EA001534B1 - Производные циклической аминокислоты или их фармацевтически приемлемые соли, фармацевтическая композиция и способ лечения депрессии, состояний паники, страха и болевых ощущений - Google Patents

Производные циклической аминокислоты или их фармацевтически приемлемые соли, фармацевтическая композиция и способ лечения депрессии, состояний паники, страха и болевых ощущений Download PDF

Info

Publication number
EA001534B1
EA001534B1 EA199800682A EA199800682A EA001534B1 EA 001534 B1 EA001534 B1 EA 001534B1 EA 199800682 A EA199800682 A EA 199800682A EA 199800682 A EA199800682 A EA 199800682A EA 001534 B1 EA001534 B1 EA 001534B1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
amino acid
cyclic amino
benzyl
carbon atoms
Prior art date
Application number
EA199800682A
Other languages
English (en)
Russian (ru)
Other versions
EA199800682A1 (ru
Inventor
Дейвид Си Хорвелл
Джастин С. Брайэнс
Клэр О. Ниин
Джильс С. Ретклифф
Original Assignee
Варнер-Ламберт Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Варнер-Ламберт Компани filed Critical Варнер-Ламберт Компани
Publication of EA199800682A1 publication Critical patent/EA199800682A1/ru
Publication of EA001534B1 publication Critical patent/EA001534B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
EA199800682A 1996-02-07 1997-01-02 Производные циклической аминокислоты или их фармацевтически приемлемые соли, фармацевтическая композиция и способ лечения депрессии, состояний паники, страха и болевых ощущений EA001534B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1127896P 1996-02-07 1996-02-07
PCT/US1997/000255 WO1997029101A1 (en) 1996-02-07 1997-01-02 Novel cyclic amino acids as pharmaceutical agents

Publications (2)

Publication Number Publication Date
EA199800682A1 EA199800682A1 (ru) 1999-02-25
EA001534B1 true EA001534B1 (ru) 2001-04-23

Family

ID=21749660

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800682A EA001534B1 (ru) 1996-02-07 1997-01-02 Производные циклической аминокислоты или их фармацевтически приемлемые соли, фармацевтическая композиция и способ лечения депрессии, состояний паники, страха и болевых ощущений

Country Status (22)

Country Link
US (1) US5929088A (enExample)
EP (1) EP0888325B1 (enExample)
JP (1) JP2000511877A (enExample)
KR (1) KR19990082349A (enExample)
AT (1) ATE218135T1 (enExample)
AU (1) AU720628B2 (enExample)
BR (1) BR9707366A (enExample)
CA (1) CA2244708A1 (enExample)
CZ (1) CZ296052B6 (enExample)
DE (1) DE69712877T2 (enExample)
DK (1) DK0888325T3 (enExample)
EA (1) EA001534B1 (enExample)
ES (1) ES2176668T3 (enExample)
HU (1) HUP9901074A3 (enExample)
IL (1) IL125562A (enExample)
NO (1) NO983612L (enExample)
NZ (1) NZ326669A (enExample)
PL (1) PL328432A1 (enExample)
PT (1) PT888325E (enExample)
SK (1) SK282665B6 (enExample)
WO (1) WO1997029101A1 (enExample)
ZA (1) ZA97991B (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL189872B1 (pl) 1996-07-24 2005-10-31 Warner Lambert Co Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu
KR100563894B1 (ko) 1997-09-18 2006-03-24 워너-램버트 캄파니 엘엘씨 가바펜틴 동족체의 신규 입체선택적 제조 방법
DE19751062A1 (de) 1997-11-18 1999-07-08 Univ Ludwigs Albert An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels
US6984659B2 (en) 1997-11-18 2006-01-10 Klinikum Der Albert-Ludwigs Universitaet 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level
NZ503980A (en) * 1997-12-16 2002-09-27 Warner Lambert Co 4(3)substituted-4(3)-aminomethyl-(thio)pyran or -piperidine derivatives (= gabapentin analogues), pharmaceuticals thereof, and their use in the treatment of neurological disorders
JP2003528148A (ja) * 2000-03-28 2003-09-24 デロレンゾ、ロバート・ジェイ 損傷に際して神経細胞中に形成される新規カルシウム損傷電流の阻害は神経細胞死を抑制する
AU2002230398A1 (en) 2000-10-06 2002-04-29 Xenoport, Inc. Bile-acid conjugates for providing sustained systemic concentrations of drugs
AU2002211863A1 (en) 2000-10-06 2002-04-15 Xenoport, Inc. Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration
GB2368579A (en) * 2000-10-31 2002-05-08 Parke Davis & Co Ltd Azole pharmaceutical agents
AU2002345638A1 (en) 2001-06-11 2002-12-23 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
CA2449729C (en) 2001-06-11 2009-11-03 Xenoport, Inc. Prodrugs of gaba analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
AU2002316231A1 (en) 2002-02-19 2003-09-29 Xenoport, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
AU2003222033A1 (en) 2002-03-20 2003-10-08 Xenoport Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof
AU2003243180A1 (en) 2002-05-17 2003-12-12 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
US20040092498A1 (en) * 2002-08-16 2004-05-13 David Blakemore Substituted glycine derivatives for use as medicaments
US7060727B2 (en) 2002-12-11 2006-06-13 Xenoport, Inc. Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof
AU2003303041B2 (en) 2002-12-13 2008-07-24 Warner-Lambert Company Llc Alpha-2-delta ligand to treat lower urinary tract symptoms
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
KR20060119971A (ko) 2003-09-11 2006-11-24 제노포트 인코포레이티드 Ｇａｂａ 유사체의 전구약물을 이용한 요실금의 치료및/또는 예방
AU2004271800A1 (en) 2003-09-12 2005-03-24 Pfizer Inc. Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
NZ579515A (en) 2003-09-17 2011-09-30 Xenoport Inc Treating or preventing restless legs syndrome using prodrugs of gaba analogs
SG147437A1 (en) 2003-10-14 2008-11-28 Xenoport Inc Crystalline form of gamma-aminobutyric acid analog
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
MX2007005306A (es) 2004-11-04 2007-06-11 Xenoport Inc Formas de dosis oral de liberacion sostenida de la prodroga gabapentina.
CA2673545A1 (en) 2006-12-22 2008-07-03 Recordati Ireland Limited Combination therapy of lower urinary tract disorders with .alpha.2.delta. ligands and nsaids
WO2009024615A1 (en) * 2007-08-23 2009-02-26 Novartis Ag Aminobenzyl-substituted cyclic sulfones useful as bace inhibitors
EP2250148B1 (en) 2008-01-25 2016-08-17 XenoPort, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use
US7868043B2 (en) 2008-01-25 2011-01-11 Xenoport, Inc. Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
ES2601852T3 (es) 2008-01-25 2017-02-16 Xenoport, Inc. Forma cristalina de sales de calcio de ácidos (3S)-aminometil-5-metil-hexanoicos y métodos de uso
ES2589915T3 (es) 2008-10-08 2016-11-17 Xgene Pharmaceutical Inc Conjugados de GABA y métodos de utilización de los mismos
WO2010084797A1 (ja) * 2009-01-21 2010-07-29 第一三共株式会社 含ヘテロ原子化合物
US9066853B2 (en) 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
CA2903000C (en) 2013-01-28 2021-10-12 Hector L. Lopez Methods of improving tolerability, pharmacodynamics, and efficacy of .beta.-alanine and use therefor
CA3099775A1 (en) 2018-05-14 2019-11-21 Xgene Pharmaceutical Inc. Process for making 1-(acyloxy)-alkyl-carabmate drug conjugates of naproxen and pregabalin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024175A (en) * 1974-12-21 1977-05-17 Warner-Lambert Company Cyclic amino acids

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
BR9206253A (pt) * 1991-07-09 1995-03-14 Nippon Soda Co Derivado de ciclo-hexanodiona heterocíclico, processo para produzir um composto, e, herbicida
US5514801A (en) * 1992-12-29 1996-05-07 Monsanto Company Cyclic sulfone containing retroviral protease inhibitors
GB9314758D0 (en) * 1993-07-16 1993-08-25 Wyeth John & Brother Ltd Heterocyclic derivatives
US5527194A (en) * 1994-02-02 1996-06-18 Brunswick Corporation Thrust sensor for marine drives
US5491152A (en) * 1994-03-23 1996-02-13 The Du Pont Merck Pharmaceutical Company Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
US5760006A (en) * 1997-06-23 1998-06-02 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating psoriasis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024175A (en) * 1974-12-21 1977-05-17 Warner-Lambert Company Cyclic amino acids

Also Published As

Publication number Publication date
ZA97991B (en) 1997-08-15
SK282665B6 (sk) 2002-11-06
SK106798A3 (en) 1999-07-12
ES2176668T3 (es) 2002-12-01
NO983612L (no) 1998-10-06
WO1997029101A1 (en) 1997-08-14
CZ245298A3 (cs) 1998-11-11
ATE218135T1 (de) 2002-06-15
PT888325E (pt) 2002-10-31
EP0888325B1 (en) 2002-05-29
HUP9901074A3 (en) 2001-08-28
EA199800682A1 (ru) 1999-02-25
CA2244708A1 (en) 1997-08-14
BR9707366A (pt) 1999-07-20
CZ296052B6 (cs) 2005-12-14
NZ326669A (en) 2001-05-25
JP2000511877A (ja) 2000-09-12
NO983612D0 (no) 1998-08-06
IL125562A0 (en) 1999-03-12
AU1529597A (en) 1997-08-28
HUP9901074A2 (hu) 2001-04-28
EP0888325A1 (en) 1999-01-07
KR19990082349A (ko) 1999-11-25
DE69712877T2 (de) 2002-11-14
DE69712877D1 (de) 2002-07-04
DK0888325T3 (da) 2002-09-16
AU720628B2 (en) 2000-06-08
US5929088A (en) 1999-07-27
PL328432A1 (en) 1999-02-01
IL125562A (en) 2001-08-08

Similar Documents

Publication Publication Date Title
EA001534B1 (ru) Производные циклической аминокислоты или их фармацевтически приемлемые соли, фармацевтическая композиция и способ лечения депрессии, состояний паники, страха и болевых ощущений
EA001214B1 (ru) Новые мостиковые циклические аминокислоты как фармацевтически применимые вещества
DE69409525T2 (de) Acetamidderivate und ihre verwendung als modifizierungsmittel des verhaltens der verdauung
DE3885889T2 (de) (r)5-pentylamino-5-oxopentanesäure-derivate mit anticholecystokininwirkung.
WO2021262810A1 (en) Cereblon binding compounds, compositions thereof, and methods of treatment therewith
US4226861A (en) N-Lower-alkyl 3-phenoxy-1-azetidinecarboxamides
DE69821815T2 (de) Thiocolchicin-Derivate mit entzündungshemmender und muskelrelaxierender Wirkung
CZ294963B6 (cs) 2-(3H)-Oxazolonové deriváty, způsob jejich přípravy, farmaceutické kompozice a jejich použití
US4556673A (en) Use of phthalyltaurine sulfonamide derivatives in treating epilepsy and arrythmia
EP0316279A2 (de) Veresterte azacyclische Hydroxyverbindungen
DD143613A5 (de) Verfahren zur herstellung von 4-amino-2-piperidino-chinazolin-derivaten
KR20090008441A (ko) 신경원인성 통증을 억제하는 피롤리딘 유사체 및 그 제조 방법
US20240368118A1 (en) Cereblon binding compounds, compositions thereof, and methods of treatment therewith
JPS6230762A (ja) 新規５−オキソ−１−イミダゾリジンアセトアミド誘導体
EP0213713A2 (en) 2-Oxopyrrolidine pharmaceutical compounds, salts thereof, and the preparation thereof
US2658067A (en) Substituted carbamic acdj esters
US3951985A (en) Lactams and process for their manufacture
US4551470A (en) Hexahydro-3,5-dioxo-1H-pyrrolizine-2-carboxylic acid and derivatives, and use for reversing electroconvulsive shock amnesia
US4021430A (en) Dihydroapovincaminic acid amines
SU1436877A3 (ru) Способ получени производных эрголина или их фармакологически приемлемых солей
US4076714A (en) 1-Methyl-4-(2-carboxy-thioxanthen-9-ylidene)-piperidine an appetite stimulant and antihistaminic agent
SU971098A3 (ru) Способ получени производных N-арил-N @ -/2-имидазолидинилиден/-мочевины
US3377245A (en) Methods and compositions for treating hypertension
JPS61210031A (ja) 抗けいれん剤および抗てんかん剤としての３‐アリルオキシアゼチジンカルボキサミド
US4022910A (en) L-3-hydroxymethyltyrosine and salts thereof for lowering blood pressure

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU