JP2000247869A - 油状物質含有粉末の製造方法 - Google Patents
油状物質含有粉末の製造方法Info
- Publication number
- JP2000247869A JP2000247869A JP4636299A JP4636299A JP2000247869A JP 2000247869 A JP2000247869 A JP 2000247869A JP 4636299 A JP4636299 A JP 4636299A JP 4636299 A JP4636299 A JP 4636299A JP 2000247869 A JP2000247869 A JP 2000247869A
- Authority
- JP
- Japan
- Prior art keywords
- gelatin
- molecular weight
- average molecular
- powder
- oily substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000843 powder Substances 0.000 title claims abstract description 40
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 239000000463 material Substances 0.000 title abstract 5
- 229920000159 gelatin Polymers 0.000 claims abstract description 41
- 108010010803 Gelatin Proteins 0.000 claims abstract description 39
- 235000019322 gelatine Nutrition 0.000 claims abstract description 39
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 39
- 239000008273 gelatin Substances 0.000 claims abstract description 38
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 23
- 238000000034 method Methods 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000001694 spray drying Methods 0.000 claims abstract description 11
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 10
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 229940046009 vitamin E Drugs 0.000 claims abstract description 10
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 10
- 239000011709 vitamin E Substances 0.000 claims abstract description 10
- 238000009472 formulation Methods 0.000 claims abstract description 7
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 5
- 239000000126 substance Substances 0.000 claims description 28
- 239000000839 emulsion Substances 0.000 abstract description 9
- 239000007788 liquid Substances 0.000 abstract description 4
- 229960000984 tocofersolan Drugs 0.000 abstract description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract description 3
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 abstract description 2
- 239000011627 DL-alpha-tocopherol Substances 0.000 abstract description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 abstract description 2
- 238000005469 granulation Methods 0.000 abstract description 2
- 230000003179 granulation Effects 0.000 abstract description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 abstract description 2
- 239000008108 microcrystalline cellulose Substances 0.000 abstract description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 abstract description 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- 239000007921 spray Substances 0.000 description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 239000003921 oil Substances 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 229940042585 tocopherol acetate Drugs 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 description 2
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 description 2
- 235000010724 Wisteria floribunda Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000001641 gel filtration chromatography Methods 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- 239000008274 jelly Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- DJAHKBBSJCDSOZ-AJLBTXRUSA-N (5z,9e,13e)-6,10,14,18-tetramethylnonadeca-5,9,13,17-tetraen-2-one;(5e,9e,13e)-6,10,14,18-tetramethylnonadeca-5,9,13,17-tetraen-2-one Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C/CCC(C)=O.CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CCC(C)=O DJAHKBBSJCDSOZ-AJLBTXRUSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 229910002039 SYLYSIA SY350 Inorganic materials 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- FHKPLLOSJHHKNU-INIZCTEOSA-N [(3S)-3-[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]oxypyrrolidin-1-yl]-(oxan-4-yl)methanone Chemical compound C(C)N1N=CC(=C1C)C=1N(C2=NC=NC(=C2N=1)O[C@@H]1CN(CC1)C(=O)C1CCOCC1)C FHKPLLOSJHHKNU-INIZCTEOSA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229950006156 teprenone Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4636299A JP2000247869A (ja) | 1999-02-24 | 1999-02-24 | 油状物質含有粉末の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4636299A JP2000247869A (ja) | 1999-02-24 | 1999-02-24 | 油状物質含有粉末の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000247869A true JP2000247869A (ja) | 2000-09-12 |
| JP2000247869A5 JP2000247869A5 (enExample) | 2005-10-27 |
Family
ID=12745053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4636299A Pending JP2000247869A (ja) | 1999-02-24 | 1999-02-24 | 油状物質含有粉末の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2000247869A (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005073286A1 (ja) | 2004-01-30 | 2005-08-11 | Asahi Kasei Chemicals Corporation | 多孔質セルロース凝集体及びその成型体組成物 |
| WO2006115198A1 (ja) | 2005-04-22 | 2006-11-02 | Asahi Kasei Chemicals Corporation | 多孔質セルロース凝集体及びその成型体組成物 |
| US7514552B2 (en) | 2003-05-30 | 2009-04-07 | Asahi Kasei Chemicals Corporation | Cellulose powder |
| JP2019006723A (ja) * | 2017-06-27 | 2019-01-17 | 大峰堂薬品工業株式会社 | ヨクイニンを含むプレミックスエキス及びその利用 |
| CN114796507A (zh) * | 2022-03-31 | 2022-07-29 | 江苏西典药用辅料有限公司 | 一种乳糖、微晶纤维素共处理物的制备工艺 |
-
1999
- 1999-02-24 JP JP4636299A patent/JP2000247869A/ja active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7514552B2 (en) | 2003-05-30 | 2009-04-07 | Asahi Kasei Chemicals Corporation | Cellulose powder |
| WO2005073286A1 (ja) | 2004-01-30 | 2005-08-11 | Asahi Kasei Chemicals Corporation | 多孔質セルロース凝集体及びその成型体組成物 |
| US8597686B2 (en) | 2004-01-30 | 2013-12-03 | Asahi Kasei Chemicals Corporation | Porous cellulose aggregate and formed product composition comprising the same |
| WO2006115198A1 (ja) | 2005-04-22 | 2006-11-02 | Asahi Kasei Chemicals Corporation | 多孔質セルロース凝集体及びその成型体組成物 |
| JP2019006723A (ja) * | 2017-06-27 | 2019-01-17 | 大峰堂薬品工業株式会社 | ヨクイニンを含むプレミックスエキス及びその利用 |
| JP7093534B2 (ja) | 2017-06-27 | 2022-06-30 | 大峰堂薬品工業株式会社 | ヨクイニンを含むプレミックスエキス及びその利用 |
| CN114796507A (zh) * | 2022-03-31 | 2022-07-29 | 江苏西典药用辅料有限公司 | 一种乳糖、微晶纤维素共处理物的制备工艺 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3258003B2 (ja) | トコトリエノール類含有粉末、その製造方法およびそれを圧縮成型してなる錠剤 | |
| AU594265B2 (en) | Therapeutic compositions | |
| EP1262198A1 (en) | Composition with sustained release of levodopa and carbidopa | |
| WO1988006457A1 (fr) | Composition medicinale contenant de l'albumine en tant que support et procede de preparation | |
| JPH04230625A (ja) | 噴霧乾燥したジクロフェナクナトリウムを含み腸溶性の被覆を有するマイクロカプセルからなる微分散した錠剤組成物の製造方法 | |
| JPH0129764B2 (enExample) | ||
| JPH0474339B2 (enExample) | ||
| KR100765005B1 (ko) | 지용성 약물을 함유하는 분말 | |
| JPWO2000027393A1 (ja) | トコトリエノール類含有粉末、その製造方法およびそれを圧縮成型してなる錠剤 | |
| JP2001501218A (ja) | 有効成分の放出が修正されたマトリックスを含む薬学的組成物の製造方法 | |
| JPS6230965B2 (enExample) | ||
| JPH037230A (ja) | ビタミンｂ群化合物の組成物およびその製造方法 | |
| JP2000247869A (ja) | 油状物質含有粉末の製造方法 | |
| JPH03501686A (ja) | 油を含んで成る自由流動性噴霧乾燥食用粉末の製造法 | |
| US4670251A (en) | Microcrystalline tableting excipient derived from whey | |
| JPS63243034A (ja) | 低融点油性物質含有錠剤 | |
| JP2002523350A (ja) | 錠剤における成分として使用する魚類ゼラチン状組成物 | |
| JP2005112744A (ja) | ユビデカレノン錠 | |
| US5534551A (en) | Aminoguanidine spray drying process | |
| IL274306B1 (en) | Method for the formulation of oil-soluble substances, and powders obtainable thereof | |
| JP2002037727A (ja) | 脂溶性薬物を配合した速崩性固形製剤及びその製造方法 | |
| JPH08157362A (ja) | 油性物質含有固形製剤の製法 | |
| JP2506812B2 (ja) | 水分散性の良いビタミンｅ含有粉末 | |
| JPH03161448A (ja) | 油脂含有組成物 | |
| JP2011037767A (ja) | 薬物および噴霧乾燥粒子を含有する口腔内速崩壊錠 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050906 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050907 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20060711 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090706 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20091216 |