JP2001511811A - ビタミンｄ化合物の標的治療放出 - Google Patents
ビタミンｄ化合物の標的治療放出Info
- Publication number
- JP2001511811A JP2001511811A JP53597498A JP53597498A JP2001511811A JP 2001511811 A JP2001511811 A JP 2001511811A JP 53597498 A JP53597498 A JP 53597498A JP 53597498 A JP53597498 A JP 53597498A JP 2001511811 A JP2001511811 A JP 2001511811A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- conjugate
- moiety
- target molecule
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
- A61K47/6898—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies using avidin- or biotin-conjugated antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Botany (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3836497P | 1997-02-13 | 1997-02-13 | |
| US60/038,364 | 1997-02-13 | ||
| PCT/US1998/002899 WO1998035704A1 (en) | 1997-02-13 | 1998-02-13 | Targeted therapeutic delivery of vitamin d compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001511811A true JP2001511811A (ja) | 2001-08-14 |
| JP2001511811A5 JP2001511811A5 (https=) | 2005-10-06 |
Family
ID=21899512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53597498A Ceased JP2001511811A (ja) | 1997-02-13 | 1998-02-13 | ビタミンｄ化合物の標的治療放出 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6929797B2 (https=) |
| EP (1) | EP0981376A1 (https=) |
| JP (1) | JP2001511811A (https=) |
| KR (1) | KR20000071039A (https=) |
| CN (1) | CN1254293A (https=) |
| AU (1) | AU750451B2 (https=) |
| BR (1) | BR9815442A (https=) |
| CA (1) | CA2279590A1 (https=) |
| HU (1) | HUP0002454A2 (https=) |
| NZ (1) | NZ336924A (https=) |
| PL (1) | PL336231A1 (https=) |
| WO (1) | WO1998035704A1 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2413499A (en) | 1997-12-17 | 1999-07-05 | Schering Aktiengesellschaft | Vitamin d derivatives with phosphorous atoms in the side chains |
| US8586781B2 (en) | 1998-04-02 | 2013-11-19 | Mbc Pharma, Inc. | Bone targeted therapeutics and methods of making and using the same |
| US7598246B2 (en) | 1998-04-02 | 2009-10-06 | Mbc Pharma, Inc. | Bisphosphonate conjugates and methods of making and using the same |
| US6896871B2 (en) | 1998-04-02 | 2005-05-24 | Mbc Research, Inc. | Biphosphonate conjugates and methods of making and using the same |
| EP1146050B1 (en) | 1999-01-20 | 2009-12-09 | Takara Bio Inc. | 4-Substituted-3,6-anhydro-galactose derivatives and their pharmaceutical use |
| US6605591B1 (en) * | 1999-11-12 | 2003-08-12 | Genelabs Technologies, Inc. | Treatment of subnormal bone mineral density |
| US6468568B1 (en) | 2000-06-16 | 2002-10-22 | General Mills, Inc. | Oligosaccharide encapsulated mineral and vitamin ingredients |
| US6436453B1 (en) | 2000-06-16 | 2002-08-20 | General Mills, Inc. | Production of oil encapsulated minerals and vitamins in a glassy matrix |
| US7829074B2 (en) | 2001-10-18 | 2010-11-09 | Nektar Therapeutics | Hydroxypatite-targeting poly(ethylene glycol) and related polymers |
| US6436386B1 (en) * | 2000-11-14 | 2002-08-20 | Shearwater Corporation | Hydroxyapatite-targeting poly (ethylene glycol) and related polymers |
| EP1383510B1 (en) * | 2001-04-10 | 2012-10-17 | MBC Pharma, Inc. | Bisphosphonate conjugates and methods of making and using the same |
| DE10156596A1 (de) * | 2001-11-13 | 2003-05-28 | Schering Ag | Vitamin D-Derivate mit Acyloxygruppen in der Seitenkette, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| BR0214679A (pt) * | 2001-12-03 | 2004-12-14 | Novacea Inc | Composições farmacêuticas compreendendo compostos a base de vitamina d ativa |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| MX2007006261A (es) * | 2004-11-22 | 2007-07-10 | Wisconsin Alumni Res Found | Analogos de 17,20(z)-deshidro vitamina d y sus usos. |
| US20100144671A1 (en) * | 2005-03-04 | 2010-06-10 | Women And Infants Hospital Of Ri, Inc. | Compositions and Methods for Cancer Treatment |
| WO2007047327A2 (en) * | 2005-10-12 | 2007-04-26 | Proventiv Therapeutics, Llc | Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency |
| WO2008035207A2 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof |
| MX2008012912A (es) * | 2006-04-06 | 2008-11-26 | Wisconsin Alumni Res Found | Analogos de 2-metilen-1a,25-dihidroxi-19,21-dinorvitamina d3 y sus usos. |
| WO2009086436A1 (en) * | 2007-12-28 | 2009-07-09 | Wisconsin Alumni Research Foundation | (20s)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin d analogs |
| US7718638B2 (en) * | 2007-12-28 | 2010-05-18 | Wisconsin Alumni Research Foundation | (20R)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs |
| US7648974B1 (en) * | 2008-07-10 | 2010-01-19 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 3,2-dihydrofuran ring |
| EP2289558A1 (en) * | 2009-08-25 | 2011-03-02 | KTB Tumorforschungsgesellschaft mbH | Bisphosphonate-prodrugs |
| US8772235B2 (en) | 2009-10-14 | 2014-07-08 | The Governors Of The University Of Alberta | Compounds having peptides conjugated to bone targeting moieties and methods of making and using thereof |
| EP2695617B1 (en) | 2009-12-23 | 2019-01-09 | Glycomyr Inc. | Vitamin D glycosides and sulfates for treating intestinal diseases |
| US8785603B2 (en) | 2011-05-20 | 2014-07-22 | Siemens Healthcare Diagnostics Inc. | Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof |
| CA2843885C (en) * | 2011-08-01 | 2020-03-10 | Mbc Pharma, Inc. | Vitamin b6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates |
| CN108524919A (zh) * | 2012-05-17 | 2018-09-14 | 延伸生物科学股份有限公司 | 用于改进的药物递送的载体 |
| US9244083B2 (en) | 2012-11-30 | 2016-01-26 | Siemens Healthcare Diagnostics Inc. | Compositions and methods for detecting vitamin D |
| US9618523B2 (en) | 2013-02-28 | 2017-04-11 | Siemens Healthcare Diagnostics Inc. | Methods and reagents for determining isomeric analytes |
| TWI731535B (zh) | 2014-03-21 | 2021-06-21 | 美商艾伯維有限公司 | 抗-egfr抗體及抗體藥物結合物 |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| CN105381470B (zh) * | 2015-11-27 | 2018-11-02 | 广东医科大学 | 一种改性染料木素及其应用 |
| EP3458479B1 (en) | 2016-06-08 | 2020-11-04 | AbbVie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
| JP2019526529A (ja) | 2016-06-08 | 2019-09-19 | アッヴィ・インコーポレイテッド | 抗ｂ７−ｈ３抗体及び抗体薬物コンジュゲート |
| EP3469000A1 (en) | 2016-06-08 | 2019-04-17 | AbbVie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
| BR112018075630A2 (pt) | 2016-06-08 | 2019-03-19 | Abbvie Inc. | anticorpos anti-cd98 e conjugados de fármaco de anticorpo |
| EP3554544A4 (en) | 2016-12-16 | 2020-07-29 | Bluefin Biomedicine, Inc. | ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE |
| WO2018195302A1 (en) | 2017-04-19 | 2018-10-25 | Bluefin Biomedicine, Inc. | Anti-vtcn1 antibodies and antibody drug conjugates |
| CA3066918A1 (en) | 2017-06-12 | 2018-12-20 | Bluefin Biomedicine, Inc. | Anti-il1rap antibodies and antibody drug conjugates |
| CN111440105B (zh) * | 2020-04-01 | 2022-05-17 | 南通华山药业有限公司 | 阿法骨化醇氨基甲酸酯衍生物及其制备方法和用途 |
| UY39610A (es) | 2021-01-20 | 2022-08-31 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| EP4593867A2 (en) | 2022-09-30 | 2025-08-06 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
| CN116082536B (zh) * | 2023-02-16 | 2024-04-26 | 广州汇元医药科技有限公司 | 具有骨靶向功能的聚合物及其制备方法和用途、纳米载体及其制备方法 |
| WO2025027529A1 (en) | 2023-07-31 | 2025-02-06 | Advesya | Anti-il-1rap antibody drug conjugates and methods of use thereof |
| TW202530255A (zh) | 2023-12-15 | 2025-08-01 | 法商亞維西亞有限公司 | 抗ｉｌ－１ｒａｐ結合結構域及其抗體－藥物偶聯物 |
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| EP0562497A1 (en) | 1992-03-27 | 1993-09-29 | Nisshin Flour Milling Co., Ltd. | 1 alpha-hydroxy vitamins D7 and D4' processes for the preparation thereof and pharmaceutical compositions |
| US6113946A (en) | 1992-04-03 | 2000-09-05 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system comprising dendrimer polycations |
| JP2520074B2 (ja) * | 1992-06-11 | 1996-07-31 | 呉羽化学工業株式会社 | 新規なエストラジオ―ル誘導体−クロラムブチル結合体、その製造方法、及び医薬製剤 |
| DK0600079T3 (da) | 1992-06-22 | 2002-04-15 | Bone Care Int Inc | Oral 1alpha-hydroxyprævitamin D |
| US5795882A (en) | 1992-06-22 | 1998-08-18 | Bone Care International, Inc. | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
| US5350745A (en) | 1993-01-29 | 1994-09-27 | Lunar Corporation | Treatment of myocardial failure |
| US5763429A (en) | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
| ES2120122T3 (es) | 1994-01-20 | 1998-10-16 | Duphar Int Res | Compuestos de vitamina d y metodo de preparar estos compuestos. |
| US5597575A (en) | 1994-06-06 | 1997-01-28 | Breitbarth; Richard | Composition for stimulating and inducing hair growth |
| US5739271A (en) | 1995-06-07 | 1998-04-14 | Gen-Probe Incorporated | Thiocationic lipids |
| SG80553A1 (en) * | 1995-07-20 | 2001-05-22 | Tanabe Seiyaku Co | Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract |
| US5691328A (en) * | 1996-02-02 | 1997-11-25 | Clarion Pharmaceuticals Inc. | Phosphoethanolamine conjugates of vitamin D compounds |
| WO1999049870A1 (en) | 1998-03-27 | 1999-10-07 | Oregon Health Sciences University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
-
1998
- 1998-02-13 JP JP53597498A patent/JP2001511811A/ja not_active Ceased
- 1998-02-13 WO PCT/US1998/002899 patent/WO1998035704A1/en not_active Ceased
- 1998-02-13 AU AU63267/98A patent/AU750451B2/en not_active Expired
- 1998-02-13 PL PL98336231A patent/PL336231A1/xx unknown
- 1998-02-13 KR KR1019997007306A patent/KR20000071039A/ko not_active Withdrawn
- 1998-02-13 CA CA002279590A patent/CA2279590A1/en not_active Abandoned
- 1998-02-13 EP EP98907468A patent/EP0981376A1/en not_active Withdrawn
- 1998-02-13 CN CN98802534A patent/CN1254293A/zh active Pending
- 1998-02-13 NZ NZ336924A patent/NZ336924A/en unknown
- 1998-02-13 BR BR9815442-7A patent/BR9815442A/pt not_active IP Right Cessation
- 1998-02-13 US US09/402,636 patent/US6929797B2/en not_active Expired - Lifetime
- 1998-02-13 HU HU0002454A patent/HUP0002454A2/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000071039A (ko) | 2000-11-25 |
| WO1998035704A1 (en) | 1998-08-20 |
| AU750451B2 (en) | 2002-07-18 |
| US6929797B2 (en) | 2005-08-16 |
| US20020136731A1 (en) | 2002-09-26 |
| PL336231A1 (en) | 2000-06-19 |
| AU6326798A (en) | 1998-09-08 |
| EP0981376A1 (en) | 2000-03-01 |
| BR9815442A (pt) | 2001-08-21 |
| CA2279590A1 (en) | 1998-08-20 |
| HUP0002454A2 (hu) | 2000-12-28 |
| NZ336924A (en) | 2001-06-29 |
| CN1254293A (zh) | 2000-05-24 |
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