-butyl 1-[(4-nitrophenyl)methyl]-6,7-bis(phenylmethoxy)-3,4-dihydro-1h-isoquinoline-2-carboxylate Chemical compound C=1C=CC=CC=1COC=1C=C2C(CC=3C=CC(=CC=3)[N+]([O-])=O)N(C(=O)OC(C)(C)C)CCC2=CC=1OCC1=CC=CC=C1 RWBJBVJVUCAMQW-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- 238000011200 topical administration Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- WRTMQOHKMFDUKX-UHFFFAOYSA-N triiodide Chemical compound I[I-]I WRTMQOHKMFDUKX-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- JQSHBVHOMNKWFT-DTORHVGOSA-N varenicline Chemical compound C12=CC3=NC=CN=C3C=C2[C@H]2C[C@@H]1CNC2 JQSHBVHOMNKWFT-DTORHVGOSA-N 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
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- 235000021089 very low-carbohydrate diet Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6115297P | 1997-09-30 | 1997-09-30 | |
| US60/061,152 | 1997-09-30 | ||
| PCT/US1998/020427 WO1999016752A1 (en) | 1997-09-30 | 1998-09-30 | β3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USING |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001518468A true JP2001518468A (ja) | 2001-10-16 |
| JP2001518468A5 JP2001518468A5 (enExample) | 2006-01-05 |
Family
ID=22033968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000513838A Pending JP2001518468A (ja) | 1997-09-30 | 1998-09-30 | β３アドレナリン受容体拮抗薬、拮抗薬合成物およびこれらの応用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US6825213B2 (enExample) |
| EP (1) | EP1023269A4 (enExample) |
| JP (1) | JP2001518468A (enExample) |
| AU (1) | AU9512298A (enExample) |
| WO (1) | WO1999016752A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005526770A (ja) * | 2002-03-13 | 2005-09-08 | ザ ユニバーシティ オブ テネシー リサーチ ファウンデイション | 置換テトラヒドロイソキノリン化合物、調製方法、およびその使用 |
| JP2012517984A (ja) * | 2009-02-16 | 2012-08-09 | アボット ゲーエムベーハー ウント カンパニー カーゲー | 複素環式化合物、これらを含む医薬組成物およびグリシントランスポーター１の阻害剤としてのこれらの使用 |
| JP2017529315A (ja) * | 2014-05-23 | 2017-10-05 | ジー ユアン タン バイオテクノロジー カンパニー リミテッド | Ａｍｐ依存性プロテインキナーゼを活性化するための医薬を製造するためのイソキノリンアルカロイド誘導体の使用 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6043253A (en) * | 1998-03-03 | 2000-03-28 | Merck & Co., Inc. | Fused piperidine substituted arylsulfonamides as β3-agonists |
| AU782148B2 (en) * | 2001-03-29 | 2005-07-07 | Molecular Design International, Inc. | Beta3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
| US6593341B2 (en) * | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
| US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
| EP2225250A2 (en) * | 2007-11-30 | 2010-09-08 | Biota Scientific Management Pty Ltd | Bicyclic ppat inhibitors as antibacterial agents |
| KR101036882B1 (ko) * | 2009-04-24 | 2011-05-25 | 주식회사 코스핀 | 공작기계의 스핀들용 부스터 |
| TWI621438B (zh) * | 2014-05-23 | 2018-04-21 | 資元堂生物科技股份有限公司 | 異喹啉生物鹼衍生物用於製備促進ａｍｐｋ活性的藥物之用途 |
| US20220281902A1 (en) * | 2019-08-19 | 2022-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial modulation to improve metabolic syndrome during aging |
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| US3818015A (en) * | 1970-12-17 | 1974-06-18 | Tanabe Seiyaku Co | 1(polymethoxybenzyl) 6 hydroxyl 1,2,3,4 tetrahydro isoquinolines |
| JPS6222768A (ja) * | 1985-07-23 | 1987-01-30 | スミスクライン・ベツクマン・コ−ポレイシヨン | 置換テトラヒドロイソキノリン誘導体 |
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| DE1250828B (de) * | 1962-10-10 | 1967-09-28 | Chinoin Gyogyszer es Vegyeszeti Termekek Gyära R.T., Budapest | Verfahren zur Herstellung des spasmolytisch wirksamen 6,7,3',4' - Tetraäthoxy -l-benzyliden-1,2,3,4tetrahydroisochinolins und seiner Salze |
| US3497516A (en) * | 1965-12-08 | 1970-02-24 | Tanabe Seiyaku Co | Tetrahydroisoquinoline compounds and preparation thereof |
| US3438989A (en) * | 1967-03-10 | 1969-04-15 | Warner Lambert Pharmaceutical | Process for the production of ( ) dihydrothebainone |
| IL33480A (en) * | 1968-12-10 | 1973-03-30 | Tanabe Seiyaku Co | 6,7-diacyloxy-tetrahydro-isoquinolines and their preparation |
| US3873704A (en) * | 1970-12-17 | 1975-03-25 | Tanabe Seiyaku Co | Novel tetrahydroisoquinoline compounds in a pharmaceutical composition |
| US3872130A (en) * | 1971-09-27 | 1975-03-18 | Mead Johnson & Co | 1-hydroxyisoquinolones |
| US3910927A (en) * | 1971-09-27 | 1975-10-07 | Mead Johnson & Co | 3-Hydroxyisoquinoline ethers |
| US3910915A (en) * | 1973-07-23 | 1975-10-07 | Searle & Co | 1-Aryl-2-{8 (substituted amino)alkanoyl{9 -1,2,3,4-tetrahydroisoquinolines |
| US3988339A (en) * | 1974-02-08 | 1976-10-26 | Smithkline Corporation | Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase |
| JPS5247474B2 (enExample) * | 1974-11-20 | 1977-12-02 | ||
| JPS5295676A (en) | 1976-02-05 | 1977-08-11 | Dainippon Pharmaceut Co Ltd | Tetrahydropapaverine derivatives |
| FR2368277A1 (fr) * | 1976-10-21 | 1978-05-19 | Sobio Lab | Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique |
| US4321254A (en) * | 1980-09-26 | 1982-03-23 | Smithkline Corporation | Antiallergic imidodisulfamides |
| US4456757A (en) * | 1981-03-20 | 1984-06-26 | Asahi Kasei Kogyo Kabushiki Kaisha | Isoquinolinesulfonyl derivatives and process for the preparation thereof |
| BG38182A1 (en) * | 1983-06-21 | 1985-11-15 | Ivanova | Tocolytic means |
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| JPH0667926B2 (ja) * | 1985-11-12 | 1994-08-31 | 旭化成工業株式会社 | 環状のイソキノリンスルホンアミド誘導体 |
| US4737504A (en) * | 1986-07-25 | 1988-04-12 | Ohio State University Research Foundation | 5-fluoro-and 8-fluoro-trimetoquinol compounds and the processes for their preparation |
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| GB8807922D0 (en) * | 1988-04-05 | 1988-05-05 | Fujisawa Pharmaceutical Co | Isoquinoline compound & process for preparation thereof |
| US5210088A (en) * | 1989-09-20 | 1993-05-11 | John Wyeth & Brother, Limited | Method of treatment and heterocyclic compounds used therein |
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| DE4026115A1 (de) * | 1990-08-17 | 1992-02-20 | Consortium Elektrochem Ind | Verfahren zur herstellung von 1-alkylisochinolinderivaten |
| GB9027055D0 (en) * | 1990-12-13 | 1991-02-06 | Sandoz Ltd | Organic compounds |
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| US5238935A (en) * | 1991-05-20 | 1993-08-24 | Schering Corporation | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme A: cholesterol acyl transferase |
| GB9127306D0 (en) * | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
| US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| JPH06247935A (ja) * | 1993-02-25 | 1994-09-06 | Banyu Pharmaceut Co Ltd | ６，７−ジアルコキシ−３，４−ジヒドロイソキノリン−８−オール類、その製造法及び該化合物を用いた６，７−ジアルコキシ−１，２，３，４−テトラヒドロイソキノリン−８−オール類の製造法 |
| AU679765B2 (en) * | 1993-06-22 | 1997-07-10 | Abbott Gmbh & Co. Kg | Isoquinoline derivatives as therapeutic agents |
| GB9322976D0 (en) * | 1993-11-08 | 1994-01-05 | Pfizer Ltd | Therapeutic agents |
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| JP3834663B2 (ja) * | 1996-02-02 | 2006-10-18 | 株式会社デ・ウエスタン・セラピテクス研究所 | イソキノリン誘導体及び医薬 |
| TW436484B (en) * | 1996-04-24 | 2001-05-28 | Dev Center Biotechnology | 1,2,3,4-tetrahydroisoquinoline derivatives having a nitrogen-containing heterocyclic methyl substituent, the preparation process and pharmaceutical composition thereof |
| US5929085A (en) * | 1996-11-06 | 1999-07-27 | Astra Aktiebolag | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase |
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| GB9724372D0 (en) * | 1997-11-18 | 1998-01-14 | Smithkline Beecham Plc | Novel compounds |
| US6043253A (en) * | 1998-03-03 | 2000-03-28 | Merck & Co., Inc. | Fused piperidine substituted arylsulfonamides as β3-agonists |
| WO1999044609A1 (en) | 1998-03-03 | 1999-09-10 | Merck & Co., Inc. | FUSED PIPERIDINE SUBSTITUTED ARYLSULFONAMIDES AS β3-AGONISTS |
| US6127381A (en) * | 1998-04-28 | 2000-10-03 | Basu; Amaresh | Isoquinoline compound melanocortin receptor ligands and methods of using same |
-
1998
- 1998-09-30 JP JP2000513838A patent/JP2001518468A/ja active Pending
- 1998-09-30 WO PCT/US1998/020427 patent/WO1999016752A1/en not_active Ceased
- 1998-09-30 AU AU95122/98A patent/AU9512298A/en not_active Abandoned
- 1998-09-30 EP EP98948579A patent/EP1023269A4/en not_active Withdrawn
-
2003
- 2003-06-25 US US10/603,678 patent/US6825213B2/en not_active Expired - Fee Related
-
2004
- 2004-10-13 US US10/964,461 patent/US7119103B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3818015A (en) * | 1970-12-17 | 1974-06-18 | Tanabe Seiyaku Co | 1(polymethoxybenzyl) 6 hydroxyl 1,2,3,4 tetrahydro isoquinolines |
| JPS6222768A (ja) * | 1985-07-23 | 1987-01-30 | スミスクライン・ベツクマン・コ−ポレイシヨン | 置換テトラヒドロイソキノリン誘導体 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005526770A (ja) * | 2002-03-13 | 2005-09-08 | ザ ユニバーシティ オブ テネシー リサーチ ファウンデイション | 置換テトラヒドロイソキノリン化合物、調製方法、およびその使用 |
| JP2012517984A (ja) * | 2009-02-16 | 2012-08-09 | アボット ゲーエムベーハー ウント カンパニー カーゲー | 複素環式化合物、これらを含む医薬組成物およびグリシントランスポーター１の阻害剤としてのこれらの使用 |
| JP2017529315A (ja) * | 2014-05-23 | 2017-10-05 | ジー ユアン タン バイオテクノロジー カンパニー リミテッド | Ａｍｐ依存性プロテインキナーゼを活性化するための医薬を製造するためのイソキノリンアルカロイド誘導体の使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU9512298A (en) | 1999-04-23 |
| EP1023269A4 (en) | 2001-06-27 |
| WO1999016752A1 (en) | 1999-04-08 |
| EP1023269A1 (en) | 2000-08-02 |
| US6825213B2 (en) | 2004-11-30 |
| US7119103B2 (en) | 2006-10-10 |
| US20040019079A1 (en) | 2004-01-29 |
| US20050096347A1 (en) | 2005-05-05 |
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