JP2000511169A - 微粒子および創傷治療におけるその用途 - Google Patents
微粒子および創傷治療におけるその用途Info
- Publication number
- JP2000511169A JP2000511169A JP09541765A JP54176597A JP2000511169A JP 2000511169 A JP2000511169 A JP 2000511169A JP 09541765 A JP09541765 A JP 09541765A JP 54176597 A JP54176597 A JP 54176597A JP 2000511169 A JP2000511169 A JP 2000511169A
- Authority
- JP
- Japan
- Prior art keywords
- thrombin
- fibrinogen
- fine particles
- microparticles
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. フイブリノゲンまたはトロンビンを自由流動性形態で含む、可溶性微粒 子。 2. トロンビンおよびカルシウムイオンを含む、請求項2記載の微粒子。 3. フイブリノゲンを含む、請求項1記載の微粒子。 4. スプレー乾燥により得られる、請求項1から3のいずれか記載の微粒子 。 5. 壁形成性材料としてのアルブミンを含む、請求項1から4のいずれか記 載の微粒子。 6. 炭水化物を追加的に含む、請求項1から5のいずれか記載の微粒子。 7. 最高50μmサイズの、請求項1から6のいずれか記載の微粒子。 8. 少なくとも90質量%が10から20μmサイズである、請求項7記載 の微粒子。 9. フイブリノゲンおよびトロンビンをそれぞれ含む、請求項1から8のい ずれか記載の可溶性微粒子の乾燥混合物。 10. 創傷治療または外科的修復に同時使用するための併合調剤としての、 フイブリノゲンおよびトロンビンをそれぞれ含む、請求項1から8のいずれか記 載の第1および第2微粒子を含む製品。
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9610340.3A GB9610340D0 (en) | 1996-05-17 | 1996-05-17 | Spray-dried products and their therapeutic use |
GB9610340.3 | 1996-05-17 | ||
GB9615436.4 | 1996-07-23 | ||
GBGB9615436.4A GB9615436D0 (en) | 1996-07-23 | 1996-07-23 | Spray-dried products and their therapeutic use |
PCT/GB1997/001308 WO1997044015A1 (en) | 1996-05-17 | 1997-05-14 | Microparticles and their use in wound therapy |
US08/858,814 US6113948A (en) | 1996-05-17 | 1997-05-19 | Microparticles and their use in wound therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000511169A true JP2000511169A (ja) | 2000-08-29 |
JP4024302B2 JP4024302B2 (ja) | 2007-12-19 |
Family
ID=27268285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54176597A Expired - Lifetime JP4024302B2 (ja) | 1996-05-17 | 1997-05-14 | 微粒子および創傷治療におけるその用途 |
Country Status (6)
Country | Link |
---|---|
US (1) | US6113948A (ja) |
EP (1) | EP0914096B1 (ja) |
JP (1) | JP4024302B2 (ja) |
AU (1) | AU702955B2 (ja) |
NO (1) | NO985340L (ja) |
WO (1) | WO1997044015A1 (ja) |
Cited By (4)
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---|---|---|---|---|
JP2012527924A (ja) * | 2009-05-28 | 2012-11-12 | プロフィブリックス ビー.ヴイ. | フィブリンシーラント |
JP2012528131A (ja) * | 2009-05-28 | 2012-11-12 | プロフィブリックス ビー.ヴイ. | 乾燥粉末組成物 |
JP2013516444A (ja) * | 2010-01-08 | 2013-05-13 | プロフィブリックス ビーブイ | 乾燥粉末フィブリンシーラント |
JP2019524348A (ja) * | 2016-08-15 | 2019-09-05 | コウシュウ・バイオシール・バイオテック・カンパニー・リミテッドGuangzhou Bioseal Biotech Co., Ltd. | 止血組成物及びその作製方法 |
Families Citing this family (70)
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US6391343B1 (en) | 1991-01-15 | 2002-05-21 | Hemosphere, Inc. | Fibrinogen-coated particles for therapeutic use |
GB9610830D0 (en) | 1996-05-23 | 1996-07-31 | Andaris Ltd | Use of hollow microcapsules |
WO1998055105A1 (en) | 1997-06-05 | 1998-12-10 | Hemosphere, Inc. | Fibrinogen-coated microspheres |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
JP2003524437A (ja) * | 1998-02-20 | 2003-08-19 | エラン・ドラッグ・デリバリー・リミテッド | 治療に用いるためのフィブリノーゲンを含んでなる生成物 |
JP3578627B2 (ja) * | 1998-05-15 | 2004-10-20 | 株式会社ホギメディカル | 創傷患部の治癒を促進する組織シーラント |
DE19849589C1 (de) * | 1998-10-27 | 2000-06-15 | Glatt Process Technology Gmbh | Fibrin-Gewebekleber-Formulierung und Verfahren zu dessen Herstellung |
KR100804434B1 (ko) * | 1998-12-23 | 2008-02-20 | 체에스엘 베링 게엠베하 | 피브린계 접착제 과립 및 이의 제조방법 |
DE19859611C2 (de) * | 1998-12-23 | 2003-07-03 | Aventis Behring Gmbh | Fibrinklebergranulat und Verfahren zu dessen Herstellung |
US7572769B2 (en) | 1998-12-23 | 2009-08-11 | Csl Behring Gmbh | Fibrin adhesive granulate and method for its preparation |
CN1198593C (zh) | 1999-06-09 | 2005-04-27 | 罗伯特·E·希弗斯 | 超临界流体辅助的喷雾和鼓泡干燥 |
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JP3576063B2 (ja) | 2000-02-22 | 2004-10-13 | 株式会社ホギメディカル | 凝固蛋白質を含む可溶性創傷治癒止血セルロース繊維とその製造方法 |
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US20040126900A1 (en) * | 2001-04-13 | 2004-07-01 | Barry Stephen E | High affinity peptide- containing nanoparticles |
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US8642831B2 (en) | 2008-02-29 | 2014-02-04 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
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GB0909129D0 (en) * | 2009-05-28 | 2009-07-01 | Quadrant Drug Delivery Ltd | Dry powder fibrin sealant |
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AU2011204557B2 (en) | 2010-01-08 | 2014-08-28 | Mallinckrodt Pharma Ip Trading D.A.C. | Fibrinogen preparations enriched in fibrinogen with an extended alpha chain |
CA2790248A1 (en) | 2010-03-15 | 2011-09-22 | Ferrosan Medical Devices A/S | A method for promotion of hemostasis and/or wound healing |
KR101814841B1 (ko) * | 2010-06-01 | 2018-01-03 | 백스터 인터내셔널 인코포레이티드 | 건조 및 안정한 지혈 조성물의 제조 방법 |
GB201101740D0 (en) | 2011-02-01 | 2011-03-16 | Haemostatix Ltd | Therapeutic agents with improved fibrinogen binding |
RU2013155713A (ru) | 2011-07-06 | 2015-08-20 | Профибрикс Бв | Составы для лечения ран |
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CN104159527B (zh) | 2012-03-06 | 2017-04-12 | 弗罗桑医疗设备公司 | 包含止血糊剂的压力容器 |
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CN109152848B (zh) | 2016-03-15 | 2022-12-09 | 马萨诸塞大学 | 抗-crispr化合物以及使用方法 |
US11413335B2 (en) | 2018-02-13 | 2022-08-16 | Guangzhou Bioseal Biotech Co. Ltd | Hemostatic compositions and methods of making thereof |
US10940233B2 (en) | 2016-10-05 | 2021-03-09 | 3M Innovative Properties Company | Fibrinogen composition, method and wound articles |
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EP3735262A4 (en) | 2018-01-03 | 2021-09-29 | Penn State Research Foundation | GLUCOSE OXIDASE COMPOSITIONS USED AS AN ANTI-CONVULSIVER IN NEWBORNS |
JP7395113B2 (ja) | 2018-05-09 | 2023-12-11 | フェロサン メディカル デバイシーズ エイ/エス | 止血組成物を調製する方法 |
EP4367228A1 (en) | 2021-07-09 | 2024-05-15 | University of Massachusetts | Modular prime editor systems for genome engineering |
WO2023018705A1 (en) | 2021-08-10 | 2023-02-16 | University Of Massachusetts | Compositions and methods for sirna treatment of muscular dystrophy |
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-
1997
- 1997-05-14 AU AU27837/97A patent/AU702955B2/en not_active Ceased
- 1997-05-14 JP JP54176597A patent/JP4024302B2/ja not_active Expired - Lifetime
- 1997-05-14 WO PCT/GB1997/001308 patent/WO1997044015A1/en active IP Right Grant
- 1997-05-14 EP EP97921960A patent/EP0914096B1/en not_active Expired - Lifetime
- 1997-05-19 US US08/858,814 patent/US6113948A/en not_active Expired - Lifetime
-
1998
- 1998-11-16 NO NO985340A patent/NO985340L/no not_active Application Discontinuation
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012527924A (ja) * | 2009-05-28 | 2012-11-12 | プロフィブリックス ビー.ヴイ. | フィブリンシーラント |
JP2012528131A (ja) * | 2009-05-28 | 2012-11-12 | プロフィブリックス ビー.ヴイ. | 乾燥粉末組成物 |
JP2013516444A (ja) * | 2010-01-08 | 2013-05-13 | プロフィブリックス ビーブイ | 乾燥粉末フィブリンシーラント |
JP2016074673A (ja) * | 2010-01-08 | 2016-05-12 | プロフィブリックス ビーブイ | 乾燥粉末フィブリンシーラント |
JP2019524348A (ja) * | 2016-08-15 | 2019-09-05 | コウシュウ・バイオシール・バイオテック・カンパニー・リミテッドGuangzhou Bioseal Biotech Co., Ltd. | 止血組成物及びその作製方法 |
Also Published As
Publication number | Publication date |
---|---|
NO985340D0 (no) | 1998-11-16 |
US6113948A (en) | 2000-09-05 |
WO1997044015A1 (en) | 1997-11-27 |
NO985340L (no) | 1999-01-18 |
AU702955B2 (en) | 1999-03-11 |
JP4024302B2 (ja) | 2007-12-19 |
EP0914096B1 (en) | 2003-08-13 |
EP0914096A1 (en) | 1999-05-12 |
AU2783797A (en) | 1997-12-09 |
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