JP2000511877A - 医薬としての新規な環状アミノ酸 - Google Patents
医薬としての新規な環状アミノ酸Info
- Publication number
- JP2000511877A JP2000511877A JP09528505A JP52850597A JP2000511877A JP 2000511877 A JP2000511877 A JP 2000511877A JP 09528505 A JP09528505 A JP 09528505A JP 52850597 A JP52850597 A JP 52850597A JP 2000511877 A JP2000511877 A JP 2000511877A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- benzyl
- carbon atoms
- treatment
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 15
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- 239000001257 hydrogen Substances 0.000 claims description 13
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Classifications
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- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
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- Neurosurgery (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
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| US1127896P | 1996-02-07 | 1996-02-07 | |
| US60/011,278 | 1996-02-07 | ||
| PCT/US1997/000255 WO1997029101A1 (en) | 1996-02-07 | 1997-01-02 | Novel cyclic amino acids as pharmaceutical agents |
Publications (2)
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| JP2000511877A true JP2000511877A (ja) | 2000-09-12 |
| JP2000511877A5 JP2000511877A5 (enExample) | 2004-11-11 |
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| JP (1) | JP2000511877A (enExample) |
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| CA (1) | CA2244708A1 (enExample) |
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| EA (1) | EA001534B1 (enExample) |
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| HU (1) | HUP9901074A3 (enExample) |
| IL (1) | IL125562A (enExample) |
| NO (1) | NO983612L (enExample) |
| NZ (1) | NZ326669A (enExample) |
| PL (1) | PL328432A1 (enExample) |
| PT (1) | PT888325E (enExample) |
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| US6001876A (en) | 1996-07-24 | 1999-12-14 | Warner-Lambert Company | Isobutylgaba and its derivatives for the treatment of pain |
| NZ502786A (en) * | 1997-09-18 | 2002-05-31 | Warner Lambert Co | Preparation of gabapentin analogues comprised of adding cyclohexanone to sodium hydride and finally heating the formed lactam in HCl and dioxan |
| US6984659B2 (en) | 1997-11-18 | 2006-01-10 | Klinikum Der Albert-Ludwigs Universitaet | 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level |
| DE19751062A1 (de) | 1997-11-18 | 1999-07-08 | Univ Ludwigs Albert | An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels |
| KR20010033153A (ko) * | 1997-12-16 | 2001-04-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 4(3)-치환-4(3)-아미노메틸-(티오)피란 또는 -피페리딘유도체(=가바펜틴 동족체), 그의 제법 및 신경 질환 치료용도 |
| AU2001247762A1 (en) * | 2000-03-28 | 2001-10-08 | Delorenzo, Robert, J | Inhibition of a novel calcium injury current that forms in neurons during injury prevents neuronal cell death |
| AU2002211863A1 (en) | 2000-10-06 | 2002-04-15 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
| EP1361847A2 (en) | 2000-10-06 | 2003-11-19 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
| GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
| US7420002B2 (en) | 2001-06-11 | 2008-09-02 | Xenoport | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| MXPA03011566A (es) | 2001-06-11 | 2004-10-28 | Xenoport Inc | Formas de dosificacion de profarmacos de analogos de gaba administrados oralmente que tienen toxicidad reducida. |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US6927036B2 (en) | 2002-02-19 | 2005-08-09 | Xero Port, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| US7026351B2 (en) | 2002-03-20 | 2006-04-11 | Xenoport, Inc. | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof |
| AU2003243180A1 (en) | 2002-05-17 | 2003-12-12 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| US20040092498A1 (en) * | 2002-08-16 | 2004-05-13 | David Blakemore | Substituted glycine derivatives for use as medicaments |
| US7060727B2 (en) | 2002-12-11 | 2006-06-13 | Xenoport, Inc. | Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof |
| DE60332387D1 (de) | 2002-12-13 | 2010-06-10 | Warner Lambert Co | Alpha-2-delta-ligand zur behandlung vonsymptomen der unteren harnwege |
| CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| KR20060119971A (ko) | 2003-09-11 | 2006-11-24 | 제노포트 인코포레이티드 | Ｇａｂａ 유사체의 전구약물을 이용한 요실금의 치료및/또는 예방 |
| DE602004024317D1 (de) | 2003-09-12 | 2010-01-07 | Pfizer | Kombinationen aus alpha-2-delta liganden und serotonin / noradrenalin-wiederaufnahmehemmern |
| WO2005027850A2 (en) | 2003-09-17 | 2005-03-31 | Xenoport, Inc. | Treating or preventing restless legs syndrome using prodrugs of gaba analogs |
| MXPA06004088A (es) | 2003-10-14 | 2006-06-27 | Xenoport Inc | Forma cristalina de un analogo del acido gamma-aminobutirico. |
| WO2005060968A1 (en) | 2003-12-11 | 2005-07-07 | Sepracor Inc. | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| EP1811986B1 (en) | 2004-11-04 | 2014-03-26 | XenoPort, Inc. | Gabapentin prodrug sustained release oral dosage forms |
| ATE511860T1 (de) | 2006-12-22 | 2011-06-15 | Recordati Ireland Ltd | Kombinationstherapie für erkrankungen der unteren harnwege mit 2 liganden und nsar |
| WO2009024615A1 (en) * | 2007-08-23 | 2009-02-26 | Novartis Ag | Aminobenzyl-substituted cyclic sulfones useful as bace inhibitors |
| EP2250143B1 (en) | 2008-01-25 | 2016-04-20 | XenoPort, Inc. | Method for the enzymatic kinetic resolution of acyloxyalkyl thiocarbonates used for the synthesis of acyloxyalkyl carbamates |
| US7872046B2 (en) | 2008-01-25 | 2011-01-18 | Xenoport, Inc. | Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use |
| WO2009094577A2 (en) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
| ES2589915T3 (es) | 2008-10-08 | 2016-11-17 | Xgene Pharmaceutical Inc | Conjugados de GABA y métodos de utilización de los mismos |
| WO2010084797A1 (ja) * | 2009-01-21 | 2010-07-29 | 第一三共株式会社 | 含ヘテロ原子化合物 |
| US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
| WO2014117176A1 (en) | 2013-01-28 | 2014-07-31 | Lopez Hector L | Methods of improving tolerability, pharmacodynamics, and efficacy of b-alanine and use therefor |
| CA3099775A1 (en) | 2018-05-14 | 2019-11-21 | Xgene Pharmaceutical Inc. | Process for making 1-(acyloxy)-alkyl-carabmate drug conjugates of naproxen and pregabalin |
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| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| US5270317A (en) * | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
| KR970010173B1 (ko) * | 1991-07-09 | 1997-06-21 | 닛뽕소다 가부시끼가이샤 | 함헤테로 시클로헥산디온 유도체, 그의 제조방법 및 제초제 |
| US5514801A (en) * | 1992-12-29 | 1996-05-07 | Monsanto Company | Cyclic sulfone containing retroviral protease inhibitors |
| GB9314758D0 (en) * | 1993-07-16 | 1993-08-25 | Wyeth John & Brother Ltd | Heterocyclic derivatives |
| US5527194A (en) * | 1994-02-02 | 1996-06-18 | Brunswick Corporation | Thrust sensor for marine drives |
| US5491152A (en) * | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
| US5760006A (en) * | 1997-06-23 | 1998-06-02 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating psoriasis |
-
1997
- 1997-01-02 HU HU9901074A patent/HUP9901074A3/hu unknown
- 1997-01-02 AT AT97901385T patent/ATE218135T1/de not_active IP Right Cessation
- 1997-01-02 EA EA199800682A patent/EA001534B1/ru not_active IP Right Cessation
- 1997-01-02 DE DE69712877T patent/DE69712877T2/de not_active Expired - Fee Related
- 1997-01-02 AU AU15295/97A patent/AU720628B2/en not_active Ceased
- 1997-01-02 PL PL97328432A patent/PL328432A1/xx unknown
- 1997-01-02 SK SK1067-98A patent/SK282665B6/sk unknown
- 1997-01-02 CA CA002244708A patent/CA2244708A1/en not_active Abandoned
- 1997-01-02 CZ CZ19982452A patent/CZ296052B6/cs not_active IP Right Cessation
- 1997-01-02 DK DK97901385T patent/DK0888325T3/da active
- 1997-01-02 IL IL12556297A patent/IL125562A/en not_active IP Right Cessation
- 1997-01-02 KR KR1019980706079A patent/KR19990082349A/ko not_active Ceased
- 1997-01-02 NZ NZ326669A patent/NZ326669A/en unknown
- 1997-01-02 JP JP09528505A patent/JP2000511877A/ja not_active Abandoned
- 1997-01-02 EP EP97901385A patent/EP0888325B1/en not_active Expired - Lifetime
- 1997-01-02 PT PT97901385T patent/PT888325E/pt unknown
- 1997-01-02 WO PCT/US1997/000255 patent/WO1997029101A1/en not_active Ceased
- 1997-01-02 US US09/077,053 patent/US5929088A/en not_active Expired - Fee Related
- 1997-01-02 BR BR9707366A patent/BR9707366A/pt not_active Application Discontinuation
- 1997-01-02 ES ES97901385T patent/ES2176668T3/es not_active Expired - Lifetime
- 1997-02-06 ZA ZA9700991A patent/ZA97991B/xx unknown
-
1998
- 1998-08-06 NO NO983612A patent/NO983612L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR19990082349A (ko) | 1999-11-25 |
| CZ245298A3 (cs) | 1998-11-11 |
| CA2244708A1 (en) | 1997-08-14 |
| DE69712877T2 (de) | 2002-11-14 |
| NZ326669A (en) | 2001-05-25 |
| NO983612L (no) | 1998-10-06 |
| ATE218135T1 (de) | 2002-06-15 |
| SK282665B6 (sk) | 2002-11-06 |
| ES2176668T3 (es) | 2002-12-01 |
| AU720628B2 (en) | 2000-06-08 |
| SK106798A3 (en) | 1999-07-12 |
| PL328432A1 (en) | 1999-02-01 |
| IL125562A0 (en) | 1999-03-12 |
| US5929088A (en) | 1999-07-27 |
| NO983612D0 (no) | 1998-08-06 |
| AU1529597A (en) | 1997-08-28 |
| BR9707366A (pt) | 1999-07-20 |
| DK0888325T3 (da) | 2002-09-16 |
| IL125562A (en) | 2001-08-08 |
| HUP9901074A2 (hu) | 2001-04-28 |
| DE69712877D1 (de) | 2002-07-04 |
| PT888325E (pt) | 2002-10-31 |
| EA001534B1 (ru) | 2001-04-23 |
| EP0888325B1 (en) | 2002-05-29 |
| EA199800682A1 (ru) | 1999-02-25 |
| CZ296052B6 (cs) | 2005-12-14 |
| ZA97991B (en) | 1997-08-15 |
| EP0888325A1 (en) | 1999-01-07 |
| WO1997029101A1 (en) | 1997-08-14 |
| HUP9901074A3 (en) | 2001-08-28 |
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