JP2001504105A - Ｇｌｐ―１ペプチドの利用 - Google Patents
Ｇｌｐ―１ペプチドの利用Info
- Publication number
- JP2001504105A JP2001504105A JP52206198A JP52206198A JP2001504105A JP 2001504105 A JP2001504105 A JP 2001504105A JP 52206198 A JP52206198 A JP 52206198A JP 52206198 A JP52206198 A JP 52206198A JP 2001504105 A JP2001504105 A JP 2001504105A
- Authority
- JP
- Japan
- Prior art keywords
- glp
- analogue
- appetite
- peptide
- satiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 title claims abstract description 121
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- UKVFVQPAANCXIL-FJVFSOETSA-N glp-1 (1-37) amide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 UKVFVQPAANCXIL-FJVFSOETSA-N 0.000 claims description 8
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- 101800004266 Glucagon-like peptide 1(7-37) Proteins 0.000 claims description 5
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims description 5
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK1270/96 | 1996-11-12 | ||
| DK127096 | 1996-11-12 | ||
| PCT/DK1997/000509 WO1998020895A1 (en) | 1996-11-12 | 1997-11-07 | Use of glp-1 peptides |
Publications (2)
| Publication Number | Publication Date |
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| JP2001504105A true JP2001504105A (ja) | 2001-03-27 |
| JP2001504105A5 JP2001504105A5 (enExample) | 2005-07-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52206198A Ceased JP2001504105A (ja) | 1996-11-12 | 1997-11-07 | Ｇｌｐ―１ペプチドの利用 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US20030232754A1 (enExample) |
| EP (2) | EP0941114B1 (enExample) |
| JP (1) | JP2001504105A (enExample) |
| AT (2) | ATE366584T1 (enExample) |
| AU (1) | AU4863797A (enExample) |
| DE (2) | DE69732572T2 (enExample) |
| ES (2) | ES2290799T3 (enExample) |
| WO (1) | WO1998020895A1 (enExample) |
| ZA (1) | ZA9710182B (enExample) |
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| US8895694B2 (en) | 2007-09-05 | 2014-11-25 | Novo Nordisk A/S | Glucagon-Like Peptide-1 derivatives and their pharmaceutical use |
| US10933120B2 (en) | 2012-03-22 | 2021-03-02 | Novo Nordisk A/S | Compositions of GLP-1 peptides and preparation thereof |
| US10960052B2 (en) | 2010-12-16 | 2021-03-30 | Novo Nordisk A/S | Solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl) amino) caprylic acid |
| US11033499B2 (en) | 2012-06-20 | 2021-06-15 | Novo Nordisk A/S | Tablet formulation comprising a GLP-1 peptide and a delivery agent |
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| JP2021515026A (ja) * | 2018-03-09 | 2021-06-17 | 上海仁会生物制▲やく▼股▲ふん▼有限公司Ｓｈａｎｇｈａｉ Ｂｅｎｅｍａｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ | 肥満の治療および体重管理のためのｇｌｐ−１組成物 |
| US11123296B2 (en) | 2012-03-22 | 2021-09-21 | Novo Nordisk A/S | Compositions comprising a delivery agent and preparation thereof |
| US11833248B2 (en) | 2018-02-02 | 2023-12-05 | Novo Nordisk A/S | Solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid |
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| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US6852690B1 (en) | 1995-08-22 | 2005-02-08 | Amylin Pharmaceuticals, Inc. | Method and composition for enhanced parenteral nutrition |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
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| US6998387B1 (en) | 1998-03-19 | 2006-02-14 | Amylin Pharmaceuticals, Inc. | Human appetite control by glucagon-like peptide receptor binding compounds |
| US7223727B2 (en) | 1998-04-09 | 2007-05-29 | Serono Genetics Institute S.A. | GSSP4 polynucleotides and polypeptides and uses thereof |
| US6720407B1 (en) * | 1998-08-28 | 2004-04-13 | Eli Lilly And Company | Method for administering insulinotropic peptides |
| US6927214B1 (en) | 1999-01-15 | 2005-08-09 | Novo Nordisk A/S | Non-peptide GLP-1 agonists |
| US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
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| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| EP1229927B1 (en) * | 1999-11-03 | 2007-12-19 | Novo Nordisk A/S | Use of a growth hormone or a growth hormone secretagogue for appetite-suppression or induction of satiety |
| AU2001261024A1 (en) | 2000-04-12 | 2001-10-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| WO2001087341A1 (en) * | 2000-05-16 | 2001-11-22 | Sanwa Kagaku Kenkyusho Co.,Ltd. | Agents for preventing or ameliorating insulin resistance and/or obesity |
| ATE405323T1 (de) * | 2001-02-09 | 2008-09-15 | Serono Genetics Inst Sa | Gssp4-polynukleotide und -polypeptide sowie deren verwendung |
| ES2320979T3 (es) | 2001-09-24 | 2009-06-01 | Imperial Innovations Limited | Pyy-36 para la reduccion o prevencion de la obesidad. |
| EP2277910A1 (en) | 2001-12-21 | 2011-01-26 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1463752A4 (en) | 2001-12-21 | 2005-07-13 | Human Genome Sciences Inc | ALBUMIN FUSION PROTEINS |
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-
1997
- 1997-11-07 DE DE69732572T patent/DE69732572T2/de not_active Expired - Lifetime
- 1997-11-07 DE DE69737916T patent/DE69737916T2/de not_active Revoked
- 1997-11-07 WO PCT/DK1997/000509 patent/WO1998020895A1/en not_active Ceased
- 1997-11-07 EP EP97911155A patent/EP0941114B1/en not_active Expired - Lifetime
- 1997-11-07 ES ES05002085T patent/ES2290799T3/es not_active Expired - Lifetime
- 1997-11-07 AU AU48637/97A patent/AU4863797A/en not_active Abandoned
- 1997-11-07 AT AT05002085T patent/ATE366584T1/de not_active IP Right Cessation
- 1997-11-07 JP JP52206198A patent/JP2001504105A/ja not_active Ceased
- 1997-11-07 AT AT97911155T patent/ATE289517T1/de not_active IP Right Cessation
- 1997-11-07 ES ES97911155T patent/ES2237790T3/es not_active Expired - Lifetime
- 1997-11-07 EP EP05002085A patent/EP1529534B1/en not_active Revoked
- 1997-11-12 ZA ZA9710182A patent/ZA9710182B/xx unknown
-
2003
- 2003-03-06 US US10/382,438 patent/US20030232754A1/en not_active Abandoned
-
2007
- 2007-03-05 US US11/714,000 patent/US20070161568A1/en not_active Abandoned
-
2009
- 2009-02-12 US US12/370,308 patent/US20090149387A1/en not_active Abandoned
-
2010
- 2010-01-04 US US12/651,685 patent/US20100113363A1/en not_active Abandoned
- 2010-10-15 US US12/905,324 patent/US20110028391A1/en not_active Abandoned
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8895694B2 (en) | 2007-09-05 | 2014-11-25 | Novo Nordisk A/S | Glucagon-Like Peptide-1 derivatives and their pharmaceutical use |
| US9409966B2 (en) | 2007-09-05 | 2016-08-09 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
| US9657079B2 (en) | 2007-09-05 | 2017-05-23 | Novo Nordisk A/S | Truncated GLP-1 derivatives and their therapeutical use |
| JP2010538049A (ja) * | 2007-09-05 | 2010-12-09 | ノボ・ノルデイスク・エー／エス | 切断型ｇｌｐ−１誘導体及びその治療的使用 |
| US10960052B2 (en) | 2010-12-16 | 2021-03-30 | Novo Nordisk A/S | Solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl) amino) caprylic acid |
| US11382957B2 (en) | 2010-12-16 | 2022-07-12 | Novo Nordisk A/S | Solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid |
| US11117947B2 (en) | 2011-04-12 | 2021-09-14 | Novo Nordisk A/S | Double-acylated GLP-1 derivatives |
| US11034746B2 (en) | 2011-04-12 | 2021-06-15 | Novo Nordisk A/S | Double-acylated GLP-1 derivatives |
| US11759502B2 (en) | 2012-03-22 | 2023-09-19 | Novo Nordisk A/S | Compositions of GLP-1 peptides and preparation thereof |
| US11123296B2 (en) | 2012-03-22 | 2021-09-21 | Novo Nordisk A/S | Compositions comprising a delivery agent and preparation thereof |
| US10933120B2 (en) | 2012-03-22 | 2021-03-02 | Novo Nordisk A/S | Compositions of GLP-1 peptides and preparation thereof |
| US11759503B2 (en) | 2012-03-22 | 2023-09-19 | Novo Nordisk A/S | Compositions of GLP-1 peptides and preparation thereof |
| US11759501B2 (en) | 2012-03-22 | 2023-09-19 | Novo Nordisk A/S | Compositions of GLP-1 peptides and preparation thereof |
| US11033499B2 (en) | 2012-06-20 | 2021-06-15 | Novo Nordisk A/S | Tablet formulation comprising a GLP-1 peptide and a delivery agent |
| US11833248B2 (en) | 2018-02-02 | 2023-12-05 | Novo Nordisk A/S | Solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid |
| US12396953B2 (en) | 2018-02-02 | 2025-08-26 | Novo Nordisk A/S | Solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid |
| JP2021515026A (ja) * | 2018-03-09 | 2021-06-17 | 上海仁会生物制▲やく▼股▲ふん▼有限公司Ｓｈａｎｇｈａｉ Ｂｅｎｅｍａｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ | 肥満の治療および体重管理のためのｇｌｐ−１組成物 |
| JP7451413B2 (ja) | 2018-03-09 | 2024-03-18 | 上海仁会生物制▲やく▼股▲ふん▼有限公司 | 肥満の治療および体重管理のためのｇｌｐ－１組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU4863797A (en) | 1998-06-03 |
| ATE366584T1 (de) | 2007-08-15 |
| DE69737916T2 (de) | 2008-04-03 |
| US20030232754A1 (en) | 2003-12-18 |
| US20070161568A1 (en) | 2007-07-12 |
| EP0941114B1 (en) | 2005-02-23 |
| WO1998020895A1 (en) | 1998-05-22 |
| EP1529534B1 (en) | 2007-07-11 |
| DE69737916D1 (de) | 2007-08-23 |
| DE69732572T2 (de) | 2005-12-29 |
| US20090149387A1 (en) | 2009-06-11 |
| ES2237790T3 (es) | 2005-08-01 |
| EP0941114A1 (en) | 1999-09-15 |
| EP1529534A3 (en) | 2005-06-08 |
| ATE289517T1 (de) | 2005-03-15 |
| EP1529534A2 (en) | 2005-05-11 |
| US20110028391A1 (en) | 2011-02-03 |
| ZA9710182B (en) | 1998-05-12 |
| DE69732572D1 (de) | 2005-03-31 |
| US20100113363A1 (en) | 2010-05-06 |
| ES2290799T3 (es) | 2008-02-16 |
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