JP2000508911A - 間葉幹細胞を用いる骨の再生および増強 - Google Patents

間葉幹細胞を用いる骨の再生および増強

Info

Publication number
JP2000508911A
JP2000508911A JP9538185A JP53818597A JP2000508911A JP 2000508911 A JP2000508911 A JP 2000508911A JP 9538185 A JP9538185 A JP 9538185A JP 53818597 A JP53818597 A JP 53818597A JP 2000508911 A JP2000508911 A JP 2000508911A
Authority
JP
Japan
Prior art keywords
bone
bmp
msc
cells
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9538185A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000508911A5 (enExample
Inventor
カディヤラ，スーダ
ブルーダー，スコット，ピー．
マッシュラー，ジョージ，エフ．
Original Assignee
オシリス セラピューティクス，インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by オシリス セラピューティクス，インコーポレイテッド filed Critical オシリス セラピューティクス，インコーポレイテッド
Publication of JP2000508911A publication Critical patent/JP2000508911A/ja
Publication of JP2000508911A5 publication Critical patent/JP2000508911A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3808—Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3821—Bone-forming cells, e.g. osteoblasts, osteocytes, osteoprogenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/42—Organic phosphate, e.g. beta glycerophosphate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/10—Mineral substrates
    • C12N2533/18—Calcium salts, e.g. apatite, Mineral components from bones, teeth, shells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
JP9538185A 1996-04-19 1997-04-17 間葉幹細胞を用いる骨の再生および増強 Pending JP2000508911A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1624596P 1996-04-19 1996-04-19
US2983896P 1996-10-28 1996-10-28
US60/029,838 1996-10-28
US60/016,245 1996-10-28
PCT/US1997/006433 WO1997040137A1 (en) 1996-04-19 1997-04-17 Regeneration and augmentation of bone using mesenchymal stem cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005353709A Division JP2006158975A (ja) 1996-04-19 2005-12-07 間葉幹細胞を用いる骨の再生および増強

Publications (2)

Publication Number Publication Date
JP2000508911A true JP2000508911A (ja) 2000-07-18
JP2000508911A5 JP2000508911A5 (enExample) 2004-12-09

Family

ID=26688354

Family Applications (2)

Application Number Title Priority Date Filing Date
JP9538185A Pending JP2000508911A (ja) 1996-04-19 1997-04-17 間葉幹細胞を用いる骨の再生および増強
JP2005353709A Withdrawn JP2006158975A (ja) 1996-04-19 2005-12-07 間葉幹細胞を用いる骨の再生および増強

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2005353709A Withdrawn JP2006158975A (ja) 1996-04-19 2005-12-07 間葉幹細胞を用いる骨の再生および増強

Country Status (9)

Country Link
US (2) US6541024B1 (enExample)
EP (3) EP2311471A3 (enExample)
JP (2) JP2000508911A (enExample)
AT (1) ATE439849T1 (enExample)
AU (1) AU731468B2 (enExample)
CA (1) CA2251983C (enExample)
DE (1) DE69739540D1 (enExample)
ES (1) ES2329953T3 (enExample)
WO (1) WO1997040137A1 (enExample)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002536076A (ja) * 1999-02-04 2002-10-29 エスディージーアイ・ホールディングス・インコーポレーテッド 骨形成ペースト組成物およびその用途
JP2003018984A (ja) * 2001-07-06 2003-01-21 Mitsubishi Chemicals Corp 多分化能を有する細胞の製造法
JP2004505747A (ja) * 2000-08-22 2004-02-26 ジンテーズ　アクチエンゲゼルシャフト　クール 骨代用材料
JP2005505311A (ja) * 2001-03-02 2005-02-24 ストライカー コーポレイション 多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法
JP2005529169A (ja) * 2002-06-06 2005-09-29 ザ ブライハム アンド ウイミンズ ホスピタル， インコーポレイテッド 活性剤を送達するための非ポリマー性造血細胞クロット
JP2005532998A (ja) * 2002-03-01 2005-11-04 セルテック アール アンド ディー インコーポレイテッド 骨密度を増減させる方法
JP2006503819A (ja) * 2002-08-29 2006-02-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 骨形成を増進するための作用剤および方法
JP2006230817A (ja) * 2005-02-25 2006-09-07 Tokyo Medical & Dental Univ 生体組織補填材、生体組織補填体およびその製造方法
WO2007039973A1 (ja) * 2005-10-06 2007-04-12 Olympus Corporation 生体組織補填材、その製造方法および使用、ならびに細胞培養方法
US8641667B2 (en) 2005-10-20 2014-02-04 DePuy Synthes Products, LLC Perfusion device and method
JP2016519665A (ja) * 2013-03-15 2016-07-07 ヒューマン バイオモレキュラー リサーチ インスティチュートＨｕｍａｎ ＢｉｏＭｏｌｅｃｕｌａｒ Ｒｅｓａｒｃｈ Ｉｎｓｔｉｔｕｔｅ 骨の成長および修復に使用するための化合物およびマトリックス
US9526737B2 (en) 2007-12-03 2016-12-27 The Regents Of The University Of California Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
US9532994B2 (en) 2003-08-29 2017-01-03 The Regents Of The University Of California Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
US9670244B2 (en) 2006-02-27 2017-06-06 The Regents Of The University Of California Oxysterol compounds and the hedgehog pathway
US9683009B2 (en) 2013-05-02 2017-06-20 The Regents Of The University Of California Bone-selective osteogenic oxysterol-bone targeting agents
US9717742B2 (en) 2012-05-07 2017-08-01 The Regents Of The University Of California Oxysterol analogue OXY133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis
WO2018151046A1 (ja) 2017-02-15 2018-08-23 ロート製薬株式会社 肺線維症治療剤、ｐｔｐｒｒ発現促進剤及び肺線維症治療用キット
WO2018225440A1 (ja) 2017-06-09 2018-12-13 国立大学法人大阪大学 拡張型心筋症治療剤
JPWO2021020268A1 (enExample) * 2019-07-26 2021-02-04
WO2024262572A1 (ja) * 2023-06-21 2024-12-26 国立大学法人 鹿児島大学 骨再生又は増生用複合体及びその製造方法

Families Citing this family (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
DE69434651T2 (de) 1993-12-07 2007-03-08 Genetics Institute, Inc., Cambridge Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
US20050186673A1 (en) * 1995-02-22 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
DE69733292T2 (de) * 1996-03-01 2006-04-27 Isotis N.V. Verfahren zur in vitro Herstellung von Knochen
US20030180705A1 (en) * 1997-01-24 2003-09-25 Asahi Medical Co., Ltd. Method of regenerating blood vessels
US20020031757A1 (en) * 1997-01-24 2002-03-14 Asahi Medical Co., Ltd. Method of regenerating a tissue
US20040224300A1 (en) * 1997-01-24 2004-11-11 Shuji Terashima Method for separating nucleated cells
US8858981B2 (en) * 1997-10-10 2014-10-14 Ed. Geistlich Soehne Fuer Chemistrie Industrie Bone healing material comprising matrix carrying bone-forming cells
US20030180263A1 (en) * 2002-02-21 2003-09-25 Peter Geistlich Resorbable extracellular matrix for reconstruction of bone
US9034315B2 (en) * 1997-10-10 2015-05-19 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Cell-charged multi-layer collagen membrane
US20050186283A1 (en) * 1997-10-10 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
JP4441115B2 (ja) * 1998-03-13 2010-03-31 オシリス セラピューティクス，インコーポレイテッド ヒト非自己間葉幹細胞を使用する方法と利用
JP2002506623A (ja) * 1998-03-14 2002-03-05 クリエイティブ バイオモレキュールズ， インコーポレイテッド 脂質およびモルフォゲンを含む、細胞分化を調節するための組成物
US6171610B1 (en) 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE60006356T2 (de) * 1999-02-04 2004-09-09 SDGI Holding, Inc., Wilmington Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung
US20030082152A1 (en) 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US6777231B1 (en) 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
US8389017B1 (en) 1999-07-08 2013-03-05 Cap Biotechnology, Inc. Calcium-containing structures and methods of making and using the same
US20020095157A1 (en) 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
ATE271886T1 (de) 1999-10-15 2004-08-15 Inst Genetics Llc Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
EP1475109A1 (en) * 1999-10-15 2004-11-10 Genetics Institute, LLC Formulations for delivery of osteogenic proteins
WO2001028603A1 (en) * 1999-10-15 2001-04-26 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
EP1228773B1 (en) * 1999-11-11 2006-05-17 Japan Tissue Engineering Co., Ltd. Transplant material and process for producing the same
GB0011244D0 (en) * 2000-05-11 2000-06-28 Smith & Nephew Inc Tissue regrafting
US7108721B2 (en) 2000-05-11 2006-09-19 Massachusetts Institute Of Technology Tissue regrafting
GB0015479D0 (en) * 2000-06-23 2000-08-16 Univ London Transcutaneous Prosthesis
EP1302203A4 (en) * 2000-07-18 2004-01-14 Nichimo Kk REINFORCEMENT MATERIAL FOR STEM CELLS
MXPA03005014A (es) * 2000-12-06 2004-09-10 Robert J Hariri Metodo para recolectar celulas madres de la placenta.
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
US20080152629A1 (en) * 2000-12-06 2008-06-26 James Edinger Placental stem cell populations
CA2365376C (en) * 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6852330B2 (en) * 2000-12-21 2005-02-08 Depuy Mitek, Inc. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6599323B2 (en) * 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
EP2314673B1 (en) * 2001-02-14 2013-07-24 Anthrogenesis Corporation Post-partum mammalian placenta, its use and placental stem cells therefrom
EP2316463B1 (en) * 2001-02-14 2017-04-12 Anthrogenesis Corporation Tissue matrices comprising placental stem cells, and methods of making them
US6723131B2 (en) 2001-02-28 2004-04-20 The Cleveland Clinic Foundation Composite bone marrow graft material with method and kit
IL141813A (en) * 2001-03-05 2010-04-15 Hadasit Med Res Service Mixture comprising bone marrow cells together with demineralized and/or mineralized bone matrix and uses thereof in the preparation of compositions for the treatment of hematopoietic dusirders
US20020182189A1 (en) * 2001-04-19 2002-12-05 Chang Chia Ning (Sophia) Compositions and methods for the repair and construction of bone and other tissue
US7011829B2 (en) 2001-05-18 2006-03-14 Kanemaru Shin-Ichi Tissue filler
CA2449008A1 (en) 2001-06-01 2002-12-12 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US20050053587A1 (en) * 2001-09-20 2005-03-10 Jacques Galipeau Cultured stromal cells and uses thereof
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US7651684B2 (en) 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US7595043B2 (en) 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US8105580B2 (en) 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US7514075B2 (en) 2001-12-07 2009-04-07 Cytori Therapeutics, Inc. Systems and methods for separating and concentrating adipose derived stem cells from tissue
CN1630526B (zh) 2001-12-07 2010-05-05 马克罗珀尔生物外科公司 用加工的脂肪抽吸细胞来治疗患者的系统和方法
JP3646167B2 (ja) * 2002-02-19 2005-05-11 独立行政法人産業技術総合研究所 フォスフォフォリンを含む複合生体材料
US7046835B2 (en) * 2002-03-07 2006-05-16 Ge Medical Systems Global Technology Company Llc Method and system for processing vascular radiographic images which have been reconstructed by three-dimensional modelling
US8313742B2 (en) 2002-03-29 2012-11-20 Depuy Acromed, Inc. Cell-containing bone graft material
US7223414B1 (en) * 2002-06-03 2007-05-29 Ahmed El-Ghannam Silica-calcium phosphate bioactive composite for improved synthetic graft resorbability and tissue regeneration
JP2004016045A (ja) * 2002-06-13 2004-01-22 Olympus Corp 培養装置
US7498040B2 (en) 2005-10-12 2009-03-03 Lifenet Health Compositions for repair of defects in osseous tissues, and methods of making the same
US7744597B2 (en) * 2002-06-26 2010-06-29 Lifenet Health Device and process for producing fiber products and fiber products produced thereby
US20040078090A1 (en) * 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US7824701B2 (en) * 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
CN1770976A (zh) * 2003-02-13 2006-05-10 人类起源公司 利用脐带血治疗患有疾病、紊乱或状况的个体的用途
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
US20040193270A1 (en) * 2003-03-31 2004-09-30 Depuyacromed, Inc. Implantable bone graft
EP2335738A1 (en) * 2003-04-01 2011-06-22 United States Government as represented by the Department of Veteran's Affaires Stem-cell, precursor cell or target cell-based treatment of wound healing
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7494811B2 (en) 2003-05-01 2009-02-24 Lifenet Health In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
CN101072572B (zh) * 2003-07-09 2013-12-11 华沙整形外科股份有限公司 富含结缔组织生长成分的骨髓组分的分离及其促进结缔组织形成的用途
US20050074877A1 (en) * 2003-07-28 2005-04-07 Mao Jeremy Jian Biological engineering of articular structures containing both cartilage and bone
AU2004261899A1 (en) 2003-08-01 2005-02-10 Norimasa Nakamura Scaffold-free self-organized 3D synthetic tissue
WO2007083504A1 (ja) * 2003-08-01 2007-07-26 Norimasa Nakamura スキャフォールドフリー自己組織性三次元人工組織（Ｓｃａｆｆｏｌｄ－ｆｒｅｅ Ｓｅｌｆ－Ｏｒｇａｎｉｚｅｄ ３Ｄ ｓｙｎｔｈｅｔｉｃ ｔｉｓｓｕｅ）
DE10336152B4 (de) * 2003-08-06 2007-02-15 Nephrogen LLC, Salt Lake City Aufreinigungsverfahren für humane mesenchymale Stammzellen
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
US7744869B2 (en) * 2003-08-20 2010-06-29 Ebi, Llc Methods of treatment using electromagnetic field stimulated mesenchymal stem cells
US20050084962A1 (en) * 2003-08-20 2005-04-21 Bruce Simon Methods of treatment using electromagnetic field stimulated stem cells
GB0321337D0 (en) * 2003-09-11 2003-10-15 Massone Mobile Advertising Sys Method and system for distributing advertisements
AU2004280616A1 (en) 2003-10-08 2005-04-21 Vet-Stem Inc. Methods of preparing and using stem cell compositions and kits comprising the same
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) * 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US8188219B2 (en) 2004-01-28 2012-05-29 The Regents Of The University Of California Bone morphogenic protein binding peptide
US8415302B2 (en) 2004-01-28 2013-04-09 The Regents Of The University Of California Surgical applications for BMP binding protein
US8193312B2 (en) 2004-01-28 2012-06-05 The Regents Of The University Of California Bone morphogenic protein binding peptide
US11395865B2 (en) * 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US20070190101A1 (en) * 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
US8657881B2 (en) * 2004-04-20 2014-02-25 Depuy Mitek, Llc Meniscal repair scaffold
US8221780B2 (en) * 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8137686B2 (en) * 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
AU2005243158B2 (en) * 2004-05-07 2010-03-25 Wisconsin Alumni Research Foundation Method of forming mesenchymal stem cells from embryonic stem cells
US7722895B1 (en) 2004-09-20 2010-05-25 Warsaw Orthopedic, Inc. Osteogenic implants with combined implant materials, and materials and methods for same
US20090319045A1 (en) 2004-10-12 2009-12-24 Truncale Katherine G Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
JP4279233B2 (ja) * 2004-10-25 2009-06-17 国立大学法人広島大学 間葉系組織再生誘導用シート及びその製造方法
WO2006052840A2 (en) * 2004-11-04 2006-05-18 University Of Virginia Patent Foundation Bone tropic peptides
EP1853283B1 (en) 2004-11-29 2015-09-16 The Regents of The University of California Activating extraction of demineralized bone matrix
CA2596957C (en) * 2004-12-03 2015-04-14 New Jersey Institute Of Technology Substrate recognition by differentiable human mesenchymal stem cells
CA2512667A1 (en) * 2005-01-07 2006-07-07 Takahiro Ochiya Human hepatocyte-like cells and uses thereof
WO2006089359A1 (en) * 2005-02-25 2006-08-31 Eugene Sherry Replacement bone tissue
JP2006289062A (ja) * 2005-03-18 2006-10-26 Pentax Corp 肥大化能を有する軟骨細胞と足場を用いた骨補填材料
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
WO2006121445A2 (en) * 2005-05-10 2006-11-16 United States Of America Department Of Veteran's Affairs Therapy of kidney diseases and multiorgan failure with mesenchymal stem cells and mesenchymal stem cell conditioned media
DE102005030614B4 (de) * 2005-06-30 2014-05-08 Biotissue Ag Zellfreies Transplantat, dessen Verwendung, Verfahren zu dessen Herstellung, dabei hergestellte Matrix mit Gel und Verfahren zur Herstellung dieser Matrix mit Gel
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US7531355B2 (en) 2005-07-29 2009-05-12 The Regents Of The University Of California Methods and compositions for smooth muscle reconstruction
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
PL1957633T3 (pl) 2005-10-13 2014-05-30 Anthrogenesis Corp Immunomodulacja z zastosowaniem komórek macierzystych łożyska
US20070105769A1 (en) * 2005-11-07 2007-05-10 Ebi, L.P. Methods of treating tissue defects
CN1990054B (zh) * 2005-12-27 2011-09-07 上海国睿生命科技有限公司 一种体外诱导人骨髓基质干细胞构建软骨的方法
AU2006332679A1 (en) 2005-12-29 2007-07-12 Anthrogenesis Corporation Co-culture of placental stem cells and stem cells from a second source
EP2471904B1 (en) * 2005-12-29 2018-10-24 Celularity, Inc. Placental stem cell populations
GB0600972D0 (en) * 2006-01-18 2006-03-01 Univ Leeds Enrichment of cells
CA2649729A1 (en) * 2006-04-17 2007-10-25 Hepacore Ltd. Methods for bone regeneration using endothelial progenitor cell preparations
EP2019653B1 (en) * 2006-04-28 2016-11-16 The University of Hong Kong Bioengineered intervertebral discs and methods for their preparation
SI2772535T1 (sl) 2006-05-31 2022-08-31 Children's Medical Center Corporation ABC5 pozitivne mezenhimske matične celice kot imunomodulatorji
JP2009539378A (ja) * 2006-06-09 2009-11-19 アントフロゲネシス コーポレーション 胎盤環境及び幹細胞を培養するためのその使用
DE102006033167A1 (de) 2006-07-10 2008-01-24 Gelita Ag Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung eines vernetzenden medizinischen Klebers
DE102006033168A1 (de) * 2006-07-10 2008-01-17 Gelita Ag Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung einer vernetzenden therapeutischen Zusammensetzung
US7993918B2 (en) * 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
WO2008029264A2 (en) * 2006-09-07 2008-03-13 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method of treating bone cancer
DE102006047346A1 (de) * 2006-10-06 2008-04-10 Transtissue Technologies Gmbh Matrix-Gel-Transplantat ohne Zellen
CA2667359C (en) 2006-10-23 2014-07-22 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
US7871605B2 (en) 2006-11-03 2011-01-18 Aastrom Bioscience, Inc. Mixed cell populations for tissue repair and separation technique for cell processing
AU2007339325A1 (en) 2006-12-19 2008-07-10 The Regents Of The University Of California Inhibition of PPAR gamma expression by specific osteogenic oxysterols
EP2687220A3 (en) 2007-02-12 2014-05-14 Anthrogenesis Corporation Treatment of inflammatory diseases using placental stem cells
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US8034014B2 (en) 2007-03-06 2011-10-11 Biomet Biologics, Llc Angiogenesis initation and growth
WO2008124494A1 (en) 2007-04-03 2008-10-16 The Cleveland Clinic Foundation Enrichment of tissue-derived adult stem cells based on retained extracellular matrix material
EP2607477B1 (en) 2007-05-03 2020-09-23 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
CA2685956A1 (en) * 2007-05-04 2008-11-13 Perth Bone & Tissue Bank A method for treating inflammation and controlled-release material capable of providing same
TWM322542U (en) * 2007-05-23 2007-11-21 Universal Scient Ind Co Ltd Testing machine
US8574825B2 (en) 2007-06-01 2013-11-05 Bacterin International, Inc. Process for demineralization of bone matrix with preservation of natural growth factors
ES2327480B1 (es) 2007-06-15 2010-08-10 Bioiberica, S.A. "disacaridos para el tratamiento de tendones, ligamentos y huesos".
WO2008157594A2 (en) 2007-06-18 2008-12-24 New Jersey Institute Of Technology Electrospun ceramic-polymer composite as a scaffold for tissue repair
US8785191B2 (en) * 2007-08-27 2014-07-22 University Of Connecticut Concentration of stem cells obtained during orthopaedic surgeries
US20090104164A1 (en) * 2007-09-26 2009-04-23 Celgene Cellular Therapeutics Angiogenic cells from human placental perfusate
RU2536242C2 (ru) 2007-09-28 2014-12-20 Антродженезис Корпорейшн Угнетение опухолей с помощью плацентарного перфузата человека и выделенных из плаценты человека вспомогательных натуральных клеток-киллеров
WO2009061447A2 (en) * 2007-11-07 2009-05-14 Anthrogenesis Corporation Treatment of premature birth complications
US9458431B2 (en) 2008-03-17 2016-10-04 Agency For Science, Technology And Research Microcarriers for stem cell culture
US20120219531A1 (en) * 2008-03-17 2012-08-30 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
EP2479260B1 (en) 2008-03-17 2016-01-06 Agency For Science, Technology And Research Microcarriers for stem cell culture
US20090325296A1 (en) 2008-03-25 2009-12-31 New Jersey Institute Of Technology Electrospun electroactive polymers for regenerative medicine applications
RU2491076C2 (ru) * 2008-03-31 2013-08-27 Аугустинус БАДЕР Способ и композиция для регенерации тканей с помощью стволовых или костномозговых клеток
WO2009125402A2 (en) 2008-04-10 2009-10-15 Bonus Therapeutics Ltd Bone-like prosthetic implants
ES2608974T3 (es) * 2008-08-14 2017-04-17 Mesoblast International Sàrl Composiciones de células madre mesenquimales purificadas
US20100055078A1 (en) * 2008-08-15 2010-03-04 The Government of the U.S.A, as represented by the Department of Veterans Affairs Methods of making a transplantable bone repair system using multipotent stem cells
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
KR20110050521A (ko) 2008-08-20 2011-05-13 안트로제네시스 코포레이션 개선된 세포 조성물 및 그의 제조 방법
US8828376B2 (en) * 2008-08-20 2014-09-09 Anthrogenesis Corporation Treatment of stroke using isolated placental cells
AU2009283161A1 (en) 2008-08-22 2010-02-25 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
IT1391252B1 (it) * 2008-10-16 2011-12-01 Univ Bari Peocedimento per l'identificazione e l'isolamento di cellule mesenchimali a spiccata capacita' osteorigenerativa
AU2009311251A1 (en) * 2008-11-04 2010-05-14 Perth Bone & Tissue Bank Carrier material for bone forming cells
US8343480B2 (en) * 2008-11-14 2013-01-01 Howmedica Osteonics Corp. Administration of stem or progenitor cells to a joint to enhance recovery from joint surgery
WO2010059828A1 (en) * 2008-11-19 2010-05-27 Anthrogenesis Corporation Amnion derived adherent cells
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
RU2570550C2 (ru) * 2008-11-21 2015-12-10 Антродженезис Корпорейшн Лечение заболеваний, расстройств или патологических состояний легких с использованием плацентарных клеток
US20100172951A1 (en) 2009-01-03 2010-07-08 Ray Wasielewski Enhanced Medical Implant
US20100274362A1 (en) * 2009-01-15 2010-10-28 Avner Yayon Cartilage particle tissue mixtures optionally combined with a cancellous construct
US9476026B2 (en) 2009-03-12 2016-10-25 New Jersey Institute Of Technology Method of tissue repair using a piezoelectric scaffold
US9771557B2 (en) 2009-03-12 2017-09-26 New Jersey Institute Of Technology Piezoelectric scaffold for nerve growth and repair
US9192655B2 (en) 2009-03-12 2015-11-24 New Jersey Institute Of Technology System and method for a hydrogel and hydrogel composite for cartilage repair applications
US9334476B2 (en) 2009-03-12 2016-05-10 New Jersey Institute Of Technology Method for nerve growth and repair using a piezoelectric scaffold
US9301975B2 (en) 2009-05-01 2016-04-05 Biocardia, Inc. Method of preparing autologous cells and method of use for therapy
JP5917392B2 (ja) 2009-05-01 2016-05-11 ビミニ テクノロジーズ リミテッド ライアビリティ カンパニー 組織及び細胞富化グラフトを最適化するシステム、方法及び組成物
EP2445512B1 (en) 2009-06-23 2018-08-29 The Regents of The University of California Enhancement of bmp retention
WO2011014824A1 (en) * 2009-07-31 2011-02-03 University Of Southern California Use of collagen type vii for maintaining and re-inducing osteogenic abilities of mesenchymal stem cells
CA2776452A1 (en) * 2009-10-02 2011-04-07 Baxter International Inc. Hematopoietic stem cells for use in the treatment of a kidney injury
US9707318B2 (en) * 2009-10-29 2017-07-18 Shaker A. Mousa Compositions of novel bone patch in bone and vascular regeneration
KR20120089339A (ko) 2009-11-12 2012-08-09 브이비아이 테크놀로지스, 엘엘씨 포자를 닮은 세포들의 계군 및 그 용도
AU2010335005B2 (en) * 2009-12-22 2016-04-21 Agency For Science, Technology And Research Treatment of bone fracture
US9163212B2 (en) 2010-01-25 2015-10-20 Warsaw Orthopedic, Inc. Osteogenic cell delivery matrix
JP2013518108A (ja) * 2010-01-26 2013-05-20 アントフロゲネシス コーポレーション 胎盤幹細胞を用いる骨関連癌の治療
US9180166B2 (en) 2010-03-12 2015-11-10 New Jersey Institute Of Technology Cartilage repair systems and applications utilizing a glycosaminoglycan mimic
US11078248B2 (en) 2010-03-19 2021-08-03 Lifenet Health BMP peptides and methods of use
CN102933703A (zh) 2010-04-07 2013-02-13 人类起源公司 使用胎盘干细胞的血管生成
AU2011237743A1 (en) 2010-04-08 2012-11-01 Anthrogenesis Corporation Treatment of sarcoidosis using placental stem cells
IT1401457B1 (it) * 2010-06-11 2013-07-26 Fond I R C C S Istituto Neurologico Carlo Besta Carrier di tipo cellulare per il trasporto mirato di almeno una molecola e/o almeno un composto molecolare ad almeno una cellula bersaglio in un mammifero umano o non umano
JP5996533B2 (ja) 2010-07-13 2016-09-21 アントフロゲネシス コーポレーション ナチュラルキラー細胞を生成させる方法
WO2012048099A2 (en) 2010-10-08 2012-04-12 Osiris Therapeutics, Inc. Nanoparticle-loaded cells
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
AR093183A1 (es) 2010-12-31 2015-05-27 Anthrogenesis Corp Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras
US8709401B2 (en) 2011-02-25 2014-04-29 Howmedica Osteonics Corp. Primed stem cells and uses thereof to treat inflammatory conditions in joints
WO2012142533A1 (en) 2011-04-13 2012-10-18 New Jersey Institute Of Technology System and method for electrospun biodegradable scaffold for bone repair
PT2714059T (pt) 2011-06-01 2019-02-04 Celularity Inc Tratamento da dor utilizando células estaminais da placenta
US9289312B2 (en) * 2011-07-13 2016-03-22 Vivex Biomedical, Inc. Spinal implants with stem cells
US9925221B2 (en) 2011-09-09 2018-03-27 Celularity, Inc. Treatment of amyotrophic lateral sclerosis using placental stem cells
US9642935B1 (en) * 2012-01-27 2017-05-09 Robert L. Bundy Synthetic, composite osteogenic bone graft
US20130216495A1 (en) 2012-02-21 2013-08-22 Baxter Healthcare Sa Pharmaceutical composition comprising cd34+ cells
US10806826B2 (en) 2013-01-09 2020-10-20 Bacterin International, Inc. Bone graft substitute containing a temporary contrast agent and a method of generating such and a method of use thereof
AU2014215458A1 (en) 2013-02-05 2015-08-13 Anthrogenesis Corporation Natural killer cells from placenta
EP2964238B1 (en) 2013-02-19 2021-01-13 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
US9186253B2 (en) * 2013-02-22 2015-11-17 Allosource Cartilage mosaic compositions and methods
WO2014143383A1 (en) 2013-03-13 2014-09-18 Agilent Technologies, Inc. Transposome tethered to a gene delivery vehicle
EP2970882B1 (en) 2013-03-15 2018-11-28 AlloSource Cell repopulated collagen matrix for soft tissue repair and regeneration
MX378814B (es) 2013-05-10 2025-03-11 Childrens Medical Center Armazón de colágeno y glicosaminoglicano coinjertado con una población de células madre abcb5+ y usos del mismo.
US9913929B2 (en) 2013-10-18 2018-03-13 Fortus Medical, Inc. Bone marrow aspirate enhanced bone graft
US9617506B2 (en) 2013-11-16 2017-04-11 Terumo Bct, Inc. Expanding cells in a bioreactor
US10173375B2 (en) 2014-03-05 2019-01-08 Bacterin International, Inc. Shaped fiber-based products and method of manufacture thereof
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
US11433163B2 (en) 2014-04-10 2022-09-06 Bonus Therapeutics Ltd. Bone repair compositions
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US11285190B2 (en) * 2015-04-20 2022-03-29 The Board Of Regents Of The University Of Texas System CLEC11a is a bone growth agent
WO2016183017A1 (en) 2015-05-08 2016-11-17 Fortus Medical, Inc. Bone fragment and tissue harvesting system
US10821004B2 (en) 2015-06-30 2020-11-03 Bacterin Interational, Inc. Expandable bone grafts and methods of manufacture thereof
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
CN104941001A (zh) * 2015-07-10 2015-09-30 奥思达干细胞有限公司 一种生物膜角膜贴片及其制备方法和应用
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. CELL EXPANSION
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
AU2017296175B2 (en) 2016-07-11 2023-11-02 Bonus Therapeutics Ltd. Cell compositions for tissue regeneration
WO2018049082A1 (en) 2016-09-07 2018-03-15 Fortus Medical, Inc. Bone void filler preparation system
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
JP7393945B2 (ja) 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド 細胞増殖
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
EP3634245A4 (en) 2017-06-07 2021-03-17 Fortus Medical, Inc. CONJUNCTIVE TISSUE PROGENITOR CELL SUCTION AND TREATMENT SYSTEM
US11464804B1 (en) * 2017-11-15 2022-10-11 Enrico Stazzone Intrathecal multifactorial infusion of heterogeneous autologous cell therapy
KR20200088445A (ko) 2017-11-22 2020-07-22 메조블라스트 인터내셔널 에스에이알엘 세포 조성물 및 치료 방법 i
WO2019182788A1 (en) 2018-03-22 2019-09-26 Fortus Medical, Inc. Osteomedullary tissue processing system
EP3784249A4 (en) 2018-04-25 2022-03-02 Children's Medical Center Corporation ABCB5 LIGANDS AND SUBSTRATES
US11583402B2 (en) 2019-07-16 2023-02-21 William Baumgartl Method for treating joint pain
US11927393B2 (en) * 2020-04-30 2024-03-12 Dci Donor Services, Inc. Fiber slurry tray and process
CN112957523B (zh) * 2021-02-09 2021-12-07 浙江大学 一种用于同步修复软硬组织缺损的仿生复合支架及其基于3d打印的成型方法
WO2022204315A1 (en) 2021-03-23 2022-09-29 Terumo Bct, Inc. Cell capture and expansion
CN113350486A (zh) * 2021-07-06 2021-09-07 深圳市人民医院 一种具有骨缺损修复功效的药物组合物及其应用
US12152699B2 (en) 2022-02-28 2024-11-26 Terumo Bct, Inc. Multiple-tube pinch valve assembly
JP7408000B1 (ja) 2022-06-20 2024-01-04 威久 山本 骨粗鬆症による骨折の推測及び予測の少なくとも一方の方法、骨折スコア出力方法、学習モデル生成方法、学習モデル、骨粗鬆症による骨折のリスク因子推定方法、グラフ作成方法、プログラム、情報処理装置、並びに、学習データセット作成方法
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1624596A (en) 1920-12-24 1927-04-12 Western Electric Co Signaling method and system
US2983896A (en) 1958-09-10 1961-05-09 Continental Connector Corp Multiple electrical connector with selectively positionable polarizing member
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
JPH05339167A (ja) * 1991-08-08 1993-12-21 Hajime Ogushi 骨形成補助剤
WO1994000567A1 (en) * 1992-06-25 1994-01-06 David Scheer Stem cell and lymphocyte storage

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002536076A (ja) * 1999-02-04 2002-10-29 エスディージーアイ・ホールディングス・インコーポレーテッド 骨形成ペースト組成物およびその用途
US8540658B2 (en) 2000-08-22 2013-09-24 DePuy Synthes Products, LLC Bone-regeneration material
JP2004505747A (ja) * 2000-08-22 2004-02-26 ジンテーズ　アクチエンゲゼルシャフト　クール 骨代用材料
US8679072B2 (en) 2000-08-22 2014-03-25 DePuy Synthes Products, LLC Bone-regeneration material
JP2005505311A (ja) * 2001-03-02 2005-02-24 ストライカー コーポレイション 多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法
JP2003018984A (ja) * 2001-07-06 2003-01-21 Mitsubishi Chemicals Corp 多分化能を有する細胞の製造法
JP2005532998A (ja) * 2002-03-01 2005-11-04 セルテック アール アンド ディー インコーポレイテッド 骨密度を増減させる方法
JP2005529169A (ja) * 2002-06-06 2005-09-29 ザ ブライハム アンド ウイミンズ ホスピタル， インコーポレイテッド 活性剤を送達するための非ポリマー性造血細胞クロット
JP2006503819A (ja) * 2002-08-29 2006-02-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 骨形成を増進するための作用剤および方法
US9532994B2 (en) 2003-08-29 2017-01-03 The Regents Of The University Of California Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
JP2006230817A (ja) * 2005-02-25 2006-09-07 Tokyo Medical & Dental Univ 生体組織補填材、生体組織補填体およびその製造方法
WO2007039973A1 (ja) * 2005-10-06 2007-04-12 Olympus Corporation 生体組織補填材、その製造方法および使用、ならびに細胞培養方法
US8641667B2 (en) 2005-10-20 2014-02-04 DePuy Synthes Products, LLC Perfusion device and method
US9670244B2 (en) 2006-02-27 2017-06-06 The Regents Of The University Of California Oxysterol compounds and the hedgehog pathway
US9526737B2 (en) 2007-12-03 2016-12-27 The Regents Of The University Of California Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
US9717742B2 (en) 2012-05-07 2017-08-01 The Regents Of The University Of California Oxysterol analogue OXY133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis
JP2016519665A (ja) * 2013-03-15 2016-07-07 ヒューマン バイオモレキュラー リサーチ インスティチュートＨｕｍａｎ ＢｉｏＭｏｌｅｃｕｌａｒ Ｒｅｓａｒｃｈ Ｉｎｓｔｉｔｕｔｅ 骨の成長および修復に使用するための化合物およびマトリックス
US9683009B2 (en) 2013-05-02 2017-06-20 The Regents Of The University Of California Bone-selective osteogenic oxysterol-bone targeting agents
WO2018151046A1 (ja) 2017-02-15 2018-08-23 ロート製薬株式会社 肺線維症治療剤、ｐｔｐｒｒ発現促進剤及び肺線維症治療用キット
WO2018225440A1 (ja) 2017-06-09 2018-12-13 国立大学法人大阪大学 拡張型心筋症治療剤
JPWO2021020268A1 (enExample) * 2019-07-26 2021-02-04
WO2021020268A1 (ja) * 2019-07-26 2021-02-04 富士フイルム株式会社 生体移植材料
JP7385664B2 (ja) 2019-07-26 2023-11-22 富士フイルム株式会社 生体移植材料
WO2024262572A1 (ja) * 2023-06-21 2024-12-26 国立大学法人 鹿児島大学 骨再生又は増生用複合体及びその製造方法

Also Published As

Publication number Publication date
ES2329953T3 (es) 2009-12-02
CA2251983C (en) 2003-12-16
WO1997040137A1 (en) 1997-10-30
AU2462297A (en) 1997-11-12
CA2251983A1 (en) 1997-10-30
ATE439849T1 (de) 2009-09-15
EP0906415A4 (en) 2005-12-21
JP2006158975A (ja) 2006-06-22
US6863900B2 (en) 2005-03-08
EP2311471A2 (en) 2011-04-20
US6541024B1 (en) 2003-04-01
EP0906415B1 (en) 2009-08-19
EP2105138A2 (en) 2009-09-30
AU731468B2 (en) 2001-03-29
EP2105138A3 (en) 2013-06-05
EP2311471A3 (en) 2013-05-15
US20030031695A1 (en) 2003-02-13
EP0906415A1 (en) 1999-04-07
DE69739540D1 (de) 2009-10-01

Similar Documents

Publication Publication Date Title
JP2000508911A (ja) 間葉幹細胞を用いる骨の再生および増強
Oryan et al. Bone injury and fracture healing biology
US10751185B2 (en) Treatment of skeletal voids with implantable substrate hydrated with bone marrow concentrate
Kasten et al. The effect of platelet-rich plasma on healing in critical-size long-bone defects
Kadiyala et al. Culture-expanded, bone marrow-derived mesenchymal stem cells can regenerate a critical-sized segmental bone defect
Petite et al. Tissue-engineered bone regeneration
Bigham-Sadegh et al. Selection of animal models for pre-clinical strategies in evaluating the fracture healing, bone graft substitutes and bone tissue regeneration and engineering
Morcos et al. Comprehensive review of adipose stem cells and their implication in distraction osteogenesis and bone regeneration
KR102248576B1 (ko) 세포 및 조직 성장을 촉진하기 위한 고체 기질
S Shekkeris et al. Clinical applications of mesenchymal stem cells in the treatment of fracture non-union and bone defects
US20250262250A1 (en) Method of treating pain associated with a cartilage defect
Cheng et al. A novel animal model treated with tooth extraction to repair the full-thickness defects in the mandible of rabbits
Singh et al. Point-of-care treatment of geometrically complex midfacial critical-sized bone defects with 3D-Printed scaffolds and autologous stromal vascular fraction
CN111107887A (zh) 包含脂肪干细胞的生物材料及其制备方法
US20220168356A1 (en) Allografts containing viable cells and methods therof
US20120195982A1 (en) Injectible, biocompatible synthetic bone growth composition
US10183095B2 (en) Treatment of skeletal voids with implantable substrate hydrated with bone marrow concentrate
Mesgarzadeh et al. Evaluation of bone regeneration in mandible large defect using undifferentiated adipose stem cells loaded on gelatin carrier: An animal model case study
Nunamaker et al. Bone grafting
Zheng et al. The impact of collagen sponge composite bone marrow mesenchymal stem cells (BMSCs) in inducing interbody fusion.
JP2006122518A (ja) 骨又は歯周組織形成用組成物
WO2024237186A1 (ja) 難治性骨欠損の予防又は治療用医薬組成物
Lopez et al. Srujan Singh, Ethan L. Nyberg b, c, Aine N. O’Sullivan b, c, Ashley Farris b, c, Alexandra N. Rindone b, c, Nicholas Zhang b, c, Emma C. Whitehead b, c, Yuxiao Zhou b, c, Eszter Mihaly b, c, Chukwuebuka C. Achebe b, c, Wojciech Zbijewski b, Will Grundy d, David Garlick d, Nicolette D. Jackson d, Takashi Taguchi e, Catherine Takawira e, Joseph Lopez f
Niechoda In vivo bone formation using Adipose Derived Stromal Stem Cells. The histomorphometry of the ovine defect model
村上弘明 Autologous bone grafts with MSCs or FGF-2 accelerate bone union in large bone defects

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040412

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040412

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20050607

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20050906

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20051017

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20051207

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20060704

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20061002

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20070111

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20070222

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070629

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070704

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070802

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070808

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070829

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070903

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20080723

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20080912