JP2000511416A5 - - Google Patents
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- JP2000511416A5 JP2000511416A5 JP1997541828A JP54182897A JP2000511416A5 JP 2000511416 A5 JP2000511416 A5 JP 2000511416A5 JP 1997541828 A JP1997541828 A JP 1997541828A JP 54182897 A JP54182897 A JP 54182897A JP 2000511416 A5 JP2000511416 A5 JP 2000511416A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9610967A GB9610967D0 (en) | 1996-05-24 | 1996-05-24 | Specific binding members,materials and methods |
| GB9610967.3 | 1996-05-24 | ||
| PCT/GB1997/001412 WO1997045544A1 (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ed-b domain of fibronectin, their construction and uses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008204682A Division JP2009050261A (ja) | 1996-05-24 | 2008-08-07 | フィブロネクチンのｅｄ―ｂドメインに対する抗体、それらの構造及び用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000511416A JP2000511416A (ja) | 2000-09-05 |
| JP2000511416A5 true JP2000511416A5 (cg-RX-API-DMAC7.html) | 2005-02-10 |
| JP4750912B2 JP4750912B2 (ja) | 2011-08-17 |
Family
ID=10794298
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54182897A Expired - Lifetime JP4750912B2 (ja) | 1996-05-24 | 1997-05-23 | フィブロネクチンのｅｄ―ｂドメインに対する抗体、それらの構造及び用途 |
| JP2008204682A Pending JP2009050261A (ja) | 1996-05-24 | 2008-08-07 | フィブロネクチンのｅｄ―ｂドメインに対する抗体、それらの構造及び用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008204682A Pending JP2009050261A (ja) | 1996-05-24 | 2008-08-07 | フィブロネクチンのｅｄ―ｂドメインに対する抗体、それらの構造及び用途 |
Country Status (28)
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| US6685943B1 (en) | 1997-01-21 | 2004-02-03 | The Texas A&M University System | Fibronectin binding protein compositions and methods of use |
| US7244826B1 (en) | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
| TWI259837B (en) * | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| US20030045681A1 (en) * | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| US20030176663A1 (en) * | 1998-05-11 | 2003-09-18 | Eidgenossische Technische Hochscule | Specific binding molecules for scintigraphy |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| EP1259548A1 (en) * | 2000-02-24 | 2002-11-27 | Eidgenössische Technische Hochschule Zürich | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
| DK1719528T3 (da) * | 2000-02-24 | 2012-01-09 | Philogen Spa | Sammensætninger og fremgangsmåder til behandling af angiogenese i patologiske læsioner |
| WO2001085777A2 (en) | 2000-05-09 | 2001-11-15 | Greenville Hospital System | Therapeutic pore-forming peptides |
| WO2001096599A2 (en) * | 2000-06-15 | 2001-12-20 | Philogen S.R.L. | Methods for quantitative determination of b-fibronectin in biological fluids and tissues |
| CA2421783A1 (en) * | 2000-09-07 | 2002-03-14 | Schering Aktiengesellschaft | Receptor in the edb fibronectin domain |
| IT1317108B1 (it) * | 2000-12-06 | 2003-05-26 | Philogen Srl | Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso. |
| US7456146B2 (en) * | 2001-05-09 | 2008-11-25 | Ghc Research Development Corporation | Lytic peptide prodrugs |
| RU2352582C2 (ru) | 2002-01-03 | 2009-04-20 | Шеринг Акциенгезельшафт | Конъюгаты, содержащие антитело, специфическое для ed-в-домена фибронектина, и их применение для обнаружения и лечения опухолей |
| SI1483297T1 (sl) * | 2002-03-11 | 2010-04-30 | Philogen Spa | Protitelesa, izvedena iz anti ED-B L19, in ki ciljajo vaskulaturo tumorja |
| NZ574146A (en) | 2002-07-15 | 2010-05-28 | Univ Texas | Peptides binding to phosphatidylethanolamine and their use in treating viral infections |
| WO2004083249A2 (en) | 2003-03-14 | 2004-09-30 | Wyeth | Antibodies against human il-21 receptor and uses therefor |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| CA2552590A1 (en) | 2004-01-05 | 2005-07-21 | Emd Lexigen Research Center Corp. | Interleukin-12 targeted to oncofoetal fibronectin |
| US20060024757A1 (en) | 2004-07-30 | 2006-02-02 | Robert Hussa | Detection of oncofetal fibronectin for selection of concepti |
| US7785591B2 (en) | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
| EP1803814A1 (en) * | 2005-12-27 | 2007-07-04 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Method of improving the antibody selection capacity in phage-display library |
| EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| US8253725B2 (en) * | 2007-12-28 | 2012-08-28 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and system for generating surface models of geometric structures |
| ES2382058T3 (es) * | 2008-01-17 | 2012-06-04 | Philogen S.P.A. | Combinación de una proteína de fusión de un anticuerpo dirigido contra el EDB de la fibronectina-IL-2, y una molécula de unión a los linfocitos B, progenitores de los linfocitos B y/o sus homólogos cancerosos |
| EP2100621A1 (en) | 2008-03-10 | 2009-09-16 | mivenion GmbH | Polyether polyol dendron conjugates with effector molecules for biological targeting |
| EP2116555A1 (en) | 2008-05-08 | 2009-11-11 | Bayer Schering Pharma Aktiengesellschaft | Use of a radioactively labelled molecule specifically binding to ED-B fibronectin in a method of treatment of Hodgkin lymphoma |
| IT1392027B1 (it) * | 2008-12-12 | 2012-02-09 | Castellani | Anticorpo monoclonale e suo uso per la identificazione della isoforma oncofetale della fibronettina (b-fn) a scopo diagnostico o terapeutico. |
| CA2778872C (en) | 2009-12-14 | 2015-06-02 | Scil Proteins Gmbh | A method for identifying hetero-multimeric modified ubiquitin proteins with binding capability to ligands |
| WO2011110490A1 (en) | 2010-03-09 | 2011-09-15 | Bayer Pharma Aktiengesellschaft | Process for the production of radioactively labelled scfv antibody fragments, kits and compositions |
| WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
| EP2721152B1 (en) | 2011-06-15 | 2019-03-27 | Navigo Proteins GmbH | Dimeric binding proteins based on modified ubiquitins |
| EP2861616A1 (en) | 2012-06-13 | 2015-04-22 | Scil Proteins GmbH | Human fusion proteins comprising single chain tnfalpha and targeting domains |
| WO2014094799A1 (en) | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Ubiquitin moieties as a means for prolonging serum half-life |
| US10611830B2 (en) * | 2013-06-06 | 2020-04-07 | Hefei Lifeon Pharmaceutical Co. Ltd. | Human antibody against ED-B domain of fibronectin and uses thereof |
| EP3253785B1 (en) | 2015-02-06 | 2019-04-10 | Navigo Proteins Gmbh | Novel egfr binding proteins |
| PL3322721T4 (pl) | 2015-07-16 | 2022-06-06 | Navigo Proteins Gmbh | Nowe białka wiążące immunoglobulinę i ich zastosowanie w oczyszczaniu na bazie powinowactwa |
| JP2018520675A (ja) | 2015-07-20 | 2018-08-02 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法 |
| WO2017084017A1 (zh) * | 2015-11-16 | 2017-05-26 | 合肥立方制药股份有限公司 | Ed-b蛋白在诊断组织增生中的应用 |
| JP2019526526A (ja) | 2016-05-04 | 2019-09-19 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ペプチドリンカーを含む化学的部分の部位特異的カップリングのための標的化合物 |
| CN109476712B (zh) | 2016-08-11 | 2022-08-02 | 纳维格蛋白质有限公司 | 新型对碱稳定的免疫球蛋白结合蛋白 |
| EP4617283A2 (en) | 2016-10-17 | 2025-09-17 | Pfizer Inc. | Anti-edb antibodies and antibody-drug conjugates |
| CN110997718B (zh) | 2017-06-07 | 2023-11-10 | 菲洛根股份公司 | 血管内皮生长因子/抗纤连蛋白抗体融合蛋白 |
| CN117430699A (zh) | 2017-09-30 | 2024-01-23 | 合肥立方制药股份有限公司 | 结合至纤维连接蛋白b结构域的蛋白 |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
| WO2020070150A1 (en) | 2018-10-02 | 2020-04-09 | Philogen S.P.A | Il2 immunoconjugates |
| EP3660039A1 (en) | 2018-11-30 | 2020-06-03 | Philogen S.p.A. | Il2 immunoconjugates |
| US11787875B2 (en) | 2019-08-15 | 2023-10-17 | Janssen Biotech, Inc. | Materials and methods for improved single chain variable fragments |
| WO2021116337A1 (en) | 2019-12-11 | 2021-06-17 | Cilag Gmbh International | Multispecific binding molecules comprising ltbr and edb binding domains and uses thereof |
| CN111171149B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的人源化单链抗体及其应用 |
| CN111234016B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的全人源单克隆抗体及应用 |
| KR102614063B1 (ko) | 2020-12-24 | 2023-12-19 | 대화제약 주식회사 | 엑스트라도메인 b 피브로넥틴에 특이적으로 결합하는 신규한 항체 |
| US20250073239A1 (en) | 2022-01-04 | 2025-03-06 | Philogen S.P.A. | Combination of an immunocytokine comprising il-12 and a kinase inhibitor |
| WO2024028258A1 (en) | 2022-08-01 | 2024-02-08 | Philochem Ag | Conjugates of psma-binding moieties with cytotoxic agents |
| EP4584256A1 (en) | 2022-09-06 | 2025-07-16 | Philochem AG | Multivalent fibroblast activation protein ligands for targeted delivery applications |
| WO2025061801A1 (en) | 2023-09-19 | 2025-03-27 | Philochem Ag | Therapeutic combination of an anti-edb fibronectin domain antibody il2 or il12 fusion protein and a lutetium-177 radioconjugate |
| WO2025221728A2 (en) | 2024-04-15 | 2025-10-23 | Janssen Biotech, Inc. | Ltbr binding molecules and uses thereof |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| ATE101203T1 (de) | 1985-01-28 | 1994-02-15 | Xoma Corp | Arab-promoter und verfahren zur herstellung von polypeptiden einschliesslich cecropinen mittels mikrobiologischer verfahren. |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4894326A (en) | 1986-04-09 | 1990-01-16 | Fred Hutchinson Cancer Research Center | Monoclonal antibody defining oncofetal structure of fibronectin |
| US5243029A (en) | 1986-04-09 | 1993-09-07 | Fred Hutchinson Cancer Research Center | Oncofetal structure of fibronectin |
| CA1341235C (en) | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
| JPH02598A (ja) * | 1987-10-09 | 1990-01-05 | De La Rue Co Plc:The | 集積回路カード |
| JP2980626B2 (ja) | 1988-01-11 | 1999-11-22 | ゾーマ・コーポレーション | ペクチン酸リアーゼのシグナル配列を含む新規プラスミドベクター |
| IT1217724B (it) * | 1988-05-26 | 1990-03-30 | Ist Naz Ric Sul Cancro | Anticorpo monoclonale specifico per una sequenza di fibronettina espressa in cellule trasformate ibridoma secernente tale anticorpo e impiego dell'anticorpo monoclonale per la diagnosi di tumori |
| US5177015A (en) | 1988-08-12 | 1993-01-05 | Fred Hutchinson Cancer Research Centre | Onco-developmentally regulated α-N-acetylgalactosaminyltransferase |
| US5843156A (en) | 1988-08-24 | 1998-12-01 | Endoluminal Therapeutics, Inc. | Local polymeric gel cellular therapy |
| JPH0276598A (ja) | 1988-09-14 | 1990-03-15 | Fujita Gakuen | 抗ｅｄ−ｂ抗体 |
| JPH04169195A (ja) * | 1990-10-31 | 1992-06-17 | Fujita Gakuen | 抗ｅｄ―ｂモノクローナル抗体 |
| DK1136556T3 (da) | 1991-11-25 | 2005-10-03 | Enzon Inc | Fremgangsmåde til fremstilling af multivalente antigen-bindende proteiner |
| US5629291A (en) | 1992-01-31 | 1997-05-13 | La Jolla Cancer Research Foundation | Methods of modulating fibronectin extracellular matrix assembly |
| US6004555A (en) | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5877289A (en) | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| US6093399A (en) | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
| US6036955A (en) | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
| US5976535A (en) | 1992-06-09 | 1999-11-02 | Neorx Corporation | Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore |
| US5561114A (en) | 1992-09-25 | 1996-10-01 | Otsuka Pharmaceutical Factory Inc. | Adsorbent for cellular fibronectin, a method for fractional purification of fibronectin and a method of hemocatharisis |
| US5491130A (en) | 1992-11-10 | 1996-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Peptide inhibitors of fibronectin and related collagen-binding proteins |
| ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| US6015897A (en) | 1993-12-07 | 2000-01-18 | Neorx Corporation | Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota |
| US5523229A (en) | 1994-03-22 | 1996-06-04 | Trustees Of The University Of Pennsylvania | Antibodies specific for oncofetal fibronectin |
| DE4417865A1 (de) | 1994-05-20 | 1995-11-23 | Behringwerke Ag | Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie |
| ITFI940095A1 (it) | 1994-05-23 | 1995-11-23 | Molteni & C | Coniugati fotodinamici aventi proprieta' biocide |
| US5648485A (en) | 1994-10-26 | 1997-07-15 | University Of British Columbia | β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins |
| WO1996023816A1 (en) | 1995-02-01 | 1996-08-08 | British Technology Group Limited | Radiolabelled proteins |
| WO1997002479A2 (en) | 1995-06-30 | 1997-01-23 | Yale University | Human monoclonal anti-tumor antibodies |
| US5808146A (en) | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| US5913884A (en) | 1996-09-19 | 1999-06-22 | The General Hospital Corporation | Inhibition of fibrosis by photodynamic therapy |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| US6394952B1 (en) | 1998-02-03 | 2002-05-28 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| US6267722B1 (en) | 1998-02-03 | 2001-07-31 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| TWI259837B (en) | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| EP1259548A1 (en) | 2000-02-24 | 2002-11-27 | Eidgenössische Technische Hochschule Zürich | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
| DK1719528T3 (da) | 2000-02-24 | 2012-01-09 | Philogen Spa | Sammensætninger og fremgangsmåder til behandling af angiogenese i patologiske læsioner |
| RU2352582C2 (ru) | 2002-01-03 | 2009-04-20 | Шеринг Акциенгезельшафт | Конъюгаты, содержащие антитело, специфическое для ed-в-домена фибронектина, и их применение для обнаружения и лечения опухолей |
| JP4169195B2 (ja) * | 2003-06-24 | 2008-10-22 | 株式会社河合楽器製作所 | 電子楽音発生装置の記録制御装置 |
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1996
- 1996-05-24 GB GB9610967A patent/GB9610967D0/en active Pending
-
1997
- 1997-05-23 NZ NZ33308397A patent/NZ333083A/xx not_active IP Right Cessation
- 1997-05-23 WO PCT/GB1997/001412 patent/WO1997045544A1/en not_active Ceased
- 1997-05-23 US US09/194,356 patent/US7273924B1/en not_active Expired - Fee Related
- 1997-05-23 PL PL97330075A patent/PL188557B1/pl not_active IP Right Cessation
- 1997-05-23 BR BRPI9709350-5A patent/BR9709350B1/pt not_active IP Right Cessation
- 1997-05-23 KR KR10-2005-7000518A patent/KR20050010081A/ko not_active Ceased
- 1997-05-23 UA UA98126836A patent/UA74129C2/uk unknown
- 1997-05-23 JP JP54182897A patent/JP4750912B2/ja not_active Expired - Lifetime
- 1997-05-23 AU AU29101/97A patent/AU729081B2/en not_active Expired
- 1997-05-23 KR KR1020067006008A patent/KR100741452B1/ko not_active Expired - Lifetime
- 1997-05-23 SK SK1612-98A patent/SK285916B6/sk not_active IP Right Cessation
- 1997-05-23 ES ES97923243T patent/ES2286831T3/es not_active Expired - Lifetime
- 1997-05-23 AT AT97923243T patent/ATE361364T1/de active
- 1997-05-23 TR TR1998/02416T patent/TR199802416T2/xx unknown
- 1997-05-23 CN CNB971949026A patent/CN100447159C/zh not_active Expired - Lifetime
- 1997-05-23 DE DE1997637683 patent/DE69737683T2/de not_active Expired - Lifetime
- 1997-05-23 IL IL12721697A patent/IL127216A0/xx active IP Right Grant
- 1997-05-23 PT PT97923243T patent/PT906426E/pt unknown
- 1997-05-23 DK DK97923243T patent/DK0906426T3/da active
- 1997-05-23 CZ CZ19983815A patent/CZ295531B6/cs not_active IP Right Cessation
- 1997-05-23 EA EA199801043A patent/EA004329B1/ru not_active IP Right Cessation
- 1997-05-23 HU HU0200546A patent/HUP0200546A2/hu unknown
- 1997-05-23 EP EP19970923243 patent/EP0906426B1/en not_active Expired - Lifetime
- 1997-05-23 SI SI9730765T patent/SI0906426T1/sl unknown
- 1997-05-23 CA CA 2256308 patent/CA2256308C/en not_active Expired - Lifetime
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1998
- 1998-10-29 IS IS4883A patent/IS2508B/is unknown
- 1998-11-23 IL IL127216A patent/IL127216A/en not_active IP Right Cessation
- 1998-11-23 NO NO19985459A patent/NO324904B1/no not_active IP Right Cessation
- 1998-11-24 BG BG102950A patent/BG65138B1/bg unknown
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2007
- 2007-08-21 US US11/842,774 patent/US8703143B2/en not_active Expired - Fee Related
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2008
- 2008-08-07 JP JP2008204682A patent/JP2009050261A/ja active Pending
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2013
- 2013-10-04 US US14/046,224 patent/US9096670B2/en not_active Expired - Fee Related