JP2000512648A - ピペリジン酢酸誘導体および血栓障害の治療におけるそれらの使用 - Google Patents
ピペリジン酢酸誘導体および血栓障害の治療におけるそれらの使用Info
- Publication number
- JP2000512648A JP2000512648A JP10502284A JP50228498A JP2000512648A JP 2000512648 A JP2000512648 A JP 2000512648A JP 10502284 A JP10502284 A JP 10502284A JP 50228498 A JP50228498 A JP 50228498A JP 2000512648 A JP2000512648 A JP 2000512648A
- Authority
- JP
- Japan
- Prior art keywords
- piperidin
- formula
- compound
- indazol
- acetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 14
- 208000007536 Thrombosis Diseases 0.000 title claims abstract description 13
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- 150000001875 compounds Chemical class 0.000 claims abstract description 168
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 11
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims abstract 2
- -1 2-piperidin-4-yl-ethyl Chemical group 0.000 claims description 35
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 31
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- 229920002554 vinyl polymer Polymers 0.000 claims description 17
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
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- 229910021529 ammonia Inorganic materials 0.000 description 6
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- 125000000217 alkyl group Chemical group 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- QEWYKACRFQMRMB-UHFFFAOYSA-N fluoroacetic acid Chemical compound OC(=O)CF QEWYKACRFQMRMB-UHFFFAOYSA-N 0.000 description 5
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- JBFGMCGEFBDZTL-UHFFFAOYSA-N tert-butyl 2-[4-(5-bromo-3-carbamoylindazol-1-yl)piperidin-1-yl]acetate Chemical compound C1CN(CC(=O)OC(C)(C)C)CCC1N1C2=CC=C(Br)C=C2C(C(N)=O)=N1 JBFGMCGEFBDZTL-UHFFFAOYSA-N 0.000 description 1
- UOUFRTFWWBCVPV-UHFFFAOYSA-N tert-butyl 4-(2,4-dioxo-1H-thieno[3,2-d]pyrimidin-3-yl)piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(CC1)n1c(=O)[nH]c2ccsc2c1=O UOUFRTFWWBCVPV-UHFFFAOYSA-N 0.000 description 1
- CCSOAUKKERHESX-CMDGGOBGSA-N tert-butyl 4-[(e)-2-[3-[1-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]piperidin-4-yl]-1-methylsulfonylindazol-6-yl]ethenyl]piperidine-1-carboxylate Chemical compound C1CN(CC(=O)OC(C)(C)C)CCC1C1=NN(S(C)(=O)=O)C2=CC(\C=C\C3CCN(CC3)C(=O)OC(C)(C)C)=CC=C12 CCSOAUKKERHESX-CMDGGOBGSA-N 0.000 description 1
- FQFILJKFZCVHNH-UHFFFAOYSA-N tert-butyl n-[3-[(5-bromo-2-chloropyrimidin-4-yl)amino]propyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCCNC1=NC(Cl)=NC=C1Br FQFILJKFZCVHNH-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 201000010875 transient cerebral ischemia Diseases 0.000 description 1
- KQTIIICEAUMSDG-UHFFFAOYSA-N tricarballylic acid Chemical class OC(=O)CC(C(O)=O)CC(O)=O KQTIIICEAUMSDG-UHFFFAOYSA-N 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 238000004879 turbidimetry Methods 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9613017.4 | 1996-06-21 | ||
| GBGB9613018.2A GB9613018D0 (en) | 1996-06-21 | 1996-06-21 | Therapeutic indazoles |
| GB9613095.0 | 1996-06-21 | ||
| GBGB9613095.0A GB9613095D0 (en) | 1996-06-21 | 1996-06-21 | Therapeutic piperidines |
| GBGB9613017.4A GB9613017D0 (en) | 1996-06-21 | 1996-06-21 | Therapeutic compounds |
| GB9613018.2 | 1996-06-21 | ||
| PCT/EP1997/003196 WO1997049699A1 (en) | 1996-06-21 | 1997-06-19 | Piperidine acetic acid derivatives and their use in the treatment of thrombotic disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2000512648A true JP2000512648A (ja) | 2000-09-26 |
Family
ID=27268341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10502284A Pending JP2000512648A (ja) | 1996-06-21 | 1997-06-19 | ピペリジン酢酸誘導体および血栓障害の治療におけるそれらの使用 |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0912555A1 (cs) |
| JP (1) | JP2000512648A (cs) |
| KR (1) | KR20000022041A (cs) |
| AP (1) | AP9801417A0 (cs) |
| AR (1) | AR008245A1 (cs) |
| AU (1) | AU3261197A (cs) |
| BR (1) | BR9709930A (cs) |
| CA (1) | CA2258753A1 (cs) |
| CZ (1) | CZ424698A3 (cs) |
| EA (1) | EA199801015A1 (cs) |
| ID (1) | ID17052A (cs) |
| IL (1) | IL127464A0 (cs) |
| IS (1) | IS4924A (cs) |
| NO (1) | NO985974L (cs) |
| PL (1) | PL330797A1 (cs) |
| TR (1) | TR199802665T2 (cs) |
| WO (1) | WO1997049699A1 (cs) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005536520A (ja) * | 2002-07-18 | 2005-12-02 | ワイス | ５−ヒドロキシトリプタミン−６リガンドとしての１−（ヘテロサイクリルアルキル）−３−スルホニルインドールまたはインダゾール誘導体 |
| JP2006518385A (ja) * | 2003-02-14 | 2006-08-10 | ワイス | ５−ヒドロキシトリプタミン−６リガンドとしてのヘテロサイクリル−３−スルホニルインダゾール |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7064215B2 (en) | 2001-07-03 | 2006-06-20 | Chiron Corporation | Indazole benzimidazole compounds |
| US7642278B2 (en) | 2001-07-03 | 2010-01-05 | Novartis Vaccines And Diagnostics, Inc. | Indazole benzimidazole compounds |
| CN101432274A (zh) | 2006-04-05 | 2009-05-13 | 惠氏公司 | 作为5-羟色胺-6配体的磺酰基-3-杂环吲唑衍生物 |
| WO2008084004A1 (en) | 2007-01-10 | 2008-07-17 | F. Hoffmann-La Roche Ag | Sulfonamide derivatives as chymase inhibitors |
| CN113655155A (zh) * | 2021-07-28 | 2021-11-16 | 任贤金 | 一种测定sph3127有关物质的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4124942A1 (de) * | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| EP0612313A1 (en) * | 1991-11-14 | 1994-08-31 | Glaxo Group Limited | Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
| GB9208740D0 (en) * | 1992-04-23 | 1992-06-10 | Glaxo Group Ltd | Chemical compounds |
-
1997
- 1997-06-18 AR ARP970102676A patent/AR008245A1/es unknown
- 1997-06-19 AU AU32611/97A patent/AU3261197A/en not_active Abandoned
- 1997-06-19 EA EA199801015A patent/EA199801015A1/ru unknown
- 1997-06-19 CA CA002258753A patent/CA2258753A1/en not_active Abandoned
- 1997-06-19 EP EP97928243A patent/EP0912555A1/en not_active Withdrawn
- 1997-06-19 BR BR9709930A patent/BR9709930A/pt not_active Application Discontinuation
- 1997-06-19 WO PCT/EP1997/003196 patent/WO1997049699A1/en not_active Application Discontinuation
- 1997-06-19 KR KR1019980710439A patent/KR20000022041A/ko not_active Withdrawn
- 1997-06-19 ID IDP972092A patent/ID17052A/id unknown
- 1997-06-19 CZ CZ984246A patent/CZ424698A3/cs unknown
- 1997-06-19 AP APAP/P/1998/001417A patent/AP9801417A0/en unknown
- 1997-06-19 IL IL12746497A patent/IL127464A0/xx unknown
- 1997-06-19 PL PL97330797A patent/PL330797A1/xx unknown
- 1997-06-19 JP JP10502284A patent/JP2000512648A/ja active Pending
- 1997-06-19 TR TR1998/02665T patent/TR199802665T2/xx unknown
-
1998
- 1998-12-15 IS IS4924A patent/IS4924A/is unknown
- 1998-12-18 NO NO985974A patent/NO985974L/no not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005536520A (ja) * | 2002-07-18 | 2005-12-02 | ワイス | ５−ヒドロキシトリプタミン−６リガンドとしての１−（ヘテロサイクリルアルキル）−３−スルホニルインドールまたはインダゾール誘導体 |
| JP2006518385A (ja) * | 2003-02-14 | 2006-08-10 | ワイス | ５−ヒドロキシトリプタミン−６リガンドとしてのヘテロサイクリル−３−スルホニルインダゾール |
Also Published As
| Publication number | Publication date |
|---|---|
| ID17052A (id) | 1997-12-04 |
| WO1997049699A1 (en) | 1997-12-31 |
| AU3261197A (en) | 1998-01-14 |
| AP9801417A0 (en) | 1998-12-31 |
| NO985974D0 (no) | 1998-12-18 |
| IL127464A0 (en) | 1999-10-28 |
| NO985974L (no) | 1999-02-17 |
| EP0912555A1 (en) | 1999-05-06 |
| CA2258753A1 (en) | 1997-12-31 |
| AR008245A1 (es) | 1999-12-29 |
| TR199802665T2 (xx) | 1999-03-22 |
| CZ424698A3 (cs) | 1999-05-12 |
| EA199801015A1 (ru) | 1999-08-26 |
| BR9709930A (pt) | 1999-08-10 |
| IS4924A (is) | 1998-12-15 |
| KR20000022041A (ko) | 2000-04-25 |
| PL330797A1 (en) | 1999-06-07 |
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