JP2001512964A - 分化した胎仔および成体ドナー細胞による核移植 - Google Patents

分化した胎仔および成体ドナー細胞による核移植

Info

Publication number
JP2001512964A
JP2001512964A JP53095898A JP53095898A JP2001512964A JP 2001512964 A JP2001512964 A JP 2001512964A JP 53095898 A JP53095898 A JP 53095898A JP 53095898 A JP53095898 A JP 53095898A JP 2001512964 A JP2001512964 A JP 2001512964A
Authority
JP
Japan
Prior art keywords
cell
cells
disease
differentiated
cicm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP53095898A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001512964A5 (OSRAM
Inventor
スティーヴン エル スティース
ホセ シーベリー
ジェームズ ローブル
ポール ゴルーク
デ リーオン エフ エイベル ポンセ
ディー ジョセフ ジェリー
Original Assignee
ユニヴァーシティー オヴ マサチューセッツ ア パブリック インスティテューション オヴ ハイアー エデュケイション オヴ ザ コモンウェルス オヴ マサチューセッツ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25123802&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2001512964(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ユニヴァーシティー オヴ マサチューセッツ ア パブリック インスティテューション オヴ ハイアー エデュケイション オヴ ザ コモンウェルス オヴ マサチューセッツ filed Critical ユニヴァーシティー オヴ マサチューセッツ ア パブリック インスティテューション オヴ ハイアー エデュケイション オヴ ザ コモンウェルス オヴ マサチューセッツ
Publication of JP2001512964A publication Critical patent/JP2001512964A/ja
Publication of JP2001512964A5 publication Critical patent/JP2001512964A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8771—Bovine embryos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8778—Swine embryos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/106—Primate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/04—Cells produced using nuclear transfer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cell Biology (AREA)
JP53095898A 1997-01-10 1998-01-05 分化した胎仔および成体ドナー細胞による核移植 Ceased JP2001512964A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/781,752 US5945577A (en) 1997-01-10 1997-01-10 Cloning using donor nuclei from proliferating somatic cells
US08/781,752 1997-01-10
PCT/US1998/000002 WO1998030683A2 (en) 1997-01-10 1998-01-05 Nuclear transfer with differentiated fetal and adult donor cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007084406A Division JP2007167078A (ja) 1997-01-10 2007-03-28 分化した胎仔および成体ドナー細胞による核移植

Publications (2)

Publication Number Publication Date
JP2001512964A true JP2001512964A (ja) 2001-08-28
JP2001512964A5 JP2001512964A5 (OSRAM) 2006-01-05

Family

ID=25123802

Family Applications (2)

Application Number Title Priority Date Filing Date
JP53095898A Ceased JP2001512964A (ja) 1997-01-10 1998-01-05 分化した胎仔および成体ドナー細胞による核移植
JP2007084406A Pending JP2007167078A (ja) 1997-01-10 2007-03-28 分化した胎仔および成体ドナー細胞による核移植

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007084406A Pending JP2007167078A (ja) 1997-01-10 2007-03-28 分化した胎仔および成体ドナー細胞による核移植

Country Status (13)

Country Link
US (4) US5945577A (OSRAM)
EP (2) EP1808484A1 (OSRAM)
JP (2) JP2001512964A (OSRAM)
CN (1) CN1248288B (OSRAM)
AT (1) ATE356203T1 (OSRAM)
AU (1) AU742363C (OSRAM)
BR (1) BR9806872A (OSRAM)
CA (1) CA2277192C (OSRAM)
DE (1) DE69837270T2 (OSRAM)
ES (1) ES2284197T3 (OSRAM)
IL (2) IL130829A0 (OSRAM)
NZ (1) NZ336612A (OSRAM)
WO (1) WO1998030683A2 (OSRAM)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000512159A (ja) * 1998-01-16 2000-09-19 アグロバイオジェン ゲーエムベーハー 胎仔線維芽細胞による効率的な核移入
JP2002500864A (ja) * 1998-01-21 2002-01-15 ユニバーシティ・オブ・ハワイ 成体の体細胞核を再構成した被核除去卵母細胞からの動物の満期の成長
JP2006522609A (ja) * 2003-04-09 2006-10-05 マギー−ウイメンズ・ヘルス・コーポレイション 動物の体細胞核移植と関係する紡錘体欠損を修正するための方法
JPWO2016140353A1 (ja) * 2015-03-04 2018-01-25 株式会社医療実験用大動物供給事業準備会社 安定した表現型を示す疾患モデルブタおよびその作製方法

Families Citing this family (216)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9517779D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US6215041B1 (en) * 1997-01-10 2001-04-10 University Of Mmassachusetts Cloning using donor nuclei from a non-quiesecent somatic cells
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US20090092588A1 (en) * 1997-01-10 2009-04-09 University Of Massachusetts As Represented By Its Amherst Campus Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease
US6235969B1 (en) * 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
US6011197A (en) * 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
JP2002512510A (ja) * 1997-03-06 2002-04-23 インフィジェン・インコーポレーテッド 動物のクローニング方法
JP2001509361A (ja) 1997-07-03 2001-07-24 ユニヴァーシティー オヴ マサチューセッツ 分化した無血清飢餓細胞からの供与核を用いるクローニング
AU8587598A (en) * 1997-07-26 1999-02-16 Wisconsin Alumni Research Foundation Trans-species nuclear transfer
CA2324009A1 (en) * 1998-03-16 1999-09-23 Relag Pty Ltd. Porcine nuclear transfer
AUPP294898A0 (en) * 1998-04-15 1998-05-07 Monash University Method of nuclear transfer
GB9808325D0 (en) * 1998-04-20 1998-06-17 Ltr Ciz Di Associazione Italia Source of nuclei for nuclear transfer
GB9811859D0 (en) * 1998-06-02 1998-07-29 Biotech & Biolog Scien Res Biological manipulation
CN1316878A (zh) * 1998-08-11 2001-10-10 安东尼C·F·佩里 进行转基因的方法
CA2342205A1 (en) * 1998-09-01 2000-03-09 Wisconsin Alumni Research Foundation Primate embryonic stem cells with compatible histocompatibility genes
US20030177513A1 (en) * 1998-11-02 2003-09-18 Yann Echelard Transgenic and cloned mammals
US6580017B1 (en) * 1998-11-02 2003-06-17 Genzyme Transgenics Corporation Methods of reconstructed goat embryo transfer
US6781030B1 (en) 1998-11-02 2004-08-24 Trustee Of Tufts College, Ballou Hall Methods for cloning mammals using telophase oocytes
JP2003523719A (ja) * 1998-11-02 2003-08-12 トラスティーズ・オブ・タフツ・カレッジ 動物のクローン化方法
US6700037B2 (en) 1998-11-24 2004-03-02 Infigen, Inc. Method of cloning porcine animals
US7531715B1 (en) 1999-01-13 2009-05-12 Ppl Therapeutics (Scotland) Double nuclear transfer method and results thereof
EP2199392A3 (en) * 1999-03-04 2010-12-15 Revivicor, Inc. Genetic modification of somatic cells and uses thereof
US20020012660A1 (en) * 1999-03-04 2002-01-31 Alan Colman Method of preparing a somatic cells for nuclear transfer
ATE394029T1 (de) * 1999-05-06 2008-05-15 Stem Cell Sciences Australia P Verfahren der zellreprogrammierung durch herstellung eines heterokaryons
AU753209B2 (en) * 1999-06-30 2002-10-10 Seoul National University Industry Foundation Method for producing cloned tigers by employing inter-species nuclear transplantation technique
EP1109890A4 (en) * 1999-06-30 2004-12-29 Hwang Woo Suk PROCESS FOR OBTAINING CLONED HUMAN EMBRYOS USING INTER-SPECIES TRANSPLANTATION TECHNIQUES OF CORES
JP3652308B2 (ja) * 1999-06-30 2005-05-25 ソウル ナショナル ユニバーシティー インダストリー ファウンデーション クローンウシの生産方法
US20050255596A1 (en) * 1999-09-07 2005-11-17 West Michael D Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer
EP1214443A4 (en) * 1999-09-07 2003-08-27 Advanced Cell Tech Inc RESTORATION OF THE TELOMER AND EXTENSION OF THE CELL LIFETIME IN CLONED ANIMALS FROM SENESCENT SOMATIC CELLS
US20040180430A1 (en) * 1999-09-07 2004-09-16 West Michael D. Methods of restoring telomere length and extending cell lifespan using nuclear transfer
EP1241931A4 (en) * 1999-09-13 2004-12-29 Univ Massachusetts CLONING PIGS USING DONORATION CELLS OR NUCLEAR CELLS OF DIFFERENTIATED CELLS AND PRODUCING PLURIPOTENT PIGS
EP2275559A3 (en) 1999-09-28 2011-03-23 Shire Human Genetic Therapies, Inc. Optimized messenger RNA
WO2002064799A2 (en) 1999-09-28 2002-08-22 Transkaryotic Therapies, Inc. Optimized messenger rna
MXPA02003733A (es) * 1999-10-15 2003-10-14 Advanced Cell Tech Inc Metodos para producir celulas progenitoras diferenciadas y celulas troncales embrionicas de lineas de descendencia defectivas.
EP1230342A4 (en) 1999-10-28 2003-04-09 Univ Massachusetts GYNOGENETIC OR ANDROGENETIC PRODUCTION OF PLURIPOTENT CELLS AND CELL LINES AND THEIR USE IN THE PRODUCTION OF DIFFERENTIATED CELLS AND TISSUES
EP1242591A1 (en) * 1999-10-29 2002-09-25 Nexia Biotechnologies, Inc. Production of transgenic animals using nuclear transfer and oocytes recovered by lopu
IL149201A0 (en) * 1999-11-02 2002-11-10 Univ Massachusetts Use of haploid genomes for genetic diagnosis, modification and multiplication
US7253334B2 (en) * 2000-12-22 2007-08-07 Aurox, Llc Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells
AU1777301A (en) * 1999-11-19 2001-05-30 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
US7820878B2 (en) * 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
US7074983B2 (en) * 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
KR100417566B1 (ko) * 1999-11-19 2004-02-05 한국생명공학연구원 체세포 핵치환 복제수정란의 대량생산방법
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
CN1293188C (zh) * 2000-01-04 2007-01-03 康涅狄格州大学 一种将长期培养的可包括人工诱导基因改变的雌或雄体细胞的细胞核转移到去核受体细胞中实现靶向基因改变的克隆动物的方法
US20060174358A1 (en) * 2001-01-04 2006-08-03 Xiangzhong Yang Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells
AU2766501A (en) 2000-01-04 2001-07-16 University Of Connecticut, The Oocyte vitrification technique
US6635802B1 (en) * 2000-01-10 2003-10-21 The Texas A&M University System Nuclear transfer using cells cultured in serum starvation media containing apoptosis inhibitors
GB0001401D0 (en) * 2000-01-22 2000-03-08 Univ Edinburgh Methods for amplifying genetic material and use thereof
WO2001068831A2 (en) * 2000-03-15 2001-09-20 The University Of Georgia Research Foundation, Inc. Effective nuclear reprogramming in mammals
AU2001295194A1 (en) * 2000-05-04 2001-11-12 Biotime, Inc. Methods and compositions for producing donor cells
AU2001261968A1 (en) * 2000-05-25 2001-12-03 Oregon Health Sciences University Pt32 sperm protein, sperm c-yes, oocyte cytoplasmic c-yes, and uses thereof
WO2002009507A1 (de) * 2000-07-27 2002-02-07 Apogene Gmbh & Co. Kg Somatischer klonierungs-gentransfer zur produktion von rekombinanten proteinen, zellen und organen
US20030032180A1 (en) * 2000-07-29 2003-02-13 Strelchenko Larissa V. Reconstituted cell lines prepared by nuclear transfer between differentiated cells
US20030172394A1 (en) * 2001-08-01 2003-09-11 Holzer George L Selection and cloning methods
EP1311530A4 (en) 2000-08-03 2004-10-06 Wim-Van Schooten PRODUCTION OF HUMANIZED ANTIBODIES IN TRANSGENIC ANIMALS
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
US20040029825A1 (en) * 2001-10-03 2004-02-12 Davies Christopher J Methods of minimizing immunological rejection of a nuclear transfer fetus
WO2002102997A2 (en) * 2000-11-30 2002-12-27 Stemron Inc. Isolated homozygous stem cells differentiated cells derived therefrom and materials and methods for making and using same
US20030027331A1 (en) * 2000-11-30 2003-02-06 Yan Wen Liang Isolated homozygous stem cells, differentiated cells derived therefrom, and materials and methods for making and using same
US7491534B2 (en) * 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
US20020142397A1 (en) * 2000-12-22 2002-10-03 Philippe Collas Methods for altering cell fate
EP1217071B1 (en) 2000-12-22 2010-04-28 Institut National De La Recherche Agronomique Position-independent and tissue specific expression of a transgene in milk of transgenic animals
NZ526888A (en) * 2001-01-02 2008-07-31 Stemron Inc Isolated homozygous stem (HS) cells and the discovery that these cells may be selected for immunotype and genotype, therefore being useful for diagnosis, transplantation and/or treatment
AUPR247901A0 (en) * 2001-01-10 2001-02-01 Garelag Pty Ltd Activation of nuclear transfer embryos
CA2435857A1 (en) 2001-01-30 2002-09-26 Rebholtz, Amy K. Methods for embryo recipient management
WO2002062131A2 (en) * 2001-02-02 2002-08-15 Infigen, Inc. Method of cloning transgenic mammalian animals using pseudonuclei
JP2004524843A (ja) 2001-02-23 2004-08-19 イーラン ファーマスーティカルズ、インコーポレイテッド Ｂａｃｅ−１のトランスジェニックノックアウト
JP2002262716A (ja) 2001-03-07 2002-09-17 National Agricultural Research Organization 株化細胞を用いて家畜個体を作出する方法
WO2002073187A1 (en) * 2001-03-09 2002-09-19 Advanced Cell Technology, Inc. Method for generating replacement cells and/or tissues
WO2002073188A1 (en) * 2001-03-13 2002-09-19 Advanced Cell Technology, Inc. Method for generating replacement cells and/or tissues
WO2002078449A2 (en) * 2001-04-02 2002-10-10 Advanced Cell Technology, Inc. Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells
AUPR446701A0 (en) 2001-04-18 2001-05-17 Gene Stream Pty Ltd Transgenic mammals for pharmacological and toxicological studies
US20030092174A1 (en) * 2001-05-14 2003-05-15 Monika Liljedahl Tissues or organs for use in xenotransplantation
US20030153044A1 (en) * 2001-05-14 2003-08-14 Monika Liljedahl Tissues or organs for use in xenotransplantation
WO2002103350A1 (en) * 2001-06-14 2002-12-27 Infigen, Inc. Methods for cloning mammals using remodeling factors
AU2002326353A1 (en) * 2001-07-09 2003-01-29 Alexion Pharmaceuticals Inc. Cloned non-human mammals from contact inhibited donor cells
US20060083722A1 (en) * 2001-07-18 2006-04-20 Advanced Cell Technology, Inc Methods and compositions for cell therapy
US20030017587A1 (en) * 2001-07-18 2003-01-23 Rader William C. Embryonic stem cells, clinical applications and methods for expanding in vitro
US20030051264A1 (en) * 2001-07-31 2003-03-13 Monika Liljedahl Genetically modified cows having reduced susceptibility to mad cow disease
CN1568366B (zh) * 2001-08-13 2013-04-24 恩布里克斯公司 注射鸟卵的方法
US20030211603A1 (en) * 2001-08-14 2003-11-13 Earp David J. Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells
IL160351A0 (en) * 2001-08-23 2004-07-25 Reliance Life Sciences Pvt Ltd ISOLATION OF INNER CELL MASS FOR THE ESTABLISHMENT OF HUMAN EMBRYONIC STEM CELL (hESC) LINES
JP2005500847A (ja) * 2001-08-24 2005-01-13 アドバンスド セル テクノロジー、インコーポレイテッド 分化誘導薬の同定のためのスクリーニング検定及び細胞治療用の分化細胞の調製
US7527974B2 (en) * 2001-11-06 2009-05-05 Shanghai Second Medical University Embryonic stem cells derived from human somatic cell—rabbit oocyte NT units
AU2002361601A1 (en) * 2001-11-06 2003-05-19 Mark C. Fishman Stem and progenitor cell capture for tissue regeneration
MXPA04005010A (es) * 2001-11-26 2005-04-08 Advanced Cell Tech Inc METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS.
US7018819B2 (en) * 2001-11-30 2006-03-28 Cellectricon Ab Method and apparatus for manipulation of cells and cell-like structures focused electric fields in microfludic systems and use thereof
US20030113910A1 (en) * 2001-12-18 2003-06-19 Mike Levanduski Pluripotent stem cells derived without the use of embryos or fetal tissue
US20040133931A1 (en) * 2003-01-08 2004-07-08 Gavin William G. Method and system for fusion and activation following nuclear transfer in reconstructed embryos
JP2005515782A (ja) * 2002-01-11 2005-06-02 ジーティーシー バイオセラピューティックス インコーポレイテッド 再構築された胚へ核を移植した後の融合および活性化のための方法およびシステム
WO2003060083A2 (en) * 2002-01-15 2003-07-24 Advanced Cell Technology, Inc. Cloning b and t lymphocytes
US20030134422A1 (en) * 2002-01-16 2003-07-17 Sayre Chauncey Bigelow Stem cell maturation for all tissue lines
US20050170506A1 (en) * 2002-01-16 2005-08-04 Primegen Biotech Llc Therapeutic reprogramming, hybrid stem cells and maturation
US20050090004A1 (en) * 2003-01-16 2005-04-28 Sayre Chauncey B. Stem cell maturation for all tissue lines
AU2003251286B2 (en) * 2002-01-23 2007-08-16 The University Of Utah Research Foundation Targeted chromosomal mutagenesis using zinc finger nucleases
US6991066B2 (en) * 2002-02-01 2006-01-31 International Business Machines Corporation Customized self-checkout system
US20030180268A1 (en) * 2002-02-05 2003-09-25 Anthony Atala Tissue engineered construct for supplementing or replacing a damaged organ
US20030229909A1 (en) * 2002-02-13 2003-12-11 The Texas A&M University System Cloning cats by nuclear transplantation
AU2003217569A1 (en) * 2002-02-21 2003-09-09 Advanced Cell Technology, Inc. Pluripotent cells comprising allogenic nucleus and mitochondria
US7736892B2 (en) 2002-02-25 2010-06-15 Kansas State University Research Foundation Cultures, products and methods using umbilical cord matrix cells
US20030161818A1 (en) * 2002-02-25 2003-08-28 Kansas State University Research Foundation Cultures, products and methods using stem cells
US20030232410A1 (en) * 2002-03-21 2003-12-18 Monika Liljedahl Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
CA2480802A1 (en) * 2002-04-01 2003-10-16 Gtc Biotherapeutics, Inc. A method for selecting cell lines to be used for nuclear transfer in mammalian species
US20030217378A1 (en) * 2002-04-05 2003-11-20 The University Of Georgia Research Foundation, Inc Cloning using rapidly matured oocytes
AU2003232003B2 (en) * 2002-04-18 2006-05-11 Idaho Research Foundation Activation of equine oocytes
WO2003090526A1 (en) * 2002-04-24 2003-11-06 University Of Georgia Research Foundation Production of cloned offspring from cooled carcasses
AU2003295309A1 (en) * 2002-04-30 2004-04-19 Nucleotech, Llc Methods for altering cell fate to generate t-cells specific for an antigen of interest
US20040091936A1 (en) 2002-05-24 2004-05-13 Michael West Bank of stem cells for producing cells for transplantation having HLA antigens matching those of transplant recipients, and methods for making and using such a stem cell bank
EP1513928B1 (en) 2002-05-24 2019-08-21 Advanced Cell Technology, Inc. A bank of stem cells for producing cells for transplantation having hla antigens matching those of transplant recipients, and methods for making and using such a stem cell bank
US7612250B2 (en) 2002-07-29 2009-11-03 Trustees Of Tufts College Nuclear transfer embryo formation method
WO2004013299A2 (en) * 2002-08-02 2004-02-12 The General Hospital Corporation Methods for the production of cells and mammals with desired genetic modifications
JP2006502748A (ja) * 2002-09-05 2006-01-26 カリフォルニア インスティテュート オブ テクノロジー 遺伝子ターゲッティングを誘発するキメラヌクレアーゼの使用方法
US20050034175A1 (en) * 2002-09-09 2005-02-10 Latif Zuhair A. Immune cloning and uses thereof
AU2003286442A1 (en) * 2002-10-16 2004-05-04 Advanced Cell Technology, Inc. Methods using gene trapped stem cells for marking pathways of stem cell differentiation and making and isolating differentiated cells
US20040077077A1 (en) * 2002-10-18 2004-04-22 Xiangzhong Yang Novel methods for the production of cloned mammals, mammals cloned according to the methods, and methods of use of same
KR100479638B1 (ko) * 2002-10-21 2005-03-31 주식회사 마크로젠 전기자극 및 막항원 표시자를 이용한 핵이식용 공여체 준비방법 및 이를 이용한 복제동물의 생산방법
JP2006505291A (ja) * 2002-11-08 2006-02-16 ヘマテック，エルエルシー プリオンタンパク質活性が低減されたトランスジェニック有蹄動物及びその用途
US7627373B2 (en) 2002-11-30 2009-12-01 Cardiac Pacemakers, Inc. Method and apparatus for cell and electrical therapy of living tissue
CN1683524A (zh) * 2003-04-08 2005-10-19 东南大学 用体细胞核移植技术制备移核胚胎干细胞的方法
US20060037086A1 (en) * 2003-04-09 2006-02-16 Schatten Gerald P Methods for correcting mitotic spindle defects and optimizing preimplantation embryonic developmental rates associated with somatic cell nuclear transfer in animals
US11311574B2 (en) 2003-08-08 2022-04-26 Sangamo Therapeutics, Inc. Methods and compositions for targeted cleavage and recombination
US20120196370A1 (en) 2010-12-03 2012-08-02 Fyodor Urnov Methods and compositions for targeted genomic deletion
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US7550263B2 (en) * 2003-09-05 2009-06-23 Gtc Biotherapeutics, Inc. Method for the production of fusion proteins in transgenic mammal milk
US7972854B2 (en) 2004-02-05 2011-07-05 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US20050186608A1 (en) * 2004-02-19 2005-08-25 Olsen Byron V. Method for the production of transgenic proteins useful in the treatment of obesity and diabetes
US7840263B2 (en) * 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US20050197496A1 (en) * 2004-03-04 2005-09-08 Gtc Biotherapeutics, Inc. Methods of protein fractionation using high performance tangential flow filtration
CA2563064A1 (en) 2004-04-22 2005-11-10 Kirin Beer Kabushiki Kaisha Transgenic animals and uses thereof
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7828711B2 (en) * 2004-08-16 2010-11-09 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular growth and regeneration using ventricular assist device
JP2006081542A (ja) * 2004-08-18 2006-03-30 Institute Of Physical & Chemical Research クローン哺乳動物の作成方法
WO2006018316A1 (en) * 2004-08-20 2006-02-23 Ingenium Pharmaceuticals Ag Methods for the production of improved live stocks and disease models for therapeutic research
US20060121004A1 (en) * 2004-12-07 2006-06-08 Yann Echelard Methods of reducing the incidence of rejection in tissue transplantation through the use of recombinant human antithrombin
US20060123500A1 (en) * 2004-12-07 2006-06-08 Gtc Biotherapeutics, Inc. Methods of prescreening cells for nuclear transfer procedures
US20060130159A1 (en) * 2004-12-09 2006-06-15 Nick Masiello Method of purifying recombinant MSP 1-42 derived from Plasmodium falciparum
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
KR100733012B1 (ko) 2005-07-26 2007-06-28 재단법인서울대학교산학협력재단 복제된 개과 동물 및 이의 생산 방법
CA2659945C (en) 2005-08-03 2014-12-16 Advanced Cell Technology, Inc. Improved methods of reprogramming animal somatic cells
US20090186097A1 (en) 2005-08-09 2009-07-23 David Lee Ayares Transgenic Ungulates Expressing CTLA4-IG and Uses Thereof
US7732202B2 (en) 2005-10-21 2010-06-08 International Stem Cell Corporation Oxygen tension for the parthenogenic activation of human oocytes for the production of human embryonic stem cells
ES2417147T3 (es) 2005-10-21 2013-08-06 Revo Biologics, Inc. Anticuerpos con actividad de citotoxicidad celular dependiente de anticuerpos mejorada, métodos para su producción y uso
US7531632B2 (en) * 2006-02-16 2009-05-12 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
CA2658813A1 (en) * 2006-07-24 2008-01-31 International Stem Cell Corporation Synthetic cornea from retinal stem cells
ES2378407T3 (es) 2006-09-01 2012-04-12 Therapeutic Human Polyclonals, Inc. Aumento de la expresión de inmunoglobulina humana o humanizada en animales transgénicos no humanos
US20100205678A1 (en) * 2007-01-05 2010-08-12 Overstrom Eric W Oocyte spindle-associated factors improve somatic cell cloning
KR100829426B1 (ko) * 2007-01-17 2008-05-15 재단법인서울대학교산학협력재단 복제개의 생산 방법
WO2008103462A2 (en) * 2007-02-23 2008-08-28 Advanced Cell Technology, Inc. Highly efficient methods for reprogramming differentiated cells and for generating animals and embryonic stem cells from reprogrammed cells
US20080222745A1 (en) * 2007-03-07 2008-09-11 Utah State University Colcemid-Treatment of Oocytes to enhance Nuclear Transfer Cloning
WO2008124142A1 (en) 2007-04-06 2008-10-16 International Stem Cell Corporation Patient-specific stem cell lines derived from human parthenogenetic blastocysts
KR100868245B1 (ko) * 2007-05-29 2008-11-11 강원대학교산학협력단 데메콜친 처리에 의한 효율적인 복제 동물의 생산방법
WO2009066934A2 (en) * 2007-11-19 2009-05-28 Seoul National University Industry Foundation Methods for improvement of birth rates in canidae on somatic cell nuclear transfer
WO2009088189A2 (ko) 2008-01-04 2009-07-16 Seoul National University Industry Foundation 형질전환된 복제개의 생산방법
EP3225252A1 (en) 2008-05-02 2017-10-04 Laboratoire Français du Fractionnement et des Biotechnologies Treatment of bleeding with low half-life fibrinogen
EP2267153A1 (en) 2009-05-26 2010-12-29 Université Claude Bernard Lyon 1 Identification of netrin-1 receptor unc5c gene mutation in solid cancers
US20120321595A1 (en) 2009-11-09 2012-12-20 The Brigham And Women's Hospital, Inc. Treatment of heart disease
ES2738476T3 (es) 2010-08-11 2020-01-23 Inst Nat Sante Rech Med Cocultivos de células del cúmulo y embriones durante procedimientos de fertilización in vitro
PL2613776T3 (pl) 2010-09-01 2021-01-11 Thomas Jefferson University Kompozycja oraz sposób naprawy i regeneracji mięśni
CA2812194C (en) 2010-09-17 2022-12-13 President And Fellows Of Harvard College Functional genomics assay for characterizing pluripotent stem cell utility and safety
CA2827348C (en) 2011-02-14 2021-02-23 Revivicor, Inc. Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
SI2709445T1 (sl) 2011-05-16 2018-11-30 The Curators Of The University Of Missouri Živali, odporne proti virusu prašičjega reprodukcijskega in respiratornega sindroma
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
CA2844435A1 (en) 2011-08-10 2013-02-14 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Highly galactosylated antibodies
EP2599859A1 (en) 2011-11-30 2013-06-05 IMBA-Institut für Molekulare Biotechnologie GmbH Haploid cells
AU2012345676B2 (en) 2011-12-01 2018-10-04 New York Stem Cell Foundation, Inc. Automated system for producing induced pluripotent stem cells or differentiated cells
EP2802647B1 (en) 2012-01-13 2020-10-28 The General Hospital Corporation Isolated human lung progenitor cells and uses thereof
CN104411815B (zh) 2012-04-30 2017-11-28 大学健康网络 用于从hPSC生成胰腺祖细胞和功能性β细胞的方法和组合物
JP6444307B2 (ja) 2012-09-25 2018-12-26 イエール ユニバーシティ 胚体内胚葉を介したヒト肺胞ｉｉ型へのヒトｉｐｓ細胞の分化
MX2015010429A (es) 2013-02-13 2016-05-16 Lab Francais Du Fractionnement Cetuximab con glicosilación modificada y sus usos.
BR112015019348A2 (pt) 2013-02-13 2017-08-22 Lab Francais Du Fractionnement Métodos para produção de proteína com glicosilação modificada e com sialilação aumentada, para aumentar a atividade de sialil transferase na glândula mamária e para produzir sialil transferase, proteína com glicosilação modificada ou proteína com sialilação aumentada, composição, sialil transferase, mamífero transgênico, e, célula epitelial mamária
CN105308071A (zh) 2013-02-13 2016-02-03 法国化学与生物科技实验室 高度半乳糖基化的抗her2抗体及其用途
AU2014217561B2 (en) 2013-02-13 2018-11-15 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Highly galactosylated anti-TNF-alpha antibodies and uses thereof
US9993504B2 (en) 2013-04-05 2018-06-12 University Health Network Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue
JP6697380B2 (ja) 2013-06-10 2020-05-20 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 多能性幹細胞の有用性および安全性を特徴付けるための初期発生ゲノムアッセイ
KR102580225B1 (ko) 2013-06-11 2023-09-20 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 SC-β 세포 및 조성물 그리고 그 생성 방법
WO2014201254A1 (en) 2013-06-12 2014-12-18 University Of Washington Through Its Center For Commercialization Methods for maturing cardiomyocytes and uses thereof
WO2015023720A1 (en) 2013-08-16 2015-02-19 Yale University Epithelial cell differentiation of human mesenchymal stromal cells
AU2014321101B2 (en) 2013-09-13 2020-12-03 University Health Network Methods and compositions for generating epicardium cells
WO2015069736A1 (en) 2013-11-08 2015-05-14 The Mclean Hospital Corporation METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS
EP3096713B1 (en) 2014-01-23 2022-09-21 President and Fellows of Harvard College Engineered polymeric valves, tubular structures and sheets
CA2950241A1 (en) 2014-06-02 2015-12-10 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Production of fc fragments
DK3183337T3 (en) 2014-08-22 2019-04-01 Procella Therapeutics Ab Use of Jagged 1 / Frizzled 4 as cell surface marker for isolation of human cardiac ventricular progenitor cells
US10596200B2 (en) 2014-08-22 2020-03-24 Procella Therapeutics Ab Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells
KR102473092B1 (ko) 2014-09-15 2022-12-01 칠드런'즈 메디컬 센터 코포레이션 히스톤 h3-리신 트리메틸화를 제거함으로써 체세포 핵 이식(scnt) 효율을 증가시키는 방법 및 조성물
CN104488853B (zh) * 2015-01-12 2016-08-24 中国农业大学 一种牛胚胎玻璃化冷冻甩管解冻和直接移植方法
WO2016131137A1 (en) 2015-02-17 2016-08-25 University Health Network Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes
WO2016178087A1 (en) 2015-05-04 2016-11-10 Biosourcing Sa Transgenic production of chorionic gonadotropin
BR112017023503A2 (pt) 2015-05-04 2018-07-31 Biosourcing Sa método, composição, e, mamífero transgênico não humano.
FR3038517B1 (fr) 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
RU2018107842A (ru) 2015-08-06 2019-09-09 Дзе Кьюрейторз Оф Дзе Юниверсити Оф Миссури Устойчивые к патогенам животные, имеющие модифицированные гены cd163
WO2017172086A1 (en) 2016-02-19 2017-10-05 Leung Chuen Yan Genetic markers for engraftment of human cardiac ventricular progenitor cells
US11534466B2 (en) 2016-03-09 2022-12-27 Aal Scientifics, Inc. Pancreatic stem cells and uses thereof
WO2017202814A1 (en) 2016-05-24 2017-11-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of neuropathological disorders characterized by a loss of cortical neurons
CA3042382A1 (en) 2016-11-02 2018-05-11 Aal Scientifics, Inc. Non-mesenchymal human lung stem cells and methods of their use for treating respiratory diseases
US10508263B2 (en) 2016-11-29 2019-12-17 Procella Therapeutics Ab Methods for isolating human cardiac ventricular progenitor cells
WO2019038587A1 (en) 2017-08-23 2019-02-28 Procella Therapeutics Ab USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE MARKER FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS
US11618884B2 (en) 2017-11-14 2023-04-04 Inserm (Institut National De La Sante Et De La Recherche Medicale) Regulatory T cells genetically modified for the lymphotoxin alpha gene and uses thereof
WO2019116096A1 (en) 2017-12-15 2019-06-20 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Production of fc fragments
US11160260B2 (en) 2018-04-17 2021-11-02 The Curators Of The University Of Missouri Methods for protecting porcine fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
WO2019227198A1 (en) 2018-05-31 2019-12-05 University Health Network (Uhn) Methods and compositions comprising tankyrase inhibitors for generating insulin producing cells
AU2019335025A1 (en) 2018-09-07 2021-04-08 Hebecell Corporation Methods and compositions for retinal neuron generation in carrier-free 3D sphere suspension culture
WO2020053661A1 (en) 2018-09-13 2020-03-19 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Methods of purifying antibodies from the milk of transgenic non-human mammals comprising the use of chitosan
EP3969569A1 (en) 2019-05-14 2022-03-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Regulatory t cells targeted by lymphotoxin alpha blocking agent and uses thereof
EP4041867A1 (en) 2019-10-09 2022-08-17 Institut National de la Santé et de la Recherche Médicale (INSERM) T cells modified to express mutated cxcr4 or partially deleted and uses thereof
CN117279502A (zh) 2020-11-20 2023-12-22 雷维维科公司 用于异种移植的生长激素受体敲除的多转基因猪
EP4404740A1 (en) 2021-09-20 2024-07-31 Revivicor Inc. Multitransgenic pigs comprising ten genetic modifications for xenotransplantation
WO2023178239A1 (en) 2022-03-16 2023-09-21 The Children's Medical Center Corporation Hpsc-derived articular chondrocyte compositions, systems and methods of use thereof
US20230330264A1 (en) 2022-04-15 2023-10-19 Smartcella Solutions Ab COMPOSITIONS AND METHODS FOR EXOSOME-MEDIATED DELIVERY OF mRNA AGENTS
CN119522044A (zh) 2022-05-26 2025-02-25 藤得食品股份有限公司 基于植物的肉丝制品及其生产方法
US20240090531A1 (en) 2022-09-16 2024-03-21 Tender Food, Inc. Plant and animal cell blended meat products and methods of producing the same
JP2026504725A (ja) 2022-12-16 2026-02-09 テンダー フード，インコーポレイテッド 植物ベースの家禽製品及びその製造方法
WO2025217332A1 (en) 2024-04-10 2025-10-16 Tender Food, Inc. Apparatus for production of food-grade fibers and methods of operating the same
WO2026083330A1 (en) 2024-10-17 2026-04-23 Roslin Cell Therapies Limited Compositions and methods for reprogramming of cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026884A1 (en) * 1993-05-14 1994-11-24 Biotechnology Research And Development Corporation Embryonic stem cells for making chimeric and transgenic ungulates
JP2000506722A (ja) * 1995-08-31 2000-06-06 ロスリン インスティテュート（エジンバラ） 核転移用の静止状態の細胞集団

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994384A (en) * 1986-12-31 1991-02-19 W. R. Grace & Co.-Conn. Multiplying bovine embryos
US5057420A (en) * 1987-06-05 1991-10-15 Granada Biosciences, Inc. Bovine nuclear transplantation
AU1439295A (en) * 1993-12-17 1995-07-03 Abs Global, Inc. Ungulate preblastocyst derived embryonic stem cells and use thereof to produce cloned transgenic and chimeric ungulates
AU1595195A (en) * 1993-12-23 1995-07-10 Abs Global, Inc. Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals
AUPM621394A0 (en) * 1994-06-10 1994-07-07 Mitchell, John Cathode connection for aluminium smelter pot
JP3790268B2 (ja) * 1994-06-15 2006-06-28 明治乳業株式会社 有蹄類のｅｇ細胞
GB9417831D0 (en) * 1994-09-05 1994-10-26 Biotech & Biolog Scien Res Biological manipulation
DE19532098A1 (de) * 1995-08-30 1997-03-06 Stuemed Gmbh Vorrichtung für endoskopische Operationen, insbesondere spreizbares Stütz-Epi-Hypopharyngo-Laryngoskop nach Feyh-Kastenbauer
GB9517779D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US5905042A (en) * 1996-04-01 1999-05-18 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Cultured inner cell mass cell lines derived from bovine or porcine embryos
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026884A1 (en) * 1993-05-14 1994-11-24 Biotechnology Research And Development Corporation Embryonic stem cells for making chimeric and transgenic ungulates
JP2000506722A (ja) * 1995-08-31 2000-06-06 ロスリン インスティテュート（エジンバラ） 核転移用の静止状態の細胞集団

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000512159A (ja) * 1998-01-16 2000-09-19 アグロバイオジェン ゲーエムベーハー 胎仔線維芽細胞による効率的な核移入
JP2002500864A (ja) * 1998-01-21 2002-01-15 ユニバーシティ・オブ・ハワイ 成体の体細胞核を再構成した被核除去卵母細胞からの動物の満期の成長
JP2006522609A (ja) * 2003-04-09 2006-10-05 マギー−ウイメンズ・ヘルス・コーポレイション 動物の体細胞核移植と関係する紡錘体欠損を修正するための方法
JPWO2016140353A1 (ja) * 2015-03-04 2018-01-25 株式会社医療実験用大動物供給事業準備会社 安定した表現型を示す疾患モデルブタおよびその作製方法
JP2021176317A (ja) * 2015-03-04 2021-11-11 株式会社ポル・メド・テック 安定した表現型を示す疾患モデルブタおよびその作製方法
US11246299B2 (en) 2015-03-04 2022-02-15 Pormedtec Co., Ltd. Disease model pig exhibiting stable phenotype, and production method thereof
JP7699330B2 (ja) 2015-03-04 2025-06-27 株式会社ポル・メド・テック 安定した表現型を示す疾患モデルブタおよびその作製方法

Also Published As

Publication number Publication date
ES2284197T3 (es) 2007-11-01
CN1248288B (zh) 2011-11-09
WO1998030683A3 (en) 1998-09-17
IL130829A0 (en) 2001-01-28
CA2277192C (en) 2011-03-15
US20020010949A1 (en) 2002-01-24
NZ336612A (en) 2002-09-27
US5945577A (en) 1999-08-31
DE69837270T2 (de) 2008-01-24
DE69837270D1 (de) 2007-04-19
JP2007167078A (ja) 2007-07-05
ATE356203T1 (de) 2007-03-15
AU742363B2 (en) 2002-01-03
EP1808484A1 (en) 2007-07-18
AU6014598A (en) 1998-08-03
BR9806872A (pt) 2000-04-18
AU742363C (en) 2007-06-28
US20050108785A1 (en) 2005-05-19
CA2277192A1 (en) 1998-07-16
EP1015572A2 (en) 2000-07-05
US6235970B1 (en) 2001-05-22
CN1248288A (zh) 2000-03-22
IL130829A (en) 2008-11-26
WO1998030683A2 (en) 1998-07-16
EP1015572B1 (en) 2007-03-07

Similar Documents

Publication Publication Date Title
CN1248288B (zh) 用分化胎儿和成年供体细胞进行的核转移
AU740709B2 (en) Embryonic or stem-like cell lines produced by cross species nuclear transplanta tion
US6215041B1 (en) Cloning using donor nuclei from a non-quiesecent somatic cells
US20020035737A1 (en) Cloning pigs using donor nuclei from differentiated cells
JP2001509361A (ja) 分化した無血清飢餓細胞からの供与核を用いるクローニング
US20010012513A1 (en) Embryonic or stem-like cell lines produced by cross species nuclear transplantation
JP2002505100A (ja) 種間核移植によって作製された胚性または幹細胞様細胞株
JP2003509031A (ja) ドナー細胞又は分化細胞からの核を使用する豚のクローニング並びに多能性豚の産生
US20020194637A1 (en) Embryonic or stem-like cell lines produced by cross species nuclear transplantation
MXPA00000201A (en) Cloning using donor nuclei from non-serum starved, differentiated cells
AU2006202185A1 (en) Cloning using donor nuclei from non-serum starved, differentiated cells
AU2006236032A1 (en) Nuclear transfer with differentiated fetal and adult donor cells
AU2011202964A1 (en) Nuclear transfer with differentiated fetal and adult donor cells
MXPA99001706A (es) Lineas celulares embrionicas o similares a las desoporte producidas por transplante nuclear de especies cruzadas
MXPA99006464A (en) Nuclear transfer with differentiated fetal and adult donor cells

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20050105

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050105

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050303

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080610

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080910

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081020

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081010

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081121

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081110

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081222

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081209

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091110

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20100301

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100406