BR0209028A - Método de transferência nuclear - Google Patents
Método de transferência nuclearInfo
- Publication number
- BR0209028A BR0209028A BR0209028-7A BR0209028A BR0209028A BR 0209028 A BR0209028 A BR 0209028A BR 0209028 A BR0209028 A BR 0209028A BR 0209028 A BR0209028 A BR 0209028A
- Authority
- BR
- Brazil
- Prior art keywords
- nuclear transfer
- transfer method
- relates
- present
- somatic cell
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 210000001082 somatic cell Anatomy 0.000 abstract 2
- 210000002257 embryonic structure Anatomy 0.000 abstract 1
- 210000004940 nucleus Anatomy 0.000 abstract 1
- 210000000287 oocyte Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Developmental Biology & Embryology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"MéTODO DE TRANSFERêNCIA NUCLEAR". A presente invenção se refere a métodos de transferência nuclear e embriões desenvolvidos a partir dos mesmos. Em particular, a presente invenção se refere a métodos de transferência nuclear compreendendo a etapa de transferir uma célula somática ou núcleos de célula somática em um oócito enucleado livre de zona pellucida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR4514A AUPR451401A0 (en) | 2001-04-20 | 2001-04-20 | A method of nuclear transfer |
| PCT/AU2002/000491 WO2002086103A1 (en) | 2001-04-20 | 2002-04-19 | A method of nuclear transfer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0209028A true BR0209028A (pt) | 2005-05-31 |
Family
ID=3828509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0209028-7A BR0209028A (pt) | 2001-04-20 | 2002-04-19 | Método de transferência nuclear |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20040177390A1 (pt) |
| JP (1) | JP2004529648A (pt) |
| CN (1) | CN1524121A (pt) |
| AU (1) | AUPR451401A0 (pt) |
| BR (1) | BR0209028A (pt) |
| CA (1) | CA2444621A1 (pt) |
| NZ (1) | NZ529007A (pt) |
| WO (1) | WO2002086103A1 (pt) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007507510A (ja) * | 2003-09-30 | 2007-03-29 | スターンベルド バイオテクノロジー ノース アメリカ, インコーポレイテッド | トランスジェニック哺乳動物の乳汁中に外因性タンパク質を産生するためのプロセスおよびそれからタンパク質を精製するためのプロセス |
| DK1922411T3 (en) * | 2005-09-08 | 2014-02-17 | Univ Aarhus | Cell nuclear |
| CN101580828B (zh) * | 2009-05-06 | 2012-06-20 | 深圳华大基因科技有限公司 | 一种细胞核移植方法 |
| CN101880690B (zh) * | 2010-06-12 | 2012-12-19 | 中国科学院西北高原生物研究所 | 藏羚羊-山羊种间克隆胚胎构建与体外培养的方法 |
| CN101880689B (zh) * | 2010-06-12 | 2012-12-19 | 中国科学院西北高原生物研究所 | 藏羚羊-牛种间体细胞核移植胚胎的构建与体外发育方法 |
| CN102766655A (zh) * | 2012-06-20 | 2012-11-07 | 中国农业科学院北京畜牧兽医研究所 | 一种生产体细胞克隆牛囊胚的方法 |
| SI2986729T1 (sl) | 2013-04-16 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Ciljana sprememba genoma podgane |
| CN110951779B (zh) | 2013-12-11 | 2024-04-16 | 瑞泽恩制药公司 | 用于靶向修饰基因组的方法和组合物 |
| EP3460063B1 (en) | 2013-12-11 | 2024-03-13 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a genome |
| DK3152312T3 (da) | 2014-06-06 | 2020-04-06 | Regeneron Pharma | Fremgangsmåder og sammensætninger til modifikation af et mållocus |
| JP6752158B2 (ja) | 2014-06-26 | 2020-09-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 標的化された遺伝子修飾のための方法及び組成物、並びに使用方法 |
| ES3013183T3 (en) | 2014-11-21 | 2025-04-11 | Regeneron Pharma | Methods for targeted genetic modification using paired guide rnas |
| CN107208113A (zh) | 2014-12-19 | 2017-09-26 | 瑞泽恩制药公司 | 用于通过单步多重靶向进行靶向遗传修饰的方法和组合物 |
| SG10201912899QA (en) | 2015-03-16 | 2020-02-27 | Regeneron Pharma | Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception |
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| WO2017064715A1 (en) | 2015-10-13 | 2017-04-20 | Fertilesafe Ltd. | Devices and methods for preparation of a biological sample for a cryoprocedure |
| US11617365B2 (en) * | 2015-10-13 | 2023-04-04 | Fertilesafe Ltd. | Devices and methods for preparation of a biological sample for a cryoprocedure |
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| RU2745563C2 (ru) | 2016-05-20 | 2021-03-29 | Регенерон Фармасьютикалс, Инк. | Способы преодоления иммунологической толерантности с использованием множества направляющих рнк |
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| WO2018064600A1 (en) | 2016-09-30 | 2018-04-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus |
| WO2018157058A1 (en) | 2017-02-27 | 2018-08-30 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of retinoschisis |
| CN110996658B (zh) | 2017-06-27 | 2024-03-26 | 瑞泽恩制药公司 | 包含人源化asgr1基因座的非人动物 |
| EP3585160A2 (en) | 2017-07-31 | 2020-01-01 | Regeneron Pharmaceuticals, Inc. | Crispr reporter non-human animals and uses thereof |
| CN110891419A (zh) | 2017-07-31 | 2020-03-17 | 瑞泽恩制药公司 | 评价crispr/cas-诱导的与外源供体核酸的体内重组 |
| EP3585159B1 (en) | 2017-07-31 | 2025-05-14 | Regeneron Pharmaceuticals, Inc. | Method of testing the ability of a crispr/cas9 nuclease to modify a target genomic locus in vivo, by making use of a cas-transgenic mouse or rat which comprises a cas9 expression cassette in its genome |
| ES2962277T3 (es) | 2017-09-29 | 2024-03-18 | Regeneron Pharma | Roedores que comprenden un locus Ttr humanizado y métodos de uso |
| EP3585163B1 (en) | 2017-11-10 | 2022-03-09 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising slc30a8 mutation and methods of use |
| CN116064611A (zh) | 2017-11-30 | 2023-05-05 | 瑞泽恩制药公司 | 包含人源化trkb基因座的非人动物 |
| KR102647714B1 (ko) | 2018-03-19 | 2024-03-18 | 리제너론 파마슈티칼스 인코포레이티드 | CRISPR/Cas 시스템을 사용한 동물에서의 전사 조절 |
| EP3849304B1 (en) | 2018-09-13 | 2024-01-10 | Regeneron Pharmaceuticals, Inc. | Complement factor h gene knockout rat as a model of c3 glomerulopathy |
| JP7449291B2 (ja) | 2018-12-20 | 2024-03-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヌクレアーゼ媒介リピート伸長 |
| CN117178959A (zh) | 2019-04-04 | 2023-12-08 | 瑞泽恩制药公司 | 包括人源化凝血因子12基因座的非人动物 |
| EP3801011A1 (en) | 2019-06-04 | 2021-04-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| US11622547B2 (en) | 2019-06-07 | 2023-04-11 | Regeneran Pharmaceuticals, Inc. | Genetically modified mouse that expresses human albumin |
| CN114008193A (zh) | 2019-06-27 | 2022-02-01 | 瑞泽恩制药公司 | Tdp-43蛋白病的建模 |
| CN110904034A (zh) * | 2019-11-15 | 2020-03-24 | 芜湖职业技术学院 | 一种去除卵细胞细胞核的方法 |
| WO2021108363A1 (en) | 2019-11-25 | 2021-06-03 | Regeneron Pharmaceuticals, Inc. | Crispr/cas-mediated upregulation of humanized ttr allele |
| CN111004775B (zh) * | 2020-01-08 | 2023-05-02 | 中国医学科学院医学生物学研究所 | 一种物理性去除卵母细胞透明带的方法 |
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| WO2021158883A1 (en) | 2020-02-07 | 2021-08-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized klkb1 locus and methods of use |
| WO2021195079A1 (en) | 2020-03-23 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use |
| US20230232796A1 (en) | 2020-06-26 | 2023-07-27 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ace2 locus |
| CN113061572A (zh) * | 2021-04-21 | 2021-07-02 | 广西壮族自治区畜牧研究所 | 手工克隆程序中无透明带胚胎培养的微穴改进方法 |
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| CN118632622A (zh) | 2021-12-08 | 2024-09-10 | 瑞泽恩制药公司 | 突变型肌纤蛋白疾病模型及其用途 |
| US20250049006A1 (en) | 2021-12-20 | 2025-02-13 | C/O Regeneron Pharmaceuticals, Inc. | Non-human animals comprising humanized ace2 and tmprss loci |
| CN114350600B (zh) * | 2022-01-26 | 2023-08-18 | 中国农业大学 | 一种提高冷冻卵母细胞体外培育质量的培养液及其应用 |
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| CA3257739A1 (en) | 2022-07-29 | 2024-02-01 | Regeneron Pharmaceuticals, Inc. | NON-HUMAN ANIMALS CONTAINING A MODIFIED TRANSFERRIN RECEPTOR LOCUS |
| AU2023320529A1 (en) | 2022-08-05 | 2025-02-06 | Regeneron Pharmaceuticals, Inc. | Aggregation-resistant variants of tdp-43 |
| US20240224964A9 (en) | 2022-09-29 | 2024-07-11 | Regeneron Pharmaceuticals, Inc. | Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes |
| IL322105A (en) | 2023-02-01 | 2025-09-01 | Regeneron Pharma | Animals comprising a modified klhdc7b locus |
| WO2025006963A1 (en) | 2023-06-30 | 2025-01-02 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for increasing homology-directed repair |
| WO2025122754A1 (en) | 2023-12-07 | 2025-06-12 | Regeneron Pharmaceuticals, Inc. | Gaa knockout non-human animals |
| WO2025250495A1 (en) | 2024-05-28 | 2025-12-04 | Regeneron Pharmaceuticals, Inc. | Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998029532A1 (en) * | 1997-01-02 | 1998-07-09 | Monash University | A method of oocyte enucleation and production of reconstituted embryos |
-
2001
- 2001-04-20 AU AUPR4514A patent/AUPR451401A0/en not_active Abandoned
-
2002
- 2002-04-19 JP JP2002583618A patent/JP2004529648A/ja active Pending
- 2002-04-19 US US10/475,168 patent/US20040177390A1/en not_active Abandoned
- 2002-04-19 CN CNA028125819A patent/CN1524121A/zh active Pending
- 2002-04-19 BR BR0209028-7A patent/BR0209028A/pt not_active IP Right Cessation
- 2002-04-19 NZ NZ529007A patent/NZ529007A/en unknown
- 2002-04-19 CA CA002444621A patent/CA2444621A1/en not_active Abandoned
- 2002-04-19 WO PCT/AU2002/000491 patent/WO2002086103A1/en not_active Ceased
-
2007
- 2007-06-08 US US11/808,383 patent/US20080092249A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1524121A (zh) | 2004-08-25 |
| AUPR451401A0 (en) | 2001-05-24 |
| NZ529007A (en) | 2005-05-27 |
| CA2444621A1 (en) | 2002-10-31 |
| JP2004529648A (ja) | 2004-09-30 |
| US20040177390A1 (en) | 2004-09-09 |
| US20080092249A1 (en) | 2008-04-17 |
| WO2002086103A1 (en) | 2002-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: APRESENTAR RELATORIO DESCRITIVO |
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| B08E | Application fees: payment of additional fee required [chapter 8.5 patent gazette] |
Free format text: COMPLEMENTAR 7A ANUIDADE DE ACORDO COM TABELA VIGENTE REFERENTE A GUIA 220805229806 E COMPROVAR RECOLHIMENTO DA 8A ANUIDADE. |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AO NAO CUMPRIMENTO DA EXIGENCIA PUBLICADA NA RPI 2082 DE 30/11/2010. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2099 DE 29/03/2011. |
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| B15K | Others concerning applications: alteration of classification |
Ipc: C12N 15/873 (2010.01) |