WO2001030980A3 - Methods and compositions for enhancing developmental potential of oocytes and zygotes - Google Patents

Methods and compositions for enhancing developmental potential of oocytes and zygotes Download PDF

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Publication number
WO2001030980A3
WO2001030980A3 PCT/CA2000/001283 CA0001283W WO0130980A3 WO 2001030980 A3 WO2001030980 A3 WO 2001030980A3 CA 0001283 W CA0001283 W CA 0001283W WO 0130980 A3 WO0130980 A3 WO 0130980A3
Authority
WO
WIPO (PCT)
Prior art keywords
oocytes
zygotes
methods
compositions
replicative
Prior art date
Application number
PCT/CA2000/001283
Other languages
French (fr)
Other versions
WO2001030980A2 (en
Inventor
Robert F Casper
Ian Rogers
Jonathan Tilly
Andrea Jurisicova
Gloria I Perez
Original Assignee
Mount Sinai Hospital Corp
Gen Hospital Corp
Robert F Casper
Ian Rogers
Jonathan Tilly
Andrea Jurisicova
Gloria I Perez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mount Sinai Hospital Corp, Gen Hospital Corp, Robert F Casper, Ian Rogers, Jonathan Tilly, Andrea Jurisicova, Gloria I Perez filed Critical Mount Sinai Hospital Corp
Priority to EP00972510A priority Critical patent/EP1234021A2/en
Priority to CA002389117A priority patent/CA2389117A1/en
Priority to JP2001533963A priority patent/JP2003512833A/en
Priority to AU11233/01A priority patent/AU1123301A/en
Publication of WO2001030980A2 publication Critical patent/WO2001030980A2/en
Publication of WO2001030980A3 publication Critical patent/WO2001030980A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to compositions and methods for enhancing the developmental potential of oocytes or zygotes by increasing intracellular levels of replicative mitochondria in the oocytes or zygotes. In one aspect of the invention, the intracellular levels of replicative mitochondria are increased by introducing replicative mitochondria into the oocytes or zygotes. The oocytes may be fertilized to obtain a zygote with increased intracellular levels of replicative mitochondria. The methods and compositions may be used to improve in vitro fertilization and embryo transfer methods, and nuclear transfer techniques.
PCT/CA2000/001283 1999-10-27 2000-10-27 Methods and compositions for enhancing developmental potential of oocytes and zygotes WO2001030980A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00972510A EP1234021A2 (en) 1999-10-27 2000-10-27 Methods and compositions for enhancing developmental potential of oocytes and zygotes
CA002389117A CA2389117A1 (en) 1999-10-27 2000-10-27 Methods and compositions for enhancing developmental potential of oocytes and zygotes
JP2001533963A JP2003512833A (en) 1999-10-27 2000-10-27 METHODS AND COMPOSITIONS FOR ENHANCED DEVELOPMENTAL CAPABILITIES OF OOCYTES AND ZYGOTS
AU11233/01A AU1123301A (en) 1999-10-27 2000-10-27 Methods and compositions for enhancing developmental potential of oocytes and zygotes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16179799P 1999-10-27 1999-10-27
US60/161,797 1999-10-27

Publications (2)

Publication Number Publication Date
WO2001030980A2 WO2001030980A2 (en) 2001-05-03
WO2001030980A3 true WO2001030980A3 (en) 2001-11-29

Family

ID=22582774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/001283 WO2001030980A2 (en) 1999-10-27 2000-10-27 Methods and compositions for enhancing developmental potential of oocytes and zygotes

Country Status (5)

Country Link
EP (1) EP1234021A2 (en)
JP (1) JP2003512833A (en)
AU (1) AU1123301A (en)
CA (1) CA2389117A1 (en)
WO (1) WO2001030980A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642329B2 (en) 2011-04-14 2014-02-04 The General Hospital Corporation Compositions and methods for autologous germline mitochondrial energy transfer

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4330995B2 (en) 2001-11-15 2009-09-16 チルドレンズ メディカル センター コーポレーション Methods for isolating, proliferating, and differentiating fetal stem cells from chorionic villi, amniotic fluid, and placenta, and methods for their therapeutic use
GB0200804D0 (en) 2002-01-14 2002-03-06 Univ Birmingham Cloning methods and other methods of producing cells
EP2987855B1 (en) 2004-05-17 2018-11-21 The General Hospital Corporation Isolation of female germline stem cells
US7955846B2 (en) 2004-05-17 2011-06-07 The General Hospital Corporation Compositions comprising female germline stem cells and methods of use thereof
AU2014202447B2 (en) * 2011-04-14 2015-05-07 The General Hospital Corporation Compositions and methods for autologous germline mitochondrial energy transfer
WO2013002880A1 (en) * 2011-06-29 2013-01-03 The General Hospital Corporation Compositions and methods for enhancing bioenergetic status in female germ cells
WO2019113743A1 (en) * 2017-12-11 2019-06-20 清华大学 Genetic modification method
CN114214270B (en) * 2021-12-17 2023-11-24 中国农业科学院北京畜牧兽医研究所 Method for regulating and controlling developmental capacity of frozen bovine oocytes and application thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MORITA YUTAKA ET AL: "Oocyte apoptosis: Like sand through an hourglass.", DEVELOPMENTAL BIOLOGY, vol. 213, no. 1, pages 1 - 17, XP002168146, ISSN: 0012-1606 *
PEREZ GLORIA I ET AL: "Further studies on the role of mitochondria in controlling oocyte apoptosis.", BIOLOGY OF REPRODUCTION, vol. 62, no. Supplement 1, 2000, Thirty-Third Annual Meeting of the Society for the Study of Reproduction;Madison, Wisconsin, USA; July 15-18, 2000, pages 132, XP001002323, ISSN: 0006-3363 *
TAKEDA K ET AL: "Dominant distribution of mitochondrial DNA from recipient oocytes in bovine embryos and offspring after nuclear transfer.", JOURNAL OF REPRODUCTION AND FERTILITY, vol. 116, no. 2, June 1999 (1999-06-01), pages 253 - 259, XP001002337, ISSN: 0022-4251 *
VAN BLERKOM JONATHAN ET AL: "Mitochondrial transfer between oocytes: Potential applications of mitochondrial donation and the issue of heteroplasmy.", HUMAN REPRODUCTION (OXFORD), vol. 13, no. 10, October 1998 (1998-10-01), pages 2857 - 2868, XP001002313, ISSN: 0268-1161 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642329B2 (en) 2011-04-14 2014-02-04 The General Hospital Corporation Compositions and methods for autologous germline mitochondrial energy transfer
US8647869B2 (en) 2011-04-14 2014-02-11 The General Hospital Corporation Compositions and methods for autologous germline mitochondrial energy transfer

Also Published As

Publication number Publication date
WO2001030980A2 (en) 2001-05-03
JP2003512833A (en) 2003-04-08
CA2389117A1 (en) 2001-05-03
AU1123301A (en) 2001-05-08
EP1234021A2 (en) 2002-08-28

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