BR9811659A - Clonagem de porcos usando-se núcleos doadores de células diferenciadas - Google Patents
Clonagem de porcos usando-se núcleos doadores de células diferenciadasInfo
- Publication number
- BR9811659A BR9811659A BR9811659-2A BR9811659A BR9811659A BR 9811659 A BR9811659 A BR 9811659A BR 9811659 A BR9811659 A BR 9811659A BR 9811659 A BR9811659 A BR 9811659A
- Authority
- BR
- Brazil
- Prior art keywords
- pigs
- cloning
- differentiated
- cells
- differentiated cell
- Prior art date
Links
- 241000282887 Suidae Species 0.000 title abstract 2
- 238000010367 cloning Methods 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 4
- 210000003754 fetus Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 210000002257 embryonic structure Anatomy 0.000 abstract 1
- 210000000287 oocyte Anatomy 0.000 abstract 1
- 230000000644 propagated effect Effects 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8778—Swine embryos
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0273—Cloned vertebrates
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8771—Bovine embryos
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
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- A—HUMAN NECESSITIES
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C12N2510/00—Genetically modified cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2517/00—Cells related to new breeds of animals
- C12N2517/04—Cells produced using nuclear transfer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
Abstract
Patente de Invenção: <B>"CLONAGEM DE PORCOS USANDO-SE NúCLEOS DOADORES DE CéLULAS DIFERENCIADAS"<D>. é proporcionado um método aperfeiçoado de transferência nuclear envolvendo o transplante de núcleo doador de célula diferenciada de porco para oócitos enucleados. As unidades de transferência nuclear resultantes são úteis para multiplicação de genótipos e genótipos transgênicos através da produção de fetos e filhotes. A produção de embriões, fetos e filhotes transgênicos ou geneticamente manipulados de porco é facilitada pelo presente método, uma vez que a fonte de células diferenciadas do núcleo doador pode ser geneticamente modificada e clonalmente propagada.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/888,057 US6235969B1 (en) | 1997-01-10 | 1997-07-03 | Cloning pigs using donor nuclei from non-quiescent differentiated cells |
PCT/US1998/012806 WO1999001164A1 (en) | 1997-07-03 | 1998-07-01 | Cloning pigs using donor nuclei from differentiated cells |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9811659A true BR9811659A (pt) | 2000-09-05 |
Family
ID=25392430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9811659-2A BR9811659A (pt) | 1997-07-03 | 1998-07-01 | Clonagem de porcos usando-se núcleos doadores de células diferenciadas |
Country Status (10)
Country | Link |
---|---|
US (4) | US6235969B1 (pt) |
EP (1) | EP1017423A4 (pt) |
JP (1) | JP2001509362A (pt) |
CN (1) | CN1210066C (pt) |
AU (1) | AU742840B2 (pt) |
BR (1) | BR9811659A (pt) |
CA (1) | CA2295294A1 (pt) |
IL (1) | IL133785A0 (pt) |
NZ (1) | NZ502124A (pt) |
WO (1) | WO1999001164A1 (pt) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9517780D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
GB9517779D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
US7291764B1 (en) * | 1997-01-10 | 2007-11-06 | University of Massachusetts, a Public Institution of Higher Education of the Commonwealth of Massachusetts, as Represented by its Amherst Campus, Office of Vice Chancellor for Research at Amherst | Cloning pigs using non-quiescent differentiated donor cells or nuclei |
US6235969B1 (en) * | 1997-01-10 | 2001-05-22 | University Of Massachusetts | Cloning pigs using donor nuclei from non-quiescent differentiated cells |
US20090092588A1 (en) * | 1997-01-10 | 2009-04-09 | University Of Massachusetts As Represented By Its Amherst Campus | Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease |
US6331659B1 (en) | 1998-01-21 | 2001-12-18 | University Of Hawaii | Cumulus cells as nuclear donors |
WO1999046982A1 (en) * | 1998-03-16 | 1999-09-23 | Relag Pty Ltd | Porcine nuclear transfer |
JPH11289916A (ja) * | 1998-04-09 | 1999-10-26 | Kazuo Shiga | 牛の筋肉組織の培養細胞を用いて受胎可能な体細胞核移植クローン胚の 作出及びクローン胚を凍結保存する方法 |
AUPP294898A0 (en) * | 1998-04-15 | 1998-05-07 | Monash University | Method of nuclear transfer |
AU6218899A (en) * | 1998-10-12 | 2000-05-01 | Geron Bio-Med Limited | Porcine oocytes with improved developmental competence |
US6781030B1 (en) | 1998-11-02 | 2004-08-24 | Trustee Of Tufts College, Ballou Hall | Methods for cloning mammals using telophase oocytes |
DK1159415T3 (da) | 1999-03-04 | 2010-05-03 | Revivicor Inc | Genetisk modifikation af somatiske celler og anvendelse deraf |
WO2001013826A1 (de) * | 1999-08-20 | 2001-03-01 | Metz Stavenhagen Peter | Wirbelsäulensegment |
US20040180430A1 (en) * | 1999-09-07 | 2004-09-16 | West Michael D. | Methods of restoring telomere length and extending cell lifespan using nuclear transfer |
US20050255596A1 (en) * | 1999-09-07 | 2005-11-17 | West Michael D | Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer |
JP2003509031A (ja) * | 1999-09-13 | 2003-03-11 | ユニバシティ オブ マサチューセッツ、ア パブリック インスチチユーション オブ ハイアー エデュケイション オブ ザ コモンウエルス オブ マサチューセッツ、アズ リプリゼンテッド バイ イッツ アマースト キャンパス | ドナー細胞又は分化細胞からの核を使用する豚のクローニング並びに多能性豚の産生 |
CA2426669A1 (en) * | 1999-10-22 | 2001-05-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | .alpha.1-3 galactosyltransferase gene and promoter |
KR100417566B1 (ko) * | 1999-11-19 | 2004-02-05 | 한국생명공학연구원 | 체세포 핵치환 복제수정란의 대량생산방법 |
WO2001049106A2 (en) * | 2000-01-04 | 2001-07-12 | University Of Connecticut | Method for cloning animals with targetted genetic alterations |
US20060174358A1 (en) * | 2001-01-04 | 2006-08-03 | Xiangzhong Yang | Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells |
EP1356031B1 (en) * | 2000-03-15 | 2011-07-27 | The University Of Georgia Research Foundation, Inc. | Effective nuclear reprogramming in mammals |
US20040033600A1 (en) | 2001-03-21 | 2004-02-19 | Palli Subba Reddy | Ecdysone receptor-based inducible gene expression system |
WO2001072120A2 (en) * | 2000-03-24 | 2001-10-04 | Geron Corporation | A strategy for maintaining pregnancy |
GB2360522A (en) | 2000-03-24 | 2001-09-26 | Geron Corp | A strategy for maintaining pregnancy |
US20030172394A1 (en) * | 2001-08-01 | 2003-09-11 | Holzer George L | Selection and cloning methods |
CA2634294A1 (en) | 2000-08-03 | 2002-02-14 | Therapeutic Human Polyclonals, Inc. | Production of humanized antibodies in transgenic animals |
US8105825B2 (en) * | 2000-10-03 | 2012-01-31 | Intrexon Corporation | Multiple inducible gene regulation system |
US20020142397A1 (en) * | 2000-12-22 | 2002-10-03 | Philippe Collas | Methods for altering cell fate |
ATE502106T1 (de) * | 2000-12-22 | 2011-04-15 | Kyowa Hakko Kirin Co Ltd | Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellen |
US7491534B2 (en) * | 2000-12-22 | 2009-02-17 | Kirin Holdings Kabushiki Kaisha | Methods for altering cell fate to generate T-cells specific for an antigen of interest |
WO2002074078A2 (en) | 2001-01-30 | 2002-09-26 | Rebholtz, Amy, K. | Method for embryo after impregnation of the recipient female |
MXPA03007492A (es) * | 2001-02-20 | 2004-10-15 | Rheogene Holdings Inc | Receptores de retinoide x quimerico y su uso en un sistema de expresion de gen inducible basado en receptor de ecdisona novedoso. |
US20030101469A1 (en) * | 2001-07-09 | 2003-05-29 | Kenneth Bondioli | Cloned non-human mammals from contact inhibited donor cells |
CN1582332A (zh) * | 2001-12-29 | 2005-02-16 | Seoul大学校产学协力财团 | 转染gfp的克隆猪、敲除gt的克隆猪及其生产方法 |
WO2003060083A2 (en) * | 2002-01-15 | 2003-07-24 | Advanced Cell Technology, Inc. | Cloning b and t lymphocytes |
US20050170506A1 (en) * | 2002-01-16 | 2005-08-04 | Primegen Biotech Llc | Therapeutic reprogramming, hybrid stem cells and maturation |
US20050090004A1 (en) * | 2003-01-16 | 2005-04-28 | Sayre Chauncey B. | Stem cell maturation for all tissue lines |
US20030217378A1 (en) * | 2002-04-05 | 2003-11-20 | The University Of Georgia Research Foundation, Inc | Cloning using rapidly matured oocytes |
NZ555876A (en) * | 2002-04-24 | 2009-04-30 | Univ Georgia Res Found | Production of cloned offspring in a cattle breeding operation |
US7612250B2 (en) * | 2002-07-29 | 2009-11-03 | Trustees Of Tufts College | Nuclear transfer embryo formation method |
EP1534819B1 (en) | 2002-08-21 | 2009-12-09 | Revivicor, Inc. | Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase |
US20050034175A1 (en) * | 2002-09-09 | 2005-02-10 | Latif Zuhair A. | Immune cloning and uses thereof |
US20040219563A1 (en) * | 2002-10-16 | 2004-11-04 | Michael West | Method using gene trapped stem cells for making pathways of stem cell differentiation and making and isolating differentiated cells |
US20040077077A1 (en) * | 2002-10-18 | 2004-04-22 | Xiangzhong Yang | Novel methods for the production of cloned mammals, mammals cloned according to the methods, and methods of use of same |
CN1683524A (zh) * | 2003-04-08 | 2005-10-19 | 东南大学 | 用体细胞核移植技术制备移核胚胎干细胞的方法 |
US7560538B2 (en) * | 2003-11-05 | 2009-07-14 | University Of Pittsburgh | Porcine isogloboside 3 synthase protein, cDNA, genomic organization, and regulatory region |
ES2680569T3 (es) * | 2004-03-17 | 2018-09-10 | Revivicor Inc. | Productos de tejidos derivados de animales que carecen de cualquier expresión de alfa-1,3-galactosiltransferasa funcional |
US20050277147A1 (en) * | 2004-06-11 | 2005-12-15 | Ameet Patki | Identifying chromosomal abnormalities in cells obtained from follicular fluid |
US20060080746A1 (en) * | 2004-09-28 | 2006-04-13 | Viagen, Inc. | Methods of embryo transfer |
KR100733012B1 (ko) * | 2005-07-26 | 2007-06-28 | 재단법인서울대학교산학협력재단 | 복제된 개과 동물 및 이의 생산 방법 |
US20090186097A1 (en) | 2005-08-09 | 2009-07-23 | David Lee Ayares | Transgenic Ungulates Expressing CTLA4-IG and Uses Thereof |
US20100205678A1 (en) * | 2007-01-05 | 2010-08-12 | Overstrom Eric W | Oocyte spindle-associated factors improve somatic cell cloning |
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1998
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- 1998-07-01 NZ NZ502124A patent/NZ502124A/xx unknown
- 1998-07-01 CN CNB988079569A patent/CN1210066C/zh not_active Expired - Lifetime
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- 1998-07-01 IL IL13378598A patent/IL133785A0/xx unknown
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2004
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2006
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CN1210066C (zh) | 2005-07-13 |
EP1017423A4 (en) | 2002-01-30 |
NZ502124A (en) | 2003-01-31 |
US20040194159A1 (en) | 2004-09-30 |
CA2295294A1 (en) | 1999-01-14 |
IL133785A0 (en) | 2001-04-30 |
WO1999001164A1 (en) | 1999-01-14 |
AU8374598A (en) | 1999-01-25 |
CN1265600A (zh) | 2000-09-06 |
JP2001509362A (ja) | 2001-07-24 |
US6235969B1 (en) | 2001-05-22 |
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