BR0209028A - Método de transferência nuclear - Google Patents

Método de transferência nuclear

Info

Publication number
BR0209028A
BR0209028A BR0209028-7A BR0209028A BR0209028A BR 0209028 A BR0209028 A BR 0209028A BR 0209028 A BR0209028 A BR 0209028A BR 0209028 A BR0209028 A BR 0209028A
Authority
BR
Brazil
Prior art keywords
nuclear transfer
transfer method
relates
present
somatic cell
Prior art date
Application number
BR0209028-7A
Other languages
English (en)
Inventor
Ian Lewis
Gabor Vajta
Tayfur Tecirlioglu
Original Assignee
Univ Monash
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Monash filed Critical Univ Monash
Publication of BR0209028A publication Critical patent/BR0209028A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"MéTODO DE TRANSFERêNCIA NUCLEAR". A presente invenção se refere a métodos de transferência nuclear e embriões desenvolvidos a partir dos mesmos. Em particular, a presente invenção se refere a métodos de transferência nuclear compreendendo a etapa de transferir uma célula somática ou núcleos de célula somática em um oócito enucleado livre de zona pellucida.
BR0209028-7A 2001-04-20 2002-04-19 Método de transferência nuclear BR0209028A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPR4514A AUPR451401A0 (en) 2001-04-20 2001-04-20 A method of nuclear transfer
PCT/AU2002/000491 WO2002086103A1 (en) 2001-04-20 2002-04-19 A method of nuclear transfer

Publications (1)

Publication Number Publication Date
BR0209028A true BR0209028A (pt) 2005-05-31

Family

ID=3828509

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0209028-7A BR0209028A (pt) 2001-04-20 2002-04-19 Método de transferência nuclear

Country Status (8)

Country Link
US (2) US20040177390A1 (pt)
JP (1) JP2004529648A (pt)
CN (1) CN1524121A (pt)
AU (1) AUPR451401A0 (pt)
BR (1) BR0209028A (pt)
CA (1) CA2444621A1 (pt)
NZ (1) NZ529007A (pt)
WO (1) WO2002086103A1 (pt)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7807862B2 (en) * 2003-09-30 2010-10-05 Sterrenbeld Biotechnologie North America, Inc. Transgenic bovine comprising human growth hormone in its serum and methods of making
US8513486B2 (en) 2005-09-08 2013-08-20 Aarhus Universitet Cell nuclear transfer
CN101580828B (zh) * 2009-05-06 2012-06-20 深圳华大基因科技有限公司 一种细胞核移植方法
CN101880689B (zh) * 2010-06-12 2012-12-19 中国科学院西北高原生物研究所 藏羚羊-牛种间体细胞核移植胚胎的构建与体外发育方法
CN101880690B (zh) * 2010-06-12 2012-12-19 中国科学院西北高原生物研究所 藏羚羊-山羊种间克隆胚胎构建与体外培养的方法
CN102766655A (zh) * 2012-06-20 2012-11-07 中国农业科学院北京畜牧兽医研究所 一种生产体细胞克隆牛囊胚的方法
DK3456831T3 (da) 2013-04-16 2021-09-06 Regeneron Pharma Målrettet modifikation af rottegenom
EP3080279B1 (en) 2013-12-11 2018-09-26 Regeneron Pharmaceuticals, Inc. Methods and compositions for the targeted modification of a genome
KR102170502B1 (ko) 2013-12-11 2020-10-28 리제너론 파마슈티칼스 인코포레이티드 게놈의 표적화된 변형을 위한 방법 및 조성물
HRP20200529T1 (hr) 2014-06-06 2020-09-04 Regeneron Pharmaceuticals, Inc. Postupci i pripravci za modificiranje ciljnog lokusa
SI3161128T1 (sl) 2014-06-26 2019-02-28 Regeneron Pharmaceuticals, Inc. Postopki in sestavki za ciljano genetsko spremembo in postopki uporabe
KR102531016B1 (ko) 2014-11-21 2023-05-10 리제너론 파마슈티칼스 인코포레이티드 쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물
ES2947714T3 (es) 2014-12-19 2023-08-17 Regeneron Pharma Métodos y composiciones para la modificación genética dirigida a través de múltiples direccionamientos en un solo paso
AU2016233250C1 (en) 2015-03-16 2022-08-18 Regeneron Pharmaceuticals, Inc. Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception
AU2016270587B2 (en) 2015-05-29 2020-12-24 Regeneron Pharmaceuticals, Inc. Non-human animals having a disruption in a C9ORF72 locus
US11617365B2 (en) * 2015-10-13 2023-04-04 Fertilesafe Ltd. Devices and methods for preparation of a biological sample for a cryoprocedure
CN108135155A (zh) 2015-10-13 2018-06-08 佛泰尔塞夫股份有限公司 制备用于低温程序的生物样品的装置及方法
CN109195443A (zh) 2016-02-16 2019-01-11 雷杰纳荣制药公司 具有突变型犬尿氨酸酶基因的非人动物
CN113831407B (zh) 2016-05-20 2024-06-11 瑞泽恩制药公司 用于使用多个引导rna来破坏免疫耐受性的方法
JP2019523009A (ja) 2016-07-29 2019-08-22 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. C末端切断型フィブリリン−1の発現をもたらす変異を有するマウス
CN109862785B (zh) 2016-09-30 2022-09-06 瑞泽恩制药公司 C9orf72基因座中具有六核苷酸重复扩增的非人类动物
AU2018224227A1 (en) 2017-02-27 2019-08-29 Regeneron Pharmaceuticals, Inc. Non-human animal models of Retinoschisis
ES2996886T3 (en) 2017-06-27 2025-02-13 Regeneron Pharma Rodents comprising a humanized asgr1 locus
KR20200033259A (ko) 2017-07-31 2020-03-27 리제너론 파마슈티칼스 인코포레이티드 생체내에서 CRISPR/Cas-매개된 파괴 또는 삭제 및 외인성 도너 핵산과의 CRISPR/Cas-유도된 재조합을 평가하기 위한 방법 및 조성물
CN110891420B (zh) 2017-07-31 2022-06-03 瑞泽恩制药公司 Cas转基因小鼠胚胎干细胞和小鼠及其应用
EP3585161A1 (en) 2017-07-31 2020-01-01 Regeneron Pharmaceuticals, Inc. Assessment of crispr/cas-induced recombination with an exogenous donor nucleic acid in vivo
US20190098879A1 (en) 2017-09-29 2019-04-04 Regeneron Pharmaceuticals, Inc. Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use
JP7097440B2 (ja) 2017-11-10 2022-07-07 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Slc30a8変異を含む非ヒト動物および使用方法
JP7361031B2 (ja) 2017-11-30 2023-10-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化trkb遺伝子座を含む非ヒト動物
EP3592140A1 (en) 2018-03-19 2020-01-15 Regeneron Pharmaceuticals, Inc. Transcription modulation in animals using crispr/cas systems
JP7222075B2 (ja) 2018-09-13 2023-02-14 リジェネロン・ファーマシューティカルズ・インコーポレイテッド C3糸球体症のモデルとしての補体因子h遺伝子ノックアウトラット
KR102925054B1 (ko) 2018-12-20 2026-02-10 리제너론 파마슈티칼스 인코포레이티드 뉴클레아제-매개 반복부 팽창
KR102661779B1 (ko) 2019-04-04 2024-04-30 리제너론 파마슈티칼스 인코포레이티드 인간화 응고 인자 12 좌위를 포함하는 비-인간 동물
US11891618B2 (en) 2019-06-04 2024-02-06 Regeneron Pharmaceuticals, Inc. Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use
MX2021015122A (es) 2019-06-07 2022-04-06 Regeneron Pharma Animales no humanos que comprenden un locus de albumina humanizado.
EP3990475A1 (en) 2019-06-27 2022-05-04 Regeneron Pharmaceuticals, Inc. Modeling tdp-43 proteinopathy
CN110904034A (zh) * 2019-11-15 2020-03-24 芜湖职业技术学院 一种去除卵细胞细胞核的方法
WO2021108363A1 (en) 2019-11-25 2021-06-03 Regeneron Pharmaceuticals, Inc. Crispr/cas-mediated upregulation of humanized ttr allele
CN111004775B (zh) * 2020-01-08 2023-05-02 中国医学科学院医学生物学研究所 一种物理性去除卵母细胞透明带的方法
WO2021154791A1 (en) 2020-01-28 2021-08-05 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
EP4099821A1 (en) 2020-02-07 2022-12-14 Regeneron Pharmaceuticals, Inc. <smallcaps/>? ? ?klkb1? ? ? ? ?non-human animals comprising a humanizedlocus and methods of use
US20230102342A1 (en) 2020-03-23 2023-03-30 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
WO2021263146A2 (en) 2020-06-26 2021-12-30 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ace2 locus
CN113061572A (zh) * 2021-04-21 2021-07-02 广西壮族自治区畜牧研究所 手工克隆程序中无透明带胚胎培养的微穴改进方法
IL312505A (en) 2021-11-04 2024-07-01 Regeneron Pharma Non-human animals comprising a modified cacng1 locus
KR20240117571A (ko) 2021-12-08 2024-08-01 리제너론 파마슈티칼스 인코포레이티드 돌연변이 마이오실린 질환 모델 및 이의 용도
US20250049006A1 (en) 2021-12-20 2025-02-13 C/O Regeneron Pharmaceuticals, Inc. Non-human animals comprising humanized ace2 and tmprss loci
CN114350600B (zh) * 2022-01-26 2023-08-18 中国农业大学 一种提高冷冻卵母细胞体外培育质量的培养液及其应用
WO2023150798A1 (en) 2022-02-07 2023-08-10 Regeneron Pharmaceuticals, Inc. Compositions and methods for defining optimal treatment timeframes in lysosomal disease
AU2023218391A1 (en) 2022-02-11 2024-07-11 Regeneron Pharmaceuticals, Inc. Compositions and methods for screening 4r tau targeting agents
US20250344681A1 (en) 2022-05-31 2025-11-13 Regeneron Pharmaceuticals, Inc. Animal model of tdp-43 proteinopathy
IL317261A (en) 2022-07-29 2025-01-01 Regeneron Pharma Non-human animals containing a modified transferrin receptor locus
JP2025525745A (ja) 2022-08-05 2025-08-07 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Tdp-43の凝集耐性バリアント
EP4593590A1 (en) 2022-09-29 2025-08-06 Regeneron Pharmaceuticals, Inc. Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes
AU2024214456A1 (en) 2023-02-01 2025-07-03 Regeneron Pharmaceuticals, Inc. Animals comprising a modified klhdc7b locus
KR20260032927A (ko) 2023-06-30 2026-03-10 리제너론 파마슈티칼스 인코포레이티드 상동성 지향 복구를 증가시키는 방법 및 조성물
WO2025122754A1 (en) 2023-12-07 2025-06-12 Regeneron Pharmaceuticals, Inc. Gaa knockout non-human animals
WO2025250495A1 (en) 2024-05-28 2025-12-04 Regeneron Pharmaceuticals, Inc. Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ336493A (en) * 1997-01-02 2001-01-26 Univ Monash A method of oocyte enucleation and production of reconstituted embryos

Also Published As

Publication number Publication date
CA2444621A1 (en) 2002-10-31
NZ529007A (en) 2005-05-27
JP2004529648A (ja) 2004-09-30
AUPR451401A0 (en) 2001-05-24
US20080092249A1 (en) 2008-04-17
US20040177390A1 (en) 2004-09-09
CN1524121A (zh) 2004-08-25
WO2002086103A1 (en) 2002-10-31

Similar Documents

Publication Publication Date Title
BR0209028A (pt) Método de transferência nuclear
BR0010616A (pt) Sequências de ácido nucléico a proteìnas envolvidas em sìntese de isoprenóide
WO2004090140A3 (en) Methods and means for increasing the tolerance of plants to stress conditions
WO2000031237A3 (en) Method of cloning porcine animals
WO2005010670A3 (en) Apparatus and method for direct memory access in a hub-based memory system
HUP0105052A2 (hu) Eljárások nukleinsav amplifikálására és szekvenálására
ATE476155T1 (de) In-vitro herstellung von transplantierbarem knorpelgewebe
BR0317265A (pt) Métodos para produzir uma disposição de elementos micro-ópticos aberrados, uma disposição de cantos de cubo com divergência controlada, e para produzir um artigo que compreende uma disposição de cantos de cubo
TW200700725A (en) Detection of nucleic acid associated with disease
WO2002010337A3 (en) Method of cloning porcine animals
WO2002014520A3 (en) Process for inducing direct somatic embryogenesis and secondary embryogenesis in monocotyledonous plant cells, and rapidly regenerating fertile plants
DK1161521T3 (da) Transplantation af hæmatopoietiske celler
BR0204359A (pt) Trocador de calor com tanque plástico - conjunto de tanque coletor, lateral
ATE365217T1 (de) Nukelinsäuresequenzen für proteine, die an der tocopherolbiosynthese beteiligt sind
AU4985201A (en) Human gene critical to fertility
WO2001009282A3 (de) Vorrichtung zum züchten und/oder behandeln von zellen
BR0016531A (pt) Método para produzir embriões clonados e adultos a partir de células cultivadas
EP1295611A4 (en) COMPOUNDS FOR THE TRANSFER OF OLIGONUCLEOTIDES (03.01.02)
WO2003051927A3 (en) Production of f(ab&#39;)2 fragments in mammalian cells
BR0013959A (pt) Clonagem de porcos usando células ou núcleos doadores a partir de células diferenciadas e produção de porcino pluripotente
WO2001030980A3 (en) Methods and compositions for enhancing developmental potential of oocytes and zygotes
WO2003027290A1 (fr) Procede pour conferer ou reguler la fertilite d&#39;un cytoplasme a sterilite male de riz bt au moyen d&#39;un gene de restauration de la fertilite, et procede d&#39;estimation de la presence d&#39;un gene de restauration de la fertilite
DK1438057T3 (da) Fyrrekogleekstrakter og anvendelser deraf
BRPI0403200A (pt) Método para recrescimento de células embriogênicas crioconservadas de conìferas
CN1558950A (zh) 体细胞起源的胚胎干细胞及其分化细胞

Legal Events

Date Code Title Description
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: APRESENTAR RELATORIO DESCRITIVO

B08E Application fees: payment of additional fee required [chapter 8.5 patent gazette]

Free format text: COMPLEMENTAR 7A ANUIDADE DE ACORDO COM TABELA VIGENTE REFERENTE A GUIA 220805229806 E COMPROVAR RECOLHIMENTO DA 8A ANUIDADE.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AO NAO CUMPRIMENTO DA EXIGENCIA PUBLICADA NA RPI 2082 DE 30/11/2010.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2099 DE 29/03/2011.

B15K Others concerning applications: alteration of classification

Ipc: C12N 15/873 (2010.01)