JP2001509362A5 - - Google Patents

Download PDF

Info

Publication number
JP2001509362A5
JP2001509362A5 JP2000500927A JP2000500927A JP2001509362A5 JP 2001509362 A5 JP2001509362 A5 JP 2001509362A5 JP 2000500927 A JP2000500927 A JP 2000500927A JP 2000500927 A JP2000500927 A JP 2000500927A JP 2001509362 A5 JP2001509362 A5 JP 2001509362A5
Authority
JP
Japan
Prior art keywords
cells
cell
method described
section
chimeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000500927A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001509362A (ja
Filing date
Publication date
Priority claimed from US08/888,057 external-priority patent/US6235969B1/en
Application filed filed Critical
Publication of JP2001509362A publication Critical patent/JP2001509362A/ja
Publication of JP2001509362A5 publication Critical patent/JP2001509362A5/ja
Pending legal-status Critical Current

Links

JP2000500927A 1997-07-03 1998-07-01 分化細胞からのドナー核を使用するブタのクローニング Pending JP2001509362A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/888,057 US6235969B1 (en) 1997-01-10 1997-07-03 Cloning pigs using donor nuclei from non-quiescent differentiated cells
US08/888,057 1997-07-03
PCT/US1998/012806 WO1999001164A1 (en) 1997-07-03 1998-07-01 Cloning pigs using donor nuclei from differentiated cells

Publications (2)

Publication Number Publication Date
JP2001509362A JP2001509362A (ja) 2001-07-24
JP2001509362A5 true JP2001509362A5 (enExample) 2006-01-05

Family

ID=25392430

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000500927A Pending JP2001509362A (ja) 1997-07-03 1998-07-01 分化細胞からのドナー核を使用するブタのクローニング

Country Status (10)

Country Link
US (4) US6235969B1 (enExample)
EP (1) EP1017423A4 (enExample)
JP (1) JP2001509362A (enExample)
CN (1) CN1210066C (enExample)
AU (1) AU742840B2 (enExample)
BR (1) BR9811659A (enExample)
CA (1) CA2295294A1 (enExample)
IL (1) IL133785A0 (enExample)
NZ (1) NZ502124A (enExample)
WO (1) WO1999001164A1 (enExample)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9517779D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US20090092588A1 (en) * 1997-01-10 2009-04-09 University Of Massachusetts As Represented By Its Amherst Campus Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease
US6235969B1 (en) * 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
US7291764B1 (en) * 1997-01-10 2007-11-06 University of Massachusetts, a Public Institution of Higher Education of the Commonwealth of Massachusetts, as Represented by its Amherst Campus, Office of Vice Chancellor for Research at Amherst Cloning pigs using non-quiescent differentiated donor cells or nuclei
US6331659B1 (en) 1998-01-21 2001-12-18 University Of Hawaii Cumulus cells as nuclear donors
JP2002511234A (ja) * 1998-03-16 2002-04-16 リレグ ピーティーワイ リミテッド ブタの核移植
JPH11289916A (ja) * 1998-04-09 1999-10-26 Kazuo Shiga 牛の筋肉組織の培養細胞を用いて受胎可能な体細胞核移植クローン胚の 作出及びクローン胚を凍結保存する方法
AUPP294898A0 (en) * 1998-04-15 1998-05-07 Monash University Method of nuclear transfer
GB2365445A (en) * 1998-10-12 2002-02-20 Geron Bio Med Ltd Porcine occcytes with improved developmental competence
US6781030B1 (en) 1998-11-02 2004-08-24 Trustee Of Tufts College, Ballou Hall Methods for cloning mammals using telophase oocytes
AU780754B2 (en) 1999-03-04 2005-04-14 Revivicor Inc Genetic modification of somatic cells and uses thereof
US6911429B2 (en) 1999-04-01 2005-06-28 Transition Therapeutics Inc. Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US6864235B1 (en) 1999-04-01 2005-03-08 Eva A. Turley Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
WO2001013826A1 (de) * 1999-08-20 2001-03-01 Metz Stavenhagen Peter Wirbelsäulensegment
US20040180430A1 (en) * 1999-09-07 2004-09-16 West Michael D. Methods of restoring telomere length and extending cell lifespan using nuclear transfer
US20050255596A1 (en) * 1999-09-07 2005-11-17 West Michael D Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer
EP1241931A4 (en) * 1999-09-13 2004-12-29 Univ Massachusetts CLONING PIGS USING DONORATION CELLS OR NUCLEAR CELLS OF DIFFERENTIATED CELLS AND PRODUCING PLURIPOTENT PIGS
CA2426669A1 (en) * 1999-10-22 2001-05-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education .alpha.1-3 galactosyltransferase gene and promoter
KR100417566B1 (ko) * 1999-11-19 2004-02-05 한국생명공학연구원 체세포 핵치환 복제수정란의 대량생산방법
US20060174358A1 (en) * 2001-01-04 2006-08-03 Xiangzhong Yang Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells
US7071372B2 (en) * 2000-01-04 2006-07-04 University Of Connecticut Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells
CA2403344C (en) * 2000-03-15 2013-05-21 The University Of Georgia Research Foundation, Inc. Effective nuclear reprogramming in mammals
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
GB2360522A (en) 2000-03-24 2001-09-26 Geron Corp A strategy for maintaining pregnancy
AU2001247732A1 (en) * 2000-03-24 2001-10-08 Geron Corporation A strategy for maintaining pregnancy
US20030172394A1 (en) * 2001-08-01 2003-09-11 Holzer George L Selection and cloning methods
CA2634294A1 (en) 2000-08-03 2002-02-14 Therapeutic Human Polyclonals, Inc. Production of humanized antibodies in transgenic animals
US8105825B2 (en) * 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
US7491534B2 (en) * 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
AU2002232858B2 (en) * 2000-12-22 2007-01-11 Sab, Llc Methods for cloning mammals using reprogrammed donor chromatin or donor cells
US20020142397A1 (en) * 2000-12-22 2002-10-03 Philippe Collas Methods for altering cell fate
WO2002074078A2 (en) 2001-01-30 2002-09-26 Rebholtz, Amy, K. Method for embryo after impregnation of the recipient female
JP4955905B2 (ja) * 2001-02-20 2012-06-20 イントレキソン コーポレーション キメラレチノイドｘ受容体および新規エクジソン受容体−ベースの誘導性遺伝子発現システムにおけるそれらの使用
WO2003005810A2 (en) * 2001-07-09 2003-01-23 Alexion Pharmaceuticals Inc. Cloned non-human mammals from contact inhibited donor cells
EP1465986A4 (en) * 2001-12-29 2005-01-26 Woo Suk Hwang GFP-TRANSFECTED CLONING PIG, GT-KNOCKOUT CLONING PIG, AND METHOD FOR THE MANUFACTURE THEREOF
WO2003060083A2 (en) * 2002-01-15 2003-07-24 Advanced Cell Technology, Inc. Cloning b and t lymphocytes
US20050170506A1 (en) * 2002-01-16 2005-08-04 Primegen Biotech Llc Therapeutic reprogramming, hybrid stem cells and maturation
US20050090004A1 (en) * 2003-01-16 2005-04-28 Sayre Chauncey B. Stem cell maturation for all tissue lines
US20030217378A1 (en) * 2002-04-05 2003-11-20 The University Of Georgia Research Foundation, Inc Cloning using rapidly matured oocytes
JP2005523031A (ja) * 2002-04-24 2005-08-04 ユニバーシテイ・オブ・ジヨージア・リサーチ・フアウンデイシヨン 冷却死骸からのクローン化された仔の生産
US7612250B2 (en) * 2002-07-29 2009-11-03 Trustees Of Tufts College Nuclear transfer embryo formation method
EP1534819B1 (en) 2002-08-21 2009-12-09 Revivicor, Inc. Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
US20050034175A1 (en) * 2002-09-09 2005-02-10 Latif Zuhair A. Immune cloning and uses thereof
EP1581636A4 (en) * 2002-10-16 2006-09-20 Advanced Cell Tech Inc METHOD OF USE OF STEM CELLS TREATED BY DERGENVALENTECHNIK (GENE TRAP) FOR MARKING STRAIN CELL DIFFERENTIATION PATHS, AND THE PREPARATION AND ISOLATION OF DIFFERENTIATED CELLS
US20040077077A1 (en) * 2002-10-18 2004-04-22 Xiangzhong Yang Novel methods for the production of cloned mammals, mammals cloned according to the methods, and methods of use of same
CN1683524A (zh) * 2003-04-08 2005-10-19 东南大学 用体细胞核移植技术制备移核胚胎干细胞的方法
AU2004290006A1 (en) * 2003-11-05 2005-05-26 University Of Pittsburgh Porcine isogloboside 3 synthase protein, cDNA, genomic organization, and regulatory region
CA2857051A1 (en) 2004-03-17 2005-09-29 David Ayares Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase
US20050277147A1 (en) * 2004-06-11 2005-12-15 Ameet Patki Identifying chromosomal abnormalities in cells obtained from follicular fluid
US20060080746A1 (en) * 2004-09-28 2006-04-13 Viagen, Inc. Methods of embryo transfer
KR100733012B1 (ko) * 2005-07-26 2007-06-28 재단법인서울대학교산학협력재단 복제된 개과 동물 및 이의 생산 방법
CA2617930A1 (en) 2005-08-09 2007-03-29 Revivicor, Inc. Transgenic ungulates expressing ctla4-ig and uses thereof
WO2008085891A1 (en) * 2007-01-05 2008-07-17 Worcester Polytechnic Institute Oocyte spindle-associated factors improve somatic cell cloning
KR100829426B1 (ko) 2007-01-17 2008-05-15 재단법인서울대학교산학협력재단 복제개의 생산 방법
KR100868245B1 (ko) 2007-05-29 2008-11-11 강원대학교산학협력단 데메콜친 처리에 의한 효율적인 복제 동물의 생산방법
AU2010282239A1 (en) * 2009-08-14 2012-03-08 Revivicor, Inc. Multi-transgenic pigs for diabetes treatment
NZ759163A (en) 2011-02-14 2023-03-31 Revivicor Inc Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
CN103173456B (zh) * 2012-12-14 2015-09-23 华南农业大学 猪Xist基因序列、猪anti-Xist siRNA序列及通过抑制猪Xist基因表达来提高猪克隆效率的方法
JP6267785B2 (ja) 2013-04-30 2018-01-24 コングク・ユニバーシティ・インダストリアル・コーペレイション・コーポレイション Ｃｍｐ−アセチルノイラミン酸ヒドロキシラーゼタゲッティングベクター、そのベクターが導入された異種間移植用形質転換動物及びその製造方法
CN103343142B (zh) * 2013-07-15 2017-07-25 云南农业大学 一种利用连续克隆技术生产孤雌生殖克隆猪的方法
WO2016140353A1 (ja) * 2015-03-04 2016-09-09 株式会社 医療実験用大動物供給事業準備会社 安定した表現型を示す疾患モデルブタおよびその作製方法
KR20230107335A (ko) 2020-11-20 2023-07-14 레비비코르 인코포레이션 이종이식을 위한 성장 호르몬 수용체 녹아웃을 갖는 다중-전이유전자 돼지
CN112759633B (zh) * 2021-01-07 2022-08-12 江西农业大学 一种可用于建立猪癌症模型的蛋白及其核酸
JP2024534702A (ja) 2021-09-20 2024-09-20 レバイビコア，インコーポレイティド 異種移植のための１０個の遺伝子改変を含むマルチトランスジェニックブタ

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994384A (en) * 1986-12-31 1991-02-19 W. R. Grace & Co.-Conn. Multiplying bovine embryos
US5057420A (en) * 1987-06-05 1991-10-15 Granada Biosciences, Inc. Bovine nuclear transplantation
GB9003791D0 (en) 1990-02-20 1990-04-18 Ludwig Inst Cancer Res Transgenic animals,cell lines therefrom,and their use
US5523226A (en) * 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
WO1994029442A2 (en) 1993-06-14 1994-12-22 Basf Aktiengesellschaft Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
AU1439295A (en) * 1993-12-17 1995-07-03 Abs Global, Inc. Ungulate preblastocyst derived embryonic stem cells and use thereof to produce cloned transgenic and chimeric ungulates
EP0739412B1 (en) * 1993-12-23 2002-02-27 Infigen, Inc. ungulate EMBRYONIC STEM CELLS AS NUCLEAR DONORS AND NUCLEAR TRANSFER TECHNIQUES TO PRODUCE CHIMERIC AND TRANSGENIC ANIMALS
DE69535752D1 (de) * 1994-04-13 2008-06-26 Biotransplant Inc Alpha(1,3)galactosyltransferase-negatives schwein
AUPM621394A0 (en) * 1994-06-10 1994-07-07 Mitchell, John Cathode connection for aluminium smelter pot
GB9417831D0 (en) * 1994-09-05 1994-10-26 Biotech & Biolog Scien Res Biological manipulation
GB9517779D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US7304204B2 (en) * 1995-08-31 2007-12-04 Roslin Institute Ungulates produced by nuclear transfer of G1 cells
US5905042A (en) * 1996-04-01 1999-05-18 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Cultured inner cell mass cell lines derived from bovine or porcine embryos
US6235969B1 (en) * 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US6215041B1 (en) * 1997-01-10 2001-04-10 University Of Mmassachusetts Cloning using donor nuclei from a non-quiesecent somatic cells
US20010039667A1 (en) * 1997-01-10 2001-11-08 University Of Massachusetts Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease
US20020012655A1 (en) * 1997-01-10 2002-01-31 Steven L. Stice Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease
IL133786A0 (en) * 1997-07-03 2001-04-30 Univ Massachusetts Cloning using donor nuclei from non-serum starved, differentiated cells
WO1999021415A1 (en) * 1997-10-28 1999-05-06 Stem Cell Sciences Pty. Ltd. Nuclear transfer for production of transgenic animal embryo
US6675205B2 (en) * 1999-10-14 2004-01-06 Arcessa, Inc. Peer-to-peer automated anonymous asynchronous file sharing
US6789132B2 (en) * 2000-02-09 2004-09-07 Seagate Technology Llc Modular disc drive architecture
US20040194158A1 (en) * 2003-03-28 2004-09-30 Baylor College Of Medicine Model for neurodegenerative disorders

Similar Documents

Publication Publication Date Title
JP2001509362A5 (enExample)
CA2277192A1 (en) Nuclear transfer with differentiated fetal and adult donor cells
AU742840B2 (en) Cloning pigs using donor nuclei from differentiated cells
AU740709B2 (en) Embryonic or stem-like cell lines produced by cross species nuclear transplanta tion
Yong et al. Nuclear-cytoplasmic interaction and development of goat embryos reconstructed by nuclear transplantation: production of goats by serially cloning embryos
Lai et al. Creating genetically modified pigs by using nuclear transfer
Kono et al. Development of enucleated mouse oocytes reconstituted with embryonic nuclei
JP2001509361A5 (enExample)
JP2001509361A (ja) 分化した無血清飢餓細胞からの供与核を用いるクローニング
JP2002537803A (ja) 異種間核移植により産生される胚性細胞株あるいは幹様細胞株
JP2002505100A5 (enExample)
JP5058166B2 (ja) 細胞核移入
JP2003509031A5 (enExample)
JP2006508676A (ja) 追加の核移植のための細胞ドナーとして体細胞核移植胚を利用する方法および系
Ohkoshi et al. In vitro oocyte culture and somatic cell nuclear transfer used to produce a live-born cloned goat
CA2336437A1 (en) A process of cell reprogramming through production of a heterokaryon
JP2005528095A5 (enExample)
CN105238817B (zh) 一种构建过量表达Leptin基因的克隆猪的方法
Chen et al. Somatic cell bovine cloning: Effect of donor cell and recipients
Zhu et al. Increasing the number of transferred embryos results in delivery of viable transgenically cloned Guangxi Bama mini-pigs
CA2405555A1 (en) Pluripotent cells comprising allogenic nucleus and mitochondria
Suzuki et al. Production of a germ-line chimera by coculture of zona-free embryos with frozen-thawed embryonic stem cells
Nagai et al. Handmade somatic cell cloning and related studies in farm animals
JP2002542779A (ja) 核導入用の終期除核卵母細胞
EP1443107A1 (en) Preparing somatic embryo by utilizing rabbit oocyte