ES2176668T3 - Aminoacidos ciclicos novedosos como agentes farmaceuticos. - Google Patents
Aminoacidos ciclicos novedosos como agentes farmaceuticos.Info
- Publication number
- ES2176668T3 ES2176668T3 ES97901385T ES97901385T ES2176668T3 ES 2176668 T3 ES2176668 T3 ES 2176668T3 ES 97901385 T ES97901385 T ES 97901385T ES 97901385 T ES97901385 T ES 97901385T ES 2176668 T3 ES2176668 T3 ES 2176668T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acids
- pharmaceutical agents
- alterations
- new
- new cycling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 2
- 230000001351 cycling effect Effects 0.000 title 1
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 230000004075 alteration Effects 0.000 abstract 3
- 208000006083 Hypokinesia Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000003483 hypokinetic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1127896P | 1996-02-07 | 1996-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2176668T3 true ES2176668T3 (es) | 2002-12-01 |
Family
ID=21749660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97901385T Expired - Lifetime ES2176668T3 (es) | 1996-02-07 | 1997-01-02 | Aminoacidos ciclicos novedosos como agentes farmaceuticos. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5929088A (enExample) |
| EP (1) | EP0888325B1 (enExample) |
| JP (1) | JP2000511877A (enExample) |
| KR (1) | KR19990082349A (enExample) |
| AT (1) | ATE218135T1 (enExample) |
| AU (1) | AU720628B2 (enExample) |
| BR (1) | BR9707366A (enExample) |
| CA (1) | CA2244708A1 (enExample) |
| CZ (1) | CZ296052B6 (enExample) |
| DE (1) | DE69712877T2 (enExample) |
| DK (1) | DK0888325T3 (enExample) |
| EA (1) | EA001534B1 (enExample) |
| ES (1) | ES2176668T3 (enExample) |
| HU (1) | HUP9901074A3 (enExample) |
| IL (1) | IL125562A (enExample) |
| NO (1) | NO983612L (enExample) |
| NZ (1) | NZ326669A (enExample) |
| PL (1) | PL328432A1 (enExample) |
| PT (1) | PT888325E (enExample) |
| SK (1) | SK282665B6 (enExample) |
| WO (1) | WO1997029101A1 (enExample) |
| ZA (1) | ZA97991B (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100491282B1 (ko) | 1996-07-24 | 2005-05-24 | 워너-램버트 캄파니 엘엘씨 | 통증 치료용 이소부틸가바 및 그의 유도체 |
| AU752444B2 (en) * | 1997-09-18 | 2002-09-19 | Warner-Lambert Company | Novel stereoselective processes for the preparation of gabapentin analogues |
| US6984659B2 (en) | 1997-11-18 | 2006-01-10 | Klinikum Der Albert-Ludwigs Universitaet | 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level |
| DE19751062A1 (de) * | 1997-11-18 | 1999-07-08 | Univ Ludwigs Albert | An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels |
| PL341231A1 (en) * | 1997-12-16 | 2001-03-26 | Warner Lambert Co | 4(3)-substitute derivatives of 4(3)aminomethyl(thio)pyrane or piperidine derivatives (analogues of garbapentin), their production and application in treating neurological disorders |
| AU2001247762A1 (en) * | 2000-03-28 | 2001-10-08 | Delorenzo, Robert, J | Inhibition of a novel calcium injury current that forms in neurons during injury prevents neuronal cell death |
| WO2002028881A1 (en) | 2000-10-06 | 2002-04-11 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
| WO2002032376A2 (en) | 2000-10-06 | 2002-04-25 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
| GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| AU2002345638A1 (en) | 2001-06-11 | 2002-12-23 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| ATE540678T1 (de) | 2001-06-11 | 2012-01-15 | Xenoport Inc | Prodrugs aus gaba-analoga, zusammensetzungen und ihre verwendungen |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| AU2002316231A1 (en) | 2002-02-19 | 2003-09-29 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| US7026351B2 (en) | 2002-03-20 | 2006-04-11 | Xenoport, Inc. | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof |
| AU2003243180A1 (en) | 2002-05-17 | 2003-12-12 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| US20040092498A1 (en) * | 2002-08-16 | 2004-05-13 | David Blakemore | Substituted glycine derivatives for use as medicaments |
| WO2004052360A1 (en) | 2002-12-11 | 2004-06-24 | Xenoport, Inc. | Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof |
| CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| BR0316572A (pt) | 2002-12-13 | 2005-10-04 | Warner Lambert Co | Ligando alfa-2-delta para o tratamento de sintomas do trato variáveis inferior, utilização e produto deste |
| JP2007505149A (ja) | 2003-09-11 | 2007-03-08 | ゼノポート，インコーポレイティド | ギャバ類似体のプロドラッグを用いる尿失禁の治療および／あるいは予防 |
| ES2334673T3 (es) | 2003-09-12 | 2010-03-15 | Pfizer Inc. | Combinaciones que comprenden ligandos alfa-2-delta e inhibidores de recaptacion de serotonina/noradrenalina. |
| WO2005027850A2 (en) | 2003-09-17 | 2005-03-31 | Xenoport, Inc. | Treating or preventing restless legs syndrome using prodrugs of gaba analogs |
| SI1677767T1 (sl) | 2003-10-14 | 2011-11-30 | Xenoport Inc | Kristalinična oblika analoga gama-aminomaslene kisline |
| CA2548917C (en) | 2003-12-11 | 2014-09-23 | Sepracor Inc. | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| CN101068538A (zh) | 2004-11-04 | 2007-11-07 | 什诺波特有限公司 | 加巴喷丁前体药物持续释放口服剂型 |
| HRP20110634T1 (hr) | 2006-12-22 | 2011-10-31 | Recordati Ireland Limited | KOMBINIRANA TERAPIJA LIGANADA α<SUB>2</SUB>δ I NSAID ZA POREMEĆAJE DONJEG URINARNOG TRAKTA |
| AU2008290561A1 (en) * | 2007-08-23 | 2009-02-26 | Novartis Ag | Aminobenzyl-substituted cyclic sulfones useful as BACE inhibitors |
| JP5291123B2 (ja) | 2008-01-25 | 2013-09-18 | ゼノポート，インコーポレイティド | （３ｓ）−アミノメチル−５−ヘキサン酸プロドラッグの結晶形態及びその使用 |
| US7868043B2 (en) | 2008-01-25 | 2011-01-11 | Xenoport, Inc. | Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
| US7872046B2 (en) | 2008-01-25 | 2011-01-18 | Xenoport, Inc. | Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use |
| BRPI0919811B1 (pt) | 2008-10-08 | 2022-04-19 | Xgene Pharmaceutical Inc | Conjugados de gaba e métodos de uso dos mesmos |
| WO2010084797A1 (ja) * | 2009-01-21 | 2010-07-29 | 第一三共株式会社 | 含ヘテロ原子化合物 |
| US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
| US10130715B2 (en) | 2013-01-28 | 2018-11-20 | Hector L. Lopez | Methods of improving tolerability, pharmacodynamics, and efficacy of β-alanine and use therefor |
| CA3099775A1 (en) | 2018-05-14 | 2019-11-21 | Xgene Pharmaceutical Inc. | Process for making 1-(acyloxy)-alkyl-carabmate drug conjugates of naproxen and pregabalin |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| US5270317A (en) * | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
| KR970010173B1 (ko) * | 1991-07-09 | 1997-06-21 | 닛뽕소다 가부시끼가이샤 | 함헤테로 시클로헥산디온 유도체, 그의 제조방법 및 제초제 |
| US5514801A (en) * | 1992-12-29 | 1996-05-07 | Monsanto Company | Cyclic sulfone containing retroviral protease inhibitors |
| GB9314758D0 (en) * | 1993-07-16 | 1993-08-25 | Wyeth John & Brother Ltd | Heterocyclic derivatives |
| US5527194A (en) * | 1994-02-02 | 1996-06-18 | Brunswick Corporation | Thrust sensor for marine drives |
| US5491152A (en) * | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
| US5760006A (en) * | 1997-06-23 | 1998-06-02 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating psoriasis |
-
1997
- 1997-01-02 DK DK97901385T patent/DK0888325T3/da active
- 1997-01-02 NZ NZ326669A patent/NZ326669A/en unknown
- 1997-01-02 PT PT97901385T patent/PT888325E/pt unknown
- 1997-01-02 WO PCT/US1997/000255 patent/WO1997029101A1/en not_active Ceased
- 1997-01-02 US US09/077,053 patent/US5929088A/en not_active Expired - Fee Related
- 1997-01-02 EA EA199800682A patent/EA001534B1/ru not_active IP Right Cessation
- 1997-01-02 PL PL97328432A patent/PL328432A1/xx unknown
- 1997-01-02 IL IL12556297A patent/IL125562A/en not_active IP Right Cessation
- 1997-01-02 DE DE69712877T patent/DE69712877T2/de not_active Expired - Fee Related
- 1997-01-02 CZ CZ19982452A patent/CZ296052B6/cs not_active IP Right Cessation
- 1997-01-02 AT AT97901385T patent/ATE218135T1/de not_active IP Right Cessation
- 1997-01-02 SK SK1067-98A patent/SK282665B6/sk unknown
- 1997-01-02 CA CA002244708A patent/CA2244708A1/en not_active Abandoned
- 1997-01-02 AU AU15295/97A patent/AU720628B2/en not_active Ceased
- 1997-01-02 JP JP09528505A patent/JP2000511877A/ja not_active Abandoned
- 1997-01-02 BR BR9707366A patent/BR9707366A/pt not_active Application Discontinuation
- 1997-01-02 EP EP97901385A patent/EP0888325B1/en not_active Expired - Lifetime
- 1997-01-02 ES ES97901385T patent/ES2176668T3/es not_active Expired - Lifetime
- 1997-01-02 KR KR1019980706079A patent/KR19990082349A/ko not_active Ceased
- 1997-01-02 HU HU9901074A patent/HUP9901074A3/hu unknown
- 1997-02-06 ZA ZA9700991A patent/ZA97991B/xx unknown
-
1998
- 1998-08-06 NO NO983612A patent/NO983612L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL328432A1 (en) | 1999-02-01 |
| IL125562A (en) | 2001-08-08 |
| HUP9901074A2 (hu) | 2001-04-28 |
| CA2244708A1 (en) | 1997-08-14 |
| NO983612D0 (no) | 1998-08-06 |
| DE69712877D1 (de) | 2002-07-04 |
| EA199800682A1 (ru) | 1999-02-25 |
| PT888325E (pt) | 2002-10-31 |
| WO1997029101A1 (en) | 1997-08-14 |
| AU1529597A (en) | 1997-08-28 |
| KR19990082349A (ko) | 1999-11-25 |
| AU720628B2 (en) | 2000-06-08 |
| NO983612L (no) | 1998-10-06 |
| NZ326669A (en) | 2001-05-25 |
| BR9707366A (pt) | 1999-07-20 |
| SK282665B6 (sk) | 2002-11-06 |
| SK106798A3 (en) | 1999-07-12 |
| ZA97991B (en) | 1997-08-15 |
| IL125562A0 (en) | 1999-03-12 |
| CZ245298A3 (cs) | 1998-11-11 |
| CZ296052B6 (cs) | 2005-12-14 |
| JP2000511877A (ja) | 2000-09-12 |
| HUP9901074A3 (en) | 2001-08-28 |
| EP0888325B1 (en) | 2002-05-29 |
| ATE218135T1 (de) | 2002-06-15 |
| US5929088A (en) | 1999-07-27 |
| EP0888325A1 (en) | 1999-01-07 |
| EA001534B1 (ru) | 2001-04-23 |
| DE69712877T2 (de) | 2002-11-14 |
| DK0888325T3 (da) | 2002-09-16 |
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