BR0209028A - Método de transferência nuclear - Google Patents
Método de transferência nuclearInfo
- Publication number
- BR0209028A BR0209028A BR0209028-7A BR0209028A BR0209028A BR 0209028 A BR0209028 A BR 0209028A BR 0209028 A BR0209028 A BR 0209028A BR 0209028 A BR0209028 A BR 0209028A
- Authority
- BR
- Brazil
- Prior art keywords
- nuclear transfer
- transfer method
- relates
- present
- somatic cell
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 210000001082 somatic cell Anatomy 0.000 abstract 2
- 210000002257 embryonic structure Anatomy 0.000 abstract 1
- 210000004940 nucleus Anatomy 0.000 abstract 1
- 210000000287 oocyte Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Developmental Biology & Embryology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"MéTODO DE TRANSFERêNCIA NUCLEAR". A presente invenção se refere a métodos de transferência nuclear e embriões desenvolvidos a partir dos mesmos. Em particular, a presente invenção se refere a métodos de transferência nuclear compreendendo a etapa de transferir uma célula somática ou núcleos de célula somática em um oócito enucleado livre de zona pellucida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR4514A AUPR451401A0 (en) | 2001-04-20 | 2001-04-20 | A method of nuclear transfer |
| PCT/AU2002/000491 WO2002086103A1 (en) | 2001-04-20 | 2002-04-19 | A method of nuclear transfer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0209028A true BR0209028A (pt) | 2005-05-31 |
Family
ID=3828509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0209028-7A BR0209028A (pt) | 2001-04-20 | 2002-04-19 | Método de transferência nuclear |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20040177390A1 (pt) |
| JP (1) | JP2004529648A (pt) |
| CN (1) | CN1524121A (pt) |
| AU (1) | AUPR451401A0 (pt) |
| BR (1) | BR0209028A (pt) |
| CA (1) | CA2444621A1 (pt) |
| NZ (1) | NZ529007A (pt) |
| WO (1) | WO2002086103A1 (pt) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007507510A (ja) * | 2003-09-30 | 2007-03-29 | スターンベルド バイオテクノロジー ノース アメリカ, インコーポレイテッド | トランスジェニック哺乳動物の乳汁中に外因性タンパク質を産生するためのプロセスおよびそれからタンパク質を精製するためのプロセス |
| WO2007028396A2 (en) * | 2005-09-08 | 2007-03-15 | Aarhus Universitet | Cell nuclear transfer |
| CN101580828B (zh) * | 2009-05-06 | 2012-06-20 | 深圳华大基因科技有限公司 | 一种细胞核移植方法 |
| CN101880690B (zh) * | 2010-06-12 | 2012-12-19 | 中国科学院西北高原生物研究所 | 藏羚羊-山羊种间克隆胚胎构建与体外培养的方法 |
| CN101880689B (zh) * | 2010-06-12 | 2012-12-19 | 中国科学院西北高原生物研究所 | 藏羚羊-牛种间体细胞核移植胚胎的构建与体外发育方法 |
| CN102766655A (zh) * | 2012-06-20 | 2012-11-07 | 中国农业科学院北京畜牧兽医研究所 | 一种生产体细胞克隆牛囊胚的方法 |
| EP3456831B1 (en) | 2013-04-16 | 2021-07-14 | Regeneron Pharmaceuticals, Inc. | Targeted modification of rat genome |
| ES2975317T3 (es) | 2013-12-11 | 2024-07-04 | Regeneron Pharma | Métodos y composiciones para la modificación dirigida de un genoma |
| MX388127B (es) | 2013-12-11 | 2025-03-19 | Regeneron Pharma | Metodos y composiciones para la modificacion dirigida de un genoma. |
| BR112016028564A2 (pt) | 2014-06-06 | 2018-01-30 | Regeneron Pharma | método para modificar um locus-alvo em uma célula. |
| SG10201911411YA (en) | 2014-06-26 | 2020-02-27 | Regeneron Pharma | Methods and compositions for targeted genetic modifications and methods of use |
| CA3176380A1 (en) | 2014-11-21 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| BR112017013104A2 (pt) | 2014-12-19 | 2018-05-15 | Regeneron Pharma | métodos para modificar um locus genômico alvo em uma célula, para intensificar a recombinação homóloga em um locus genômico alvo em uma célula e para produzir uma geração f0 de um animal não humano. |
| BR112017019620A2 (pt) | 2015-03-16 | 2018-05-15 | Regeneron Pharmaceuticals, Inc. | ?roedor geneticamente modificado, célula ou tecido, métodos para produção de um roedor geneticamente modificado e de uma população de neurônios motores, métodos para seleção de um agente candidato para modular a disfunção neuronal motora e de um agente candidato para redução do estresse oxidativo em um neurônio motor, ácido nucleico, e, célula de roedor? |
| ES2784360T3 (es) | 2015-05-29 | 2020-09-24 | Regeneron Pharma | Animales no humanos que tienen una interrupción en un locus C9ORF72 |
| US11617365B2 (en) * | 2015-10-13 | 2023-04-04 | Fertilesafe Ltd. | Devices and methods for preparation of a biological sample for a cryoprocedure |
| WO2017064715A1 (en) | 2015-10-13 | 2017-04-20 | Fertilesafe Ltd. | Devices and methods for preparation of a biological sample for a cryoprocedure |
| EP3416479A1 (en) | 2016-02-16 | 2018-12-26 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a mutant kynureninase gene |
| WO2017201476A1 (en) | 2016-05-20 | 2017-11-23 | Regeneron Pharmaceuticals, Inc. | Methods for breaking immunological tolerance using multiple guide rnas |
| BR112019001783A2 (pt) | 2016-07-29 | 2019-05-07 | Regeneron Pharmaceuticals, Inc. | mamífero não humano, e, métodos para produzir o mamífero não humano e de triagem de um composto. |
| US10781453B2 (en) | 2016-09-30 | 2020-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a hexanucleotide repeat expansion in a C9ORF72 locus |
| US11064685B2 (en) | 2017-02-27 | 2021-07-20 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of retinoschisis |
| KR20240135035A (ko) | 2017-06-27 | 2024-09-10 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 asgr1 유전자좌를 포함하는 비인간 동물 |
| RU2019143568A (ru) | 2017-07-31 | 2021-09-02 | Регенерон Фармасьютикалс, Инк. | Способы и композиции для оценки crispr/cas-индуцированной рекомбинации с экзогенной донорной нуклеиновой кислотой in vivo |
| KR20200033259A (ko) | 2017-07-31 | 2020-03-27 | 리제너론 파마슈티칼스 인코포레이티드 | 생체내에서 CRISPR/Cas-매개된 파괴 또는 삭제 및 외인성 도너 핵산과의 CRISPR/Cas-유도된 재조합을 평가하기 위한 방법 및 조성물 |
| KR102780441B1 (ko) | 2017-07-31 | 2025-03-17 | 리제너론 파마슈티칼스 인코포레이티드 | Cas-형질전환 마우스 배아 줄기 세포 및 마우스 및 이것의 용도 |
| EP3585162B1 (en) | 2017-09-29 | 2023-08-30 | Regeneron Pharmaceuticals, Inc. | Rodents comprising a humanized ttr locus and methods of use |
| CN111565566B (zh) | 2017-11-10 | 2022-10-21 | 瑞泽恩制药公司 | 包含slc30a8突变的非人动物及使用方法 |
| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化trkb遺伝子座を含む非ヒト動物 |
| CN111885915B (zh) | 2018-03-19 | 2023-04-28 | 瑞泽恩制药公司 | 使用crispr/cas系统对动物进行转录调制 |
| ES2974200T3 (es) | 2018-09-13 | 2024-06-26 | Regeneron Pharma | Rata nuligénica para el gen del factor H del complemento como modelo de glomerulopatía C3 |
| KR20210105914A (ko) | 2018-12-20 | 2021-08-27 | 리제너론 파마슈티칼스 인코포레이티드 | 뉴클레아제-매개 반복부 팽창 |
| AU2020253532B2 (en) | 2019-04-04 | 2024-06-20 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized coagulation factor 12 locus |
| WO2020247452A1 (en) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| SG11202111256XA (en) | 2019-06-07 | 2021-11-29 | Regeneron Pharma | Non-human animals comprising a humanized albumin locus |
| WO2020264339A1 (en) | 2019-06-27 | 2020-12-30 | Regeneron Pharmaceuticals, Inc. | Modeling tdp-43 proteinopathy |
| CN110904034A (zh) * | 2019-11-15 | 2020-03-24 | 芜湖职业技术学院 | 一种去除卵细胞细胞核的方法 |
| WO2021108363A1 (en) | 2019-11-25 | 2021-06-03 | Regeneron Pharmaceuticals, Inc. | Crispr/cas-mediated upregulation of humanized ttr allele |
| CN111004775B (zh) * | 2020-01-08 | 2023-05-02 | 中国医学科学院医学生物学研究所 | 一种物理性去除卵母细胞透明带的方法 |
| JP2023511626A (ja) | 2020-01-28 | 2023-03-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化pnpla3遺伝子座を含む非ヒト動物および使用方法 |
| WO2021158883A1 (en) | 2020-02-07 | 2021-08-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized klkb1 locus and methods of use |
| EP4125348A1 (en) | 2020-03-23 | 2023-02-08 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use |
| WO2021263146A2 (en) | 2020-06-26 | 2021-12-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ace2 locus |
| CN113061572A (zh) * | 2021-04-21 | 2021-07-02 | 广西壮族自治区畜牧研究所 | 手工克隆程序中无透明带胚胎培养的微穴改进方法 |
| WO2023081847A1 (en) | 2021-11-04 | 2023-05-11 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a modified cacng1 locus |
| CA3238939A1 (en) | 2021-12-08 | 2023-06-15 | Gaurang Patel | Mutant myocilin disease model and uses thereof |
| US20250049006A1 (en) | 2021-12-20 | 2025-02-13 | C/O Regeneron Pharmaceuticals, Inc. | Non-human animals comprising humanized ace2 and tmprss loci |
| CN114350600B (zh) * | 2022-01-26 | 2023-08-18 | 中国农业大学 | 一种提高冷冻卵母细胞体外培育质量的培养液及其应用 |
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| KR20250048010A (ko) | 2022-07-29 | 2025-04-07 | 리제너론 파마슈티칼스 인코포레이티드 | 변형된 트랜스페린 수용체 좌위를 포함하는 비-인간 동물 |
| CA3261296A1 (en) | 2022-08-05 | 2024-02-08 | Regeneron Pharma | TDP-43 VARIANTS RESISTANT TO AGGREGATION |
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| WO2025006963A1 (en) | 2023-06-30 | 2025-01-02 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for increasing homology-directed repair |
| WO2025122754A1 (en) | 2023-12-07 | 2025-06-12 | Regeneron Pharmaceuticals, Inc. | Gaa knockout non-human animals |
| WO2025250495A1 (en) | 2024-05-28 | 2025-12-04 | Regeneron Pharmaceuticals, Inc. | Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998029532A1 (en) * | 1997-01-02 | 1998-07-09 | Monash University | A method of oocyte enucleation and production of reconstituted embryos |
-
2001
- 2001-04-20 AU AUPR4514A patent/AUPR451401A0/en not_active Abandoned
-
2002
- 2002-04-19 WO PCT/AU2002/000491 patent/WO2002086103A1/en not_active Ceased
- 2002-04-19 JP JP2002583618A patent/JP2004529648A/ja active Pending
- 2002-04-19 CN CNA028125819A patent/CN1524121A/zh active Pending
- 2002-04-19 BR BR0209028-7A patent/BR0209028A/pt not_active IP Right Cessation
- 2002-04-19 US US10/475,168 patent/US20040177390A1/en not_active Abandoned
- 2002-04-19 CA CA002444621A patent/CA2444621A1/en not_active Abandoned
- 2002-04-19 NZ NZ529007A patent/NZ529007A/en unknown
-
2007
- 2007-06-08 US US11/808,383 patent/US20080092249A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AUPR451401A0 (en) | 2001-05-24 |
| NZ529007A (en) | 2005-05-27 |
| CA2444621A1 (en) | 2002-10-31 |
| US20080092249A1 (en) | 2008-04-17 |
| WO2002086103A1 (en) | 2002-10-31 |
| JP2004529648A (ja) | 2004-09-30 |
| CN1524121A (zh) | 2004-08-25 |
| US20040177390A1 (en) | 2004-09-09 |
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Legal Events
| Date | Code | Title | Description |
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| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
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| B08E | Application fees: payment of additional fee required [chapter 8.5 patent gazette] |
Free format text: COMPLEMENTAR 7A ANUIDADE DE ACORDO COM TABELA VIGENTE REFERENTE A GUIA 220805229806 E COMPROVAR RECOLHIMENTO DA 8A ANUIDADE. |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2099 DE 29/03/2011. |
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| B15K | Others concerning applications: alteration of classification |
Ipc: C12N 15/873 (2010.01) |