JP2001503029A - アベルメクチンおよびミルベマイシンの注射製剤 - Google Patents
アベルメクチンおよびミルベマイシンの注射製剤Info
- Publication number
- JP2001503029A JP2001503029A JP10514237A JP51423798A JP2001503029A JP 2001503029 A JP2001503029 A JP 2001503029A JP 10514237 A JP10514237 A JP 10514237A JP 51423798 A JP51423798 A JP 51423798A JP 2001503029 A JP2001503029 A JP 2001503029A
- Authority
- JP
- Japan
- Prior art keywords
- avermectin
- castor oil
- milbemycin
- solvent
- sesame oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.ゴマ油、中長鎖(medium−chain)のトリグリセリド、グリコ ールエステルまたは脂肪酸エステルを含んでなる溶媒混合物並びに一価もしくは 多価の脂肪族もしくは芳香族アルコールおよびそれらの誘導体(例えば、環状カ ーボネート;アセテート;アセタール;ケタール)またはヒマシ油よりなる群か らのさらなる溶媒を基材とするアベルメクチン(avermectin)および ミルベマイシン(milbemycin)の注射製剤。 2.以下の組成: 1.活性化合物0.2〜5%m/v; 2.ゴマ油60〜90%v/v; 3.10〜30容積%の中長鎖のトリグリセリドまたはグリコールエステルまた は脂肪酸エステル; 4.一価もしくは多価の脂肪族もしくは芳香族アルコールおよびそれらの誘導体 またはヒマシ油よりなる群からの1〜20%補助溶媒; 5.適当ならば、さらなる補助剤、 を有することを特徴とする請求の範囲第1項に記載の製剤。 3.以下の組成: 60〜90%v/vのゴマ油、および10〜30%v/vのオレイン酸エチルま たはMiglyol(商標)812またはMiglyol(商標)840、およ び1〜5%v/vのベンジルアルコールまたは10〜20%v/vのヒマシ油、 および場合により1000ppmまでの安定剤よりなる溶媒混合物中の0.2〜 5%m/vのアベルメクチンまたはミルベマイシン、 の請求の範囲第1項に記載の製剤。 4.以下の組成: 1%m/vのイベルメクチン、65〜90%v/vのゴマ油、10〜20%v/ vのオレイン酸エチル、および1〜3%v/vのベンジルアルコールまたは10 %v/vのヒマシ油、および場合により500ppmまでの安定剤、 の請求の範囲第1項に記載の製剤。 5.活性化合物をヒマシ油またはベンジルアルコール中に(部分的に)溶解し そして残余の溶媒を添加するか或いは活性化合物をすべての3種の溶媒の混合物 中に溶媒することを特徴とする請求の範囲第1項に記載の製剤の製造方法。 6.請求の範囲第1項に記載の製剤中の溶解化剤としてのヒマシ油またはベン ジルアルコールの使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19638045.6 | 1996-09-18 | ||
DE19638045A DE19638045A1 (de) | 1996-09-18 | 1996-09-18 | Injektionsformulierungen von Avermectinen und Milbemycinen |
PCT/EP1997/004867 WO1998011902A1 (de) | 1996-09-18 | 1997-09-08 | Injektionsformulierungen von avermectinen und milbemycinen |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2001503029A true JP2001503029A (ja) | 2001-03-06 |
JP2001503029A5 JP2001503029A5 (ja) | 2005-02-10 |
JP4822196B2 JP4822196B2 (ja) | 2011-11-24 |
Family
ID=7806009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51423798A Expired - Fee Related JP4822196B2 (ja) | 1996-09-18 | 1997-09-08 | アベルメクチンおよびミルベマイシンの注射製剤 |
Country Status (18)
Country | Link |
---|---|
US (1) | US6617314B2 (ja) |
EP (1) | EP0939638B1 (ja) |
JP (1) | JP4822196B2 (ja) |
KR (1) | KR20000035978A (ja) |
CN (1) | CN1130203C (ja) |
AR (1) | AR008844A1 (ja) |
AT (1) | ATE228845T1 (ja) |
AU (1) | AU750874B2 (ja) |
BR (2) | BR9712058B1 (ja) |
CA (1) | CA2265952C (ja) |
DE (2) | DE19638045A1 (ja) |
DK (1) | DK0939638T3 (ja) |
ES (1) | ES2184135T3 (ja) |
HK (1) | HK1022845A1 (ja) |
NZ (1) | NZ334673A (ja) |
PL (1) | PL332137A1 (ja) |
WO (1) | WO1998011902A1 (ja) |
ZA (1) | ZA978352B (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013522216A (ja) * | 2010-03-09 | 2013-06-13 | ヤンセン バイオテツク,インコーポレーテツド | 非水性高濃度減粘懸濁製剤 |
JP2014510077A (ja) * | 2011-03-09 | 2014-04-24 | ヤンセン バイオテツク,インコーポレーテツド | 抗体の非水性高濃度減粘懸濁製剤 |
JP2015509978A (ja) * | 2012-03-13 | 2015-04-02 | バイエル・ニュージーランド・リミテッド | 長時間作用型の組成物 |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US7030155B2 (en) | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
KR20000025762A (ko) * | 1998-10-14 | 2000-05-06 | 유충식 | 이버멕틴류의 가용화 조성물 |
GB9827727D0 (en) * | 1998-12-16 | 1999-02-10 | Pfizer Ltd | Antiparasitic formulations |
GB0000313D0 (en) | 2000-01-10 | 2000-03-01 | Astrazeneca Uk Ltd | Formulation |
AU781682B2 (en) | 2000-03-20 | 2005-06-09 | Zoetis Services Llc | Sustained-release compositions for parenteral administration |
US6872708B2 (en) * | 2001-09-10 | 2005-03-29 | Mitsukazu Matsumoto | Local injection prescription |
US7396819B2 (en) * | 2003-08-08 | 2008-07-08 | Virbac Corporation | Anthelmintic formulations |
US7582612B2 (en) | 2004-03-12 | 2009-09-01 | Hartz Mountain Corporation | Multi-action anthelmintic formulations |
AU2009271299B2 (en) * | 2008-06-24 | 2014-09-11 | Boehringer Ingelheim Animal Health USA Inc. | Anthelminthic formulations |
JP2012517994A (ja) | 2009-02-16 | 2012-08-09 | ファイザー・インク | 高投与量ドラメクチン製剤 |
CN101773467B (zh) * | 2010-01-20 | 2015-09-09 | 北京大北农动物保健科技有限责任公司 | 一种美贝霉素或美贝霉素肟的兽用缓释注射液及制备方法 |
US9072668B2 (en) | 2010-03-09 | 2015-07-07 | Janssen Biotech, Inc. | Non-aqueous high concentration reduced viscosity suspension formulations of antibodies |
CN103417478B (zh) * | 2012-05-18 | 2014-09-10 | 中国农业科学院兰州畜牧与兽药研究所 | 一种以水为基质的伊维菌素o/w型注射液及其制备方法 |
US20170196802A1 (en) * | 2016-01-08 | 2017-07-13 | Abon Pharmaceuticals, Llc | Long Acting Injectable Formulations |
US20210137960A1 (en) | 2018-02-01 | 2021-05-13 | Yale University | Compositions and methods for inhibition of nuclear-penetrating antibodies |
CN114107097B (zh) * | 2021-11-10 | 2024-03-05 | 河北兴柏农业科技股份有限公司 | 一种阿佛曼链霉菌活性孢子的固体发酵工艺 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ197796A (en) * | 1980-08-04 | 1984-11-09 | Merck & Co Inc | Stabilised aqueous formulations containing ivermectin |
NZ210505A (en) * | 1983-12-22 | 1988-06-30 | Merck & Co Inc | Parasiticidal compositions containing avermectin or milbemycin derivatives |
US6001822A (en) * | 1989-04-11 | 1999-12-14 | Pfizer Inc. | Antiparasitic formulations |
ES2052173T3 (es) * | 1989-04-11 | 1994-07-01 | Pfizer | Composiciones inyectables que contienen 25-cyclohexil-avermectina b1. |
NZ234802A (en) * | 1989-08-14 | 1992-11-25 | Merck & Co Inc | Long acting injectable formulations comprising an avermectin compound and triacetin. treatment for internal and external parasites of animals |
US5030650A (en) | 1989-09-11 | 1991-07-09 | American Cyanamid Company | 13-halo-23-imino derivatives of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents |
US5055486A (en) | 1989-12-22 | 1991-10-08 | American Cyanamid Company | 13-alkyl-23-imino derivative of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents |
ES2086022T3 (es) * | 1991-07-23 | 1996-06-16 | American Cyanamid Co | Composiciones estables para administracion parenteral y su uso. |
ATE180671T1 (de) * | 1991-09-30 | 1999-06-15 | Merck & Co Inc | Hydrierte rizinusöl-enthaltende injizierbare formulierungen mit verlängerter wirkstoffabgabe |
GB2275193A (en) * | 1993-02-17 | 1994-08-24 | Merck & Co Inc | Formulations for the topical delivery of avermectins |
DE4443888A1 (de) * | 1994-12-09 | 1996-06-13 | Bayer Ag | Dermal applizierbare Formulierungen von Parasitiziden |
CA2233016C (en) * | 1995-09-25 | 2007-07-17 | Ashmont Holdings Limited | Anthelmintic macrocyclic lactone compositions |
DE19613972A1 (de) * | 1996-04-09 | 1997-10-16 | Bayer Ag | Injektionsformulierungen von Avermectinen und Milbemycinen auf Basis von Rizinusöl |
RU2140737C1 (ru) * | 1998-09-22 | 1999-11-10 | Мосин Владимир Александрович | Средство для профилактики и лечения паразитарных заболеваний животных |
CN1219393A (zh) * | 1998-11-13 | 1999-06-16 | 王玉万 | 一种含阿维菌素或伊维菌素的兽用抗寄生虫油剂口服液及其制备方法 |
-
1996
- 1996-09-18 DE DE19638045A patent/DE19638045A1/de not_active Withdrawn
-
1997
- 1997-09-08 ES ES97944849T patent/ES2184135T3/es not_active Expired - Lifetime
- 1997-09-08 AT AT97944849T patent/ATE228845T1/de active
- 1997-09-08 DE DE59708905T patent/DE59708905D1/de not_active Expired - Lifetime
- 1997-09-08 WO PCT/EP1997/004867 patent/WO1998011902A1/de active IP Right Grant
- 1997-09-08 AU AU46215/97A patent/AU750874B2/en not_active Ceased
- 1997-09-08 EP EP97944849A patent/EP0939638B1/de not_active Expired - Lifetime
- 1997-09-08 CA CA002265952A patent/CA2265952C/en not_active Expired - Lifetime
- 1997-09-08 BR BRPI9712058-8A patent/BR9712058B1/pt not_active IP Right Cessation
- 1997-09-08 NZ NZ334673A patent/NZ334673A/xx not_active IP Right Cessation
- 1997-09-08 JP JP51423798A patent/JP4822196B2/ja not_active Expired - Fee Related
- 1997-09-08 BR BRPI9715298A patent/BRPI9715298B8/pt active IP Right Grant
- 1997-09-08 PL PL97332137A patent/PL332137A1/xx unknown
- 1997-09-08 US US09/254,615 patent/US6617314B2/en not_active Expired - Lifetime
- 1997-09-08 CN CN97198028A patent/CN1130203C/zh not_active Expired - Fee Related
- 1997-09-08 KR KR1019997001893A patent/KR20000035978A/ko not_active Application Discontinuation
- 1997-09-08 DK DK97944849T patent/DK0939638T3/da active
- 1997-09-17 ZA ZA9708352A patent/ZA978352B/xx unknown
- 1997-09-18 AR ARP970104297A patent/AR008844A1/es active IP Right Grant
-
2000
- 2000-03-31 HK HK00101987A patent/HK1022845A1/xx not_active IP Right Cessation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013522216A (ja) * | 2010-03-09 | 2013-06-13 | ヤンセン バイオテツク,インコーポレーテツド | 非水性高濃度減粘懸濁製剤 |
JP2014510077A (ja) * | 2011-03-09 | 2014-04-24 | ヤンセン バイオテツク,インコーポレーテツド | 抗体の非水性高濃度減粘懸濁製剤 |
JP2015509978A (ja) * | 2012-03-13 | 2015-04-02 | バイエル・ニュージーランド・リミテッド | 長時間作用型の組成物 |
Also Published As
Publication number | Publication date |
---|---|
AU750874B2 (en) | 2002-08-01 |
BRPI9715298B8 (pt) | 2016-04-26 |
AU4621597A (en) | 1998-04-14 |
KR20000035978A (ko) | 2000-06-26 |
HK1022845A1 (en) | 2000-08-25 |
US6617314B2 (en) | 2003-09-09 |
CN1230890A (zh) | 1999-10-06 |
NZ334673A (en) | 2000-10-27 |
EP0939638B1 (de) | 2002-12-04 |
ES2184135T3 (es) | 2003-04-01 |
CN1130203C (zh) | 2003-12-10 |
WO1998011902A1 (de) | 1998-03-26 |
DK0939638T3 (da) | 2003-03-24 |
AR008844A1 (es) | 2000-02-23 |
CA2265952A1 (en) | 1998-03-26 |
US20020160967A1 (en) | 2002-10-31 |
ATE228845T1 (de) | 2002-12-15 |
ZA978352B (en) | 1998-03-24 |
PL332137A1 (en) | 1999-08-30 |
DE59708905D1 (de) | 2003-01-16 |
BR9715298B1 (pt) | 2014-10-14 |
CA2265952C (en) | 2009-11-17 |
BR9712058A (pt) | 1999-08-24 |
JP4822196B2 (ja) | 2011-11-24 |
BR9712058B1 (pt) | 2009-05-05 |
DE19638045A1 (de) | 1998-03-19 |
EP0939638A1 (de) | 1999-09-08 |
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